Tdark CSNK2A3 Casein kinase II subunit alpha 3

Protein Summary

Description

Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q8NEV1
• CK II alpha 3

Gene Name

• CSNK2A3

Ensembl ID

• ENST00000528848
• ENSP00000473553
• ENSG00000254598

Symbol

• CSNK2A1P
• CSNK2A1P

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
tissue	0.76
cellular component	0.75
protein domain	0.73
tissue sample	0.47

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Ck2 Family / Casein Kinase Ii Subunit Alpha 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.86   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 11   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.86   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0