Tchem | Casein kinase II subunit alpha' |
This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]
Comments
Property Summary
Ligand Count | 100 |
NCBI Gene PubMed Count | 174 |
PubMed Score | 221.26 |
PubTator Score | 26.07 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Carcinoma, Squamous Cell | 110 | 0.0 | 0.0 |
Skin Neoplasms | 69 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Squamous cell carcinoma | 129 |
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8520 | 9.6e-08 |
diabetes mellitus | 1728 | 1.4e-03 |
psoriasis | 6694 | 5.0e-03 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.5e-03 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.3e-02 |
Disease | log2 FC | p |
---|---|---|
diabetes mellitus | -1.100 | 1.4e-03 |
intraductal papillary-mucinous carcinoma... | -1.100 | 5.5e-03 |
intraductal papillary-mucinous neoplasm ... | -1.100 | 1.3e-02 |
ovarian cancer | -1.700 | 9.6e-08 |
psoriasis | 1.200 | 5.0e-03 |
Accession | P19784 CK II alpha' |
Symbols |
CK2A2 CSNK2A1 CK2alpha' |
CHEMBL3699249
pIC50 7.60
CHEMBL1928905
pKi 7.62
CHEMBL1233807
pKi 7.68
CHEMBL3699246
pIC50 7.68
CHEMBL595730
pKi 7.68
CHEMBL3699298
pIC50 7.71
CHEMBL3759193
pIC50 7.72
CHEMBL3699299
pIC50 7.80
CHEMBL3699243
pIC50 7.81
CHEMBL475251
pKd 7.85
CHEMBL3758777
pIC50 7.85
CHEMBL3758895
pIC50 7.89
CHEMBL3760064
pIC50 7.92
CHEMBL3758270
pIC50 7.92
CHEMBL2087023
pIC50 7.96
CHEMBL3760009
pIC50 7.96
CHEMBL3759349
pIC50 7.96
CHEMBL1230165
pIC50 7.96
CHEMBL3758519
pIC50 8.00
CHEMBL3759755
pIC50 8.00
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKI 1 - 70 LKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 71 - 140 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 141 - 210 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK 211 - 280 RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 281 - 350 //