| Tclin | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Pulmonary alveolar proteinosis, congenital | 2 |
| Schizophrenia | 1160 |
| Disease | Target Count |
|---|---|
| Chemotherapy-induced neutropenia | 3 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 2.6e-81 |
| lung carcinoma | 2843 | 2.0e-27 |
| malignant mesothelioma | 3232 | 3.8e-07 |
| tuberculosis | 2010 | 1.3e-05 |
| Astrocytoma, Pilocytic | 3081 | 3.5e-05 |
| osteosarcoma | 7950 | 2.9e-04 |
| lung cancer | 4740 | 4.0e-04 |
| medulloblastoma, large-cell | 6241 | 3.4e-03 |
| cutaneous lupus erythematosus | 1057 | 4.0e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.0e-02 |
| glioblastoma | 5792 | 3.5e-02 |
| interstitial cystitis | 2312 | 3.6e-02 |
| Disease | Target Count |
|---|---|
| Surfactant Metabolism Dysfunction, Pulmonary, 4 | 1 |
| Disease | log2 FC | p |
|---|---|---|
| Astrocytoma, Pilocytic | 1.300 | 3.5e-05 |
| cutaneous lupus erythematosus | 1.100 | 4.0e-03 |
| glioblastoma | 1.400 | 3.5e-02 |
| interstitial cystitis | 1.300 | 3.6e-02 |
| lung cancer | -1.300 | 4.0e-04 |
| lung carcinoma | -2.000 | 2.0e-27 |
| malignant mesothelioma | 3.500 | 3.8e-07 |
| medulloblastoma, large-cell | -1.100 | 3.4e-03 |
| osteosarcoma | -2.307 | 2.9e-04 |
| psoriasis | 1.300 | 2.6e-81 |
| subependymal giant cell astrocytoma | 1.283 | 1.0e-02 |
| tuberculosis | -1.100 | 1.3e-05 |
MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVV 1 - 70 EPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWAR 71 - 140 GPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLL 141 - 210 DTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENR 211 - 280 YNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFL 281 - 350 RIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT 351 - 400 //
