Tbio CSF1 Macrophage colony-stimulating factor 1

Protein Summary

Description

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P09603
• A8K6J5
• Q13130
• Q14086
• Q14806
• Q5VVF3
• Q5VVF4
• Q9UQR8
• CSF-1

Gene Name

• CSF1

Ensembl ID

• ENST00000329608
• ENSP00000327513
• ENSG00000184371
• ENST00000369801
• ENSP00000358816
• ENST00000369802
• ENSP00000358817
• ENST00000420111
• ENSP00000407317

Symbol

• MCSF
• CSF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
biological term	0.93
PubMedID	0.93
transcription factor perturbation	0.91
disease perturbation	0.9

Protein Classes

DTO Classes

Macrophage Colony-stimulating Factor 1 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2057.19   (req: < 5)

Gene RIFs: 206   (req: <= 3)

Antibodies: 753   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2057.19   (req: >= 5)

Gene RIFs: 206   (req: > 3)

Antibodies: 753   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0