Property Summary

NCBI Gene PubMed Count 32
PubMed Score 316.00
PubTator Score 1035.36

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (2)

Disease log2 FC p
psoriasis -1.500 1.1e-04
osteosarcoma -1.740 1.4e-05

Protein-protein Interaction (7)

Gene RIF (9)

PMID Text
26361074 Paretic muscle in hemiparetic stroke survivors had lower CS concentration.
23139858 The citrate synthase knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production, but great increases in glycolytic metabolism.
22485150 Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression.
20877624 Observational study of gene-disease association. (HuGE Navigator)
19479947 These results provide an important basis for the study of mitochondrial dysfunction due to aberrant CSa trafficking.
17298551 Observational study of gene-disease association. (HuGE Navigator)
15714131 It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis.
15711981 possible role of CS-specific autoantibodies in the pathomechanism of allograft vasculopathy
12531911 Responses of skeletal and cardiac muscles in CS activity and gene expression at 1 and 48 h after endurance training. Acute effect of exercise on training-induced elevation in CS activity in rat soleus but not ventricle muscles.

AA Sequence

MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYG      1 - 70
GMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKE     71 - 140
WAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLP    141 - 210
CVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGS    211 - 280
ALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVL    281 - 350
RKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY    351 - 420
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG                            421 - 466
//

Text Mined References (37)

PMID Year Title
26361074 2016 Skeletal muscle fiber characteristics and oxidative capacity in hemiparetic stroke survivors.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23456168 2013 Genome-wide association study in Han Chinese identifies three novel loci for human height.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23139858 2012 Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22485150 2012 Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor ? (ROR?).
21630459 2011 Proteomic characterization of the human sperm nucleus.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20833797 2011 Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19479947 2009 Identification and characterization of the mitochondrial targeting sequence and mechanism in human citrate synthase.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17298551 2007 Single nucleotide polymorphisms in succinate dehydrogenase subunits and citrate synthase genes: association results for impaired spermatogenesis.
16751257 2006 Housekeeping genes for phylogenetic analysis of eutherian relationships.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15714131 2005 Enhanced citrate synthase activity in human pancreatic cancer.
15711981 2005 Detection of citrate synthase-reacting autoantibodies after heart transplantation: an epitope mapping study.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15242332 2004 Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
14760703 2004 Proteomic identification of brain proteins that interact with dynein light chain LC8.
14743216 2004 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12549038 2000 [Cloning and tissue expression pattern analysis of the human citrate synthase cDNA].
12531911 2003 Citrate synthase expression and enzyme activity after endurance training in cardiac and skeletal muscles.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12198136 2002 Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex.
11377425 2001 Interaction of human recombinant alphaA- and alphaB-crystallins with early and late unfolding intermediates of citrate synthase on its thermal denaturation.
9809442 1998 Cloning and molecular analysis of the human citrate synthase gene.
9792662 1998 Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate.
9543345 1998 Human mitochondrial function during cardiac growth and development.
7285903 1981 Demonstration of physical interactions between consecutive enzymes of the citric acid cycle and of the aspartate-malate shuttle. A study involving fumarase, malate dehydrogenase, citrate synthesis and aspartate aminotransferase.
318158 1978 Chromosomal assignment and regional localization of CS, ENO2, GAPDH, LDHB, PEPB, and TPI in man-rodent cell hybrids.