Property Summary

NCBI Gene PubMed Count 11
PubMed Score 26.56
PubTator Score 7.25

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (10)

Disease log2 FC p
nephrosclerosis -1.224 5.2e-03
malignant mesothelioma -1.600 9.3e-07
osteosarcoma -1.215 3.1e-02
sonic hedgehog group medulloblastoma -1.600 3.4e-04
medulloblastoma, large-cell -1.400 4.0e-03
adrenocortical carcinoma -1.086 2.2e-04
pancreatic ductal adenocarcinoma liver m... -2.168 3.0e-03
active Crohn's disease -1.100 1.2e-02
ulcerative colitis -1.400 3.0e-05
ovarian cancer -2.100 1.1e-10

Synonym

Accession Q9Y2S2 A0PJ43 B3KN92 Q0VDI1 Q7Z4Z9 Q9P0G7
Symbols GDH
HEL30
lambda-CRY

Gene

PANTHER Protein Class (2)

PDB

3F3S  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (1)

PMID Text
3170592 rabbit lambda-crystallin constitutes 7-8% of total lens protein

AA Sequence

MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEE      1 - 70
QLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQ     71 - 140
CIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLV    141 - 210
EEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKV    211 - 280
NQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ                                   281 - 319
//

Text Mined References (14)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23648065 2013 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
21269460 2011 Initial characterization of the human central proteome.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.
15809331 2005 Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057823 2004 The DNA sequence and analysis of human chromosome 13.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12527201 2003 Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
3170592 1988 Lambda-crystallin, a major rabbit lens protein, is related to hydroxyacyl-coenzyme A dehydrogenases.