| Tbio | Cytotoxic and regulatory T-cell molecule |
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 5.9e-19 |
| osteosarcoma | 7950 | 3.4e-05 |
| primary Sjogren syndrome | 735 | 5.1e-05 |
| ependymoma | 4679 | 1.5e-04 |
| gastric cancer | 459 | 1.4e-03 |
| cutaneous lupus erythematosus | 1057 | 2.0e-03 |
| lung cancer | 4740 | 2.7e-03 |
| subependymal giant cell astrocytoma | 2287 | 3.1e-03 |
| interstitial cystitis | 2312 | 9.2e-03 |
| glioblastoma | 5792 | 1.1e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.1e-02 |
| medulloblastoma | 720 | 4.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.700 | 2.1e-02 |
| cutaneous lupus erythematosus | 2.500 | 2.0e-03 |
| ependymoma | -1.800 | 1.5e-04 |
| gastric cancer | 1.100 | 1.4e-03 |
| glioblastoma | -1.400 | 1.1e-02 |
| interstitial cystitis | 1.600 | 9.2e-03 |
| lung cancer | -1.900 | 2.7e-03 |
| medulloblastoma | -1.700 | 4.1e-02 |
| non-small cell lung cancer | -1.768 | 5.9e-19 |
| osteosarcoma | -2.873 | 3.4e-05 |
| primary Sjogren syndrome | 2.200 | 5.1e-05 |
| subependymal giant cell astrocytoma | -5.341 | 3.1e-03 |
MWWRVLSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSK 1 - 70 YQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLM 71 - 140 CSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKLVA 141 - 210 PFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLG 211 - 280 LARKKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEKNGQ 281 - 350 SSHPMRCMNYITKLYSEAKTKRKENVQHSKLEEKHIQVPESIV 351 - 393 //
