Property Summary

NCBI Gene PubMed Count 1,722
PubMed Score 33883.52
PubTator Score 27912.77

Knowledge Summary


No data available


  Disease (5)

Disease Target Count Z-score Confidence
Cardiovascular system disease 194 0.0 2.0
Disease Target Count Z-score Confidence
systemic lupus erythematosus 172 0.0 5.0
Disease Target Count Z-score Confidence
diabetes mellitus 1663 6.934 3.5
Hypertension 293 6.4 3.2
Kidney disease 397 6.26 3.1
Cerebrovascular disease 231 6.194 3.1
Pneumonia 133 6.088 3.0
Heart disease 279 6.07 3.0
Appendicitis 18 5.995 3.0
Crohn's disease 304 5.915 3.0
Ankylosing spondylitis 138 5.85 2.9
Anemia 252 5.667 2.8
Lipid metabolism disorder 102 5.63 2.8
Vasculitis 64 5.598 2.8
Cancer 2346 5.442 2.7
Osteomyelitis 20 5.387 2.7
ulcerative colitis 2087 5.369 2.7
Septic arthritis 8 5.291 2.6
Hypersensitivity reaction type II disease 235 5.252 2.6
Pancreatitis 97 5.234 2.6
Chronic obstructive pulmonary disease 147 5.176 2.6
Kawasaki disease 24 5.075 2.5
Obstructive sleep apnea 28 5.006 2.5
Acute cystitis 37 4.942 2.5
Synovitis 72 4.903 2.5
tuberculosis 1563 4.838 2.4
Arthropathy 34 4.817 2.4
Leukopenia 42 4.738 2.4
Epidural abscess 2 4.699 2.3
Psoriatic arthritis 85 4.681 2.3
Osteoarthritis 96 4.65 2.3
Polycystic Ovary Syndrome 334 4.632 2.3
Peripheral artery disease 8 4.564 2.3
Peritonitis 37 4.522 2.3
Takayasu's arteritis 54 4.491 2.2
Diarrhea 155 4.442 2.2
Collagen disease 25 4.431 2.2
Chorioamnionitis 15 4.402 2.2
Exanthem 39 4.364 2.2
Liver disease 219 4.355 2.2
Fatty liver disease 86 4.3 2.2
Hyperglycemia 120 4.273 2.1
Pyuria 6 4.261 2.1
Myopathy 128 4.255 2.1
Diverticulitis 8 4.207 2.1
Peripheral vascular disease 90 4.066 2.0
Cholecystitis 8 4.065 2.0
adult-onset Still's disease 6 4.061 2.0
Respiratory failure 30 4.018 2.0
Rheumatic fever 16 4.001 2.0
Aortic aneurysm 34 3.941 2.0
Influenza 142 3.936 2.0
Thrombocytopenia 105 3.928 2.0
Aortitis 4 3.893 1.9
Pericarditis 14 3.854 1.9
Pelvic inflammatory disease 21 3.831 1.9
Hyperhomocysteinemia 34 3.83 1.9
Human immunodeficiency virus infectious disease 129 3.821 1.9
Tonsillitis 18 3.794 1.9
Cellulitis 13 3.771 1.9
Brucellosis 24 3.731 1.9
Mediastinitis 7 3.73 1.9
Transient cerebral ischemia 14 3.716 1.9
Bacteriuria 13 3.7 1.8
Amyloidosis 68 3.644 1.8
Bronchitis 44 3.642 1.8
Asthma 349 3.63 1.8
Hypothyroidism 89 3.618 1.8
Major Depressive Disorder 106 3.591 1.8
Pharyngitis 17 3.565 1.8
Hyperuricemia 35 3.543 1.8
Gout 93 3.532 1.8
Pulmonary Embolism 45 3.513 1.8
Dementia 129 3.496 1.7
Intestinal obstruction 16 3.484 1.7
Osteoporosis 259 3.484 1.7
Pleural empyema 10 3.481 1.7
Reactive arthritis 7 3.481 1.7
Intermittent claudication 16 3.469 1.7
Pericardial effusion 10 3.469 1.7
Perinatal necrotizing enterocolitis 18 3.405 1.7
interstitial lung disease 292 3.392 1.7
Limb ischemia 12 3.375 1.7
cystic fibrosis 1670 3.374 1.7
Uveitis 103 3.371 1.7
Thrombophilia 37 3.347 1.7
Brain disease 84 3.331 1.7
protein-energy malnutrition 8 3.324 1.7
Gastroenteritis 46 3.305 1.7
Bronchiectasis 29 3.239 1.6
Chlamydia 18 3.227 1.6
Subacute thyroiditis 5 3.217 1.6
Hyperinsulinism 63 3.205 1.6
Cervical adenitis 3 3.201 1.6
Necrotizing fasciitis 9 3.2 1.6
Urticaria 53 3.198 1.6
Vesicoureteral reflux 28 3.184 1.6
Neuropathy 210 3.141 1.6
Funisitis 8 3.117 1.6
Neurodegenerative disease 383 3.057 1.5
Hyperandrogenism 32 3.052 1.5
Subdural empyema 7 3.044 1.5
Epididymitis 7 3.042 1.5
Age related macular degeneration 84 3.02 1.5
Henoch-Schoenlein purpura 13 3.008 1.5
Bilirubin metabolic disorder 39 3.006 1.5


  Differential Expression (2)

Gene RIF (1776)

27333717 CPR level was correlated with COPD severity.
27295905 Increased serum and drainage fluid CRP after colorectal anastomosis is associated with anastomotic leak.
27096761 The study simultaneously evaluated both PCT and soluble TREM-1 along with CRP in febrile patients with autoimmune diseases.
27049070 serum levels of c-reactive protein (CRP) and [acutephysiology and chronic health evaluation II score and sequential organ failure assessment score, functional independence measure and Barthel index of activities of daily living, were assessed.
27044366 Neutrophilic asthma patients had raised CRP compared to eosinophilic asthma patients and controls.
27022914 high levels of PAI-1 are detected when D allele is present, whereas greater interdialytic gain is associated with the presence of I allele.
26963617 cardioprotective effects of metformin might be especially effective in diabetic patients with high levels of CRP.
26942752 CRP is a poor predictor of the occurrence of microbial invasion of the amniotic cavity and histological chorioamnionitis, even at early gestational ages.
26871443 Inverse association has been found between plasma IgG antibody to Aggregatibacter actinomycetemcomitans and high CRP levels in patients with metabolic syndrome and periodontitis.
26850725 ANGPTL8 is increased in subjects with MetS and it was significantly associated with HsCRP levels in different subgroups.
26832367 Elevated C-reactive protein serum levels predict subsequent joint damage in inflammatory polyarthritis.
26824043 People with new-onset diabetes mellitus based on HbA1c had higher mean hs-CRP level.
26817828 Serum CRP was higher in patients with non-dipping essential hypertension compared to dipping hypertension and controls.
26771969 Report prolonged post-PCI inflammatory reaction, reflected by elevated CRP, and increased thrombin generation.
26728665 High serum CRP levels are associated with recurrence in hepatocellular carcinoma.
26721294 Chronic low-level CRP increases were associated with increased risk of bacterial infections, gram-negative infections in particular.
26718567 CRP-associated SNPs and CRP levels are significantly associated with risk of ischemic stroke and recurrent stroke.
26700933 We found that elevated levels of estradiol and SHBG in HT [Hormone therapy] users were associated with elevated levels of CRP and lower levels of TFPI, both of which may be related to a prothrombotic milieu in HT [Hormone therapy ]users.
26698253 high-sensitivity C-reactive protein concentration can be an indicator of diabetic nephropathy in diabetes mellitus patients.
26665555 Serial measurement of CRP is recommended for screening of infectious complications of colorectal resection.
26635226 appears to be related with current treatment Health-related quality of life appears to be related to positive sputum smear or culture within the previous year, and particularly CRP and age
26625129 Association of Irisin and CRP Levels with the Radiographic Severity of Knee Osteoarthritis.
26607724 Role of CRP in the pathogenesis of atherosclerosis
26579988 Elevated CRP was associated with fatigue, appetite changes, and sleep problems in depression.
26576922 concentrations of the C-reactive protein, myeloperoxidase and soluble CD40 ligand taken from peripheral vein were closely similar to the concentration found in coronary blood of ACS patients
26566216 C-reactive protein stratified the outcomes, systemic weakness, and pancreatic tumor burden. C-reactive protein is an indicator of the aggressiveness of advanced PCa.
26559885 hypothesize that ACS should not be prepared and administered if elevated C-reactive protein (CRP) levels are present at the moment of obtaining the patient's blood because of the potential detrimental effect.
26530188 Data indicate that antecedent C-reactive protein (CRP) was associated with future serum albumin.
26525102 genetic association study in Quebec City population: Data suggest total plasma n-6 fatty acid phospholipid levels and C-reactive protein are modulated by SNPs in PLA2G4A and PLA2G6 alone or in combination with fish oil dietary supplementation.
26497374 results support an important association between rs1800206 minor allele (V) of PPAR alpha and lower CRP level; the interaction analysis showed a combined effect between rs1800206 and rs135539 on the lower CRP level
26474473 Serum hs-CRP levels were consistently lower in the high ADPN group during 2-year follow-up
26473826 C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism is associated with Aortic Valve Calcification in Patients with Aortic Stenosis.
26458341 An analysis of the hsCRP level from the control arms of case-control studies derived a mean hsCRP value of 1.88 mg/l, which is higher than the western population where values < 1 mg/l are classified as low cardiovascular risk
26456189 The inflammatory (INF) group exhibited changes in metabolic parameters that predispose this group to chronic disease, where CRP gene polymorphisms modulated the risk of being in the INF group depending on individual plasma fatty acid and lipid profile.
26453329 The coupling between IL-6 and CRP requires increased adiposity, likely through release of IL-6 by visceral fat
26451493 Vigorous physical activity was associated with lower odds of having an elevated serum C-reactive protein level.
26434105 The C-reactive protein level on postoperative day 3 is a valuable predictor of anastomotic leakage after esophagectomy and might allow for earlier management of this complication.
26425690 Two of these proteins were verified in a separate patient cohort: values of CRP and LRG1 combined gave a highly significant indication of extended survival post one week of radiotherapy treatment.
26391131 Elevated hsCRP levels were associated with a greater risk of total stroke, even after adjustment for potential confounders and cardiovascular risk factors.
26390126 Data show that patients with a c-reactive protein/albumin ratio (CRP/Alb ratio) > 0.50 had worse survival than patients with a CRP/Alb ratio </= 0.50.
26357470 The levels of CRP in the stable COPD patients were not significantly different when compared to those in the control subjects. Female sex and FVC (% predicted) were associated with CRP levels greater than 3 mg/dL in the COPD group.
26354559 A significant association was found between high-sensitive C-reactive protein and pruritus in uremic hemodialysis patients.
26351389 CRP levels are higher after surgery in Crohn's disease patients compared with colorectal cancer patients.
26348353 This study is the first to show that, in addition to gender and BMI, also a leading SNP in ANRIL is explanatory for inter-individual variation in hsCRP levels in periodontitis patients of North European descent.
26339617 CRP and Alb are both promising biomarkers in identification of non-small cell lung cancer patients with poor prognosis and form a possible target for intensifying their therapies.
26339423 High serum level of hsCRP is an independent risk factor of short-term progression to NASH in patients with NIDDM and NAFLD.
26310275 Our results suggest that CRP genetic polymorphism is a novel risk predictor of lymphatic metastasis
26308525 High plasma C-Reactive Protein Concentrations were associated with motor deterioration in Parkinson Disease.
26302926 The association with Serum-Copper remained statistically significant following further adjustment for hs-CRP in the same model.
26299079 Erythrocyte sedimentation rate and C-reactive protein levels could be used in the differential diagnosis of papillary thyroid carcinoma and nodular goiter.
26283879 serum high-sensitivity C-reactive protein is higher in patients with Alzheimer's Disease than controls
26280117 Elevated C-reactive protein levels were predictive of outcome after aneurysmal subarachnoid hemorrhage.
26271020 Among adrenomedullin, CRP, and PCT, procalcitonin demonstrates the highest correlation with the severity of infection.
26266345 CRP genetic variants previously reported to influence circulating c-reactive protein may not be linked to the development of coronary artery disease.
26260869 Plasma CRP levels were significantly associated with the presence and severity of lower extremity arterial disease in patients with type 2 diabetes mellitus.
26256894 Suggest that high CRP related cardiovascular risk in greater in women than men.
26247033 Our study highlights the utility of the CRP levels in early prediction of DSS and severe dengue in adult patients.
26241961 we identify higher levels of CRP, eotaxin and MCP-1 in serum of periodontitis patients
26232108 This study, besides defining a serum panel for glioblastoma discrimination, identified IL1beta as a potential candidate for developing targeted therapy.
26229958 This meta-analysis identified seven cohort studies (2006~2013), providing information on the change in serum hs-CRP levels in atrial fibrillation patients receiving atorvastatin therapy.
26226010 This study investigates the association of CRP (C-reactive protein) single-nucleotide polymorphisms (SNPs) with plasma CRP levels and radiographic severity in African Americans with early and established rheumatoid arthritis
26222902 Carriers of the CCR5-Delta32 deletion had normal CRP levels but a borderline significant increased risk of cardiovascular diseases.
26218286 High C-Reactive Protein Levels are associated with the risk of death in Parkinson Disease.
26208640 follow-up C-reactive protein showed better predictive properties for outcome parameters compared to C-reactive protein assessed upon admission or within 24 h
26202142 Thrombocytosis and Raised CRP Levels Predicts Advanced Stage in Esophageal Carcinoma.
26177029 obesity and sarcopenic obesity are associated with increased levels of serum hs-CRP among males.
26161003 BDNF may have a protective role in counteracting the inflammatory effects of hsCRP.
26146067 plasma levels of chemerin and CRP are elevated in patients with acute coronary syndrome
26130785 High sensitivity-CRP may be used as a marker for intracranial and/or extracranial artery occlusion.
26125767 YKL-40 and CRP can be used to evaluate the effects of sepsis treatment.
26106150 Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.
26106052 Mean levels of plasma C-reactive protein were higher in schizophrenia patients compared to controls.
26098322 The combination of C-reactive protein levels and intraplaque neovascularization detected by contrast-enhanced ultrasound may allow more accurate evaluation of carotid atherosclerotic plaque stability.
26096228 serum miR-145 was strong positively correlated with plasma hs-CRP and moderate positively correlated with serum IL-6 in acute ischemic stroke patients.
26088452 the results of the conducted retrospective study suggest that high baseline level of CRP was independently associated with worse outcome of patients with advanced-stage NSCLC treated with erlotinib
26080030 serum zinc levels may be inversely related to inflammatory markers (IL-6, TNF-alpha, and CRP)
26079659 levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
26077975 Platelet activation markers are associated with Crohn's disease activity in patients with low C-reactive protein.
26063371 The promoter SNPs in CRP gene, CRP -717A > G and -286C > T > A gene polymorphisms, were proposed as possible biomarkers and suggested to be used to predict ischemic stroke in some researches.
26060162 There was no difference in CRP level between patients with complicated and uncomplicated appendicitis, and non-appendicitis abdominal pain.
26058824 Results show overexpression of CRP in 73.3% of patients with HBV-hepatocellular carcinoma (HCC) and suggest CRP as a diagnostic biomarker for alpha-fetoprotein(-) HBV-related HCC.
26046926 CRP level was not significantly different in neutropenic systemic inflammatory response syndrome patients and sepsis patients.
26044709 CRP was higher in diabetic hypertensive subjects as compared with nondiabetic subjects with and without hypertension.
26043285 Data suggest that overweight is the only significant factor affecting up-regulation of follicular and luteal phase C-reactive protein serum levels in adolescents with type 1 diabetes relative to controls; studies were conducted in Chile.
26032849 High CRP and bilirubin serum levels have a prognostic association with in-hospital MACE in male patients with STEMI.
26026588 High pretreatment serum CRP level predicts a poor long-term prognosis for small-cell lung cancer, which should be considered in defining the prognosis with other prognosticators in C-SCLC patients.
26026118 In our study, an increase in serum CRP level and decrease in serum albumin levels were correlated with the presence of peritoneal metastasis
26025192 Blood CRP level is not associated with chronic kidney disease.
26021292 Report association between elevated expression of P2X7 receptor in monocytes and high serum CRP and cytokine levels in type 2 diabetics.
26018813 C-reactive protein is increased in saliva of COPD patients compared to controls.
26013149 Intraoperative synovial C-reactive protein is as useful as frozen section to detect periprosthetic hip infection.
26013044 CRP variants that influenced circulating CRP levels in chronic inflammatory conditions are also associated with RPL, pointing to CRP as RPL candidate gene.
25999661 Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population.
25994228 Change in CRP over 13 years was to a similar extent positively associated with increase in HbA1c in type 2 diabetic patients. Evidence suggests that systemic inflammation may have a role in development of type-2 diabetes and its complications.
25993353 the risk genotype of CRP rs1205 gene is associated with the development of hypercholesterolemia
25991421 using pre-storage and post-storage leukoreduction methods in erythrocyte transfusions did not change CRP or IL-6 levels, which are indicators of acute-phase response.
25990058 analysis of the decrease in CRP level without changes in TNF-alpha or IL-6 concentrations after the low-calorie diet and balneological treatment
25986475 Thus, serum CRP level has an important prognostic significance in patients with osteosarcoma, and high CRP level is associated with worse overall survival.
25982004 urinary magnesium and serum C-reactive protein may have a role in hypomagnesuria in obese women
25974422 Higher serum levels of C-reactive protein were associated with cerebral small vessel disease.
25970741 Data suggest baseline levels of adiponectin, CRP, tissue plasminogen activator, and fibrinogen or changes in these levels do not explain increased risk of diabetes type 2 in overweight women with glucose intolerance and histories of gestational diabetes.
25963492 Our results showed PCT as a valuable marker of bacterial infections in febrile patients. PCT was superior to CRP, IL-6 or SAA in the early identification of bacterial infection
25957466 Maternal blood IL-6 and CRP levels were elevated in women with subclinical intra-amniotic infection.
25935447 Present meta-analysis evaluates the diagnostic value of CRP to rule out postoperative infectious complications following major abdominal surgery, aiding patient selection for early discharge.
25926728 C-reactive protein/procalcitonin could not differentiate between bacterial and viral infections in patients with COPD exacerbation requiring ED visits.
25922147 There was a direct association between exceeding established postoperative day 2, 3 and 4 CRP thresholds and the severity of complications defined by the Clavien-Dindo grade.
25921150 Plasma CRP is significantly increased in hypertensive patients with impaired glucose tolerance compared to hypertensive patients without impaired glucose tolerance and controls.
25917100 CRP also directly contributes to adaptive immunity, that is, native CRP binds specifically to human Jurkat T cells and to mouse naive CD4(+) T cells and modulates their Th1 and Th2 responses
25916065 Serum high-sensitivity C-reactive protein may be a marker for diagnosing significant fibrosis in patients with chronic hepatitis B, and can reflect the severity of liver damage.
25916049 Suggest that an increase in CRP levels alone is not a predictor for postoperative ileus following surgery for colorectal surgery.
25913621 High C-reactive protein expression is associated with metastatic bone and soft tissue sarcoma.
25911075 Cardiometabolic risk factors such as TC-to-HDL-C ratio correlate with hs-CRP levels in children and adolescents. Long-term prospective studies are needed to confirm the association between hs-CRP and cardiometabolic risk in children
25903822 Elevated CRP was associated with myocardial infarction in rheumatoid arthritis patients.
25893544 Icosapent ethyl (eicosapentaenoic acid ethyl ester) significantly lowered hsCRP levels in patients with metabolic syndrome.
25889630 CRP could play an important role in the bony destructive process in RA through the induction of RANKL expression and direct differentiation of osteoclast precursors into mature osteoclasts.
25887518 CRP rs2808629 was associated with Diabetic retinopathy in the Chinese patients with type 2 diabetes.
25886998 Lipid pool area detected by IB-IVUS is correlated positively with the translesional hs-CRP level in coronary plaques.
25879749 enhances activation of coagulation in anca-associated vasculitis
25874450 Elevated serum hs-CRP levels were correlated with poor survival for NPC patients in the IMRT era, playing a complementary role to TNM stage and EBV DNA
25864110 CRP suppresses expression of N-cadherin (p < 0.01), a mesenchymal marker of EMT, and ZEB-1, an EMT-related transcription factor (p < 0.01). These findings suggest that CRP inhibits EMT in a MCA-38 tumor-bearing mouse model.
25855626 High CRP is associated with increased risk of Epithelial Ovarian Cancer.
25854969 No association was found between CRP level and severity of coronary artery disease.
25832424 CRP stimulated the expression of RAGE in coronary artery endothelial cells, accompanied by markedly increased ROS generation, phosphorylation of ERK1/2 and NF-kappaB p65, as well as translocation of NF-kappaB p65 to the nuclei.
25829237 Adolescents with less educated parents tended to have higher levels of CRP, which may be explained by their lower levels of positive affect.
25827033 rs1130864 was significantly associated with increased PTSD symptoms, odds of PTSD diagnosis, and CRP level.
25822970 In IL-18 -137 (G/C) polymorphism homozygous GG is significantly associated with occurrence of coronary artery disease and CRP levels were significantly higher in GG genotype subjects when compared to GC and CC.
25821796 Levels of anti-CCP and CRP are associated with increased cIMT and cardiovascular risk supporting a clinical role of the measurement of cIMT in RA in predicting and preventing cardiovascular events.
25817719 CRP immunoreactivity was detected in the syncytiotrophoblast.CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.
25809368 CRP values can be used as an independent marker of endovascular therapy outcome.
25804952 Elevated serum level of CRP were associated with metabolic syndrome.
25804556 the number of supportive family members predicted lower hs-CRP levels, whereas the number of ambivalent family members predicted higher.
25781366 Serum CRP was higher in Crohn's disease patients with endoscopic recurrence after ileocolonic resection when compared with those in endoscopic remission.
25768928 association between CRP and cardiometabolic phenotypes
25735198 Pooled results from published data indicate that increased CRP levels are associated with overall survival in prostate cancer patients.
25711952 However, average levels of CRP at baseline were relatively low, so it remains possible that AF patients with higher levels of CRP may benefit from CRP-directed therapy.
25708781 CRP is useful parameter in reflecting patient's physical mobility in ankylosing spondylitis.
25697203 Procalcitonin, like C-reactive protein, is elevated in bacterial gastroenteritis (p=0.001), but these markers are not a predictor of hospitalization.
25691533 Plasma copeptin, CRP and procalcitonin concentrations were positively correlated with APACHE II score in patients with sepsis, and reflected disease severity.
25690104 Authors conclude that both phosphocholine-dependent and phosphocholine-independent mechanisms are involved in the CRP-mediated decrease in bacteremia and the resulting protection of mice against pneumococcal infection.
25682033 mCRP is increased in acute myocardial infarction; circulating mCRP might be a potential biomarker for its diagnosis and severity assessment
25658658 Losses in total lean body mass are independently associated with improvements in inflammatory state (CRP levels) in obese postmenopausal women with impaired glucose disposal.
25651736 Delta neutrophil index has a high diagnostic power for predicting sepsis and survival, similar to procalcitonin and better than CRP.
25651728 The integration of the serum concentrations of SAA, CRP and apo A-I into an acute phase index (API) offers an opportunity to triage diabetic foot patients who may benefit from personalized medicine.
25651710 Neither serum nor gingival crevicular fluid levels of hs-CRP differed with disease severity in chronic periodontitis.
25636121 Elevated C-reactive protein at diagnosis was associated with a higher risk of progression to surgery in patients with Crohn's disease.
25618827 Elevated plasma CRP (8.6mgl(-1)) has been identified as a prognostic factor for poor CSS, OS and DFS in prostate cancer patients undergoing radiotherapy.
25613713 The main findings of this study are that, in acute stroke patients, levels of LBP, IL-10, IL-6 and CRP show a different time course in patients with and without post-stroke infection.
25604866 C-reactive protein (hsCRP) has a role in change in mammographic density over time
25603416 Genetic polymorphisms may play role in variations of CRP levels in patients with ankylosing spondylitis.
25603415 rs1130864 and rs1417938 were associated with decreased risk of depression in women. rs1205 was found to be nominally associated with both an increased risk of depression and lower circulating CRP levels in women.
25596909 Data suggest serum CRP is up-regulated during first trimester in women who will undergo early pregnancy failure; however, it is unclear whether CRP level can serve as biomarker for threatened spontaneous abortion, at least in spontaneous pregnancy.
25594234 C-reactive protein/erythrocyte sedimentation rate disagreements are common in inflammatory/infectious diseases.
25552313 Results show that CRP harbours a decameric conformation in different crystal assemblies and cristallization conditions. In the presence of Tat, its involves zinc ions The zinc ions increasing the stability of the decamer.
25552313 The dimeric pentamers of CRP are stabilized by two zinc ions trapped within a cleft of the effector face of CRP in the presence of HIV-1 Tat protein
25548320 the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vitro
25542737 Patients with non-affective psychosis had significantly higher hsCRP levels than controls.
25526927 Neuromyelitis spectrum disorder patients with spinal cord atrophy have significantly higher levels of CRP than those without spinal cord atrophy.
25501922 Results suggest that CRP may be useful to identify inflammatory bowael disease patients who can benefit from first-line treatment with i.v. iron.
25492251 Admission serum hs-CRP level >9 mg/l is an independent predictor for acute kidney injury following primary percutaneous coronary intervention in ST elevation in myocardial infarction patients
25491624 COPD is associated with higher levels of serum CRP (and Bisphenol A).
25491620 There was a positive correlation between the serum levels of CRP and psoriasis score.
25470633 We observed strong association of C-Reactive Protein with diabetic retinopathy.
25467832 Concentrations of hs-TnT and hs-CRP are weakly associated with a significant increase in coronary artery disease burden and change in plaque composition over 24 months.
25463127 drug eluting stent polymers increase eosinophil cationic protein levels following percutaneous coronary intervention independently of C-reactive protein
25460573 High-sensitivity C-reactive protein is an independent risk factor for non-vertebral fractures in women and men
25449469 A novel link was found between high-sensitivity C-reactive protein and the impact of ABO blood group on coronary artery disease.
25436306 Higher initial serum CRP level is associated with lower mortality risk in pneumonia patients with liver cirrhosis.
25436282 Serum ghrelin level can be used with CRP as an important marker in establishing the mucosal damage in inflammatory bowel diseases.
25433580 data indicate that 30-day supplementation with 112 mg/day CFB (CFB-1) resulted in a significant reduction of LDL, TG, TC, IL-1beta, IL-6, MCP-1, and CRP.
25426618 C-reactive protein was the most influential factor in prescribing prophylactic antibiotics in acute pancreatitis.
25426616 The serum levels of IL-17, IL-23, and CRP are correlated with the severity of acute pancreatitis and represent valuable prognostic factors in the assessment of disease severity.
25411996 plasma IL-6 and serum CRP concentrations are more effective in predicting the severity of the clinical course in the early phase of LVAD therapy
25392126 Data suggest that ultrasensitive CRP levels in serum are up-regulated during luteal phase in healthy adolescents; urinary 2-hydroxyestrone levels are also up-regulated.
25380841 In hemodialysis patients, the inflammatory process alters hemoglobin level in converse correlation with CRP concentration with a linear relationship pattern.
25373740 In rheumatoid arthritis patients, C-reactive protein and erythrocyte sedimentation rate increased with age.
25364078 serum from OSA alters endothelial cell repair function and activates monocyte migration--partly driven by VEGF and CRP, suggesting an unfavorable balance between the pro-healing and pro-injury factors that may promote vascular injury in OSA
25359432 Data show that DAS28, the core parameter for inflammatory activity in rheumatoid arthritis (RA), can be used for clinical decision-making without adjustment for C-reactive protein (CRP) gene variants.
25354266 Juvenile Arthritis Disease Activity Score based on C-reactive protein level can be used in disease classification.
25351965 There was no significant difference in serum CRP between Kawasaki disease patients with or without pericardial effusion.
25344970 The prognostic utility of CRP increased later, after 48 hours of acute pancreatitis.
25340395 pre-operative C-reactive protein has a role in shorter survival, inflammation and prognosis in node-negative breast cancer patients
25338987 Elevated pretreatment serum CRP levels are associated with metastasis in esophageal cancer.
25336462 Elevated CRP was associated with the presence of COPD and respiratory symptoms (cough, wheezing).
25335739 In overall analysis, high circulating C-reactive protein (CRP) and interleukin-6 (IL-6) level were significantly associated with shorter OS in NSCLC
25331535 hs-CRP levels were not helpful in the prediction of methacholine bronchial hyper-responsiveness in children.
25329583 ). There was no statistically significant association between the primary outcome and baseline S-100B levels, baseline high-sensitivity C-reactive protein or interleukin-6 levels, or changes in high-sensitivity C-reactive protein or interleukin-6 levels.
25314633 The CRP variant rs2794521 shows a strong association with PE in Han Chinese women. Pregnant women with the TT genotype of rs2794521 have higher odds of having PE, which further supports a possible role for CRP in PE.
25306212 There was no relationship between CRP and secondhand smoke exposure (measured by hair nicotine) in children and adolescents.
25299643 The HF component of brachial artery diameter oscillation during FMD measurement correlated well with FMD and increased in the presence of elevated C-reactive protein levels in subjects with ischemic heart disease .
25296733 there was positive correlation (p < 0.0001) between those biomarkers and the tumor grades. We also noticed an association between VEGF and IL-8 as well as CRP and IL-6.
25286759 In conclusion, serum CRP level is useful to predict the prognosis of metastatic prostate cancer patients, and high serum CRP level is a significantly independent predictor of worse overall survival.
25277876 Decreased serum levels of CRP and hs-CRP may contribute to a more sensitive prediction in providing a more accurate efficacy reference in the metformin drug in Type 2 Diabetes Mellitus patients.
25260501 Higher serum CRP is associated with lower odds of experiencing high quality of life (QoL) when measured either emotionally or relationally, but people with more than 6 mg/L of serum CRP did not show an association between levels of CRP and QoL.
25230678 CRP was positively correlated with renal dysfunction in patients with myocardial infarction.
25222341 Soluble urokinase plasminogen activator receptor, but not high-sensitive C-reactive-protein, might have a role in coronary artery calcifications in healthy middle-aged subjects
25194730 Monomeric C-reactive protein is the major isoform present in local inflammatory lesions.
25190127 High C-Reactive Protein serum levels are associated with inflammation in hepatocellular carcinoma.
25187575 A novel rare CRP-coding variant (rs77832441-A; p.Thr59Met) was associated with 53% lower mean CRP levels.
25185422 CRP directly impacts proliferation of hPASMCs via modulation of Akt, ERK1/2, and NF-kappaB pathways
25172979 CRP and YKL-40 may have roles as biomarkers in diabetic retinopathy
25172166 There is a significant difference in the results between patients with negative and positive appendicitis with regards to CRP level (32 vs. 73; P < .001).
25171778 Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.
25170663 Elevated CRP on admission is an independent predictor of an unfavorable outcome and is only slightly associated with the clinical and radiological severity of the bleeding in primary intracerebral hemorrhage.
25159654 Both CRP and procalcitonin were significantly higher in patients with postoperative fistula or abscess after sleeve gastrectomy.
25158036 Elevated serum CRP was associated with increased ovarian cancer risk.
25155623 The ACE insertion/deletion genotype is significantly associated with CRP elevations during pregnancies complicated by disturbed uteroplacental dysfunction.
25153416 serum procalcitonin, interleukin 6, and C-reactive protein levels according to non-specific surgical stimulation
25145487 a large prospective colorectal adenoma chemoprevention study found no significant relationship between CRP levels and occurrence of adenomas, advanced neoplasms, or serrated polyps
25136879 Present the incremental predictive value of cystatin C over the creatinine-based MDRD formula on all-cause mortality for coronary artery disease patients undergoing PCI.
25132319 No significant associations of CRP level with frailty were observed in elderly men.
25123708 Preoperative C-reactive protein level >/= 0.5 mg/dL was an independent prognostic factor in patients undergoing gastrectomy for gastric cancer.
25105149 Smoking quantity is positively associated with type 2 diabetes and suggest that the association between smoking and type 2 diabetes might be mediated by CRP.
25081365 C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts
25079465 Consumption of a synbiotic food for 9 weeks by pregnant women had beneficial effects on insulin actions compared to the control food, but did not affect fasting blood glucose or serum hs-CRP concentrations.
25070920 Measurement of CRP in synovial fluid rather than serum does not offer diagnostic advantage in detecting periprosthetic joint infections.
25070472 Serum Hs-CRP/APN ratio correlates with an increased risk of atherosclerosis progression.
25043606 The findings give support to the hypothesis that elevated circulating CRP may play a direct role in the etiology of colorectal cancer.
25027406 results suggested that the CRP rs3093059 polymorphism may contribute to increased hepatocellular carcinoma risk in hepatitis B virus-infected patients in the Chinese population.
25027167 C-reactive protein genetic variants have a combined effect along with smoking on severity of coronary artery disease.
25019591 Trait hostility was associated with increased blood CRP levels.
25019352 Both the MBL and CRP can serve as inflammatory markers in predicting the outcome of patients with CAP.
25014522 Procalcitonin, CRP, and to a lesser degree WBC provided some prognostic information on CAP outcomes
25005858 levels not in different in women with threatened preterm labor compared to those with uncomplicated pregnancy
24991721 Data indicate that procalcitonin and C-reactive protein (PCT/CRP) ratio was the best marker for discrimination between tumor fever and infection.
24991031 Elevated CRP serum levels are not predictive of cognitive decline, but IL-6 levels are.
24989682 Our meta-analysis may provide first evidence showing that genetic variants within the CRP locus are unlikely to modulate risk of IS.
24982116 Monomeric CRP localized with inflammatory cells in inflamed human striated muscle, human atherosclerotic plaque, and infarcted myocardium. mCRP is proposed as a pathogenic factor in atherosclerosis and myocardial infarction.
24981713 Elevated CRP level is an independent risk factor for chronic kidney disease development.
24980707 CRP expression is increased in serum of women exposed to biomass combustion exposure.
24975656 increased levels in Chinese children with sleep-disordered breathing
24974939 We hypothesized that periodontitis may be associated with C-reactive protein levels, serum levels of lipids and peripheral blood counts, and that these characteristics serve as markers for a link between periodontitis and cardiovascular disease.
24969579 Elevated levels of hs-CRP are associated with high prevalence of depression in japanese patients with type 2 diabetes.
24969183 There is a correlation between decreased sleep quality in hemodialysis patients and elevated CRP levels.
24965144 C-reactive protein haplotype AGT influences coronary heart disease risk in Northwest Indians
24956415 Adherence to the DASH diet resulted in a significant reduction of serum insulin levels and CRP levels in obesity patients.
24952865 Genetic polymorphisms affect cystatin C concentrations independently of kidney function. However, the polymorphisms were not observed to be associated with outcome, nor did they improve risk prediction or discriminative models.
24948846 pentameric CRP has a role in acute myocardial infarction and ischemia/reperfusion (I/R) injury; nonnative pentameric CRP has been implicated in atherosclerosis [review]
24937391 Serum levels of cortisol, copeptin, and their ratio could differentiate severe sickle cell anemia from mild or moderate disease.
24928820 Increased CRP was associated with cognitive impairment in a cohort of elderly Chinese subjects.
24928303 Data indicate that elevated serum C-reactive protein (CRP) values are related to a lower gain in muscle strength over time in patients with established knee osteoarthritis (OA).
24924697 Elevated serum CRP level is independently associated with a poor prognosis in hepatocellular carcinoma patients.
24913743 Serum CRP, when combined with classical pleural fluid biochemistries, improves the diagnostic accuracy in identifying those patients with non-purulent parapneumonic effusions who need chest drainage.
24909972 CRP remained significantly associated with depression in a dose-response fashion among men but women after being adjusted for body weight. Abnormal body weight,explained a substantial part of the relationship between CRP and depression among women
24905620 High serum CRP levels are associated with squamous cell cervical cancer.
24889374 Elevated serum C-reactive protein is associated with non-small cell lung cancer.
24886302 Both PCT and CRP can be used for upper and lower urinary tract infection differentiation, but PCT has higher sensitivity and specificity in predicting pyelonephritis than CRP.
24885051 In a large population of patients with dilated cardiomyopathy, the circulating concentrations of NT pro-BNP and hs-CRP, but not big-ET, were independent markers of all-cause mortality.
24884805 CPR gene expression in COPD patients are responsible for the secretion of this molecule in different cell types.
24878684 CRP levels increase in the first week after major surgery but to a much larger extent in infected than in noninfected patients
24877114 The serum CRP showed a marked increase on the 3rd postoperative day while the peak of serum PCT was earlier, even if much lower, on the first day.
24862635 SNPs rs2794520, rs1205, and rs3093059 of CRP gene, as well as haplotype C-C-C-C-C may be important biomarkers for susceptibility to low handgrip strength and high serum CRP level in elders.
24861467 correlation of high-sensitivity C-reactive protein with systolic blood pressure can be interpreted as a potential effect of hypertensive heart disease reflecting a state of high-risk milieu with elevated inflammatory markers
24844401 single-nucleotide polymorphisms in the CRP gene are not associated with risk of overall or lethal prostate cancer
24838548 Serum levels of c-reactive protein have high predictive value for determining severity and early neurobehavioral outcome after acute stroke.
24836084 Blood levels of CRP, IL-6 and TNFalpha-R2 are not associated with incident depression.
24835491 CONCLUSION: This meta-analysis showed the evidence that CRP 1059G/C and 1846G/A polymorphisms were risk factors for the development of colorectal cancer, and CRP 1846G/A polymorphism is also a protective factor for decreasing breast cancer.
24835352 Because CRP is an independent predictor of QTc interval and presence of QT prolongation, it could be considered in the risk assessment for hypertensive patients.
24827394 Acute alcohol exposure decreased C-reactive protein levels in critically ill nontrauma patients.
24811768 Serum CRP was higher in men with coronary artery disease than in healthy controls. CRP showed significant positive correlation with angiographic severity of atherosclerosis.
24808122 not associated with group A streptococcus infection in patients with acute pharyngitis
24798783 CRP is an accurate biomarker to predict left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus.
24796336 Among patients with rheumatoid arthritis, CRP>10 mg/L compared with <1 mg/L was associated with increased risk of myocardial infarction.
24795153 After lower extremity endovascular interventions, elevated preprocedural hsCRP levels are associated with femoral-popliteal interventions, and with late cardiovascular events.
24790070 Serum CRP is a simple but powerful marker of mortality in congenital heart defect-pulmonary arterial hypertension patients and should be incorporated in the risk stratification and routine assessment of these patients.
24784714 The contribution of maternal BMI to the development of third trimester impaired glucose tolerance appears to be greater than hsCRP.
24771073 The 1059G>C polymorphism in C-reactive protein was found to not be a useful marker in stroke prediction.
24762112 High body mass index is associated with short telomere length observationally and might possibly be mediated through elevated C-reactive protein.
24761881 Genotype CC of rs1800947 in the C-reactive protein gene may increase susceptibility to colorectal cancer.
24751480 Describe significant associations between CRP and aortic valve and peripheral arterial disease in a population-based cohort of African-Americans.
24719979 Elevated hsCRP levels in conjunction with abnormal lipid profiles may be strongly associated with weight gain in postmenopausal women.
24716628 In a population surveillance of Arabs, there was an association between C-reactive protein levels and increased risk for metabolic syndrome.
24716416 Multivariate logistic regression indicated that hs-CRP and a history of smoking were independently associated with the incidence of vasospastic angina
24715304 Our results suggest that serum ARG and CRP together can efficiently diagnose Head and neck squamous cell carcinoma.
24711458 topological localization is an important, but often overlooked, factor that determines the contribution of mCRP and other proinflammatory mediators to chronic vascular inflammation
24709882 Serum PTX3, MMP-9 and C-reactive protein expression was significantly higher in the acute coronary syndrome patients compared with controls.
24696367 We have shown that c-reactive protein gene polymorphisms are higher in control subjects than psoriatic arthritis patients
24694904 In prehypertension, there is an association between serum sialic acid and high-sensitivity C-reactive protein levels and blood pressure.
24670724 Among patients suffering from myocardial infarction, periodontitis is highly prevalent and associated with elevated levels of serum C-reactive protein.
24660532 Higher levels of prooxidant-antioxidant balance values and a slight increase in hs-CRP concentration in patients with beta-thalassemia major, were found.
24656623 higher serum levels in rheumatoid arthritis patients
24636767 In patients with ischaemic stroke the GG genotype of CRP gene polymorphism is associated with significantly higher CRP concentration in relation to AG genotype
24635486 This review summarizes the role of CRP in Crohn's disease.
24633920 CRP genetic polymorphism may be a novel predictor of the risk of lymph node metastasis in invasive breast cancer.
24630704 In patients with stable coronary artery disease treated with PCI and statin therapy, CRP but not LDL-C was independently associated with increased risk of 1-year mortality.
24627113 In this multiethnic cohort, when hsCRP-quartile was higher than IL-6 quartile, ischemic stroke risk was increased, and conversely when IL-6 quartiles were elevated relative to hsCRP, the risk was decreased.
24625581 in non-small cell lung carcinoma, there is a negative correlation present between the levels of HDL-C and CRP
24622110 16 inflammation-related genetic variants are associated with serum C-reactive protein level.
24611307 the importance of the quantification of C-reactive protein in patients with community-acquired pneumonia.
24610897 Obese hypertensive men, matched for anthropometric measurements, have plasma CRP concentrations similar to those of obese normotensive men, but greater than those of lean normotensive men.
24603645 Data indicate that C-reactive protein (CRP)was positively associated with household poverty and worse nutritional indicators.
24602049 This study aimed to evaluate the effect of gene polymorphisms of CYP2C9, VKORC1, thrombomodulin (THBD) and C-reactive protein (CRP) on the risk of bleeding complications of warfarin at therapeutic INR in Korean patients with mechanical cardiac valves
24588117 CRP levels are elevated in a substantial proportion of asymptomatic hereditary angioedema patients.
24587705 elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis.
24587064 CRP is associated with HDL-cholesterol levels among polymyositis patients
24577623 Smoking increases plasma CRP levels, and other factors such as sex and oral contraceptive use modify this relationship.
24574805 An increase in the CRP level by > 100%, 3-6 months before endoscopy predicts gastrointestinal hemorrhage.
24574329 The serum IFNalpha level as well as the C-reactive protein (CRP) genotype affect the CRP response in systemic lupus erythematosus patients.
24572983 ANCOVA showed that serum beta2M levels were significantly associated with serum CRP (p=0.012, p for trend <0.001), and GGT levels had similar results (p=0.211, p for trend=0.035).
24568622 After a kidney transplant, pentraxin 3 may not be useful in determining inflammatory status, and high sensitivity C-reactive protein may be better than pentraxin 3 as a marker of inflammation.
24565000 REVIEW: findings of CRP in schizophrenia
24564178 CRP levels are elevated in a large proportion of patients with at least one cardiovascular risk factor, without diabetes mellitus who are not receiving statin therapy.
24558995 Subclinical inflammation manifested by higher serum levels of C-reactive protein was identified in schoolchildren with higher percentage of fat mass
24558466 Elevated plasma levels of hsCRP, sICAM-1 and sE-selectin were positively and significantly associated with increased risk of dyslipidemia among Mongolians.
24554512 Effects of metformin or an oral contraceptive containing cyproterone acetate on serum c-reactive protein, interleukin-6 and soluble vascular cell adhesion molecule-1 concentrations in women with polycystic ovary syndrome.
24548663 Data from the Framingham Offspring Study (ages 30-80 years) suggest that serum CRP levels are not associated with sleep disorders (neither low nor high sleep duration) and the associated risk of coronary heart disease.
24530944 Levels of high-sensitivity C-reactive protein are elevated in patients with acute heart failure.
24524956 Hs-CRP and NT-proBNP substantially improve risk prediction in vascular surgery patients when added to an established predictive tool.
24523037 Among recent lacunar stroke patients, CRP levels predict the risk of recurrent strokes and other vascular events
24521195 Restrictive RV physiology is associated with significantly higher BNP and CRP levels with poorer balance of systemic oxygen transport following repair of tetralogy of Fallot.
24517733 CRP promoted atherosclerosis by directly increasing the transcytosis of LDL across endothelial cells and increasing LDL retention in vascular walls.
24506399 The C-reactive protein associated either with nutritional status or the waist to hip ratio is an effective biochemical marker of cardiovascular risk
24505819 Rapid CRP testing helped exclude pulmonary tuberculosis among HIV infected individuals.
24501104 The evaluation of serum N-terminal prohormone brain-type natriuretic peptide, troponin-I, and high-sensitivity C-reactive protein levels in children with congenital heart disease
24474658 CRP gene polymorphism contributes genetic susceptibility to dyslipidemia in Han Chinese population.
24470529 The combination of hs-CRP, NT-proBNP, and day pulse pressure improves risk discrimination in peripheral arterial disease patients.
24457057 The biomarker signature consisting of TNFR-II, TGF-alpha, TIMP-1 and CRP is significantly prognostic of survival in patients with high-risk melanoma.
24456036 In type 1 diabetes, parameters of wave reflection are related to serum markers of inflammation, ICAM1 and C-reactive protein.
24451691 half- and full-marathon wheelchair races increased plasma IL-6, but not TNF-alpha and high-sensitivity C-reactive protein
24446242 High serum C-reactive protein levels are associated with pancreatic cancer.
24440351 pro-apoptotic pathway of CRP-CD32-Nox2-p53-BTG2 may contribute to the retardation of the atherogenic process
24434384 Short-term oral N-acetylcysteine treatment might result in the reduction of IL-6 and hs-CRP in patients who are on regular hemodialysis.
24422709 These results indicate that elevations in plasma CRP are not associated with impaired endothelial progenitor cell function.
24418758 C-reactive protein is often mutated at -286 in human cancers.
24410968 Rosuvastatin can protect against pro-inflammatory effects of human CRP in a manner that is not dependent on achieving a reduction in circulating levels of human CRP.
24403485 High C-reactive protein expression is associated with glioma.
24380782 SNPs 1444C/T and 1919A/T related to an increased risk for obstructive sleep apnea in childhood
24379064 Serum CRP is significantly higher in community acquired pneumonia compared to tuberculosis.
24378957 Correlation of human S100A12 and high-sensitivity C-reactive protein as gingival crevicular fluid and serum markers of inflammation in chronic periodontitis and type 2 diabetes.
24374086 Acute coronary syndrome patients with moderate depressive symptoms who had higher CRP levels had higher levels of platelet microparticles.
24368157 Prematurity and 1958G>A were not associated. Increases in the inflammatory marker C-reactive protein (logistic regression, p = 0.055) and BMI (chi-square, p = 0.0113) were associated with AA genotype in women with low folate
24363360 Serum hs-CRP levels in OA were modestly but statistically significantly higher than controls [Review and Meta-Analysis].
24360158 Both age and C reactive protein are significant predictors for metabolic syndrome by one year follow-up in male workers.
24356040 Assessment of intratumoral CRP expression may be a useful tool for predicting the prognosis in patients with clear cell renal cell carcinoma.
24351805 Recurrent preeclampsia was related to elevated pre-pregnancy levels of C-reactive protein and fibrinogen when compared to women who did not develop recurrent disease.
24347428 CRP levels were higher in polycystic ovary syndrome women than in controls.
24342328 CRP gene +1059 G/C polymorphism may be associated with increased CHD risk among Caucasians and more evidences need to validate the conclusion.
24339203 An increased baseline CRP level predicts improved therapeutic response at the primary end point for subjects with psoriatic arthritis treated with both golimumab and infliximab.
24338120 Elevated cord blood CRP was associated with preterm birth <32 wks gestational age, and with a decreased risk of chronic lung disease.
24313319 This study suggests that increased CRP levels before and during conditioning are associated with baseline clinical factors and that elevated pretransplant CRP levels predict a poorer survival in stem cell transplantation.
24312587 relationships between HDL-C, hs-CRP, with central arterial stiffness
24305621 Elevated levels of CRP were linked to a decreased risk of longitudinal cognitive decline in the very old subjects not carrying an APOE e4 allele.
24300392 high sensitivity-CRP from systemic circulation was higher than coronary circulation in the acute myocardial infarction group, while there was no significant difference between systemic and coronary circulation in the stable coronary artery disease group
24290960 CRP was increased in pediatric burn patients and was correlated with burn severity.
24289571 Serum CRP level was significantly related to TNM stage.
24286072 The pathophysiological role of CRP and its potential interpretation in the inflammatory processes observed in critically ill patients, is discussed.
24266503 Bereaved respondents had higher levels of inflammatory biomarkers IL-6 and sE-selectin, but not CRP and sICAM-I than the non-bereaved.
24262327 CRP>10 mg/L is independently predictive of early hematoma growth and early neurological worsening, both of which are associated with increased mortality.
24259949 Nesfatin-1 is present in articular tissues and may contribute to the physiopathologic changes in OA. Nesfatin-1, accompanied with hsCRP and IL-18, could have roles in the progression of knee osteoarthritis
24254894 When the patients with overt and nonovert DIC were compared, the PrC level was lower, and PCT, PAI-1, IL-6, and IL-10 levels were higher in the patients with overt DIC.
24247268 CRP may be a useful surrogate marker for evaluating chronic kidney disease risk in male adults.
24247217 C-reactive protein level is significantly associated with central obesity and chronic kidney disease in a cross-sectional study from southern China.
24244755 C-reactive protein and B-type natriuretic peptide yield either a non-significant or a modest incremental value to traditional risk factors in predicting long-term overall mortality in older adults.
24243751 The results suggest that idiopathic cardiac arrhythmias of unknown origin in children are not associated with selected pro-inflammatory markers of infections i.e. elevated IL-6, CRP or -174 G>C IL-6 polymorphism.
24239465 Studies indicate that elevated C-reactive protein (CRP) level was associated with higher stage and higher grade in renal cell carcinoma (RCC).
24231564 Results suggest that a higher level of CRP on the first day after ischemic stroke coexists with CRP 717GG genotype status; AA genotype is a predictor of greater improvement of the neurological condition
24228880 C-reactive protein (CRP) decreased endothelial nitric oxide synthase (eNOS) activity during EC activation. CRP also activated GSK-3beta by dephosphorylating its Ser9 level and reducing beta-catenin protein expression in a time-dependent manner.
24222151 Increased CRP concentration is associated with recurrence and low response to therapy in rectal cancer.
24222149 Increased CRP concentration is associated with low response to therapy in stage IV colorectal cancer.
24217304 Determination of C-reactive protein and carotid intima-media thickness could help in the diagnosis of coronary artery disease and for predicting coronary events.
24217195 Plasma advanced glycation end products (AGEs), receptors for AGEs and their correlation with inflammatory markers in middle school-age children.
24209691 hs-CRP is inversely related to bilirubin, suggesting that low bilirubin is implicated in enhanced low-grade systemic inflammation. CRP was higher in metabolic syndrome patients than controls.
24206243 CRP plays a pathogenic role in acute kidney injury by inhibiting G1/S-dependent tubular epithelial cell regeneration.
24204905 Diabetes mellitus contributes to CAS development in men with low hs-CRP levels.
24197824 Increased concentration of CRP in obese type 2 diabetic patients is related to obesity and diabetes itself.
24164492 In the prediction of PE, age and D-dimer levels are relevant, while CRP level is not.
24163955 Report C-reactive protein was not reliable diagnostic test to identify chorioamnionitis in women with premature rupture of membranes.
24152229 findings suggest that metabolic syndrome and high CRP were independently associated with increased prevalence of CKD in Chinese adults
24150223 CRP was higher in depressed patients, with or without manic symptoms, than in controls. CRP was associated with manic symptoms in depressed men.
24148787 Since a high preoperative serum CRP level was closely correlated with nodal disease, it could be used as an additional marker to help identify patients with penile cancer who may benefit from inguinal lymph node dissection.
24146936 The mean maximum CRP concentration during acute phase was significantly higher in infants who developed stricture (p<0.001), as was the mean duration of the elevation of CRP levels (p<0.001).
24146927 the serum c-reactive protein (CRP), nerve growth factor (NGF) and pro-inflammatory cytokine/chemokine interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and IL-8 expression in patients with interstitial cystitis/bladder pain syndrome, was measured.
24135623 C-reactive protein polymorphism rs3091244 is significantly related with AAA presence and correlated with higher CRP levels and AAA diameter.
24130817 Baseline CRP and CRP kinetics may be useful to predict the prognosis of metastatic nasopharyngeal carcinoma
24126766 CRP serum levels are significantly associated with left ventricular diastolic dysfunction.
24105071 serum PEDF levels are closely associated with hs-CRP in women with PCOS. PEDF may play a role in the development of chronic inflammation in PCOS
24102428 Serum CRP levels are elevated at the onset of COPD exacerbations and are positively associated with Ang-2 levels. CRP levels decrease during the course of COPD exacerbations.
24102179 Increased C-reactive protein is associated with colon cancer.
24097561 an involvement of the NF-kappaB pathway in mediating different effects of C-reactive protein on proximal Chronic thromboembolic pulmonary hypertension-pulmonary arterial endothelial cells
24095158 Increased circulating inflammatory factor CRP is associated with greater risk of atrial fibrillation in the general population and among patients who underwent coronary artery bypass grafting (CABG) or catheter ablation procedure.
24085705 Elevated perceived stress was significantly associated with lower CRP levels in men but not in women.
24084772 An elevated pre-operative CRP level represents an independent prognostic factor that predicts poor prognosis.
24074718 Plasma CRP was significantly increased in burn patients with sepsis comparted to those without.
24072695 CRP was associated with fatal and nonfatal coronary artery disease events, as well as nonfatal peripheral arterial disease events.
24072269 Elevated hsCRP is not associated with breast cancer outcome.
24061501 Increased serum levels of serum amyloid a, phospholipase A2 group IIA , and C reactive protein were observed in patients with benign prostate hyperplasia, localized and metastasized prostate cancer in comparison to healthy individuals.
24060429 Serum CRP was higher in pediatric burn patients with acute kidney injury compared to burn patients without kidney injury.
24057344 High preprocedural plasma uPA and serum CRP levels are indicative of angina recurrence after successful PTCA, and are valuable for the prognosis of restenosis.
24055729 Genetic association studies suggest a synergistic effect of the CRP C allele with classical risk factors for premature coronary artery disease.
24051868 Major adverse cardiac events can be predicted in patients with acute coronary syndrome whose CRP values are low or moderately elevated.
24045283 in cirrhotic patients with spontaneous bacterial peritonitis, the initial hs-CRP level was an independent prognostic factor for higher in-hospital mortality and lower antibiotic response rate
24039853 Homocysteine and C-reactive protein associated with progression and prognosis of intracranial branch atheromatous disease.
24028935 Human CRP induces endothelial dysfunction in a rat model of type 1 diabetes.
24025976 Weekly CRP measurement was useful in the identification of patients with pyogenic liver abscess with good outcome and adequacy of antibiotic therapy of 5 weeks or less.
24016543 Red cell distribution width but not high sensitivity-CRP was associated with coronary heart disease mortality independent of traditional risk factors in a cohort with no pre-existing cardiovascular disease.
24012914 Studied sTREM-1, procalcitonin and C-reactive protein in postmortem serum in a series of sepsis-related fatalities and control individuals who underwent medico-legal investigations.
24010569 the current meta-analysis indicates that CRP rs3093059 (T>C) polymorphism may be associated with decreased risk of MI, especially among Asian populations.
24007461 A progressive increase in the hs-CRP level was associated with a corresponding decline in the serum albumin level.
24005810 ROC analysis identified a C-reactive protein value of 80 mg/l to be the optimal cutoff.
23991042 Results indicate that age, male gender, and C-reactive protein level were positively associated with serum beta2-microglobulin levels.
23985781 Circulating CRP level is positively associated with colorectal cancer risk.
23981122 Data suggest that both urotensin II (UTS2) and C-reactive protein (CRP) are elevated in sera of subjects with polycystic ovary syndrome; UTS2 may play role in physiopathology of insulin resistance and increased cardiovascular events in such patients.
23980698 This study indicates that SNP rs1130864 in the CRP gene is an independent predictor of 3-month functional outcome in patients with first-onset IS in a Han Chinese population.
23978367 High sensitivity-CRP can be used to identify a high-risk group for recurrent events in patients with manifest atherosclerosis.
23977389 257 DNA methylation sites in 240 genes significantly associated with serum levels of CRP adjusted for age, sex, body mass index and smoking status, and corrected for multiple testing, were identified.
23968978 Our data highlight the strong connection between the circulating inflammatory biomarkers CRP and IL-6 and platelet gene expression, adjusting for cardiovascular disease risk factors.
23959964 Athletes with femoroacetabular impingement had a 276% increase in plasma CRP levels.
23959959 The median plasma CRP was 1.9 mg/L (1.0-3.4) and 33 % of the participants had elevated CRP.
23957657 Serum CRP level is not a reliable indicator of reflux nephropathy
23955613 High-sensitivity C-reactive protein levels were significantly higher in Parkinson's disease patients compared to controls.
23955082 a molecular basis for S1P-induced transcriptional activation of CRP and its functional significance in the acquisition of the invasive phenotype of human breast epithelial cells under inflammatory conditions
23953546 Elevated CRP levels may indicate activation of a systemic inflammatory process caused by psychiatric comorbidities in orthotopic liver transplant recipients.
23950953 Electronegative subfraction of low-density lipoprotein stimulated Local C-reactive protein production via LOX-1 in cultured human aortic endothelial cells.
23941472 the CRP-286 (C>T>A) A genotype polymorphism and specific IgG antibodies isotype levels can contribute to a reduced risk of early onset sepsis.
23940726 The CRP variants, rs876538 and rs3093068, previously associated with other cardiovascular disease phenotypes, show suggestive association with preeclampsia(PE) in this American Indian population, further supporting a possible role for CRP in PE.
23935961 Elevated baseline high-sensitivity CRP was associated with increased risk of future sepsis events.
23932860 Levels of CRP and interleukin (IL)-6 are independently associated with right ventricular structure and function in a multi-ethnic population.
23911413 Studies indicate taht C-reactive protein acquires ligand-binding specificity post-secretion after a switch from its native pentameric conformation.
23910616 Studies show IL-6 and CRP are important in systemic sclerosis both in pathogenesis and clinical manifestations and may be useful indicators of disease activity, severity, and poor prognosis.
23888317 Data indicate that C-reactive protein (CRP) and the CRP/albumin ratio showed opposite behavior in groups, significantly reducing their values in treated patients.
23887753 serum C-reactive protein concentrations were significantly higher in patients with abdominal sepsis compared with patients with pulmonary sepsis during the first five days of sepsis progression
23875844 High-sensitivity CRP measurements during the first trimester of pregnancy are helpful in predicting pre-eclampsia.
23867726 Weak evidence suggests that SNPs in FADS1/2 may influence high sensitivity C-reactive protein levels in young adults.
23857741 elderly men with high hs-CRP have increased risk of fractures, and that these fractures are mainly vertebral.
23852903 CRP and mean platelet volume are higher in the ischemic stroke patients who died in comparison to those who survived
23844046 C-reactive protein genetic variants are not associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore.
23836113 A ultra-high C-reactive protein level in hospitalized inflammatory bowel disease patients is associated with significant complications.
23835994 suPAR and the non-specific inflammatory markers CRP and PCT may have roles in development of community acquired pneumonia in children
23828261 Elevated C-reactive protein is associated with myelofibrosis.
23813850 D-dimer >/=5.67 mug/mL, CRP >/=11.21 mg/L are risk factors independently associated with inhospital death in acute aortic dissection.
23813627 In the setting of true coronary bifurcations treated by drug-eluting stents, baseline CRP levels were significantly associated with both the incidence and the extent of periprocedural myocardial injury.
23813138 C-reactive protein and procalcitonin were reliable markers of bacterial infection in subjects admitted due to complications of liver cirrhosis.
23808014 The pre-operation level of C-reactive protein can be used as prognostic marker of development of cardio-vascular complications, post-operative fibrillation of atriums after application of coronary artery bypass in particular
23803251 PSP/reg and CRP are differentially regulated by HNF1A and HNF4A in maturity-onset diabetes of the young
23801460 Report significant relationship between omega-3 fatty acid and C-reactive protein levels and peripheral arterial disease in coronary artery patients.
23784529 High-sensitivity C-reactive protein level is a clinical parameter that could predict left ventricular end diastolic pressure and left ventricular dysfunction, but was not associated with the severity of coronary artery disease
23774275 Long-term supplementation with modest amounts of omega-3 fatty acids did not affect hsCRP levels in patients with a history of myocardial infarction.
23773138 these results that elevated maternal C-reactive protein in pregnancy is associated with a higher risk of eczema, and C-reactive protein in cord blood with a higher risk of wheezing and lower respiratory tract infections in the first 4 yrs.
23766379 Significant inverse correlations emerged between educational status and CRP, and between anger control and CRP.
23763486 These results show that acrolein stimulates the synthesis of IL-6 and CRP, which function as protecting factors against acrolein toxicity.
23755178 Both the CRP single nucleotide polymorphism rs7553007 and KRAS/BRAF mutations were independent prognostic factors for colorectal cancer patients with synchronous liver metastasis.
23742758 Combined serum Cat S and hs-CRP levels are better in predicting the inflammatory activity of abdominal aortic aneurysm lesions in the clinical setting.
23735372 Report independent association between CRP and homocysteine levels obtained several years after ischemic stroke in young adults and subsequent mortality, even when adjusting for traditional risk factors.
23731527 A single nucleotide polymorphism is discovered in CRP in patients with carotid artery disease and impaired renal function.
23729554 Data suggest that resistin not only contributes directly to metabolic syndrome but also contributes indirectly to early atherosclerosis via insulin resistance and up-regulation of blood insulin/C-reactive protein levels in obese children in China.
23725496 In a rural Chinese population, high C-reactive protein and metabolic syndrome were associated with an increased risk of microalbuminuria.
23724977 High sensitive CRP does not give any extra value in evaluation of cardiovascular risk or all-cause mortality of older subjects with metabolic syndrome.
23724031 Pretreatment serum CRP levels represent an independent predictor of clinical outcome for patients with extranodal natural killer (NK)/T-cell lymphoma.
23716069 We identified a significant (p<0.001) biphasic relationship between total cholesterol(TC) and CRP in inflammation: TC increased within the healthy CRP range of less than 5 mg/l, but decreased with CRP levels above 10 mg/l.
23702388 the prospective relationship between CRP and fracture risk in a large cohort study, was examined.
23698155 Although elevated body mass index is significantly associated also with elevated CRP and inflammation in African Americans, the relationship is stronger among both adolescents and young adults.
23697277 COPD patients present higher serum CRP and GGT values than healthy subjects independently from their smoking habits
23692330 increased serum levels at the age of 1 yr correlate with decreased allergic sensitization at the age of 4.5 yr
23688319 Maternal plasma sTRAIL concentrations are lower (while those of CRP are higher) in women with preeclampsia than in those with uncomplicated pregnancies. These findings are consistent with the evidence of intravascular inflammation in this disorder.
23688010 Data suggest that chronic up-regulation of circulating level C-reactive protein (as in obesity) may worsen leptin resistance and contribute to pathogenesis of cardiovascular disease. [REVIEW]
23684514 elevated levels of CRP are associated with lower cognitive functioning in individuals with bipolar disorder
23674518 The correlation between leptin and CRP in patients with T2DM, was studied.
23665253 Excess sedentary behavior is associated with CRP and depressive symptoms, independently from physical activity and adiposity.
23635436 Preoperative elevation of serum CRP to be an independent prognostic indicator of colorectal carcinoma.
23627410 Elevated serum CRP levels are positively associated with early breast cancer.
23624671 Nearly twice as many adults with atypical Major Depressive Disorder had C-Reactive Protein levels in the high cardiovascular risk range than did those with no MDD or nonatypical MDD.
23618082 High C-reactive protein expression is associated with hepatocellular carcinoma with malignant portal vein invasion.
23604041 Increased C-reactive protein is associated with elevated carotid intima-media thickness in Chinese adults with normal LDL. Low-grade inflammation plays an independent and important role in atherosclerosis.
23592127 These results suggest that the increase in FeNO indicates the acute exacerbation of asthma, and the elevation of serum PCT and CRP levels may be associated with bacterial infection.
23592000 A polymorphism in C-reactive protein and its protein level were associated with chronic periodontitis in a Chinese population.
23591413 Biomarkers of inflammation, YKL-40 and C-reactive protein, vary in parallel with the intake of traditional Inuit diet.
23579782 Our findings question the use of isolated CRP values to assign definitive risk status and to make long-term management decisions in individual patients in routine clinical practice.
23578742 the rheumatoid arthritis patients have high levels of inflammatory marker hs-CRP and altered lipid profile.
23576062 CRP is a regulator of the type I IFN response to SLE immune complexes (ICs). CRP increased intracellular processing of ICs in late endosomes, which is associated with decreased synthesis of type I IFN after intracellular toll-like receptor activation.
23575330 CRP concentrations identified groups of HIV patients with very high or very low tuberculosis risk.
23547018 High CRP levels were considered as a prognostic parameter and indicator of severity of Acute exacerbations of COPD. Increased mortality risk was found to be associated with high CRP values.
23539615 Preprocedural hsCRP levels are significantly related to the incidence of contrast-induced nephropathy in patients with STEMI undergoing PCI.
23535585 study finds that C-reactive protein (CRP) exacerbates Renal ischemia-reperfusion injury (IRI)-induced acute kidney injury (AKI) which might make C-reactive protein a promising therapeutic target for the treatment of AKI
23527487 This review discusses the general properties of CRP and pentraxin (PTX)3 as prototypes of short and long pentraxins, respectively.
23518675 The levels of resistin and hs-CRP in women with subclinical hypothyroidism, and potential effects of L-thyroxine therapy on those levels, were determined.
23516493 NT-proBNP, CRP and suPAR levels were higher in black compared to white men
23515055 Longitudinal monitoring of C-reactive protein levels in chronic hemodialysis patients may help to identify patients at risk of death.
23494263 molecular dynamics and interaction properties of CRP
23492986 C-reactive protein measured at 48 hours hospital admission showed good prognostic accuracy for severe acute pancreatitis, pancreatic necrosis and in-hospital mortality.
23484158 mulberry leaf powder exhibited antioxidant activity and mulberry leaf powder has potential to decrease serum triglyceride, LDL, and CRP levels in mild dyslipidemia patients without causing severe adverse reactions.
23468212 Medical expulsive therapy success for management of small distal ureteric calculi could be predicted with plasma CRP. Patients with CRP >21.9 mg/L have a low stone expulsion rate and should be referred for an immediate, minimally invasive ureteroscopy.
23463453 Data from a follow-up study in Japan suggest that elevated high-sensitivity CRP level in serum of apparently healthy subjects may help to identify high-risk individuals for the development of type 2 diabetes.
23450030 Elevated CRP levels were seen in 84 of 318 patients with sarcoma of bone before treatment; these patients had a poorer disease-specific survival (57% at five years) than patients with a normal CRP (79% at five years) (p < 0.0001).
23440541 among Iranian subjects, the inflammatory marker, hs-CRP, was strongly and positively associated with a marker of oxidative stress and also with several traditional risk factors of cardiovascular disease
23434327 Data suggest that CRP and soluble CD40 ligand (sCD40L) are up-regulated in plasma of women with polycystic ovary syndrome (PCOS) compared with control women; in PCOS, CRP and sCD40L are positively correlated with insulin resistance.
23428789 There was a 28% prevalence of an elevated CRP level in patients with schizophrenia and related disorders.
23427015 Patients with high CRP level showed worse clinical outcomes regarding cardiac death and major adverse cardiac and cerebrovascular events after off-pump coronary artery bypass grafting.
23425215 The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. TRIAL REGISTRATION: No.:NCT00605540.
23411851 For treatment of active infective endocarditis, a better operative result is expected when preoperative CRP levels are decreasing.
23409097 An increase in C-reactive protein is a poor parameter for early detection of complications in the critically ill surgical patient in the ICU by means of diagnostic procedures or therapeutic (re)-interventions.
23401350 Baseline CRP levels are predictive of long-term interstitial lung disease progression in systemic scleroderma.
23399387 There was no interaction between CRP and the other LP molecules.
23397258 C-reactive protein gene is not implicated in the pathogenesis of systemic sclerosis.
23393371 Postoperatively elevated serum CRP may be a prognostic indication after elective hepatic resection for patients with hepatocellular carcinoma
23392788 genetic polymorphisms of renin angiotensin system are not associated with increased serum CRP in coronary artery disease.
23383155 Pre-treatment levels of C-reactive protein and squamous cell carcinoma antigen are useful for predicting the aggressiveness of pharyngolaryngeal carcinoma.
23379491 In end stage renal disease patients on regular hemodialysis, serial levels of mean CRP were statistically significantly higher in the group with non-infected catheters compared with those using arteriovenous fistulas
23375154 C-RP increases the progression of peripheral arterial disease in type 2 diabetes.
23375121 MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease.
23367494 High-sensitivity CRP is significantly elevated in children and adolescents with excess weight as compared to normal-weight individuals.
23361365 C-reactive protein expression and STAT3 activation are reduced in docosahexaenoic acid and eicosapentaenoic treated HepG2 cells.
23343124 Data indicate that genetic polymorphisms of the PPP1R3B gene may contribute to variations in plasma lipids and C-reactive protein (CRP) levels among Chinese Han individuals.
23306163 High-sensitivity C-reactive protein was independently associated with serum cystatin C in systemic lupus erythematosus.
23288467 In a primary care setting, one single measurement of NT-pro-BNP, but not of hs-CRP significantly improves the prediction of incident cardiovascular events
23285029 The percentage of CD14(high)CD16(+) monocytes after trauma correlated strongly with plasma C-reactive protein (CRP) transforming growth factor-beta (TGF-beta), and macrophage colony-stimulating factor (M-CSF) levels.
23277135 The +1444T allele of CRP gene was significantly more common among suicide attempters compared with the +1444C allele.
23274882 A dual-biomarker strategy of hsTnT and hsCRP is highly discriminative for patients with normal cardiac structure and function and provides incremental value beyond the Framingham risk score.
23272049 stromal interaction molecule 1 has a role in erythrocyte sedimentation and C-reactive protein activity in HLA-B27 positive ankylosing spondylitis patients
23270673 Plasma visfatin level was significantly associated with plasma C-reactive protein level using multivariate linear regression. Thus, the SNP-1535 C>T of visfatin gene seemed to be potentially involved in the inflammatory component of TBI
23266263 CRP levels were excessively elevated in these patients in the absence of clinical infection and significantly higher compared to resections of supratentorial lesions
23263911 Persistent elevated C-reactive protein after treatment is an independent marker of a poor prognosis in patients with hepatocellular carcinoma
23257395 Data suggest that elevated circulating CRP levels have a high heritable component in women in Pennsylvania with polycystic ovary syndrome and their families.
23257175 IL-6 augments mechanical strain-induced CRP synthesis in vessels via the stretch-activated channel-NF-kappaB pathway.
23254959 High levels of CRP were associated with increasing lung cancer risk
23254637 C-reactive protein serum levels are decreased among Mexican American Alzheimer's disease cases and do not appear to be related to clinical variables, copared to non-Hispanic whites.
23241067 High sensitivity C-reactive protein blood levels associate with moderate to severe carotid artery stenosis but do not differentiate symptomatic and asymptomatic patients.
23228375 Greater levels of high-sensitivity troponin T, N-terminal pro-brain natriuretic peptide (Hs-TnT), NT-proBNP and high sensitivity C-reactive protein Hs-CRP are associated with increased risk of death, not just from cardiovascular disease(CVD)
23225486 an elevated pretransplant serum ferritin level, but not an elevated serum CRP level, is a strong risk factor for overall mortality (hazard ratio, 2.16; P = 0.002).
23224322 CRP induced decline of protein S-nitrosylation by activating NF-kappaB via reduction of S-nitrosylation of p65.
23221172 Suggest CRP may mark an obesity/inflammation preterm delivery pathway that is distinct from the pathway indicated by chorioamnionitis.
23220502 Data suggest that serum levels of cardiac Troponin I (cTnI) and high sensitivity C-reactive protein (hs-CRP) will be increased if the glucose-lowering rate is over this range, which means that cardiovascular endpoints might be induced.
23212764 CRP 1846C>T genetic polymorphism may be a novel predictor of risk of lymph node metastasis in submucosal thoracic esophageal squamous cell carcinoma
23212397 High hsCRP is associated with a greater independent risk of periprocedural myocardial infarction, as defined by the universal definition, but is not an independent determinant of mortality after percutaneous coronary intervention.
23206444 Patients with stable chronic obstructive pulmonary disease had higher serum C-reactive protein concentrations than healthy controls. [Meta-analysis]
23197841 Lower International Personality Item Pool conscientiousness was cross-sectionally associated with elevated CRP. NEO Five-Factor Inventory openness was negatively associated with CRP.
23197238 The aim of this study was to assess the effect of 3-month continuous positive airway pressure therapy on brachial artery flow-mediated dilation and plasma C-reactive protein levels in patients with obstructive sleep apnea syndrome.
23182717 Data show that a photodynamic therapy (PDT) dose-dependent upregulation of CRP gene, as well as of PTX3 and ficolin 1 genes in lung tumor A549 cells, and indicate critical role played by PI3K/Akt/AP-1 pathway.
23170819 Data suggest that the difference in serum CRP between initial and 24 hour follow-up is associated with mortality in the total population of patients with acute organophosphate poisoning in a retrospective cohort study in Republic of Korea.
23166385 Elevated C-reactive protein level is associated with recurrent or refractory aggressive lymphoma.
23159256 Plasma levels of CRP and IL-6 were higher in women reporting sexual abuse in adolescence compared to those reporting no abuse (p=0.04 and 0.03, respectively) in analyses adjusted for confounders including age and childhood adiposity
23158132 Data found that venous thromboembolism was associated with IL-6 and CRP levels, and there was an association of IL-6 and its promoter polymorphism at -572G/C with the risk of VTE.
23157807 CRP and matrix metallopeptidase (MMP)-9 plasma levels are increased in patients with acute coronary syndrome.
23151748 hsCRP, a marker of systemic inflammation, is associated with large-artery compliance and possibly small-artery changes in young asymptomatic individuals.
23151405 Plasma CRP and interleukin (IL)-6 are prospectively associated with new-onset fatigue, supporting the hypothesis that low-grade inflammation has a role in the development of fatigue.
23141922 Data indicate that due to its low cost and easy accessibility, serum C-reactive protein (CRP) may be a useful biomarker for localized upper tract urothelial carcinoma (UTUC).
23139417 The phosphocholine-binding pocket on CRP is necessary for CRP-mediated initial protection of mice against lethal pneumococcal infection.
23132698 Patients with active acromegaly have significantly lower values of hs-CRP compared with patients with controlled disease and even lower values of hs-CRP compared with control subjects.
23126320 Elevated levels of serum C-reactive protein in sciatica patients are closely associated with neuropathic pain.
23125484 Study indicates that CRP superiorly to apolipoproteins and lipid profile facilitates the risk stratification for acute coronary syndrome occurrence.
23124693 Serum CRP levels were higher in FMS and significantly correlated with body mass index, erythrocyte sedimentation rate, IL-8, and IL-6 levels, suggesting that inflammation may contribute to the symptoms.
23116196 Data from women with polycystic ovary syndrome in Argentina suggest that risk of insulin resistance (as seen in metabolic syndrome) in these patients is increased if the women exhibit high serum CRP values (and obesity as well).
23116190 In an African American sample, hostile affect, as measured by the Cook Medley Hostility Scale, was significantly associated with greater plasma CRP levels.
23111890 Estradiol can interfere with CRP pro-inflammatory effects via activation signals using a rapid, non-genomic pathway.
23104422 siRNA to PKC delta attenuates the proinflammatory effect of human CRP in spontaneously diabetic BB rats and could have implications with regard to attenuating inflammation and vascular complications in T1DM.
23087294 Elevated high-sensitive C-reactive protein predicts poor early and midterm outcomes after coronary artery bypass.
23087143 Inhibited Ang II- and IL-6-induced expression of CRP both in protein and mRNA levels.
23078984 Although not statistically significant the CRP level was lower in the mindfulness intervention group, a change which may have clinical significance. A larger effect on CRP (as compared to control) occurred among non-obese participants.
23066418 Passive smoking causes significant rise in plasma TNFa and IL4 with a dose dependent effect
23049543 genetic association studies in Mexico: TT genotype of SNP in CRP (rs1130864) is associated with obesity and type 2 diabetes; CRP haplotype 2 (TGAG) is associated with increased serum levels of CRP; CRP haplotype 7 (TGGG) is associated with obesity.
23046580 CRP gene polymorphisms have significant association with genetic susceptibility of HT and quantitative traits of blood pressure.
23026925 CRP is a useful predictor of metronidazole treatment failure in mild-to-moderate C. difficile infection.
23013513 Simvastatin decreases the pro-inflammatory marker hsCRP while ezetimibe monotherapy or the combination with simvastatin has no effect.
22989605 Serum level of C-reactive protein is elevated during atrial fibrillation.
22982460 Data suggest that in women 8-oxodG is associated with hsCRP and is independently related to select cardiovascular risk factors.
22976070 We investigated whether interleukin-6 and C-reactive protein were associated with the severity of dilated Virchow Robin spaces in the eldery.
22957001 Changes in hs-CRP but not baseline hs-CRP are associated with rhythm outcome after atrial fibrillation catheter ablation.
22949303 Elevated high-sensitivity CRP levels in systemic lupus erythematosus are associated with cardiovascular risk factors.
22918393 CA9, osteopontin and CRP were univariately prognostic for overall survival (OS).
22914173 Data from a sub-Saharan population in the capital city Ouagadougou, Burkina Faso, suggest that CRP is associated with adiposity; elevated plasma CRP may be biomarker for risk of cardiovascular diseases in adult populations in developing countries.
22912790 CRP was associated with increased risk of lung cancer, especially among men, in a meta-analysis of 1918 cases.
22911253 tumoral CRP production controlled by CRP genetics significantly influences tumor behavior.
22909410 Higher levels of C-reactive protein were associated with increased risk of developing cardiovascular disease.
22906998 results showed that IL-6 and CRP are implicated in both cancer characteristics and hepatic reserve and thus remain a useful prognostic indicator for hepatocellular carcinoma survival
22906275 Circulating IGF-1 and CRP levels may have potential as indicators of exacerbation, malnutrition and muscle wasting in patients with COPD
22901456 Pentameric CRP binds to monocytes, inhibiting LDL-induced monocyte activation. Monomeric CRP may promote inflammation.
22886358 CRP has a significant impact on overall survival of patients with metastatic renal cell carcinoma carcinoma treated with tyrosine kinase inhibitors.
22884413 Both higher education and household income predicted smaller increases in CRP over the 13 years of follow-up independent of age, sex, race, CARDIA center, body mass, medical diagnoses, medications, and hormone use (among women)
22875596 CRP SNPs rs3093059 & rs3091244 presented statistical associations with ischemic stroke in Han Chinese. rs876537 & rs2794521 were also analyzed. The CRP SNPs were associated with decreased risk of ischemic stroke and elevated plasma hsCRP.
22875408 The anti-inflammatory and antioxidative properties of eicosapentaenoic acid may make it an effective therapeutic strategy for adverse cardiac remodeling associated with CRP overexpression.
22869540 Plasma resistin levels were significantly associated with plasma C-reactive protein level and single nucleotide polymorphism -420C>G of the resistin gene could be involved in the inflammatory component of intracerebral hemorrhage.
22867744 Studies indicate that pharmaceutical grade serum amyloid P component and C-reactive protein were isolated and purified.
22857740 Our study demonstrated that the serum CRP level is a statistically significant prognostic parameter for patients with advanced metastatic renal cell carcinoma.
22847196 A higher level of serum CRP may serve as an indicator of delayed post-polypectomy hemorrhage.
22843654 Serum CRP, IL-6 levels and the ratio CRP/IL-6 are associated with descending aortic aneurysmal dimensions.
22836155 Study highlights the utility of both CRP and PAPP-A levels as determinants of plaque instability in acute coronary syndrome.
22832641 Values of CRP higher than 10 mg/L increase 4 times the possibilities of finding locally advanced renal cell carcinoma in the pathological study of the surgical specimen
22828776 CRP 1059G/C gene variation influences plasma CRP levels. Conversely, this polymorphism was not associated with the risk for acute myocardial infarction.
22821639 Serum CRP could be considered a useful and cost-effective biomarker for predicting outcomes after liver transplantation for hepatocellular carcinoma.
22816656 Data indicate that oxidative stress measured by increased concentration of urine 8-epi-PGF2alpha is strongly associated with C-reactive protein (CRP) levels.
22813921 Serum albumin, CRP and body mass index at the start of hemodialysis therapy were able to individually stratify the risk of long-term mortality in end stage renal disease patients.
22813435 A strong and robust association between job strain and CRP was observed in age and sex adjusted models
22801596 Antisense oligonucleotides to either PKC-alpha or p47phox attenuates the pro-inflammatory effects of human C-reactive protein on macrophages in diabetic rats.
22796263 In healthy young adults, salivary CRP levels peaked at awakening, and they were lower during the daytime. CRP levels exhibited moderate to high stability over 2 days of sample collection.
22783989 higher serum levels is a risk factor significantly associated with pre-eclampsia
22783580 the levels of adiponectin, hs-CRP, and TNF-alpha were increased for all patients with chronic renal failure (CRF).
22780440 extent of periodontal infection was associated with elevated levels of C-reactive protein among those subjects whose HDL-C value was below the median value of 1.3 mmol/l or LDL-C above the median value of 3.4 mmol/l.
22763479 plasma CRP levels were substantially associated with common genetic variants in the CRP gene and could predict the development of hypertension.
22750226 Oct-1 acts as a transcriptional repressor of C-reactive protein expression and it does so by occupying its cognate site on the promoter and also via other transcription factors by an as yet undefined mechanism
22748017 CRP improved the performance of the prediction model in the diagnosis of smear-negative tuberculosis among symptomatic HIV patients.
22732721 Postoperative CRP can be a useful prognostic factor for both poor outcome and symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage
22704860 C-reactive protein levels were associated with atrial fibrillation recurrence after successful cardioversion.
22685586 Data indicate that plasma exchange reduced plasma levels of the examined biomarkers: 23% for NT-proBNP, 64% for CRP, 31% for procalcitonin and about 14%for troponin T.
22685243 There were no consistent associations between symptoms of insomnia and hsCRP levels
22683644 CRP can prime neutrophils and enhance the respiratory burst induced by antineutrophil cytoplasmic antibody (ANCA) and might be pathogenic in ANCA-associated vasculitis
22681496 Elevated CRP does not appear to be a fundamental consequence of early life stress among healthy adults; lower-quality physical health and well-being are significantly related to plasma CRP.
22676422 The association of hs-CRP to arterial stiffness parameters differs between men and women.
22672862 Data suggest that High IL-6 and CRP values related to neonatal sepsis might have a significant role in the pathogenesis of non-thyroidal illness (NTI) in premature infants.
22645408 Although the level of serum hs-CRP decreased significantly, there was a significant association between hs-CRP and NT-proBNP in HCV-infected patients.
22642594 unstable angina patients compared to control subjects CRP may have a role in the inflammatory response after acute coronary syndromes
22641545 Report significance of high sensitivity C-reactive protein and D-dimer in evaluating intracardiac thrombus and spontaneous echo contrast in patients referred for transesophageal echocardiography.
22617158 CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer
22614460 Variation in the CRP gene affects serum protein levels.
22607374 Data show that patients with procalcitonin concentrations above decisional thresholds had higher C-reactive protein concentrations and lower glomerular filtration rate (eGFR).
22592028 In patients with high levels of high-sensitivity C-reactive protein, incidence of stent thrombosis was decreased by pre-procedural statin therapy.
22588996 Racial differences in CRP among men aged 57-74 are little changed after adjusting for both socioeconomic and behavioral risk factors; for women aged 57-74, however, behavioral risk factors explain 30% of the relationship between race and CRP.
22580582 High CRP was positively associated with change in total knee pain, as well as change in the pain at night in bed and while sitting/lying in knee osteoarthritis.
22576068 High serum C-reactive protein levels are associated with lymph node metastasis, advanced tumor stage and tumor recurrence in oral cavity squamous cell carcinoma.
22570140 CRP pattern could provide information regarding prediction of cardiovascular events in acute aortic dissection.
22569435 Omega-3 fatty acids did not affect C-reactive protein levels in hemodialysis patients.
22569431 The CRP standard assay presents a reasonable alternative to the hs-CRP assay in patients on hemodialysis.
22562290 TNF-a serum levels were in the upper normal range within the first 12 h from symptom onset and increased continuously until day six, while IL-6 and CRP increased subsequently with a peak on day one after ST-segment elevation myocardial infarction
22558327 CRP elevations above 10 mg/L in obese women are likely to be from chronic rather than acute inflammation, and that CRP thresholds above 10 mg/L may be warranted to distinguish acute from chronic inflammation in obese women.
22556030 CRP level is elevated in one-quarter of systemic sclerosis patients, especially early disease. It is correlated with disease activity, severity, poor pulmonary function, and shorter survival.
22554299 There were few associations between early environmental farming factors and human serum C-reactive protein levels, and between human serum C-reactive protein levels and atopic sensitization in 4.5-yearold children.
22552174 In patients with persistent Atrial Fibrillation and preserved LVEF, SAA and C-Reactive Protein levels are independent predictors of AF subacute recurrence rate.
22547903 adiponectin, leptin, resistin, and CRP may have roles in peripheral arterial occlusive disease
22545649 not correlated with prognosis in aortic stenosis
22533665 Both leptin and CRP levels were associated with cardiovascular risk factors as well as metabolic syndrome score in both men and women although gender-specific differences were observed.
22529527 hs-CRP, which is a sensitive marker of systemic inflammation, is increased in patients with mitral annulus calcification
22497530 in cancer patients, the concomitance of b and T alleles with elevated CRP levels may represent an early clinical predictor for the development of a more aggressive form of cachexia.
22492993 conducted a genome-wide association analysis of CRP levels in African Americans and confirmed that the genetic variants with the strongest effects are all within and around the CRP locus
22490475 Study demonstrated that hs-CRP and homocysteine are well associated with the 10-year CAD risk estimated using NCEP ATP III in Koreans and combination of hs-CRP and homocysteine can have strong synergy in predicting the development of CAD.
22474034 There is an increased 10-year risk of coronary heart disease associated with increased plasma concentration of CRP in patients newly diagnosed with intermittent claudication.
22467322 CRP can be used as an adjunct in evaluating the tumor markers-carcinoembryonic antigen (CEA) and squamous cell cancer antigen (SCC-Ag).
22464286 Elevated hsCRP levels are independently associated with risk of prediabetes in Indians.
22459389 Inflammatory C-reactive protein levels are positively associated with body mass index parameters and subclinical organ damage.
22457095 Total bilirubin correlates inversely with high sensitivity C-reactive protein and coronary endothelial function.
22449109 Elevated plasma high-sensitivity-CRP independently predicts risk of all-cause death within 3 months after acute ischemic stroke in Chinese patients.
22446726 Measurement of CRP plasma concentration at discharge may be useful as a marker of early left ventricular systolic dysfunction in patients after a first ST-segment-elevation myocardial infarction
22444955 only C-reactive protein showed differences between the first and the 4th quartile regarding mortality from alcoholic hepatitis.
22437883 CRP levels were significantly correlated with diabetic ketoacidosis diagnosis
22435454 The CST3 G73A polymorphism is associated with AD in Caucasian populations, but not in Asians.
22430136 This study suggests CRP and NFkappaB may function collectively to drive prostate cancer progression in a subset of patients
22428468 crp is a sensitive marker for diabetic nephropathy predicting its progression and severity in type 1 diabetics
22418989 Study shows that low albumin and high CRP levels are the main predictors for death in ESRD patients on hemodialysis.
22418747 Suggest that elevated serum CRP levels are associated with prehypertension in multi-ethnic Asian populations.
22392590 A non-linear relation between hs-CRP and adiposity was found, more so in women than men, in particular at low hs-CRP levels. Findings suggest sex difference in the relationship between adiposity and CRP might be mediated by leptin.
22365588 It was shown that an elevated baseline C-reactive protein level is an independent predictor of increases in prospective medical-care expenditures among community-dwelling elderly.
22357713 CRP levels were associated with severity of white matter hyperintensities as well as global markers of brain atrophy.
22330622 Carotid artery stenting was associated with a significant increase in plasma CRP, IL-6 and TNF-alpha.
22329434 A CRP gene promoter triallelic polymorphism was associated with CRP gene promoter activity, determined the plasma level of CRP, and predicted the risk of atrial fibrillation.
22328138 Data suggest that C-reactive protein (CRP) serum levels can be used as additional prognostic parameter in patients with diffuse large B cell type lymphoma.
22316276 Data suggest that serum C-reactive protein is not significantly elevated in Turkish adolescents/young adults in early stages of polycystic ovary syndrome compared to age-/BMI-matched control subjects.
22316266 Report elevated serum C-reactive protein levels in type 2 diabetics with/without macrovascular complications.
22311704 The elevation of CRP before treatment predicts a poor prognosis in patients with locoregionally advanced laryngeal carcinoma treated with chemoradiotherapy.
22306563 CRP concentrations varied across the menstrual cycle, attaining the highest and most variable levels during menses. CRP was inversely associated with endogenous estradiol and positively associated with luteal progesterone.
22297435 High sensitivity-C-reactive protein is elevated in opiate dependence both per se, and when controlled for age.
22296194 c-reactive protein as prognostic and causative biomarker in heart disease
22284830 serum levels correlates with asthma severity
22277294 CRP level at admission is significantly associated with early neurologic deterioration in acute ischemic stroke.
22267767 CRP may contribute to persistent obstruction of proximal pulmonary arteries in chronic thromboembolic pulmonary hypertension by promoting vascular remodelling, endothelial dysfunction and in situ thrombosis.
22267750 In primary prevention implantable defibrillator candidates, combining a myocardial heterogeneity index with inflammatory biomarker C-reactive protein, identified a subgroup with a very low risk for adverse cardiac events.
22267327 Novel genetic determinants of CRP completely unrelated to previously known CRP regulators were identified during inflammation.
22260948 Childhood maltreatment is associated with increased CRP levels, in patients with a first-episode psychosis.
22257305 Cystatin C equation may be widely used to estimate glomerular filtration rate in Chinese patients with chronic kidney disease.
22241816 CRP gene -717AG or GG genotypes is associated with cardiovascular benefit to Chinese peritoneal dialysis patients with cholesterol levels of 200 mg/dl or greater.
22222005 The hypothesis that high-sensitivity C-reactive protein levels during both acute (48 h after IS) and convalescent (21 days after ischemic stroke (IS)) phases are equally important in predicting 90-day clinical outcome after acute IS, was tested.
22208681 In this population-based study, we observed independent categorical association of increased C-reactive protein with carotid artery intima-media thickness progression in young adults.
22205174 High sensitivity-CRP was associated with increased cholesterol and cardiovascular changes supporting that it may be a useful biomarker for detecting asymptomatic vascular and coronary heart disease resulting from obesity.
22203929 CRP and IL-6 are commonly involved in the pathways of periodontitis and transient ischemic attacks.
22196954 Soluble CD40 ligand, high sensitive C-reactive protein and fetuin-A levels in patients with essential thrombocythemia.
22192441 Frail people have raised serum concentrations of C-reactive protein. However, frail individuals carrying the CRP1846G>A polymorphism seem less able to mount an efficient allostatic response, which may underpin their increased odds of frailty.
22190020 The effect of a low-glycemic load diet on inflammatory markers and adipokines in normal and overweight subjects is reported.
22178353 Identification of an association between genetic variants of the IFI30 gene and CRP levels in obesity.
22166506 This study indicates that NT-pro-BNP might be a more useful laboratory marker as an adjuvant diagnostic tool for Kawasaki disease than hs-CRP.
22158621 Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis.
22153152 Report relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women.
22134501 Admission and postoperative CRP levels are higher in patients with a poor outcome than in those with a favorable outcome, but CRP values do not predict delayed cerebral ischemia or cerebral infarction.
22119118 After reperfusion, C-reactive protein is the strongest independent predictor of left ventricular remodeling following myocardial infarction.
22104116 Suggest that high levels of CRP predicts the risk of metabolic syndrome, independent of obesity and insulin resistance in Indians.
22103876 Studies suggest that CRP is directly involved in development of inflammation in response to cerebral ischemia, a phenomenon exacerbated by aging; antagonists to CRP binding to complement and phagocytes might prevent cerebrovascular disease. [REVIEW]
22095223 Elevated YKL-40 levels are associated with increased risk of gastrointestinal cancer, independently of CRP levels, whereas elevated CRP levels are associated with increased risk of lung cancer, independently of YKL-40 levels
22082888 Visceral fat mass was a significant and independent predictor for serum hs-CRP levels in Japanese subjects with mild obesity and/or impaired glucose tolerance.
22079264 Comparative levels of macrophage migration inhibitory factor, procalcitonin, osteoprotegerin, interleukin-8, hs-C reactive protein, D-dimer in febrile neutropenia, newly diagnosed cancer patients, and infectious fever.
22056216 In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors.
22055258 Data suggest that level of high-sensitivity CRP in serum is independent cardiac risk predictor in type 2 diabetic subjects even with normal lipid profiles and can serve as risk measure for cardiovascular diseases (including coronary heart disease).
22048011 Elevated levels of CRP and exposure to HSV-1 are associated with the severity of cognitive impairment in schizophrenia.
22038335 Results suggest that high hs-CRP levels provide prognostic information in elderly patients with chronic kidney disease.
22025360 Elevated high-sensitivity C-reactive protein is associated with advanced stage gastric cancer and postgastrectomy disease recurrence
22025173 [review] CRP levels have been shown to predict survival in patients with urological cancers, and the incorporation of CRP into prognostic models for urological cancers improves the models' predictive accuracy.
22019953 analysis of the role of procalcitonin (Pro-CT) and/or C-reactive protein (CRP) in fever
22019947 Data suggest that serum high sensitivity C-reactive protein levels exhibit significant positive correlations with percentage body fat and subcutaneous fat area in subjects with type 2 diabetes mellitus.
22018511 Serum concentration of CRP is significantly associated with sex, several cardiovascular risk factors and selected renal function markers, which extends similar findings in Europe and in North America to a population in the African region.
22014839 These data suggested that echocardiography-based epicardial fat measurement can be clinically feasible and was related to several metabolic abnormalities and independently associated fatty liver disease.
22004660 A functional variant in the 3'UTR of the CRP gene was shown to be associated with severe pre-eclampsia in an American Indian population.
21993388 no correlation between high sensitive CRP serum levels and systemic lupus erythematosus disease activity
21970447 Combined endurance and resistance training resulted in significant decreases in plasma C-reactive protein in young females.
21958326 serum levels predict mortality in chest pain patients in Argentina
21951717 Data show that CRP levels are higher in IBS patients than controls, but still in the normal laboratory range, which may support the existence of low-grade gut inflammation believed to occur in IBS.
21937998 Results demonstrated that variants in several loci are significantly associated with plasma CRP in Filipino young adults, suggesting shared genetic influences on circulating CRP across populations and age groups.
21934067 CRP peptide impacts neutrophil interactions with endothelial cells and platelets, critical inflammatory events triggering acute coronary artery disease.
21933586 Serum Hs-CRP and IL-6 levels can be considered as the indexes to judge the degree of CHD and may reflect the activity of plaque in CHD patients.
21931794 Data identified rs3093059 in CRP and rs1892534 in LEPR as major cis and trans-acting contributor respectively, to the variance in hsCRP levels in North Indian population.
21928234 Elevated C-reactive protein predicted contrast-induced nephropathy after percutaneous coronary intervention in myocardial infarction.
21923250 evaluation whether the combined use of serum lactate, interleukin (IL)-6, and C-reactive protein (CRP) is able to simultaneously establish both the septic status and the prognosis of acute abdomen
21915265 Plasma CRP concentrations associate with cognitive performance in part through pathways independent of (risk factors for) cardiovascular disease.
21901123 During the first 14 days of postoperative sepsis, LBP plasma concentrations showed a time course that was very similar to CRP with a high concordance in the pattern of day-to-day changes
21890096 Women who undergo indicated preterm delivery are at increased risk of raised CRP in later life.
21883780 In acute coronary syndrome, CRP protein levels are significantly elevated among patients reporting infective and inflammatory potential precipitants.
21872279 Preoperative CRP level greater than 20 mg/L is significantly associated with worse survival than undetectable CRP in patients with stage I or II non-small cell lung cancer.
21868617 Findings demonstrate the value of measuring CRP in addition to standard inflammatory biomarkers to improve mortality prediction in hemodialysis patients.
21859817 Serum pentameric C-reactive protein may not affect platelet activation. Monomeric C-reactive protein, dissociating from pentameric C-reactive protein on activated platelet surface, may contribute to atherothrombotic complications by promoting thrombosis.
21856781 To define how CRP modulates the classic complement pathway, we studied the interaction of CRP with the classic pathway inhibitor C4bp. Monomeric CRP (mCRP), but not pentameric CRP (pCRP), binds C4bp and enhances degradation of C4b and C3b.
21845926 Evidence for different allele frequencies between Tsimane and other populations; correlations of CRP and apoE alleles suggest these variants are under selection in response to a high infection environment.
21843630 participants with detectable levels of CRP evidenced worse memory performance after a delay compared to those with undetectable levels of CRP
21839826 The cognitive function of patients with high baseline CRP levels might remain impaired even if their mood symptoms improve after antidepressant treatment
21832113 There is notable gender difference for the CRP pattern and the relationship of CRP with adiposity during adolescence
21831326 CRP gene variation affects early senile plaque development in prodromal Alzheimer's disease, independent of APOE genotype.
21821037 Data show that analysis of CRP concentrations in paired serum and saliva samples from cardiac patients gave a positive correlation (r2=0.84, p<0.001) and the salivary CRP concentration capable of distinguishing healthy from diseased patients.
21819975 Elevated CRP level in patients with Alzheimer's disease suggests the presence of inflammatory activity
21816845 C-reactive protein has a role in celecoxib-associated cardiovascular toxicity but not adenoma recurrence or celecoxib treatment efficacy
21814873 Data indicate that hsCRP (blood level of high sensitivity C-reactive protein) is a clinically valid biomarker for diagnosis of HNF1A-MODY (maturity-onset diabetes mellitus due to mutation in hepatocyte nuclear factor 1 alpha) in European populations.
21804277 The increase of adhesion molecules, homocysteine and hs-CRP in polygenic hypercholesterolemia subjects compared to the isolated hypertriglyceridemia group reflects their high cardiovascular risk.
21801245 We showed no evidence for a role of hs-CRP, C3 and C4 in the association between BMI and asthma symptoms in overweight children.
21794939 CRP is produced and released within the coronary circulation of patients with acute coronary syndrome; this is associated with impairment of endothelial function.
21773944 Three CRP gene polymorphisms may not contribute to the genetic background of psoriasis in Chinese-Taiwanese.
21757662 Relationship between C-reactive protein, systemic oxygen consumption, and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
21741099 the A3872G polymorphism had a significant impact on CRP levels in patients with DM2 exhibiting CAD.
21740772 The results showed that hsCRP presents a general biomarker for inflammation in patients with unstable angina.
21737650 Presence of the CRP1919T>A polymorphism was associated with impaired overall survival in patients with cervical cancer. The CRP gene polymorphism CRP5237A>G was associated with decreased serum CRP levels.
21730823 Postoperative cTnI levels seem to be superior to CK-MB and hs-CRP levels for the prediction of 1-year cardiovascular mortality and morbidity in patients undergoing elective vascular surgery.
21729973 Before a first ischaemic coronary event, persistent mild-to-moderate depressive symptoms were associated with increased hsCRP.
21729568 There was no statistical difference of 1059 G/C genotype and mutation frequency of allele between deep vein thrombosis group and control group.
21720757 These results indicate relationship between many polymorphisms in CRP gene and risk of acute myocardial infarction.
21719129 Vascular inflammation is increased in individuals with higher C-reactive protein levels compared to those with lower levels.
21716910 Serial CRP measurements during the first week of antimicrobial therapy may be useful as a prognostic factor for mortality in cirrhotic patients with bacteremia.
21714897 The ratio of C-reactive protein to prealbumin is independently associated with mortality after adjustment for age, gender, sepsis and sequential organ failure assessment.
21700090 N-terminal pro-brain natriuretic Peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in older men with and without pre-existing cardiovascular disease
21697747 Sixteen weeks of resistance training, endurance training, or concurrent training in middle-age healthy men did not affect low and moderate IL-6, TNF-alpha, and CRP levels.
21696613 Measurement of CRP and BNP is useful for distinguishing acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema.
21685272 CRP exerts a local effect on endothelial cells via P-selectin expression, which promotes platelet adhesion and subsequent thrombus formation.
21679689 this study has provided the first proposal on the novel insights into how CRP directly affects cell cycle in cells.
21658317 CRP may be considered as a good marker of jonit prosthesis infection, distinguishing between patients with and without infection, and between patients with infection and those with previous infection.
21655904 Lymphocyte count was significantly associated with hyper-LDL cholesterolemia independently of hs-CRP in apparently healthy Japanese.
21647738 findings demonstrate convincing evidence that genetic variants in C-reactive protein (CRP), and HNF1A contribute to plasma CRP in Filipino women and provide the first evidence that exposure to a pathogenic environment may modify the genetic influence at the HNF1A, LEPR, and 6q16.1 loci on plasma CRP level
21645137 IL-6 and CRP concentrations were significantly increased in CU patients as compared with the healthy subjects, whereas they decreased remarkably upon the spontaneous remission.
21640994 Hs-CRP may be associated with white blood cell count in metabolic syndrome patients treated with Ginkgo biloba
21630214 High CRP levels are associated with significantly greater embolization during carotid artery stenting in symptomatic patients, particularly in dishomogenous plaque.
21625240 Elevations in serum CRP and visfatin may contribute to accelerated atherogenic processes in a spinal cord-injured population.
21624120 Data indicate that the level of disease activity, as measured by time-integrated DAS28-CRP, anti-CCP and IgM-RF positivity and a high baseline joint damage, affects subsequent progression of radiographic damage in early rheumatoid arthritis.
21617097 In type 1 diabetes, adiponectin but not hs-CRP was increased (P<0.01), whereas in type 2 diabetes, hs-CRP but not adiponectin was increased (P<0.01).
21602602 These outcomes strongly support a role of the GPIb-IX-V complex in the interactions of modified C-reactive protein with blood platelets
21592994 Results showed biomarkers of inflammation (CRP, IL-6), coagulation (D-dimer), and tissue fibrosis (HA) measured pre-ART and at 1 month are associated with higher risk of AIDS events, IRIS, or death.
21575917 relationship between C-reactive protein (CRP) and alpha1-antitrypsin (AAT) in the AAT deficiency diagnostic setting to verify whether variations in the CRP gene could influence CRP
21570260 anxiety symptoms alone increased the probability for elevated CRP levels
21565862 Increase in inflammation mediatiors Il6/C-reactive protein is associated with the loss of skeletal muscle in free-living non-sarcopenic older men and women.
21553357 A gene polymorphism in acetyl-coenzyme A carboxylase beta may be associated with the C-reactive protein level in a prediabetic and diabetic population.
21546857 CRP has no prognostic value in melanoma patients treated with adjuvant interferon-alpha.
21536287 Increased serum omega-6 fatty acid and C-reactive protein levels appear to be independently associated with the unfavorable conditions related to arterial stiffness/wave reflection and inflammation.
21526633 This study showed that diabetics have significantly higher serum C-reactive protein compared to the apparently controls; there was a positive and significant correlation between C-reactive protein and fasting blood glucose among both patients and controls
21519150 Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy.
21516340 Results indicate that these polymorphisms can indirectly influence performance, contribute to higher susceptibility to exercise-induced inflammation or protection against it, and perhaps affect future risks of CVD in athletes.
21508123 Serum levels of high-sensitivity C-reactive protein were not associated with future development of venous thromboembolism.
21493089 The relationship between the level of the inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and posttraumatic stress disorder (PTSD) symptomology in a random sample of 115 police officers, was examined.
21476028 Elevated CRP plasma concentrations are associated with decreased survival in patients with colorectal peritoneal carcinomatosis.
21468168 Procalcitonin, C-reactive protein and neopterin levels vary depending on the clinical status in chronic obstructive pulmonary disease.
21465964 Serum hs-CRP 9high sensitivity C-reactive protein )levels show significant correlation with the severity of Coronary Artery Disease as assessed by angiographic Gensini score.
21458205 Higher levels of CRP are independently associated with an increased risk of perioperative myocardial damage and early adverse cardiovascular events in patients undergoing elective vascular surgery.
21455669 Suggest diets high in fiber may benefit breast cancer survivors via reductions in C-reactive protein and systemic inflammation.
21447704 Human CRP overexpression facilitated the development of insulin resistance and hepatosteatosis in obese mice.
21444086 hs-CRP has a role in incidence of total and ischemic strokes among middle-aged Japanese men and women
21415385 a role for CRP in promoting differentiation of human monocytes toward a proinflammatory M1 phenotype.
21414621 Abnormal ABI, and elevated fibrinogen/CRP are highly prevalent among individuals otherwise at low-intermediate cardiovascular risk.
21413847 C-reactive protein gene allelic variation is associated with C-reactive protein levels in both sexes and with carotid artery elasticity
21406102 C-reactive protein levels predict the risk of myocardial infarction among white men.
21404895 sPLA2-IIA, CRP, and C3d are significantly more activated in atherosclerotic aortic valves compared to degeneratively changed aortic valves.
21402418 The combination of clinical risk markers and C-reactive protein helps to exclude the presence of transesophageal echocardiographic markers in patients with atrial fibrillation.
21383176 Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein.
21360619 Under physiological conditions, phosphoethanolamine is bound with higher affinity by human SAP than by human CRP.
21357824 Hs-CRP is elevated at the initial presentation in approximately 3 of 4 cases of acute pericarditis.
21357282 These findings are consistent with the hypothesis that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome.
21325757 The serum levels of resistin and leptin were positively associated with CRP level in patients with rheumatoid arthritis, suggesting that these adipokines may act as pro-inflammatory cytokines in this disease.
21325005 genetic data indicate that C reactive protein concentration itself is unlikely to be even a modest causal factor in coronary heart disease - meta-analysis
21324310 statistical association between variations in the ATF3 gene and levels of nine serum inflammatory markers, including C reactive protein
21323571 increased serum levels in patients with premature coronary artery disease; correlate with the degree of angiographic blockade
21315565 Report C-reactive protein levels were predictive of coronary disease risk in Turkish adults of both sexes.
21309632 In women with indicated cervical cerclage between 17 and 26 weeks of gestation, increased levels of serum CRP on post-cerclage day 1 or 2 might be ominous signs for very preterm birth.
21309051 Gestational diabetes is associated with loss of natural variation of C-reactive protein and serum amyloid A, suggesting altered modulation of inflammation.
21305296 CRP level has a highly significant, strong linear correlation with erythrocyte sedimentation rate (ESR) as a valid and sensitive assessment index of disease activity in Korean patients with rheumatoid arthritis; CRP can be used as an alternative to ESR.
21296900 The median level of CRP was higher in patients with atherothrombotic stroke, followed by cardioembolic stroke
21296145 CRP SNPs were not associated with affective status or metabolic syndrome, but the association of adolescent emotional problems with metabolic syndrome was stronger in those who were homozygous for the C allele of rs1205 than in T carriers.
21294915 High serum C-reactive protein and IL-6 is associated with lymph node metastasis in breast cancer.
21293934 C-reactive protein gene polymorphism is associated with colorectal cancer.
21287288 Data suggest that dietary fats rich in stearic acid do not seem to increase postprandial inflammation, as indicated by serum C-reactive protein and IL-6 levels.
21284020 Serum CRP and urinary NGF levels are elevated in patients with overactive bladder and interstitial cystitis/bladder pain syndrome.
21270838 Genetic variants in the CRP gene are significantly associated with plasma CRP levels but not with hypertension.
21258804 No change in serum CRP level was noted in patients with knee osteoarthritis treated with mud pack therapy.
21226995 The new International Diabetes Federation (IDF), American Heart Association (AHA) and National Heart, Lung, and Blood Institute (NHLBI) definition of metabolic syndrome may have a stronger relationship with serum hsCRP than the IDF definition.
21218608 C-reactive protein is associated with right ventricular dysfunction, which is a predictor of prognosis in pulmonary embolism.
21215477 As a categorical variable, CRP has potential as a marker of future cardiovascular disease risk, when the influence of age and gender are taken into account.
21204606 Circulating CRP levels were found to be higher among patients with complete hydatidiform mole.
21203342 An age-dependent elevation of serum hs-CRP levels may be accelerated in normal subjects with one or two risk alleles in the ARMS2/HTRA1 locus compared to those with homozygous wild-type alleles.
21196492 IL6 locus regulates the serum CRP levels and inflammatory pathways.
21195701 HNF1A polymorphisms are independently associated with CRP level in Taiwanese
21194909 Elevated CRP, but not elevated matrix metalloproteinase-9, associates with increased risk of unstable angina, myocardial infarction and death in patients with stable coronary heart disease.
21190868 Findings indicate that IL-6 is a powerful independent predictor of future CV events in high-risk Japanese patients, suggesting its predictive value is superior to hs-CRP.
21182750 none of studied C-reactive protein variants was associated with schizophrenia
21173540 Severity of low-grade inflammation in cardiovascular disease is related to increases in plasma CRP and B-type natriuretic peptide (BNP).
21173097 High C-reactive protein is associated with Inflammation and thrombosis in essential thrombocythemia and polycythemia vera.
21172733 Serum CRP and hematoma volume are predictors of short-term mortality in spontaneous intracerebral hemorrhage.
21167068 Insulin resistance was associated with CRP levels independent of abdominal obesity in Chinese patients with type 2 diabetes.
21162890 The level of MMP-9 was positively associated with that of hs-CRP in stroke patients.
21161711 CRP levels in patients with Parkinson's disease (PD) are associated with a higher prevalence of coronary artery disease, but are not associated with PD duration or severity, or with neuropsychiatric complications other than reported depression.
21149504 Common variants of the genes encoding CRP, TNF-, and IL-6 were not significantly associated with the risk of clinical diabetes in postmenopausal women.
21146168 LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP.
21143879 Results suggest that higher CRP and gamma-glutamyl transferase levels were synergistically associated with metabolic syndrome and insulin resistance.
21143859 Report increased C-reactive protein levels in patients with type 2 diabetes and/or ischemic heart disease.
21136015 A persistent increase of plasma fibrinogen/C-reactive protein is associated with an increased risk of early atherosclerosis.
21135979 Report significant differences between serum CRP levels in children in different categories of physical activity.
21108561 The aim of the study was to evaluate the extent to which serum high-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide measurement alone or together could be prognostic biomarkers in patients with stable coronary artery disease.
21105323 no relation between carriage of CRP alleles/genotypes of CRP and one year prognosis in patients with myocardial infarction
21094359 central obesity, low HDL cholesterol, and CRP polymorphisms are major determinants of higher hsCRP levels in Chinese patients receiving treatment with rosuvastatin.
21089116 CRP had no prognostic value in acute heart failure patients with an infectious complication. Noninfected patients with higher CRP at discharge had worse prognosis.
21086905 In chronic sarcoidosis patients, elevated CRP appears to identify a subset with more severe disease who may respond better to treatment with infliximab.
21081932 High serum C-reactive protein is associated with colorectal cancer.
21080913 Observational study of gene-disease association. (HuGE Navigator)
21071964 C-reactive protein (CRP) expression in renal allografts is associated with deteriorating one-year graft function in acute as well as chronic allograft dysfunction in chronic kidney failure transplant patients.
21067752 hs-CRP and TNF-alpha, but not TGF-beta, IL-6, IL10 or proBNP may have a role in cardiovascular event risk in patients with atherosclerotic occlusive disease
21062467 Polymorphism of HNF1A is associatted with decreasd CRP levels, but not with coronary artery disease.
21059738 Observational study of gene-disease association. (HuGE Navigator)
21054877 Observational study of gene-disease association. (HuGE Navigator)
21054666 Suggest that tissue advanced glycation end products level is one of the independent determinants of hsCRP in hemodialysis patients.
21044781 Observational study of gene-disease association. (HuGE Navigator)
21044752 CRP+1444C>T polymorphism was associated with CRP levels in Mexican adolescents and could be used as a genetic marker for the early detection of individuals at risk for developing obesity-related conditions
21044752 Observational study of gene-disease association. (HuGE Navigator)
21043803 Serum levels of CRP were not significantly higher among subjects with periodontitis than among controls. A statistically significant positive association between percentages of sites with bleeding on probing and log-transformed CRP values was observed.
21037509 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21037097 Collaboration among CRP, M-ficolin, and G protein-coupled receptor 43 under acidosis curtails interleukin (IL)-8 production, thus preventing immune overactivation during bacterial infection.
21034294 genetic variants in the CRP gene that are associated with lifetime plasma CRP levels were also associated with salivary cortisol levels after awakening, in basal, non-inflammatory conditions.
21034294 Observational study of gene-disease association. (HuGE Navigator)
21033124 The levels of Serum IL-8, CRP and TNF-alpha in coronary heart disease group were significantly higher than those in control group.
21029457 Study in type 2 diabetic patients shows a significant association of hs-CRP levels with the G(-866)A polymorphism of uncoupling protein 2 beyond the effect of major confounders.
21029360 Elevated plasma hCRP levels promote thrombus formation on injured smooth muscle cell-rich neointima by enhancing TF expression.
20979755 The level of NT-proBNP in conjunction with hs-CRP can predict the prognosis of heart failure patients.
20978825 Adiponectin inhibits CRP production in HepG(2) cells elicited by IL-6, by downregulating STAT3 phosphorylation.
20974458 Higher CRP levels in pregnancy are associated with wheezing and lower respiratory tract infections in offspring.
20972697 Data show that CRP, but not YKL-40, is associated with the cholesterol levels in statin treated patients.
20967757 human CRP plays an active role in inducing hepatic insulin resistance in the rat, at least in part by activating ERK1/2, with downstream impairment in the insulin signaling pathway.
20952358 can be used as a biomarker for myocardial ischemia
20949557 C-reactive protein AA genotype was associated with colon and rectal cancers.
20949557 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20939118 Data suggest that C reactive protein values can be considered as an independent factor to determine the duration of the antibiotic treatment for pyogenic liver abscess after complete percutaneous drainage.
20930309 these data suggest that local production of serum amyloid P and c-reactive protein in the alzheimer disease brain does not substantially contribute to the CSF levels.
20929699 Elevated levels of CRP are associated with vessel burden in clinically and angiographically defined unstable angina pectoris.
20929576 The thromboelastometry lysis index proves to be a more reliable biomarker of severe sepsis in critically ill adults than are procalcitonin, IL6, and C-reactive protein levels.
20883364 elevated serum IL-6 levels are reflected in elevated hs-CRP levels in systemic sclerosis patients.
20881941 For each doubling of serum alkaline phosphatase, the odds of elevated serum CRP (over 3 mg/l) were increased 2.73-fold in the non-chronic and 2.50-fold in the chronic kidney disease sub-populations, respectively.
20877716 Observational study of gene-disease association. (HuGE Navigator)
20874781 In cancer patients elevated CRP was not independently associated with venous thromboembolism. CRP was significantly associated with worse survival.
20856253 Boys who carry the GG genotype of CRP +2147 A/G and the CC genotype of IL-6R rs2229238 C/T have a greater risk of having abnormal body size and of developing obesity than individuals who do not have these genotypes.
20856253 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20855565 Observational study of gene-disease association. (HuGE Navigator)
20855282 Treatment with metoprolol succinate reduces serum levels of VEGF and CRP in elderly hypertensive patients with chronic heart failure.
20852043 Increased human CRP expression exacerbates left ventricular dysfunction and adverse LV remodeling after myocardial infarction without affecting infarct size in mice.
20850446 This hsCRP assay is a robust and inexpensive tool designed for use in large-scale population health research. Our results indicate that DBS CRP is less stable than previously reported.
20846939 High C-Reactive Protein is associated with increased mortality.
20846522 Data show that non-alcoholic fatty liver disease is independently associated with increased cardiovascular disease risk, especially among elderly subjects and those with increased C-reactive protein level.
20843812 Findings suggest that conformationally altered proteins form a CRP-ligand in acidic environment, regardless of the identity of the protein.
20836727 In patients with polycystic ovary syndrome, serum CRP levels were higher than age and BMI-matched controls. Furthermore, BMI was strongly related to CRP only in overweight patients with PCOS.
20819268 In chronic obstructive pulmonary disease patients, we found elevated plasma adiponectin, IL-6 and CRP levels
20813565 strong association of increased hs-CRP levels with vasoocclusive crisis in children with sickle cell disease
20805569 Persons with diabetes who had higher levels of CRP and body mass index were less likely to have diabetic retinopathy
20797493 Observational study of gene-disease association. (HuGE Navigator)
20734449 Albumin/creatinine ratio was a better predictor of long-term mortality after acute myocardial infarction than CRP.
20733302 Genetic variation in the C-reactive protein gene is associated with microangiopathic but not macroangiopathic or cardioembolic stroke in a large German stroke sample.
20733302 Observational study of gene-disease association. (HuGE Navigator)
20730440 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20727736 Observational study of gene-disease association. (HuGE Navigator)
20722986 Elevated level of CRP is a useful parameter in the severity of clinical risk of pre-eclampsia in patients with BMI < 25 kg/m(2) at third trimester.
20709501 Some biomarker levels, including higher glycosylated HbA1C, are associated with an increased risk of premature mortality in patients on antiepileptic monotherapy.
20706769 Data suggest that compared to high sensitive C-reactive protein, serum C3 might be a better inflammatory marker of insulin resistance in the non-diabetic Chinese population.
20704541 [review]CRP as a marker but also an active player in the development of venous thrombosis; further evidence is needed to establish which event comes first--thrombosis or inflammation.
20703235 cigarette smoking is a risk factor for renal function alteration in healthy smokers and is characterized by a high estimated glomerular filtration rate and a high urinary protein associated with an increase in the hs-CRP.
20691829 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20690093 Cystatin C can predict the presence and severity of coronary artery disease.
20686879 C-reactive protein 1846T/T genotype is an independent predictor of a poor prognosis in patients with non-small cell lung cancer.
20686879 Observational study of gene-disease association. (HuGE Navigator)
20683147 Elevated C-reactive protein is associated with metabolic impairment leading to cardiovascular diseases.
20680929 Elevated C-reactive protein and soluble E-selectin were associated with higher HOMA-IR among residents of Inner Mongolia.
20679960 Observational study of gene-disease association. (HuGE Navigator)
20676960 High-sensitivity CRP was an independent factor for future development of diabetes mellitus in essential hypertensive patients.
20670634 CRP induces the inflammatory responses through increasing IL-6 generation and reducing PPARgamma expression in VSMCs, which is mediated by TLR4/IRF3/NF-kappaB signal pathway
20669343 high sensitive C-reactive protein and apelin levels after percutaneous coronary intervention and drug-eluting stent implantation
20651278 Interleukin 6, but not high-sensitivity C-reactive protein or fibrinogen, is an independent predictor of sudden death in asymptomatic European men.
20640440 Circulating pentraxin3 and C-reactive protein significantly increased immediately after peak ergometer exercise, while they did not increase after 70% anaerobic threshold exercise.
20638228 Elevated preprocedural serum CRP levels are associated with higher rates of restenosis, reintervention, and any-cause death after endovascular therapy in hemodialysis patients with peripheral arterial disease.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20626701 examinee the relationship between cardiac autonomic control derived from heart rate variability, high-sensitivity C-reactive protein and physical activity
20626239 Presence of increased CRP and higher insulin resistance values in women with polycystic ovary syndrome could contribute to increased diabetogenic and atherogenic risk in these patients.
20626020 Our findings suggest higher diagnostic usefulness of serum IL-6 than CRP in the diagnosis and prognosis of patients with PC and in the differentiation with CP.
20623261 Suggest the combination of CRP and IL-6 would be a useful serologic tool to complement others when diagnosing periprosthetic hip infection.
20618287 CRP is an independent predictor of CVD[cardiovascular disease] in Aboriginal people
20614004 hs-CRP, PAI-1, and S100B levels did not differ at all time points between appropriate-for-gestational-age and intrauterine growth-restricted groups.
20610232 Upregulation of monocyte proinflammatory cytokine production by CRP could be significantly related to ongoing myocardial damage.
20605213 Synergistic influence of CRP levels and the at risk genotype of the CFH gene resulted in a super-additive risk for prevalent late AMD (age-related macular degeneration) and AMD progression.
20599197 C-reactive protein and homocysteine may affect subclinical coronary plaque subtype
20596713 Admission CRP is a strong risk marker of bad short-term prognosis after an incident acute myocardial infarction; in contrast to non-diabetic patients in diabetic patients, admission CRP is not independently associated with longterm prognosis
20596037 This study showed that, in a Japanese general population, HIGH SERUM CRP was a marker for relatively short-term risk of ischemic stroke in Prehypertension subjects
20592333 presence of the -174C allele determines to some extent higher plasma CRP and IL-6 concentrations pre- and postoperatively in coronary artery bypass grafting surgery patients
20587599 The presence of diabetes, elevated CRP levels and reduced glomerular filtration on admission is associated with an excessive hospital mortality in myocardial infarction.
20581772 The study aimed to compare humoral marker concentration shifts (hsCRP, Nt-proBNP) and hemodynamic left ventricular systolic function index changes, determined by means of echocardiography in the first hours of acute coronary syndromes.
20573938 Baseline CRP levels were higher among participants who developed diabetes (median (interquartile range) 1.44 (2.39) vs 0.78 (1.21) mg/l) or fatal CVD (1.49 (2.47) vs 0.84 (1.30) mg/l) compared with controls (both P<0.0001).
20556836 The measurement of high-sensitivity CRP did not prove useful in the assessment of disease activity or glucocorticoid treatment in pediatric inflammatory bowel disease patients that had undetectable standard CRP.
20552244 Observational study of gene-disease association. (HuGE Navigator)
20546810 C-reactive protein was strongly associated with metabolic syndrome and its individual components, but is not an independent predictor of subclinical atherosclerosis in postmenopausal Chinese women.
20539018 High levels of C-reactive protein associate with metabolic syndrome in young adults.
20538960 CRP variants associated with the apnea-hypopnea index as a continuous trait, and OSA as a dichotomous trait in European Americans
20538960 Observational study of gene-disease association. (HuGE Navigator)
20538278 AngII has ability to induce CRP expression in endothelial cells through AT(1)-ROS-ERK1/2 and JNK-NF-kappaB signal pathway, which strengthens understanding of the proinflammatory and proathroscerotic actions of AngII.
20538124 Genetic polymorphisms in the PTGS1 and CRP genes appear to be candidates for a possible gene-drug interaction influencing the acute coronary risk associated with NSAID use.
20538124 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20537668 elevated level of High-sensitivity C-reactive proteinin Japanese nondementia patients with type 2 diabetes mellitus is characterized by increased hippocampus volume and insulin resistance
20531240 Data show that combined ESR and CRP at 24 hours can predict severe AP accurately.
20522534 Serial measures of plasma CysC are highly correlated with the development of acute kidney injury after cardiopulmonary bypass.
20511616 There is no evidence of association between serum CRP levels or genetic variation in the CRP gene with the prevalence, incidence or progression of osteoarthritis independent of body mass index.
20511616 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20502295 Maternal serum cystatin C, CRP, and uterine artery mean resistance index are independent predictors of preeclampsia
20494378 Independent associations in metabolic syndrome between the combined ICAM1-CRP (rs5491 and rs3091244) genotypes and MetS were found by multivariate analysis
20494378 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20494358 visceral fat thickness is the strongest contributor to the systemic CRP concentrations in patients with vascular diseases.
20489166 Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels.
20485444 Observational study of gene-disease association. (HuGE Navigator)
20466978 Elevated CRP levels robustly associated with increased risk of venous thromboembolism (VTE), but this may not necessarily be a causal association because genetically elevated CRP did not associate with VTE risk.
20466978 Observational study of gene-disease association. (HuGE Navigator)
20465852 Preoperative serum CRP level increased in colorectal cancer patients but did not correlate with prognosis.
20453690 Elevated preoperative C-reactive protein is associated with systemic inflammatory response in patients undergoing resection. for non-small cell lung cancer.
20453000 Observational study of gene-disease association. (HuGE Navigator)
20443669 Diagnostic value of interleukin-6 and C-reactive protein on early onset bacterial infection in preterm neonates with respiratory distress.
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20437055 Reduction in high sensitivity-CRP concentrations seemed to be associated with strength gains and adiposity loss.
20423919 Observational study of gene-disease association. (HuGE Navigator)
20423474 Increased levels of CRP and TRX in subjects with mildly reduced glomerular filtration rate(GFR). The GFR-CRP link and the GFR-TRX link appeared to be mediated, at least partly, by alterations in blood pressure and plasma lipids.
20406964 Observational study of gene-disease association. (HuGE Navigator)
20403997 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20386340 Adiposity is positively related to serum CRP in prepubescent children, independent of the effects of fitness or physical activity. In addition, physical activity is inversely associated with CRP levels
20371432 Almost all of the acute-phase proteins were closely related to rheumatoid arthritis activity (based on DAS28) and their places in the downgrade scale were as follows: CRP, Tf, AGP, Hp and AAT.
20359087 C-reactive protein levels are higher in children with OSAHS and habitual snoring, and are also related to abnormal behavior.
20348053 CRP levels in pregnancy may be increased in pregnant women with multiple sclerosis, but may also be increased in normal pregnancies.
20346514 High-sensitivity CRP and polymorphisms in the CFH and ARMS2/HTRA1 genes are independently associated with risk of age-related macular degeneration (AMD). Higher CRP level tends to confer a higher risk of AMD within most genotype groups.
20346360 Observational study of gene-disease association. (HuGE Navigator)
20339904 sRAGE modulates the synthesis of hs-CRP through TNF-alpha.
20339115 In the C-reactive protein transgenic mouse model of carotid artery injury, mouse C3 is essential for the effect of human CRP.
20333461 Data show that the CRP C allele of rs1205 and IL-6 A allele of rs1130864 were significantly associated with higher serum CRP levels as well as with a decreased adenoma risk.
20333461 Observational study of gene-disease association. (HuGE Navigator)
20306065 Inter-group analysis revealed significant differences of C-reactive protein and leptin blood levels between the ovulatory and anovulatory cycles with higher values at periovulatory phase in the ovulatory cycles.
20237496 Observational study of gene-disease association. (HuGE Navigator)
20233980 Impaired kidney function, as measured by cystatin C, has an independent association with sudden cardiac death risk among elderly persons without clinical cardiovascular disease.
20227921 Significant increases in the plasma inflammatory markers D-dimer and CRP were identified prior to the initiation of antiretroviral therapy in subjects who eventually developed infectious IRIS manifestations within 12 months of initiation of therapy.
20227257 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20220110 C-reactive protein (CRP), which is not specific for infection, aggravates vulnerability of the immature rat brain to hypoxic-ischemic brain damage.
20219150 Psychological distress was not related to hsCRP
20215002 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20214668 MMP-9 levels are associated with disease severity in chronic urticaria patients and CRP levels.
20211068 The level of CRP is associated with an increased risk of lung cancer.
20200627 Meta-analysis suggests that preprocedurally elevated levels of CRP are associated with greater coronary in-stent restenosis after stenting and that this impact appears more prominent in unstable-angina patients.
20200626 Serum levels of hs-CRP varied over 24 hours, whether patients had coronary artery disease or normal coronary arteries.
20190687 hs-CRP can provide additional prognostic information for the risk stratification of chronic heart failure patients.
20186934 Elevated CRP levels are associated with ileal pouch anal anastomosis and inflammation.
20184536 The infectious group was subdivided into bacterial and viral infections, significantly higher leukocyte, C-reactive protein values were observed.
20184533 The C-reactive protein variants and corresponding haplotypes studied here have a major influence on risk of stroke and stroke recurrence.
20184533 Observational study of gene-disease association. (HuGE Navigator)
20184510 VCAM-1, ICAM-1 and hsCRP were significantly associated with long term outcomes of patients with stable angina pectoris beyond the risk associated with traditional risk factors.
20179497 we demonstrate that preoperative CRP levels as low as 3 mg/l are associated with increased long-term mortality and extended hospital length of stay in coronary artery bypass graft-only surgery
20173307 CRP-exposure inhibits VEGF-induced endothelial cell migration
20170291 High hs-CRP predicts a higher incident SZSRDS (Short Zung Self Rating Depression Scale) score and depressed mood among older men, suggesting a possible inflammatory etiology for depression.
20145925 Among the genetic polymorphisms tested, CRP -717C>T was significantly associated with stress hyperglycemia during esophagectomy.
20145925 Observational study of gene-disease association. (HuGE Navigator)
20145391 4 CRP SNps were measured in acute ischemic stroke patients. Haplotype 4 was associated with a 20.6 mg/l stronger increase in CRP level as compared with haplotype 1.
20145391 Observational study of gene-disease association. (HuGE Navigator)
20142117 Simvastatin and ezetimibe lowered C-reactive protein in patients with hypercholesterolemia.
20138378 In patients receiving percutaneous coronary intervention with drug eluting stents, poor renal function and high CRP are additively associated with a higher risk of hard endpoints and are independent predictors of mortality.
20136960 Serum C-raective protein can be used to effectively disease activity in patients with idiopathic ulcerative colitis.
20131075 Data show that procalcitonin is better than C-reactive protein for diagnosing sepsis and septic shock, mainly at admission, and is related to disease severity.
20083961 determined the effects of 10 wk of resistance or aerobic exercise training on interleukin-6 (IL-6) and C-reactive protein (CRP).
20078877 Observational study of gene-disease association. (HuGE Navigator)
20078870 CRP was associated with chronic kidney disease however not albuminuria in multivariable-adjusted analyses in African Americans
20075574 High-sensitivity C-reactive protein is a reliable biological marker for the inflammatory component of metabolic syndrome in Japanese.
20075509 Elevated levels of C-reactive protein and fibrinogen and reduced level of adiponectin can be used for early diagnosis of type 2 diabetes mellitus and can predict diabetic complications.
20075180 THP-1 cells differentiated into macrophage-like cells by treatment with phorbol 12-myristate 13-acetate internalized fluorescently labeled CRP.
20074254 Demonstrate the inhibitory effect of atorvastatin on CRP-induced inflammatory response in cultured pulmonary artery smooth was associated with NF-kappaB pathway.
20068351 Combination of high metabolic syndrome and MS was strongly associated with an increased risk of chronic kidney disease
20060752 The average MMP-9 and CRP concentrations increased with increasing degrees of relative wall stress in abdominal aortic aneurysms.
20056955 Observational study of gene-disease association. (HuGE Navigator)
20056225 serum YKL-40 and hsCRP levels are independently associated with lesion progression in patients with coronary artery disease
20047081 Results describe the associations between plasma IGF-I versus interleukin 6 (IL-6) and the acute phase proteins high sensitive C-reactive protein (hsCRP) and YKL-40 in a population-based study comprising 629 individuals, aged 50-89 years.
20042240 These data reveal the molecular basis of the specific interaction of CFHR4 with native CRP and suggest a role for CFHR4 in enhancing opsonization via CRP binding.
20036017 Following drug eluting stent implantation a positive correlation was found between C-reactive protein levels and intimal hyperplasia volume.
20034371 Correlation between local CRP production and the degree of severity of coronary artery disease in diabetic vasculopathy.
20031768 Increased preprocedural serum CRP levels would predict higher major adverse cardiac events and restenosis rates after sirolimus-eluting stents implantation in patients on hemodialysis.
20024640 CRP may have more accurately selected high-risk subjects due to its association with very many risk factors, thus representing an integrative marker of the total inflammatory burden of an individual.
20017311 1444CC polymorphism of CRP is highly associated with symptomatic carotid artery stenosis.
20017311 Observational study of gene-disease association. (HuGE Navigator)
20006362 this study reports significantly increased levels of CRP not only in diabetic subjects with metabolic syndrome but also in prediabetic subjects and nondiabetic subjects with metabolic syndrome
20005739 Data show that IL-6 and hsCRP were higher in patients with left ventricular systolic dysfunction (LVSDF) than in preserved LV ejection function (PLVEF), and that IL-6 and hsCRP decreased after treatment in LVSDF, but not in PLVEF.
20004425 These findings confirm that insulin resistance is strongly associated with CRP levels independent of abdominal obesity in nondiabetic Taiwanese
19965533 CRP SNPs that were associated with higher levels of CRP did not predict CKD progression. The rs2808630_GG genotype was associated with higher risk of CKD progression, and in patients with this genotype, ACEIs did not slow progression.
19965533 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19962488 polymorphism in the CRP gene contributes to both CRP levels and HRV
19962488 Observational study of gene-disease association. (HuGE Navigator)
19956729 Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MAPK/Erk and androgen receptor pathways
19954777 CRP and TNFalpha increased significantly but reacted differently during heavy physical activity
19948975 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
19947988 No SNP or haplotypes of C-reactive protein were associated with risk among white Cardiovascular Health Study participants. Among black participants, the haplotype tagged by A790T was associated with a lower risk for incident pneumonia.
19947988 Observational study of gene-disease association. (HuGE Navigator)
19946607 Results show the CRP -286 A-allele was associated with an increased susceptibility to uncomplicated Plasmodium falciparum malaria.
19946607 Observational study of gene-disease association. (HuGE Navigator)
19944144 In linear regression models adjusted for age, sex and education, experiences of discrimination were associated with higher levels of CRP
19942863 In hypertensive subjects high serum CRP and P wave dispersion are interrelated and associated with atrial fibrillation
19931932 High-sensitivity C-reactive protein may be a novel predictor for cerebrovascular events in diabetic patients.
19929715 Observational study of gene-disease association. (HuGE Navigator)
19923014 C-reactive protein was negatively associated with physical performance when adjusted for the confounding factors. The level of C-reactive protein may be a useful indicator for detecting lower physical performance in the elderly.
19914996 Elevated C-reactive protein levels are associated with micro/macroalbuminuria independent of diabetes, hypertension.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19906786 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19903811 Both 2 mM Ca(2+) and 140 mM NaCl are essential for the integrity of CRP in functional studies and understanding the role of CRP in the acute phase response.
19900432 C-reactive protein and gamma-glutamyltransferase levels were significantly higher in participants with diabetes than in those without.
19879773 These results suggest that a combination of serum soluble interferon-alpha/beta receptor and high-sensitivity-CRP thresholds may be more reliable diagnostic parameter for gastrointestinal and hepatobiliary-pancreatic cancer.
19874580 this is the first study to show an inverse association between c-reactive protein and joint pain threshold in rheumatoid arthritis.
19864399 Inflammatory Index can predict serum high-sensitivity CRP and provide additional evidence that diet plays a role in the regulation of inflammation.
19857676 Observational study of gene-disease association. (HuGE Navigator)
19857655 Observational study of gene-disease association. (HuGE Navigator)
19855269 Suggest that elevated hs-CRP might reflect the inflammatory activity of the coronary atherosclerotic plaque even in the setting of stable angina pectoris.
19853918 CRP binding is enhanced by conformational bending at the neck region of M-ficolin, to avoid steric hindrance by the COL domain.
19851048 The increased carotid intima-media thickness and hs-CRP in indoor barbecue workers suggest that chronic carbon monoxide exposure may increase the risk of atherosclerotic cardiovascular events.
19850925 X-ray scattering showed that FH became more compact when binding to CRP, which is consistent with CRP binding at two different FH sites.
19850242 in patients with prediabetes or diabetes, women had significantly higher concentrations than did men for hs-CRP(high sensitivity C reactive protein)
19834334 CRP genotype is associated with a greater left ventricular (LV) growth to exercise, supporting a causal association between CRP and LV growth
19834334 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19833744 Results describe a significant inverse correlation between serum amyloid A and IgG levels and anti-SSA antibody titers as well as a trend towards an inverse correlation between SAA and ANA and RF titers, but not between CRP and these autoantibodies.
19821022 no statistically significant associations were found between the SNPs of C-reactive protein and cognition
19821022 Observational study of gene-disease association. (HuGE Navigator)
19818961 We confirmed an association between ApoE genotype and serum CRP.
19816870 Patients with acute coronary syndrome present with high levels CRP in the acute phase, which remain elevated compared to healthy populations. CRP levels in the index event were predictive of long-term cardiovascular mortality.
19816865 Elevated levels of cystatin C are independently associated with inducible ischemia among outpatients with stable coronary disease.
19808368 Higher levels of CRP/BNP/troponin T are strong, independent predictors of mortality in community patients with heart failure.
19806245 elevated levels are associated with increased risk of venous thromboembolism
19801321 findings suggest that the CRP 1059G>C genetic polymorphism is 1 determinant of serum CRP levels after esophagectomy in patients with thoracic esophageal cancer
19800416 Multivariate regression analysis demonstrated that age- and smoking-adjusted plasma CRP levels were associated negatively with HDL-C
19796676 study found that haplotypic variation in the CRP locus moderates an association of depressive symptoms with circulating CRP, which is partially mediated by BMI
19783155 Data suggest that high maternal matrix metalloproteinase-9 concentration, but none of the other cytokines or C-reactive protein, is significantly associated with spontaneous preterm birth.
19766699 The MMSE could discriminate between controls and patients with dementia but not between the subtypes and homocysteine was significant for patients with VaD.
19762397 Data suggest the variability of high-sensitivity C-reactive protein in systemic lupus erythematosus reduces its usefulness as a predictor of coronary artery disease risk in lupus and potentially in other chronic inflammatory diseases.
19762396 Observational study of gene-disease association. (HuGE Navigator)
19760027 polymorphisms in IL10, and also possibly in CRP and other genes related to immune response or obesity may be associated with colorectal cancer.
19760027 Observational study of gene-disease association. (HuGE Navigator)
19755616 Elevated basal C-reactive protein (CRP) level may be important in the pathogenesis of systemic lupus erythematosus, even though CRP responsiveness to noninfectious inflammation of SLE is decreased.
19755616 Observational study of gene-disease association. (HuGE Navigator)
19751919 Plasma CRP (C-reactive protein) is associated with prevalent MCI (mild cognitive impairment)and with nonamnestic MCI in elderly, nondemented persons in a population-based setting.
19736479 C-Reactive protein is a valuable predictive marker in predialysis chronic kidney disease.
19736474 C- Reactive protein was not associated with coronary artery disease related mortality in hemodialysis patients.
19729797 PCOS and obesity induce an increase in serum inflammatory cardiovascular risk markers (high sensitivity CRP, interleukin-6, and TNF-alpha).
19728551 Blood levels may indicate postoperative complications in patients with colorectal or stomach cancers.
19719993 Elevated hs-CRP concentrations were not related to rejection after heart transplantation.
19719987 Plasma Hs-CRP and left ventricular ejection fraction were not correlated with serum uric acid and pulmonary capillary wedge pressure.
19715516 Serum levels of high-sensitivity C-reactive protein and procalcitonin are biomarkers for transplantrelated complications such as graft-versus-host disease or infection.
19706826 Changes in serum levels of inflammatory marker C-reactive protein was positively associated with increases in fatigue symptoms
19695857 Suggest that elevated CRP per se does not cause cardiovascular disease; however, inflammation per se possibly contributes to CVD. (Viewpoint/Review).
19692168 Observational study of gene-disease association. (HuGE Navigator)
19692124 Our data did not show significant association between the CFH Y402H polymorphism and photodynamic treatment (PTD); however, CRP genetic variants were associated with a positive response to PTD for neovascular age-related macular degeneration.
19692124 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19680263 show that monomeric CRP directs Factor H to the surface of apoptotic and necrotic endothelial cells and identify phosphocholine as one binding moiety for this complex.
19670170 Report changes in serum C-reactive protein and TNF-alpha in hemodialysis patients depends on type of vascular access.
19667982 Given the data available in mid-2009, elevated CRP per se does not seem to cause atherothrombotic cardiovascular disease.
19645035 An increase in plasma CRP levels was associated with an increased prevalence of atrial fibrillation in idiopathic dilated cardiomyopathy patients.
19644070 Lp-PLA2 mass levels decrease modestly, whereas hsCRP and Lp-PLA2 activity appear stable over time. Acutely after stroke and MI, hsCRP increases whereas Lp-PLA2 mass and activity levels decrease.
19643942 COPD patients had significantly lower levels of osteoprotegrin than subjects without COPD and higher CRP (c reactive protein) levels;CRP was elevated in patients with frequent exacerbations
19643839 Blacks, women, and obese people were at highest risk for increased high-sensitivity C-reactive protein
19642908 higher plasama levels correlate with recurrences in patients with brain infarction
19631649 Results suggest that CRP may promote coagulation by enhancing the expression and activity of TF and reducing that of TFPI by activating NF-kappaB and extracellular signal-regulated kinases 1 and 2 via FcgammaR II.
19626399 Interleukin-6 is a stronger prognostic predictor than high-sensitive C-reactive protein in patients with chronic stable heart failure.
19625176 Observational study of gene-disease association. (HuGE Navigator)
19624831 These results provided functional evidence supporting the association of the SNP rs2794521 of the CRP gene with coronary heart diseaseprobably through regulating the expression level of CRP by different variations of rs2794521
19620133 Collectively, these data suggest that C-reactive protein impairs glycocalyx function, resulting in endothelial dysfunction.
19619902 study concludes that serum levels of hsCRP are increased in clinically stable Arab patients with schizophrenia and appear related to the disorder's clinical expression
19617288 Monomeric CRP (mCRP), but not native pentameric (nCRP), decreased acetylated LDL uptake in human endothelial cells independent of CD16, CD32, or LOX-1; data support a protective role of mCRP in cardiovascular disease.
19615354 an association of increased GA, hsCRP and sICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus
19614793 Report no change in C-reactive protein levels in patients with diabetes mellitus in response to therapy.
19609738 Patients with increased CRP levels have a significantly higher risk of poor outcome or death of ischemic stroke at 3 months.
19602903 The acceleration of arterial wall stiffness in CKD is associated with additional factors, i.e. fetuin A deficiency and higher CRP and IL-6.
19595394 Preprocedural hs-CRP is more a predictor of global cardiovascular risk than a predictor of stent-related complications.
19594772 Low C-reactive protein distinquishes cytomegalovirus from tuberculosis and bacterial infections in renal transplant recipients
19584180 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19578796 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19577754 Suggest that a heightened baseline inflammatory status of metabolic syndrome may predispose acute coronary syndrome patients to an augmented hs-CRP response.
19576194 the significance of the TNF/IL-10 ratio and C-reactive protein (CRP) in patients of acute myocardial infarction as a marker for CAD in the atherosclerosis-prone North Indian population
19571581 Leptin stimulated C-reactive protein production by human coronary artery endothelial cells.
19568166 Measurement of C-reactive protein levels added to those of cardiac troponin I and B-type natriuretic peptide improves the risk assessment of long-term adverse cardiac outcome after cardiac surgery.
19567438 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
19565490 There are disease-specific associations between anti-Jo-1 antibody-positive interstitial lung disease and serum levels of CRP as well as the interferon-gamma-inducible chemokines CXCL9 and CXCL10.
19560102 In the oldest-old, high CRP levels are associated with increased odds of all-cause dementia, particularly in women.
19545442 This study indicate that CRP may play an important role in the immune responses to malaria, and that the -286 C/T/A CRP polymorphism may be a contributing factor to the lower susceptibility to malaria seen in the Fulani.
19545442 Observational study of gene-disease association. (HuGE Navigator)
19538326 Increased levels of CRP indicated a more pronounced systemic inflammation in periodontitis patients; elevated levels of CRP can be considered as an independent risk factor for developing cardiovascular disease.
19534672 higher levels in the patients with the left ventricular dysfunction of an ishemic origin than those of non-ischemic
19533498 Observational study of gene-disease association. (HuGE Navigator)
19527514 Observational study of gene-disease association. (HuGE Navigator)
19525580 Very low levels of hs-CRP were not bimodally distributed but were significantly related to metabolic risk factors in Japanese.
19523464 The Dimension Vista cTnI, CK-MB, MYO, NTproBNP, and hsCRP methods demonstrate acceptable performance characteristics for use as an aid in the diagnosis and risk assessment of patients presenting with suspected acute coronary syndromes.
19522741 CRP modulates prostanoid metabolism to favor vascular occlusion.
19521085 increased high-sensitivity CRP (hs-CRP) level in patients with Parkinson's disease observed; results could support hypothesis that neuroinflammation contributed to pathogenesis of PD & elevated hs-CRP may have clinical value as risk factor for PD
19520972 Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques.
19501644 We conclude that the level of high sensitive c-reactive protein is not a biomarker for the total number of functional somatic symptoms in the general population.
19501581 Studies indicate that insulin resistance also stimulates the production of CRP and PAI-1, both markers of an inflammatory state.
19499327 CRP have a protective role towards the clearance of damaged-erythrocytes in tuberculosis and visceral leishmaniasis.
19495883 CRP genetic polymorphism is associated with lymph node metastasis in thoracic esophageal squamous cell cancer.
19495883 Observational study of gene-disease association. (HuGE Navigator)
19494488 The presence of the T allele within the CRP gene C1444T polymorphism may be associated with a higher risk of further ischemic events in symptomatic intracranial atherosclerotic disease patients.
19494488 Observational study of gene-disease association. (HuGE Navigator)
19492468 Observational study of gene-disease association. (HuGE Navigator)
19482283 Higher serum hs-CRP levels were associated with higher mortality from cardiovascular disease in Japanese.
19480860 Findings indicate that the proposed CRP/CD11b ratio test could potentially assist physicians in determining an appropriate antibiotic treatment in patients with severe bacterial infection.
19473152 Periodontitis cases had significantly higher levels of C-reactive protein than non-cases. Probing pocket depth, clinical attachment loss, plaque and gingivitis indices were positively associated with elevated levels of C-reactive protein.
19469014 A positive association between CRP and prevalence odds of large adenomas was not modified by either smoking or being overweight.
19461040 Patients with transient ischemic atack have a high-risk mechanism (large vessel stenosis or cardioembolism) or will experience stroke/death within 90 days. In contrast to CRP, both Lp-PLA(2) mass and activity were associated with this composite end point.
19439303 In Japanese patients with stable coronary artery disease receiving only medical treatment, higher hsCRP levels were found to be associated with a significantly increased risk for further cardiovascular events.
19439300 Inflammatory markers (CRP/IL6) are not useful indices of cardiovascular disease risk in South Asian and European origin infants in Britain.
19437230 elevated in pre-eclampsia
19436686 Systemic inflammatory biomarkers IL-6, CRP, and TNF-alpha were moderately repeatable over a 12 month period in chronic obstructive pulmonary disease patients.
19436676 Report nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein.
19436291 study suggests association between PSA and CRP variants in prostate cancer; CRP alleles previously found to protect against increased CRP levels are now suggested to be associated with metastatic prostate cancer, indicated by elevated PSA
19436122 Coronary arterial remodeling, fibrous cap thickness and hs-CRP level in patients with acute coronary syndrome are associated with each other.
19433520 Observational study of gene-disease association. (HuGE Navigator)
19428053 The genetic variant of CRP gene is associated with carotid atherosclerosis, independently of traditional vascular risk factors.
19428053 Observational study of gene-disease association. (HuGE Navigator)
19426506 We identified a CRP gene SNP associated with lower postoperative CRP levels in patients undergoing coronary artery bypass surgery with cardiopulmonary bypass
19426506 Observational study of gene-disease association. (HuGE Navigator)
19423540 Observational study of gene-disease association. (HuGE Navigator)
19415283 CRP and the risk of atherosclerotic events.
19415164 Serum leptin is an independent factor associated with C-reactive protein in Korean type 2 diabetic patients.
19410251 After adjustment for the major cardiovascular risk factors, four CRP SNPs were significantly associated with serum CRP levels in women (p<0.05), whereas the -286C>T>A and +1444C>T polymorphisms were associated with CRP levels in men.
19410251 Observational study of gene-disease association. (HuGE Navigator)
19403254 Body temperature and CRP are two parameters leading to comparable information in more than 80% of infected patients receiving specific antibiotic therapy.
19394732 Despite variability over time, inflammation assessed by using CRP level is a strong predictor of mortality.
19390179 C-reactive protein (CRP) is significantly associated with the risk of having a first ischemic stroke, especially for small-vessel disease. The CRP 1444 (CC/CT vs. TT) polymorphism was associated with plasma levels of CRP.
19390179 Observational study of gene-disease association. (HuGE Navigator)
19387251 The combination of elevated CRP and cTnI increased the risk of adverse cardiac events after sirolimus-eluting stent implantation.
19377253 In type 2 diabetic patients, microalbuminuria is accompanied by elevated HS-CRP (high sensitivity C-reactive protein)
19377212 in early type 2 diabetic nephropathy IL6 (interleukin 6) and HS-CRP (high sensitivity C reactive protein) are elevated and are independently associated with urinary albumin excretion
19375128 both CRP and metabolic syndrome are independent factors associated with stroke among ethnic Chines
19369869 A high CRP level predisposes to increased cardiovascular risk in MetS.
19362308 CRP and homocysteine levels may affect the development and progression of abnormal heart rate recovery in polycystic ovary syndrome.
19360108 Levels of IL-4, IL-8, IL-13, ICAM-1, and VCAM-1 were higher but not significant and levels of IL-10 and IFN-gamma were significantly lower in hsCRP positive patients.
19359657 Continuously-infused human C-reactive protein is neither proatherosclerotic nor proinflammatory in apolipoprotein E-deficient mice.
19358836 The CRP concentration in the rural Chinese population was lower than that of Caucasians and strongly related to the metabolic syndrome, especially in women.
19351632 C-reactive protein level increased significantly after atrial fibrillation ablation. High C-reactive protein level was associated with fewer early arrhythmia recurrences.
19343415 CRP may contribute to myocardial damage in dilated cardiomyopathy via activation of the complement system and chemotaxis of macrophages.
19337791 Circulating levels of autoantibodies to oxidized low-density lipoprotein and C-reactive protein levels correlate with endothelial function in resistance arteries in men with coronary heart disease.
19328934 Plasma C-reactive protein may be associated with airway inflammation after lung transplantation.
19323703 In patients with early stages of hypertension and subclinical atherosclerosis, a very strong influence of CRP levels on the occurrence of future cardiovascular and cerebrovascular events is found.
19322079 Both hs-CRP and NT-proBNP have additional value in the prediction of postoperative cardiac events in vascular surgery patients. Their integrated use improves cardiac risk stratification.
19297456 Higher CRP concentrations found in women appear to be due to their greater accumulation of subcutaneous fat than that observed in men.
19297430 Individuals with high baseline CRP concentrations may benefit from moderate-fat, high polyunsaturated fat diets, whereas those with low baseline CRP concentrations may obtain greater lipid-lowering benefits from low-fat diets
19282863 Observational study of gene-disease association. (HuGE Navigator)
19282606 Elevated pro-operative C-reactive protein predicts major postoperative complications following off-pump coronary artery bypass surgery.
19282426 Letter: Elevated C-reactive protein levels identify a subgroup of depressed patients in whom antidepressant therapy is preferable to psychotherapy.
19281089 C-reactive protein correlates with tissue oxygen availability in patients with stable COPD.
19276622 C-reactive protein did not discriminate echolucent from echogenic carotid plaques in either gender.
19272152 Our findings suggest that common genetic variation in CRP genes may contribute to heterogeneity of COPD population associated with systemic inflammation
19272152 Observational study of gene-disease association. (HuGE Navigator)
19270348 Atorvastatin downregulates lipopolysaccharide-induced expression of C-reactive protein in cultured A549 cells.
19268941 Our data provide novel evidence for the detrimental action of CRP in vivo by impairing eNOS-dependent vasodilation and uncoupling of eNOS.
19268605 Data show that maternal serum concentrations of ADMA, SDMA or L-arginine are not directly associated with IL-6 and TNF-a or C-reactive protein oncentrations during normal pregnancy.
19267370 Observational study of gene-disease association. (HuGE Navigator)
19267250 results suggest that circulating CRP do not influence prostate cancer risk
19267250 Observational study of gene-disease association. (HuGE Navigator)
19262552 Data suggest that the CRP gene -717A allele confers a protective effect against ischemic stroke.
19262552 Observational study of gene-disease association. (HuGE Navigator)
19255512 CRP from patients with Plasmodium falciparum binds specifically to red blood cells through distinct molecules. Such binding altered the normal discoid-shape of RBC with increased membrane fluidity and hydrophobicity.
19252093 CRP is a novel ligand for the oxidized LDL receptor LOX-1.
19251259 C-reactive protein may have a role in the pathogenesis of atherosclerosis and myocardial injury
19248087 HLA-B27 positivity determined the age at ankylosing spondylitis onset. Male sex and an elevated C-reactive protein (CRP) level were associated with radiographic sacroiliitis in early stage axial spondylarthritis.
19244088 Study of association of the inflammatory markers serum amyloid A (SAA) and C-reactive protein (CRP) with retinal microvascular parameters in hypertensive individuals with and without type 2 diabetes.
19240794 long-term sleep restriction may lead to persistent changes in the immune system and the increased production of IL-17 together with CRP may increase the risk of developing cardiovascular diseases
19238141 Chromosome 12q may harbor quantitative trait loci (QTLs) jointly regulating body mass index and C-reactive protein in white women.
19228486 This article reviews recent studies that address the relationship of CRP gene polymorphisms to inflammation and cardiovascular risk.
19225207 Tentative cut point of high-sensitivity C-reactive protein for a component of metabolic syndrome in Japanese.
19203753 C-reactive protein could be involved in an enhanced anti-inflammatory feedback circuit in acute coronary syndrome
19202332 C-reactive-protein levels associated with infection predict short- and long-term outcome after supratentorial intracerebral hemorrhage.
19201207 Postoperative C-reactive protein does not seem to be a useful marker in predicting outcome after 48 hours in the intensive care unit
19201044 treatment of THP-1 cells with 100 microg of CRP/ml/10(6) cells for 24 h, augmented the expression of RAGE and EN-RAGE genes
19193941 C-reactive protein decreased following resistance exercise training in young African-American men.
19191811 Increased serum C-reactive protein concentration is associated with severe chronic periodontitis.
19188531 Depression and CRP are positively associated in clinical and community samples. Review.
19179966 hs-CRP level positively correlated with upper gastrointestinal lesions severity.
19178964 Left atrial appendage velocity and C-reactive protein are independently associated with the risk of thromboembolism in patients with atrial fibrillation undergoing transesophageal echocardiography.
19172699 In women suffering from polycystic ovary syndrome, pregnancy complications were associated with elevated blood/serum levels of haemoglobin and C-reactive protein
19170684 We propose that CRP may contribute to the neovascularization process and because of its abundant presence, be important in modulating angiogenesis in both acute stroke and later during neuro-recovery
19170196 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19168253 Periodontal treatment with topical antibiotics improves HbA1c through reduction of C reactive protein in type 2 diabetics.
19160050 Serum concentrations of hs-CRP in H. pylori infected peptic ulcer patients and in H. pylori infected asymptomatic carriers were higher than in a healthy control group.
19155486 Purified human CRP provides protection from immune thrombocytopenia in a mouse adoptive transfer system; the activating effect of CRP induces a suppressive-type mouse macrophage.
19147740 contrary to our prediction, elevated CRP was positively associated with good memory in very old nondemented subjects
19139754 The effect of BMI and waist circumference on the levels of circulating CRP may be mediated by an adipose-related factor acting in an allele-specific way through the CRP gene.
19139754 Observational study of gene-disease association. (HuGE Navigator)
19139603 In recently diagnosed hypertensive subjects, hsCRP and sE-selectin levels are related to awake systolic blood pressure variability.
19138871 CRP levels are inversely associated with IGF-I concentrations in black male smokers; however, the causal nature of the association is unclear and should be studied further
19136826 stable chronic heart failure patients had low hsCRP intraindividual variability between repeated measurements but significant variability in terms of risk over 3 weeks
19136614 Data identify monomeric C-reactive protein-lipid raft interaction as an important mechanism in mediating cellular responses to mCRP and lend further support to the notion of mCRP regulation of endothelial cell function during inflammation.
19130414 Glucose at admission and resistin are independently associated with elevated levels of CRP in men during the early stage of acute myocardial infarction.
19128923 Raised serum C-reactive protein concentration at the time of presentation of advanced pancreatic cancer carries a poor prognosis independent of biliary tract obstruction.
19125286 no change in plasma hs-CRP during the marathon race, but this was increased 3.4-fold by day 1, returning to the pre-race level on day 4. Plasma hs-CRP increased 40-fold by the end of the 200-km race and was still increased on day 6 of recovery
19122170 Prognostic utility of apoB/AI, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22.
19118119 Circulating bacterial-derived DNA fragments are associated with higher levels of C-reactive protein and IL-6 in hemodialysis patients.
19117239 In patients with a history of paroxysmal or persistent atrial fibrillation treated with catheter ablation, elevated levels of IL-6 and hs-CRP before ablation are independent predictors of recurrence.
19111610 plasma level increase following the reconstructive repair of a damaged anterior cruciate ligament
19101671 CRP polymorphisms are independently associated with increased or decreased CRP level in Taiwanese. CRP genotypes/haplotypes interact with obesity to set CRP level.
19101671 Observational study of gene-disease association. (HuGE Navigator)
19100387 Single nucleotide polymorphisms at the -390 position of the CRP gene promoter region influence CRP basal levels in such a way that the "C" allele correlated with the lowest and the "T" with the highest after kidney transplantation.
19100387 Observational study of gene-disease association. (HuGE Navigator)
19096002 In a prospective Netherlands population study a high serum level of 3 CRP single were found to be associated with incident COPD for former smokers but not for never smokers.
19096002 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19095725 Observational study of gene-disease association. (HuGE Navigator)
19084272 These data identify CFHR4 as a novel ligand for native CRP, and suggest a role for CFHR4 in opsonization of necrotic cells.
19081678 high interleukin-6 and C-reactive protein levels, as well as low urinary cortisol levels in females were associated with the T allele of ACE, which may result in allele-specific binding of the transcription factor, E2F1
19078972 Serum C-reactive protein, Procalcitonin and amyloid A levels were found to be elevated in premature infants with neonatal sepsis
19077918 results provide limited support for associations between genetic variation in CRP and colorectal polyp risk.
19077918 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19077177 Observational study of gene-disease association. (HuGE Navigator)
19076828 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19075099 Although circulating C-reactive protein (CRP) levels are associated with aortic pulse wave velocity, CRP does not have a causal role in the development of arterial stiffness. CRP may simply act as a marker of vascular damage.
19075099 Observational study of gene-disease association. (HuGE Navigator)
19074985 CRP measurement is independently associated with short-term mortality risk in type 2 diabetic individuals.
19074515 summary of studies examining effect of genetic & environmental factors on baseline plasma hsCRP concentrations, with main focus CRP genetic polymorphisms & dietary components affecting hsCRP concentration & associations with risk of CVD [review]
19073362 Study revealed normal levels of hsCRP in spite of the dyslipidemic status in patients with glycogen storage disease type IA and III.
19072030 Observational study of gene-disease association. (HuGE Navigator)
19067532 C-reactive protein may have a role in metabolic syndrome
19055599 the effect of CRP genetics on early atherosclerotic changes is modulated by the FCGR2A genetics.
19055599 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19040303 The functional CRP gene polymorphisms assessed in our study do not seem to play a major role in the pathogenesis of GCA in individuals from Northwestern Spain.
19034331 High C reactive protein and high serum fibrinogen provide prognostic information in chronic kidney disease patients.
19029268 Early measurements of IL-6 in extracorporeal membrane oxygenation patients could give prognostic information beyond that of C-reactive protein.
19026696 The significant association between the AGTR1 polymorphism and hsCRP levels, which appears to be independent of anthropometric and metabolic traits, is yet another indication of a direct influence of renin-angiotensin system on inflammation.
19026696 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19025443 Serum leptin, hs-CRP, insulin, and uric acid increased significantly with increased body mass index and may allow for eary of metabolic syndrome.
19023151 In patients undergoing percutaneous coronary intervention, the preprocedural osteopontin (OPN) and C reactive protein (CRP) levels are independent predictors for further cardiovascular events, but not for restenosis.
19019335 Observational study of gene-disease association. (HuGE Navigator)
19011614 the structural mechanism for pentraxin's binding to FcgammaR and its functional activation of FcgammaR-mediated phagocytosis and cytokine secretion
19010993 higher levels of C-reactive protein in young adults are associated with subsequent decline in lung function
19008293 CRP up-regulates M-CSF release from human monocyte-derived macrophages and human aortic endothelial cells and increased macrophage proliferation.
19004040 hs-CRP (high sensitivity C Reactive protein) was associated with disease activity but not with overall damage accrual; it correlated with specific domains of the damage index
18997194 As previously shown in women, a prediction model in men that incorporates high-sensitivity C-reactive protein and parental history significantly improves global cardiovascular risk prediction in men.
18996288 Observational study of gene-disease association. (HuGE Navigator)
18983663 C-reactive protein (CRP) level predicts rheumatoid arthritis progression to major joint replacement after standardisation for relevant risk factors.
18974842 Observational study of gene-disease association. (HuGE Navigator)
18971492 Polymorphisms in the CRP gene are associated with marked increases in CRP levels and thus with a theoretically predicted increase in the risk of ischemic vascular disease.
18971492 Observational study of gene-disease association. (HuGE Navigator)
18957790 C-reactive protein elevation and rapid angiographic progression of nonculprit lesion in patients with non-ST-segment elevation acute coronary syndrome.
18953261 Assessment of the prognostic value of C-reactive protein in the prognosis of acute pancreatitis.
18952164 elevated levels in nondiseased moderately overweight nonsmokers are reduced following 2 month treatment with vitamin C; randomized control clinical trial
18948966 The FTO rs9939609 T>A polymorphism contributes to variation in plasma CRP levels independently of obesity indices.
18937150 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18924263 Higher serum high-sensitivity CRP levels are positively associated with diabetes mellitus in a sample of US non-Hispanic blacks.
18853133 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18853099 Chinese type 2 diabetic patients with serum CRP levels in the lower range as other ethnic groups can lead to the development of micro-albuminuria.
18852001 Autoantibodies against mCRP are prevalent in patients with lupus nephritis and are associated with disease activity and renal tubulointerstitial lesions
18845301 C-reactive protein may have a role in metabolic syndrome in the elderly
18842390 In the nondiabetic population, smoking associates differently with subclinical inflammation between genders, with a decreased adiponectin level in women and with an increased hs-CRP level in men.
18842294 Observational study of gene-disease association. (HuGE Navigator)
18841009 patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression
18840622 High-sensitivity C-reactive protein is not independently associated with peripheral subclinical atherosclerosis.
18836266 Examine the role of high-sensitivity C-reactive protein in asymptomatic intra- and extracranial large artery diseases.
18835219 troponin I (TnI) and high sensitivity C-reactive protein (hsCRP)blood levels were unchanged by exercise in trained athletes
18829218 C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism.
18829218 Observational study of gene-disease association. (HuGE Navigator)
18823889 In patients with chronic stable angina extension score and CRP levels predict cardiac adverse events, regardless of the presence or absence of flow limiting coronary lesions.
18818748 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18810717 Measures of inflammation, such as CRP, and indices of atherosclerosis, such as coronary calcium store, are likely to provide distinct information regarding cardiovascular risk
18810599 Our study suggests that in the acute phase of the cerebral infarction CRP might be either a marker of cardioembolism or a predictive factor for short-term mortality.
18805592 first trimester concentrations of maternal plasma CRP in low risk subjects do not appear to be significantly associated with CRP genotype.
18805592 Observational study of gene-disease association. (HuGE Navigator)
18805107 In a population-based cohort of African Americans, circulating CRP concentration was heritable and associated with several traditional cardiovascular risk factors, particularly body mass index.
18801352 Data show that secondary antiphospholipid syndrome patients had significantly elevated serum high-sensitivity C-reactive protein levels in comparison to primary antiphospholipid syndrome patients.
18793001 unique haplotype combinations in the CRP gene may modify the risk of developing systemic lupus erythematosus and influence circulating CRP levels
18793001 Observational study of gene-disease association. (HuGE Navigator)
18791482 central adiposity was most strongly associated with C-reactive protein in women, whereas percent fat was the strongest predictor of systemic inflammation in men
18790479 Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population.
18786923 Complement factor H binds to denatured rather than to native pentameric C-reactive protein.
18785307 There was a positive strong correlation between Asymmetric dimethylarginine and C reactive protein levels in young men with familial Mediterranean fever.
18784972 Discrete episodes of unemployment may have long-term implications for future CRP levels.
18764931 a role for CRP in direct stimulation of angiogenesis and therefore may be a mediator of neovessel formation in the intima of vulnerable plaques.
18759279 Adiposity is independently associated with CRP levels in women with rheumatoid arthritis, and thus may confound the estimation of RA disease activity when serum CRP concentration is used as a surrogate for systemic inflammation.
18757054 PC-Acro, IL-6 and CRP have a role in silent brain infarction
18755462 Complement C3 and C-reactive protein have a role in myocardial infarction
18753952 In a population free of major cardiovascular disease (CVD) at baseline, CRP was significantly related to risk of CVD.
18753723 The level of serum IL-6 or genetic IL-6 polymorphism is correlated with the complexity of coronary plaque in patients with stable coronary artery disease (CAD).
18714384 Findings do not support a causal association between circulating CRP and coronary disease risk, but very large genetic association studies would be required to rule this out.
18714384 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18714381 Multivariable standard regression analysis and Mendelian randomization analysis suggest that the association of CRP with carotid atheroma may not be causal.
18710885 CRP +1444 C-->T and TNF-alpha -308 G-->A polymorphisms are associated with predisposition to Kawasaki disease and, in patients with Kawasaki disease, increased carotid arterial stiffness and intima-media thickness in the long-term.
18708524 CRP directly increases macrophage lipoprotein lipase expression and secretion. Given the predominant role of macrophage LPL in atherogenesis, LPL might represent a novel factor underlying the adverse effect of CRP on the diabetic vasculature.
18704713 an etiological role for CRP in some cancers
18704199 If elevated serum/plasma levels of CRP are associated with neovascular age-related macular degeneration, it is likely not due to genetic variation within CRP, but likely due to variations in some other genetic as well as epidemiological factors.
18704199 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
18702945 CRP is higher in apo E3/3 than in 3/4 subjects and in women compared with men, but remains unchanged by 6 months of standard aerobic exercise training to reduce cardiovascular disease risk. How apo E genotype affects CRP is not known.
18700811 The nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables, was examined.
18700811 Observational study of gene-disease association. (HuGE Navigator)
18695743 The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.
18688084 high serum C-reactive protein levels is associated with cardiovascular disease in a socioeconomically disadvantaged population
18685607 Middle aged hypertensives with obstructive sleep apnea had increased levels of CRP, IL-6, IL-18, TNF-alpha, and asymmetric dimethyl-arginine.
18676680 Observational study of gene-disease association. (HuGE Navigator)
18675273 although G-CSF induces an inflammatory reaction leading to CRP production, it has direct beneficial effects protecting ECs from the deleterious effects of CRP through activation
18667998 The hypertriglyceridemic waist contributes to the metabolic syndrome and most likely is an important factor increasing high-sensitivity C-reactive protein levels and consequently, relative coronary risk in patients with type 2 diabetes of any sex and age.
18654021 Increased CRP was associated with hypertension, there were interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension in Mongolian people.
18654020 Report effects of N-terminal pro-B-type-natriuretic peptide and C-reactive protein vs angiographic severity in predicting major adverse cardiovascular events and clinical restenosis after coronary angioplasty.
18650775 PTX3 was an early indicator of shock in patients with severe meningococcal disease that followed a pattern of induction distinct from CRP.
18636307 Erythrocyte Nitric oxide synthase activity, nitric oxide, erythrocyte sedimentation rate, serum C-reactive protein, and plasma Homocysteine values in Behcets patients were significantly higher than those of the control group
18632424 Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass
18622582 increased hsCRP levels are associated with CRMS severity. These association may be important when treating patients with CRMS.
18621860 C-reactive protein can stimulate smooth muscle cell migration by a mechanism that may involve upregulation and activation of PDGFRbeta
18616717 Acute-phase reactants, such as C-reactive protein and fibrinogen, and WBCs count were independently and inversely associated with a direct measure of cardiorespiratory fitness (VO(2 max)) in women with polycystic ovary syndrome.
18609102 The diagnostic performance of hsCRP in distinguishing 3-vessel coronary artery disease from less extensive forms of coronary atherosclerosis is more accurate in a group of subjects without the apoE epsilon4 allele than in patients with it.
18609082 weaker association observed between CRP and creatinine-based measures reflects the misclassification of elderly frail subjects as having normal kidney function rather than suggests cystatin C itself to be a marker of inflammation
18607165 findings suggested that more chronic, severe inflammation might be involved in the pathogenesis of variant angina, manifested by increased counts of circulating inflammatory cells and elevated plasma levels of CRP and IL-6.
18605934 plasma alkaline phosphatase may have a role in systemic inflammation in Hong Kong Chinese, but it is unknown whether C-reactive protein has a similar role
18591402 Elevated CRP levvels may be useful in risk stratification for pulmonary disease in people with metabolic syndrome.
18577830 High high sensitivity-CRP levels are related to obesity and central distribution of body fat, leading to a higher cardiovascular risk among Mexican subjects
18573495 IL1B genetic variation may have a role in CRP level regulation and this association may be modified by obesity
18573197 C-reactive protein levels are linearly associated with levels of N-terminal-probrain natriuretic peptide in cross-sectional and longitudinal analyses of patients with rheumatoid arthritis.
18573122 The IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for type 2 diabetes.
18566104 CRP levels at diagnosis were related to the extent of disease in patients with ulcerative colitis;a predictor of surgery in subgroups of patients with either ulcerative colitis or Crohn's disease
18562472 NT-proBNP and hsCRP can independently predict all-cause mortality in a non-dialysis CKD population and may have a useful role in risk stratification.
18556380 PD patients after peritonitis may be associated with prolonged systemic inflammation. CRP (C-reactive protein ) was a better serum marker for monitoring inflammatory status and predicting long-term prognosis in our study.
18551710 Maternal type 1 diabetes increases the foetal plasma CRP concentration and thus might predispose the offspring to development of atherosclerosis.
18541797 Low levels of high-sensitivity C-reactive protein are associated with a significantly more rapid cognitive decline than are high levels in patients with Alzheimer disease, as indexed using the Blessed Dementia Scale.
18523031 Normal levels of C-reactive protein and IL-6, along with the elevated levels of IL-8 in patients with permanent atrial fibrillation (AF), but not in those with paroxysmal AF, suggest a link between a low-grade inflammatory reaction and long-lasting AF.
18513823 lymphovascular invasion and pathologic tumor size are associated with preoperative serum CRP level in resected non-small cell lung cancer
18513241 C reactive protein (CRP) might be a sensitive marker for severe asthma.
18508060 C-reactive protein and tissue factor have roles in acute coronary syndrome
18505467 Low paraoxonase-I activity relates to higher CRP, independently of adipokines, as well as of obesity and lipids. Low paraoxonase-I activity in type 2 diabetes mellitus may contribute to cardiovascular risk via an enhanced systemic low-grade inflammation.
18500540 Functional role for rs3091244(T) in cardiovascular diseases.
18500540 Observational study of gene-disease association. (HuGE Navigator)
18499652 None of the genetic variants affecting circulating C-reactive protein was consistently associated with the prevalence of angiographic Coronary Artery Disease.
18499652 Observational study of gene-disease association. (HuGE Navigator)
18493116 Serum CRP concentration is favorably related to physical performance, even within a very low range in a community-based elderly population aged 70 years and over
18491455 The Vitamin D receptor b, a, T, alleles were more frequent in dialysis patients with elevated serum level of C-reactive protein compared with patients with normal C-reactive protein level.
18489822 ET-1 was found to be significantly elevated in the plasma in the AIS. There is association between ET-1 and CRP on the fifth day after AIS. Plasma levels of ET-1 and its association with CRP levels may be used as additional biomarkers for AIS.
18486609 In the presence of PEt, CRP bound to native low-density lipoprotein in serum also.
18476570 The high-sensitivity C-reactive protein level appeared to be increased with age and correlated to all the components of metabolic syndrome .
18464913 Observational study of gene-disease association. (HuGE Navigator)
18458051 Baseline levels of high-sensitivity C-reactive protein are associated with future arterial events in symptomatic peripheral arterial disease patients but cannot stand alone as a predictive tool.
18450770 Data show that hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.
18443549 CRP has a role in true bacteremia in children
18439552 There are several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.
18436884 The chemokine receptor CCR5-del32 frameshift mutation is associated with low levels of C-reactive protein, decreased intima-media thickness, and cardiovascular disease risk
18436879 IL6 and CRP levels are associated with presence of white matter lesions (WML) and brain infarcts (BI)
18436879 Observational study of gene-disease association. (HuGE Navigator)
18433460 CRP at levels found during episodes of inflammation directly binds to the activated form of alphaIIbbeta3 and inhibits platelet aggregation.
18428198 Elevated plasma C-reactive protein is associated with androgen-independent prostate cancer.
18425592 the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk
18422436 Observational study of gene-disease association. (HuGE Navigator)
18421029 Elevated C-reactive protein could serve as a marker for carotid stenosis but was not useful to identify plaques at risk for symptomatic conversion.
18418236 in patients with coronary artery disease, combined use of NT-proBNP (N-terminal-probrain natriuretic peptide ) and hsCRP (high sensitivity C reactive protein) significantly increased predictive value for future cardiovascular events
18415802 high sensitivity C-reactive protein is expressed differently in different ethnic groups in Israel
18414778 Evidence of linkage for plasma C-reactive protein levels as a determinant of obesity-related metabolic diseases has been identified on chromosomes 12p11.23 and 12q15.
18413218 Elevated CRP in Type 1 diabetes is associated with poor glycemic control, larger body habitus, and other factors comprising the insulin resistance syndrome, but not with complications.
18412163 Results provide evidence of specific interactions between CRP and FcgammaR (predominantly FcgammaRI) naturally expressed on macrophage-like cells.
18404970 Serum adiponectin level was decreased and serum CRP and TNF-alpha levels were increased in obese children. Our findings suggest that childhood obesity is associated with inflammatory processes.
18403728 CRP levels were clearly associated with future coronary heart disease events in a general population of Japanese.
18401567 carriers of the rarer G allele had significantly higher CRP plasma concentrations in CAD(-) subjects (P = 0.031) and higher homocysteine concentrations in CAD(+) group (P < 0.001)
18401567 Observational study of gene-disease association. (HuGE Navigator)
18394761 CRP increases after ST segment elevated myocardial infarct, depending on infarct sice, and may be a prognostic marker after myocardial revascularization.
18393253 The results suggest that CRP1444C/T (T allele as risk factor) genetic polymorphisms may be associated with the non-valvular atrial fibrillation in the Chinese Han population.
18393253 Observational study of gene-disease association. (HuGE Navigator)
18389332 Report synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling, and C-reactive protein in hypertensive patients with primary hypercholesterolemia.
18388037 Study suggests that in essential hypertension there is an association between protein-bound sialic acid and C-reactive protein, which reflects the clustering of cardiovascular risk factors in these patients.
18388036 Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina.
18386294 quantitative insulin sensitivity check index was negatively correlated with hs-CRP
18385816 CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.
18385743 Essential hypertensive non-dippers compared to dippers exhibit higher hs-CRP values, irrespective of the dipping status definition.
18385179 in post-myocardial patients, heritability of lung function is at least partly controlled by the C reactive protein gene.
18385179 Observational study of gene-disease association. (HuGE Navigator)
18383516 C-reactive protein single-nucleotide polymorphism is not associated with endometrial cancer
18383516 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18379563 The association between obesity and CRP is at least as strong in African Americans and Hispanic Americans as in white Americans
18378435 The results of structural equation model (SEM) in the Taiwanese women showed that obesity was positively associated with elevated CRP (B=0.69, p<0.001).
18373721 In a cohort of 496 Caucasian SLE families we estimated basal CRP heritability, h(2)= 27.7%. We typed a dense map of CRP single nucleotide polymorphisms (SNPs) and found that seven were associated with basal CRP.
18373721 Observational study of gene-disease association. (HuGE Navigator)
18372435 There was no association between CRP or anti-CRP antibody levels with atherosclerosis or statin use.
18369665 IL1B promoter haplotypes characterized by homozygosity for the common allele at -3737, were associated with raised serum levels of C-reactive protein
18365276 Examine association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea.
18362454 Combination of CRP and HMW-adiponectin reflects further metabolic abnormalities compared with each of them in type 2 diabetic subjects.
18359028 hsCRP in HIV-infected patients is associated with traditional cardiovascular risk factors but does not affect CD4 cell counts
18356846 C-reactive protein, migration inhibitor factor (MIF), leptin, and visfatin levels decreased after weight loss.
18347963 CRP was associated with lower scores on cognitive tests of frontal lobe function among females and these associations were driven by the overweight/obese female group.
18347271 serum CRP level after hepatectomy not only may reflect residual liver function but also may have important metabolic role in regeneration; early dampened CRP response after liver resection may reflect poor hepatic reserve that may have prognostic utility
18344622 C-reactive protein (CRP) level is independently associated with left ventricular mass index, and suggest that measurement of CRP may provide clinically important prognostic information to supplement left ventricular hypertrophy.
18333373 increased C reactive protein (CRP) levels in systemic scleroderma correlated with P selectin and Platelet Glycoprotein GPIIbIIIa complex expression.
18332893 CRP and C1q regulate the behaviour of platelets, and that this may be an important immunoregulatory mechanism during inflammatory conditions
18328265 Levels of high sensitivity C-reactive protein and tumor necrosis factor-alpha have a cumulative effect on the mean values of carotid artery intimal medial thickness in Asian Indian subjects with normal glucose tolerance.
18327405 CRP modulates the expression of genes that contribute to both pro- and anti-inflammatory responses in human monocytes. Among these novel anti-inflammatory effects, we show clearly that CRP activates the LXRalpha pathway.
18322245 The function of CRP to prevent formation of foam cells may influence the process of atherogenesis.
18316365 High-sensitivity CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bifurcation.
18312679 Serum high sensitivity CRP is independently negatively associated with volume of tibial but not patella cartilage suggesting that subclinical inflammation may predispose to knee cartilage loss in tibial compartment.
18305316 CRP and pro-inflammatory cytokines (IL-6 and IL-8) are strong predictors of all-cause and cardiovascular mortality.
18297417 Data show that Serum high-sensitive C-reactive protein levels are increased in manic bipolar disorder patients, as compared to euthymic, depressed patients and healthy controls.
18296838 C-reactive protein (CRP) levels increased with the increase in conditions of metabolic syndrome (MeS). In patients with acute myocardial infarction AMI, MeS is associated with systemic inflammation.
18289549 CRP may have a role in carotid atherosclerosis independent of visceral obesity
18288276 Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of metabolic syndrome
18285696 CRP showed no significant association with mortality in hemodialysis patients
18285551 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18280482 CRP increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK 1/2 signaling dependent pathway
18279706 CRP levels at nephrology consultation were an independent predictor of death in this cohort of oncology patients with acute renal failure
18266777 Observational study of gene-disease association. (HuGE Navigator)
18263601 We found statistically significant associations between four CRP SNPs and CRP serum concentrations. These were not associated with overall or cause-specific mortality, but two were weakly associated with cardiovascular death.
18263601 Observational study of gene-disease association. (HuGE Navigator)
18262272 findings show that IL-1beta NFkappakappaB- & C/EBPbeta-dependently induces IL-6-synthesis in hepatocytes; IL-6 consecutively stimulates CRP production; this mechanism may be crucial for acute phase response in general & CRP production in particular
18250134 hsCRP levels should be adjusted for BMI, ethnicity, education level, disease activity and medications when conducting cardiovascular risk assessment in patients with lupus.
18245530 Serum CRP can be seen as a novel, widely available independent prognostic variable of ovarian cancer.
18241613 CRP may have a role in atherogenesis and endothelial dysfunction, reducing vasodilatation and affecting vascular smooth muscle cells
18235049 In a population of young subjects with type 1 diabetes, there was a significant increase in CRP levels after the onset of microalbuminuria, likely reflecting a general state of inflammation.
18226879 Data show that cognitive and affective dimensions of hostility, and traitnegative affect are positively associated with plasma levels of CRP.
18226363 The purpose of this study was to analyse morphological changes in small blood vessels of the cardiac syndrome x patients with increased CRP levels
18219765 Serum C-reactive protein concentration is not associated with asthmatic inflammation expressed by bronchial hyperreactivity and should not be considered a marker of the local inflammatory process in atopic or non-atopic asthma.
18219371 CRP has predictive value for CT-evidence of brain edema.
18218989 These findings suggest that CRP in plaques or found circulating in CVD patients can influence DC function during atherogenesis.
18217154 Human CRP did not play a pathogenetic role in early murine atherogenesis in LDLR knockout mice.
18216376 No relationship between serum CRP levels and the presence and severity of coronary artery disease in patients with stable angina.
18214695 Pre-diagnostic plasma C-reactive protein concentration was not associated with an increased risk of colorectal adenoma
18206145 Levels are increased in young women with polycystic ovary syndrome.
18200582 Results of ischemia-modified albumin and CRP were correlated with final diagnoses of nonischemic chest pain (NICP) and acute coronary syndrome (ACS).
18182444 These data demonstrate that rs3093061 at the -707 site within the CRP gene is an systemic lupus erythematosus susceptibility locus.
18182444 Observational study of gene-disease association. (HuGE Navigator)
18178503 C-reactive protein is useful as a biological marker in synovial fluid for diagnosing septic arthritis.
18172744 C-reactive protein (CRP) serum levels are associated with increased risk and worse outcome of ischaemic events, a serious prognostic sign in Fabry disease.
18171282 Apolipoprotein E-epsilon 4 carriers had significantly lower levels of C-Reactive Protein yet significantly higher levels of Cytomegalovirus antibodies
18167554 Observational study of gene-disease association. (HuGE Navigator)
18165866 The present study demonstrates that CRP could enhance apoptosis in hypoxia-stimulated myocytes through the mitochondrion-dependent pathway but CRP alone has no effects on neonatal rat cardiac myocytes under normoxia.
18096828 CRP inhibits cholesterol efflux from human foam cells derived from THP-1 and PBMCs in vitro though oxidative stress, ERK1/2 activation, and downregulation of intracellular cholesterol transport molecules ABCA1 and ABCG1.
18083122 CRP 1059G>C polymorphism is one possible genetic determinant for the difference between intra- and extracranial atherosclerosis
18083122 Observational study of gene-disease association. (HuGE Navigator)
18078625 Rheumatoid arthritis patients were less likely to have elevated erythrocyte sedimentation rate (ESR)/depressed C-reactive protein. ESR as a measure of inflammation in rheumatic disease may be limited in infection, renal insufficiency, and low albumin.
18075240 Higher serum levels of CRP could predict the subsequent renal impairment in patients admitted with the worsening of heart failure symptoms.
18071779 children with history of Kawasaki disease have increased levels of hsCRP (high sensitivity C reactive protein)
18063701 the response to vascular injury provoked by human C-Reactive Protein in ovariectomized C-reactive protein transgenic mice depends on Fc gamma RI and probably requires its expression by F4/80+ cells
18060926 high prevalence of common and uncommon inflammatory conditions in individuals with high CRP concentrations
18056120 Observational study of gene-disease association. (HuGE Navigator)
18055714 elevated serum C-Reactive Protein (CRP) levels are associated with a less favorable prognosis in patients with surgically treated endometrial cancer
18055473 Observational study of gene-disease association. (HuGE Navigator)
18054331 CC genotype of OLR-1 G501C polymorphism is associated with susceptibility and serum C-reactive protein concentration in Chinese essential hypertensive population
18036188 C-reactive protein may play a role in coronary disease, but does not explain the European gradient of CVD risk
18023360 CRP could significantly increase resistin expression in cultured human PBMC, and this effect was inhibited by simvastatin, suggesting that CRP and resistin might be involved in the pathogenesis of atherosclerosis
18005189 in colorectal cancer patients c-reactive protein levels and Ki67 (proliferation-related Ki-67 antigen) expression were associated with poorer cancer-specific survival; Ki67 labelling index and C-reactive protein were correlated
18000615 Observational study of gene-disease association. (HuGE Navigator)
18000615 in a Spanish population study, 2.9% of the total variation in circulating CRP levels seem to be explained by genetic variations within the CRP locus. Furthermore, serum leptin levels are strongly associated with serum CRP levels
17991470 Acetylcholine-induced vasodilation in the forearm, but not flow mediated vasodilation, was inversely related to CRP and e-selectin levels independently of traditional risk factors in elderly subjects
17981284 Observational study of gene-disease association. (HuGE Navigator)
17957146 Serum CRP was significantly elevated and serum retinol was significantly lower children with type 1 diabetes. Healthy children with CRP levels above 0.6 mg/L had lower levels of retinol.
17956875 Observational study of gene-disease association. (HuGE Navigator)
17952446 24 hrs following surgery, CRP and IL-6 levels were significantly higher in the abdominal hysterectomy group compared to laparoxcopic hysterectomy and total laparoscopic hysterectomy with transsection of uterine vessels
17943468 Women whose labor will start with PROM have higher CRP values at post-date follow-up than women whose labor starts otherwise.
17942113 CRP uncouples eNOS resulting in increased superoxide production, decreased nitric oxide production and altered eNOS phosphorylation.
17934713 Data show that CRP was the most informative for differentiating grade 1 from grade 2 diabetic foot ulcers.
17925606 Observational study of gene-disease association. (HuGE Navigator)
17925606 the CRP synonymous 1059G/C polymorphism affects CRP levels in patients with unstable angina
17920229 Intraplaque hemorrhage evaluated by MRI identified neurologically unstable patients with increased levels of high-sensitivity C-reactive protein regardless of the degree of carotid stenosis.
17917609 in women with early atherosclerosis, higher c-reactive protein levels were predictors of adverse events (cerebrovascular or cardiovascular disease or death)
17909163 CRP is differentially present in nipple aspirate fluid and varies by Gail model risk factors
17900590 using a haplotype-based analysis showed no evidence for an association of the Creactive proteinhaplotypes tested with Type 2 Diabeste mellitus
17900590 Observational study of gene-disease association. (HuGE Navigator)
17891599 There was no relationship between investigated genotypes or haplotypes of estrogen receptor alpha and levels of C-reactive protein in postmenopausal women.
17888441 In blacks, the haplotype tagged by 3872A (rs1205) was associated with increased risk of non-CV mortality, relative to other haplotypes;this haplotype was associated with decreased risk of early but not decreased risk of late CV mortality in blacks
17888441 Observational study of gene-disease association. (HuGE Navigator)
17885262 The association between hsCRP and progression of early carotid atherosclerosis shows sex differences. In further studies analyzing the role of inflammation for cardiovascular diseases and atherosclerosis, these sex differences should be considered.
17880812 In diabetic children with microangiopathy hsCRP level was insignificantly higher compared to controls and to diabetic children without complications. Correlation analysis showed interrelations between hsCRP and systolic blood pressure and HbA1c.
17878753 In long-lasting persistent AF, lower levels of CRP appear to be associated with maintenance of sinus rhythm after pharmacological cardioversion irrespective of the use of RAS inhibitors.
17878721 Sleep apnea is independently associated with raised levels of CRP and fibrinogen in patients with acute ischemic stroke.
17873311 performance. C-reactive protein was not found to be superior to other acute phase proteins in the differential diagnosis of cancer and infection and in differentiating early stage disease from advanced stage.
17852826 Reference intervals were established with a high analytic performance for OPN and an acceptable analytic performance for OPG and total sRANKL. The study revealed low biological variation for OPN and total sRANKL and high biological variation for hsCRP.
17852082 Suggest low C-reactive protein in healthy individuals may represent physiological status.
17851695 While genetic variation in the IL-6 gene was associated with circulating IL-6 and CRP concentrations, there is little evidence for association between common IL-6 gene variation and adverse cardiovascular outcomes in this population of older adults.
17851127 Baseline CRP levels are independently predictive of future Coronary Heart Disease.
17845537 Serum level of C-reactive protein is a marker of poor prognosis in hepatocellular carcinoma patients.
17827818 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17806085 CRP was identified in the blood of colon neoplasm patients.
17785926 The impact of the IL6 -634G allele on serum C-reactive protein elevation is greater in nonsmokers than in current smokers.
17785206 CRP enhances myeloma cell proliferation under stressed conditions and protects myeloma cells from chemotherapy drug-induced apoptosis in vitro.
17765290 The data imply that the CRP gene may be a longevity gene in humans.
17763921 The inflammatory markers, hsCRP, ESR, WBC, fibrinogen, and TNF-alpha, were raised in all patients but were significantly higher in rheumatoid arthritis patients with coronary artery disease who also had periodontal disease.
17722225 Data show that C-reactive protein can predict tumor necrosis factor-alpha blocker retention rate in axial ankylosing spondylitis.
17714718 investigated the association of CRP with extent and progression of atherosclerosis in multiple vessel beds in a large, population-based cohort study
17714716 in patients with cardiovascular disease or dyslipidemia, adiponectin was independently positively associated with serum HDL-cholesterol, sVCAM-1 (vascular cell adhesion molecule 1), female gender and negatively with hs-CRP (C reactive protein)
17706955 Plasma concentration of CRP and interleukin 6 concentrations increased, and was positive correlated with Thrombosis In Myocardial Infarction frame count in patients with slow coronary flow compared with normal coronary flow subject
17702963 Observational study of gene-disease association. (HuGE Navigator)
17702862 hCRP is not proatherogenic but instead slows atherogenesis, possibly through proteasome-mediated protein degradation
17700210 Observational study of gene-disease association. (HuGE Navigator)
17697822 population-based study suggests that the combined presence of unfavorable CFH and CRP genetic profiles is associated with risk of MI.
17693973 The pleiotropic association between CRP and obesity, adipokines and cardiovascular risk factors might prove it to be an important link between inflammatory reaction and atherogenesis in which adipose tissue hormones are involved.
17676666 CRP was quantitated using PVDF affinity probes and MALDI-MS.
17673235 The relationship between CRP levels and small vessel disease-related lesions was not apparent in Japanese elderly. The impact of inflammation in the pathogenesis of small vessel disease-related brain lesions seems to be weak.
17653654 This is the first report to demonstrate consistent and profound elevation of hs-CRP in cases of non-alcoholic steatohepatitis compared with in cases of simple nonprogressive steatosis
17652155 A higher gene expression of CRP, IL-6, and both IL-6 membrane receptors in subcutaneous samples of inflamed patients than in healthy controls.
17652082 IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
17650829 Serum hs-CRP levels may be related to the state of asthma exacerbation and allergic inflammation.
17641153 Observational study of gene-disease association. (HuGE Navigator)
17641153 The researchers found evidence that five single nucleotide polymorphisms in the CRP gene are associated with circulating CRP levels at two different time points over the life course.
17635239 Patients who did not achieve an early-mid treatment CRP level of <5 mg/L, had a shorter time to disease progression or relapse (P = 0.001) as well as a reduced overall survival
17623828 High CRP level is one of the major contributors to the risk of type 2 diabetes.
17623721 The relation between CRP levels in end stage kidney disease (ESRD) is not a sensitive method for the determination of inflammatory status in ESRD.
17615382 Leptin induces CRP expression in human coronary artery endithelial cells via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2
17613401 Characterization of monomeric CRP can be complicated by the its propensity to interact with immunoglobulins and other proteins. Such interactions could serve to eliminate excess of monomeric CRP and to scavenge altered, damaged and denatured proteins.
17600233 Our observations suggest that CRP is not causally involved in the pathogenesis of cerebral small vessel disease.
17598370 CRP and low albumin, markers of inflammation, predict cardiovascular events and morbidity in chronic kidney disease patients before initiation of chronic hemodialysis.
17597836 Short-term unfavorable prognosis seems to be associated with elevated serum hsCRP levels in patients with stroke.
17596285 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17596285 study concludes that polymorphic variants of the CRP & Fcgamma-receptor genes are associated with the clinical phenotype in systemic lupus erythematosus
17588586 Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice
17584642 Data show that serum levels of IL-6 and hs-CRP are elevated in women with GDM, which are the most significant factors affecting HOMA-IR.
17581635 CRP does not act alone but collaborates with other plasma pattern recognition receptors to form stable pathogen recognition complexes when targeting a wide range of bacteria for destruction.
17575367 Adiponectin was lower and hsCRP higher in the subjects with metabolic syndrome than in those without it
17573060 Adiponectin, leptin and hs-CRP were associated with variables of cholesterol metabolism. A high ratio of cholesterol synthesis to absorption is characterized by high serum leptin and low adiponectin concentrations.
17561469 Observational study of gene-disease association. (HuGE Navigator)
17561469 data suggest that human CRP gene 1059 G>C polymorphism is associated with plasma CRP concentration among Chinese in Taiwan receiving coronary angiography
17531242 C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells
17530289 A locus on chromosome 10 influences C-reactive protein levels in two independent populations.
17519779 No a useful markers of acute cellular rejection during the first year after heart transplantation, but may be a marker for allograft vasculopathy.
17513778 CRP directs uptake of Streptococcus pneumoniae to Fc gamma receptors on dendritic cells, enhancing effective uptake and presentation of bacterial antigens and stimulating protective adaptive immunity.
17511977 Observational study of gene-disease association. (HuGE Navigator)
17511977 The C reactive protein (CRP) 1009A>G genotypes and associated haplotypes were associated with lower fasting serum high sensitivity-CRP concentrations in elderly Chinese men.
17499233 Increased serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha are associated with the presence and severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus
17498578 Observational study of gene-disease association. (HuGE Navigator)
17498578 results suggest a contribution of P-selectin and CRP genes in modulating susceptibility to cognitive decline after cardiac surgery
17477815 Observational study of gene-disease association. (HuGE Navigator)
17477779 Observational study of gene-disease association. (HuGE Navigator)
17477779 No significant associations of serum CRP levels with the genotypes of CRP C1444T and IL-1B C-31T were observed. TNF-A -1031CC polymorphism was significantly associated with high CRP values.
17460724 In the Stanislas Family Study, epsilon4 allele of the APOE gene was associated with lower hs-CRP concentration, but not with 5-year changes.
17459567 CRP serum levels are closely associated with lymph node status but cannot be used as prognostic parameter in patients with vulvar cancer.
17456635 evaluate the role of acute phase of inflammation in the elderly patients with suspected and confirmed pulmonary embolism
17452737 Serum CRP and cytokines increased drastically in postop hip-fracture elderly patients. Only CRP significantly and independently increased in patients with impaired mental status and in patients with complications after hip fracture surgery.
17449922 Measurement of the serum hs-CRP level is a simple, cheap, and highly reproducible assay and correlates with IMT and FMD in obese children.
17449131 The presence of metabolic syndrome X in women with previous gestational diabetets is associated with high levels of C-reactive protein
17433639 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17400881 Angiotensin-converting enzyme and C-reactive protein may have roles in chronic obstructive pulmonary disease
17395501 Serum hsCRP for predicting risk of cardiovascular disease is confounded by obesity, ethnicity, gender and comorbidities
17383146 increased serum CRP might have an important independent role in increased arterial stiffening and the measurement of serum CRP is a useful predictor for the degree of improvement of arterial stiffening in hypothyroid patients.
17382928 Observational study of gene-disease association. (HuGE Navigator)
17382928 variation in the IRAK1 gene is associated with CRP concentration in Caucasian women in the Diabetes Heart Study
17380191 CRP may be a risk marker for mental stress induction in patients with coronary artery disease.
17372148 A study as to in predicting type 2 diabetes risk in a sample of French Canadian cardiac patients.
17369452 These in vivo observations support the hypothesis that CRP modulates NO metabolism and may have implications regarding the mechanisms by which CRP modulates vascular disease.
17355643 Observational study of genotype prevalence. (HuGE Navigator)
17355554 Observational study of gene-disease association. (HuGE Navigator)
17355554 during the acute phase of stroke/transient ischemic attack, individuals with the AG/GG genotype had significantly elevated CRP concentrations as opposed to those with the AA genotype (2.02 +/- 1.59 vs. 1.73 +/- 1.69 mg/l, P = 0.027)
17351284 Exploration of whether inflammation (measured by plasma C-reactive protein (CRP) levels) is related to insulin resistance and to parameters of metabolic syndrome, independent of obesity.
17350021 These data suggest that the presence of high producer CRP genotype is deleterious to carotid elasticity in men.
17350021 Observational study of gene-disease association. (HuGE Navigator)
17347578 Serum levels of albumin and CRP correlated with dialysis patients' treatment costs. Achieving the Kidney Disease Outcomes Quality Initiative targets may be associated with lower costs.
17343862 A major gene influencing CRP levels appears to be located on chromosome 5p15, with an effect that is independent of diabetes. Another gene on 3p21 may control CRP variation but only in the presence of a diabetic or insulin-resistant environment.
17335903 c-Rel((1-300)) binding to C/EBPbeta increases the affinity of C/EBPbeta for the C/EBP binding site at -53 on the CRP promoter
17335789 Observational study of gene-disease association. (HuGE Navigator)
17327459 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
17327459 findings support the hypothesis that serum CRP enhances the development of diabetes
17325687 body mass index and waist circumference were associated positively with leptin, HOMA, and hs-CRP, and negatively with HDL-Cholesterol
17293598 complement control protein 6-8 is able to interact with DNA and necrotic cells, but in contrast the His-384 allotype binds these ligands more strongly than the Tyr-384 variant
17292342 Patients presenting early with chest pain with elevated CRP concentrations have a greater long-term risk for death and heart failure.
17289011 Elevated CRP concentrations in early pregnancy are associated with an increased risk of preterm delivery.
17279354 CRP may cause insulin resistance by increasing IRS-1 phosphorylation at Ser(307) and Ser(612) via JNK and ERK1/2, respectively, leading to impaired insulin-stimulated glucose uptake, GLUT4 translocation, and glycogen synthesis
17264952 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17261875 investigated the interaction of CRP with oxLDL/beta2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus
17234298 International Diabetes Federation definition of metabolic syndrome has a stronger relationship with serum CRP in Chinese men than by ATP III definition.
17220790 The effect of mycophenolate on c reactive protein levels is warranted after kidney transplantation.
17219082 Observational study of gene-disease association. (HuGE Navigator)
17219082 The +1444C/T variant in the CRP gene influences the basal CRP level in normal people.
17211240 CRP secretion is substantially heritable in humans, demonstrating pleiotropy (shared genetic determination) with other features of the metabolic syndrome, such as BMI, triglycerides or BP
17202380 CRP acts on the effector cells of the immune system to enhance cell-mediated cytotoxicity
17185152 Observational study of gene-disease association. (HuGE Navigator)
17164456 Genetic variation in the CRP gene is associated with plasma CRP levels and cardiovascular disease risk in older adults.
17157301 in a prospective study of subjects without previous documented CAD, high sensitive C Reactive Protein (hs-CRP) levels at baseline were associated with angiographic characteristics and clinical consequences of plaque instability during follow up
17149558 NT-proBNP levels correlate with PCT and CRP levels in septic patients.
17148079 Observational study of gene-disease association. (HuGE Navigator)
17148079 results suggest that mortality from Streptococcus pneumoniae may be associated with polymorphism of the promoter region of the CRP gene
17143564 The magnitude of the systemic inflammatory response triggered by coronary angioplasty assessed as an increase in CRP level and the history of coronary angioplasty concerning nontarget stenosis remain independent predictors of lesion re-narrowing.
17141244 sex differences in CRP may reflect sex-related differences in the inflammatory responses to obesity, and may in part, be mediated by leptin.
17138933 Serum amyloid P (SAP) and C-reactive protein (CRP) may represent different facets of inflammation. The association of SAP with cardiovascular disease in these older adults further supports the role of innate immunity in atherosclerosis.
17126343 investigated the role of C-reactive protein response to PCI in the risk of clinical restenosis or new coronary stenosis, considering PCI as a model to stimulate inflammati
17114654 Observational study of gene-disease association. (HuGE Navigator)
17113059 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17113035 underlying mechanism depends on fluid-phase interaction between C1q and C-reactive protein
17110595 novel mechanism of inflammatory gene regulation(C-reactive protein) by LXR ligands
17101857 Observational study of gene-disease association. (HuGE Navigator)
17101857 Genetic variation within C-reactive protein (CRP) is associated with serum CRP levels in the general population and may be associated with prevalent coronary heart disease.
17082472 C-reactive protein is a marker for active carotid atherosclerosis but not for small vessel disease-related brain lesions.
17079491 age-related macular degeneration(AMD) risk-conferring allele alters the binding properties of CFH, thereby leading to choroidal CRP deposition, contributing to AMD pathogenesis
17044846 there is association between serum CRP levels and polymorphisms within the CRP and APOE genes in sib-ships with type 2 diabetes mellitus, a population at increased risk for cardiovascular disease
17044845 Observational study of gene-disease association. (HuGE Navigator)
17011566 LDL cholesterol (LDL-C), smoking and WBC count are, but levels of adiponectin, insulin and CRP are not significantly related to chronic heart disease death
17003778 An elevated preoperative C-reactive protein was associated with increased tumour stage, interleukin-6 and interleukin-10 concentrations.
16984505 Observational study of gene-disease association. (HuGE Navigator)
16984505 C allele of the CRP +1059G/C polymorphism is associated with decreased serum CRP levels and increased likelihood of disease involvement of the terminal ileum in Crohn's disease patients
16963054 An aggregation of metabolic risk factors is associated with elevated hs-CRP levels among overweight individuals, particularly in women in Japan
16916777 The plasma levels of CRP and troponin I were also significantly higher in this group of nine patients, and correlated with urinary protein excretion.
16908949 C-reactive protein may have a role in development of carotid atherosclerosis
16881737 inflammation marker C-reactive protein was significantly and positively associated with level of antibodies to Chlamydia pneumoniae only in heavily exposed (>or=1000 mGy) survivors
16879213 prostaglandin-endoperoxide synthase 2 polymorphisms, prostaglandin-E receptor 2 polymorphisms, and C-reactive protein concentrations may have a role in atherothrombosis
16864904 serum amyloid A and C-reactive protein are expressed differently in exudates and transudates
16858645 Observational study of gene-disease association. (HuGE Navigator)
16854501 Observational study of gene-disease association. (HuGE Navigator)
16854501 C-reactive protein plays a role in development of dementia.
16847147 CRP at concentrations known to predict future vascular events upregulates RAGE expression in human endothelial cells at both the protein and mRNA level. Silencing of the RAGE gene prevents CRP-induced macrophage chemoattractant protein 1 activation.
16840032 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16832152 Observational study of gene-disease association. (HuGE Navigator)
16832152 Single-nucleotide polymorphisms (SNPs) of the human CRP gene and the T-T-G haplotype are genetic markers for elevated basal CRP levels and appear to be susceptibility markers for atherosclerosis.
16832147 CRP gene haplotype is associated with blood CRP levels in the elderly, and associated with pulse wave velocity, is an indicator of arteriosclerosis.
16809564 South Asians have elevated C3 & CRP levels; results suggest they have a greater level of chronic subclinical inflammation independent of family history of stroke; C3 is more likely to cluster with features of insulin resistance syndrome compared with CRP
16809555 Observational study of gene-disease association. (HuGE Navigator)
16809555 Genetic variants at the CRP locus were associated with CRP levels, but no association was detected for overall ischemic stroke
16803998 Observational study of gene-disease association. (HuGE Navigator)
16778366 Elevated levels of CRP are associated with the presence and extent of angiographically verified Coronary Artery Disease.
16765355 Widespread vascular CRP mRNA expression, a correlation between serum hsCRP, intimal hypertrophy and plaque CRP, and a coronary hsCRP gradient suggest vascular secretion may contribute to serum CRP levels
16764962 C-reactive protein is associated with leptin and interleukin 6 blood levels in Japanese type 2 diabetic patients.
16751408 CRP limits excessive complement activation on targets via its interactions with both factor H and C4b-binding protein (C4BP).
16733231 Observational study of gene-disease association. (HuGE Navigator)
16731635 Observational study of gene-disease association. (HuGE Navigator)
16731635 Results show a strong impact of single-nucleotide polymorphisms of the C-reactive protein (CRP) gene on plasma CRP, but no direct evidence that genetically controlled CRP levels controlled by CRP SNPs contributed to cardiovascular disease phenotypes.
16723442 Observational study of gene-disease association. (HuGE Navigator)
16719793 The EPC clonogenic potential seems to be related to hs-CRP and VEGF levels even in healthy population supporting the concept that these mediators are involved in physiological ECs function.
16698114 High serum C-reactive protein was associated with non-small cell lung cancer
16685271 An elevated preoperative C-reactive protein concentration is an independent predictor of poor cancer-specific survival in gastro-esophageal cancers.
16682383 Observational study of gene-disease association. (HuGE Navigator)
16681424 C-reactive protein has a role in advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus
16643876 the shared specificity as well as their shared capability to activate complement, suggest that IgM and the pentraxins CRP and SAP exert similar functions in the removal of apoptotic cells
16618976 Changes in circulating adipokine (CRP)levels are involved in the improvement of the metabolic state by exercise and may be useful markers for evaluation and prescription of exercise.
16603696 in human aortic endothelial cells, CRP upregulates monocyte-endothelial adhesion by activation of NF-kappaB through engaging the Fcgamma receptors CD32 and CD64.
16580524 C-reactive protein augmented MMP-1 and -10 messenger ribonucleic acid expression in vascular endothelial cells. Might provide a link between inflammation and plaque vulnerability.
16565153 A common CRP polymorphism is associated with differences in CRP concentration, free from confounding; null association of the variant with coronary events suggests possible residual confounding in CRP-coronary event association in observational studies
16550411 The genetic architecture of C-reactive protein (CRP) is described with special emphasis on the detection and characterization of rare variants.
16549465 C-reactive protein (CRP) concentrations may modulate diet-induced changes in plasma lipid and lipoprotein concentrations
16534007 Observational study of gene-disease association. (HuGE Navigator)
16511556 Observational study of gene-disease association. (HuGE Navigator)
16501036 C-reactive protein levels are increased after oral administration of 17beta-estradiol in healthy post-menopausal women, but not after intranasal administration
16500582 CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP.
16417933 study demonstrated that Leishmania donovani can be induced to start differentiation in response to CRP binding; findigs show that the response requires the binding of CRP specifically to lipophosphoglycan
16409458 In cultured PBMC cells from patients with angina, added IFN and CRP further increase TF levels that may contribute to the hypercoagulable state in coronary disease.
16405882 CRP changes with age. Females have higher CRP values than males. CRP values in Aboriginal people are substantially higher than other populations.
16380821 Review discusses clinical significance of different levels of CRP, its role in induction or protection from autoimmunity, and the presence of specific CRP autoantibodies in different autoimmune diseases.
16352308 Observational study of gene-disease association. (HuGE Navigator)
16352308 Homozygous carriers of the CRP 3' UTR +1444C>T polymorphism do not have a significantly increased risk of spontaneous venous thromboembolism.
16344720 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16306468 serum hsCRP may have a role in development of ischemic stroke in Japanese men
16266402 Observational study of gene-disease association. (HuGE Navigator)
16266402 Increased CRP levels are associated with atherothrombosis
16257408 In a British cohort with risk factor levels representative of a contemporary Western population, CRP concentration was among the strongest predictors of CAD incidence and mortality
16221209 In patients with renal cell carcinomas, a tumor-derived origin of some plasma CRP is likely.
16213874 This prospective study shows that levels of C-reactive protein, as a marker of the early pregnancy inflammatory response following frozen embryo replacement cycles, may be absent or suppressed, in contrast to that following in vitro fertilization
16189249 Clustering of family history of diabetes, testosterone and IGF I abnormalities, and high high-sensitive C-reactive protein is associated with metabolic syndrome in Chinese middle-aged men.
16170833 CRP levels were elevated in pregnancy compared to postpartum.
16153429 CRP significantly decreases the expression of thrombomodulin and EPCR in human endothelial cells, thereby promoting thrombogenic conditions.
16151032 CRP may have a role in atherosclerotic plaque formation in men but not women
16148535 Evidence in this review suggests that C-reactive protein is a proatherogenic molecule that plays an active role.
16131811 CRP exerted a proinflammatory effect in mesangial cells by inducing MCP-1 gene expression via NF-kappaB activation, which was mediated, at least in part, through intracellular calcium and reactive oxygen species
16123325 CRP is a procoagulant and has implications for atherothrombosis
16109328 Results suggest that CRP is related to measures of arterial wave reflection and stiffness in asymptomatic subjects from the community.
16087807 May be a risk factor for and biological marker of stroke and other cerebral small-vessel diseases.
16087790 Recombinant and natural C-reactive protein have opposite effects on atherosclerosis in apolipoprotein E-deficient mice.
16061741 Persons with higher CRP levels tended to have more prevalent and incident lacunar infarcts, and thus inflammatory processes may be involved in the pathogenesis of cerebral small-vessel disease.
16051899 Observational study of gene-disease association. (HuGE Navigator)
16051899 common genetic variants of CRP (3'UTR 1846C/T) and IL-6 (-174G/C) are significantly associated with the risk of stroke after cardiac surgery and may have a role in inflammation in post-cardiac surgery stroke
16026589 Observational study of gene-disease association. (HuGE Navigator)
16026589 both IL-1B +3954 (C-->T) and CRP +1059 (G-->C) polymorphisms influence baseline CRP values and act independently of each other in male subjects
16005367 Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.
16005364 significantly higher levels in patients with metabolic syndrome than in those without.
15997206 Data demonstrate that serum C-reactive protein level was related with gestational diabetes mellitus and weight gain during pregnancy in late second and early third trimesters.
15996056 CRP regulation of monocyte TF could contribute to the higher than expected atherosclerotic vascular disease seen in patients with inflammatory rheumatic disease
15993896 Elevations in pCRP level in medically healthy personality disordered subjects with higher scores of trait aggression and hostility.
15955391 CRP levels increase continuously across the spectrum of fasting glucose in both sexes.
15955385 CRP was significantly associated with body mass index.
15950309 demonstration that CRP is a strong associating factor of metabolic syndrome in Korean population
15920074 Association between dietary fiber and level of this protein, an inflammation marker, in diabetes, hypertension, obesity, or a combination of these conditions.
15920065 Magnesium intake is inversely associated with plasma C-reactive protein (CRP) levels.
15920036 mildly elevated levels of CRP in plasma do not contribute to the development of early atherosclerosis in hypercholesterolemic E3L/CRP transgenic mice
15919817 present results do not suggest that human CRP is either proatherogenic or atheroprotective in vivo
15897982 Observational study of gene-disease association. (HuGE Navigator)
15894827 circulating C-reactive protein may have a role in acute myocardial infarction
15894122 under certain circumstances, acute, pulsatile release of IL-6 does not stimulate synthesis of CRP
15887860 CRP levels of Type 2 diabetic(t2dm) men with coronary heart disease(CHD) were higher than non-diabetic men with CHD. Positive correlation between serum CRP and HbA1c, fasting insulin and HOMA-IRin T2DM.
15878871 analysis of C-reactive protein binding to FcgammaRI, FcgammaRIIa, and C1q
15867284 CRP is modified in low-fat soy protein diets, suggesting that inflammation may not only attenuate lipid responses, but also aggravate dyslipidemia in hypercholesterolemic subjects consuming a cholesterol-lowering diet.
15866055 Presence or absence of hypertension and retinopathy should be taken into consideration for the interpretation of the serum high sensitivity-CRP in diabetic patients.
15860734 CRP mediates its biological effects on aortic endothelial cells via binding and internalization through Fcgamma receptors, CD32 and CD64
15859024 The highest association with mortality as well as with cardiovascular diseases, diabetes and rheumatoid arthritis is found for serum CRP above 10 mg/l
15853546 Review summarizes new roles for C-reactive protein, an acute phase reactant, which appears to be a promising biomarker for cardiovascular disease, possibly more predictive than cholesterol, and it may play an etiological role.
15808312 reduced levels in Echerichia coli-infected patients with liver cirrhosis, but not abolished even in patients with advanced liver dysfucntion
15798966 results suggest that high levels of plasma high-sensitivity C-reactive protein (HSCRP) are associated with depressed cardiovascular autonomic function and hyperinsulinemia
15798948 study showed that plasma adiponectin and tumor necrosis factor alpha (TNF-alpha) were independently and reversely associated with insulin resistance and C-reactive protein levels were related to TNF-alpha and obesity
15797975 Observational study of gene-disease association. (HuGE Navigator)
15795363 CRP specifically induced hyporeactivity to phenylephrine in artery rings mediated via antagonism by NO. CRP did not alter eNOs expression but increased expression of GTP cyclohydrolase-1, the rate-limiting enzyme in the synthesis of tetrahydrobiopterin.
15778807 Observational study of gene-disease association. (HuGE Navigator)
15777561 Observational study of gene-