| Tbio | Dihydropyrimidinase-related protein 1 |
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Schizophrenia | 1160 |
| Social Anhedonia | 2 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.4e-32 |
| ependymoma | 4679 | 1.6e-06 |
| group 4 medulloblastoma | 1855 | 2.8e-04 |
| osteosarcoma | 7950 | 8.1e-04 |
| atypical teratoid/rhabdoid tumor | 357 | 1.6e-02 |
| spina bifida | 1074 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| lung cancer | 4740 | 3.01 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid/rhabdoid tumor | -1.100 | 1.6e-02 |
| ependymoma | -1.200 | 1.6e-06 |
| group 4 medulloblastoma | 1.100 | 2.8e-04 |
| lung carcinoma | 2.700 | 1.4e-32 |
| osteosarcoma | 1.511 | 8.1e-04 |
| spina bifida | 1.674 | 3.8e-02 |
MSYQGKKSIPHITSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGI 1 - 70 DVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVD 71 - 140 ITSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQK 141 - 210 RILEMGITGPEGHALSRPEELEAEAVFRAITIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIA 211 - 280 ASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTL 281 - 350 IPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTI 351 - 420 TAKSHKSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKAFPEHLYQRVKIRNKVFG 421 - 490 LQGVSRGMYDGPVYEVPATPKYATPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVA 491 - 560 PPGGRSNITSLG 561 - 572 //
