Tbio CRISP2 Cysteine-rich secretory protein 2

Protein Summary

Description

May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.

Uniprot Accession IDs

• P16562
• A8K8M0
• Q53FF2
• Q5U8Z9
• Q7Z7B2
• CRISP-2

Gene Name

• CRISP2

Ensembl ID

• ENST00000339139
• ENSP00000339155
• ENSG00000124490
• ENST00000616725
• ENSP00000484609
• ENST00000618917
• ENSP00000482890

Symbol

• GAPDL5
• TPX1
• CT36
• TPX1
• TSP1
• GAPDL5
• CRISP-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.83
protein domain	0.73
cell type or tissue	0.7
cell line	0.5
microRNA	0.5

Protein Classes

PANTHER Classes

Protein / Defense/immunity Protein / Cysteine-rich Secretory Protein 2

DTO Classes

Protein / Immune Response / Cysteine-rich Secretory Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.42   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.42   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0