| Tbio | Cysteine-rich PDZ-binding protein |
Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.
This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]
This gene encodes a protein that binds to the PDZ3 peptide recognition domain. The encoded protein may modulates protein interactions with the cytoskeleton. A mutation in this gene resulted in short stature with microcephaly and distinctive facies. [provided by RefSeq, Jun 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 7.2e-14 |
| malignant mesothelioma | 3232 | 1.0e-05 |
| medulloblastoma, large-cell | 6241 | 1.3e-05 |
| hepatocellular carcinoma | 547 | 5.6e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.0e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.3e-03 |
| pancreatic cancer | 2398 | 6.0e-03 |
| pancreatic carcinoma | 562 | 6.0e-03 |
| osteosarcoma | 7950 | 6.4e-03 |
| tuberculosis and treatment for 3 months | 179 | 7.1e-03 |
| ovarian cancer | 8520 | 1.9e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| 3-M syndrome | 15 | 3.916 | 2.0 |
| Isolated growth hormone deficiency | 30 | 3.762 | 1.9 |
| Seckel syndrome | 34 | 3.535 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| hepatocellular carcinoma | 1.100 | 5.6e-05 |
| intraductal papillary-mucinous adenoma (... | 1.500 | 3.0e-03 |
| intraductal papillary-mucinous carcinoma... | 1.600 | 5.3e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.600 | 2.4e-02 |
| lung carcinoma | 1.100 | 7.2e-14 |
| malignant mesothelioma | 1.100 | 1.0e-05 |
| medulloblastoma, large-cell | -1.100 | 1.3e-05 |
| osteosarcoma | -1.301 | 6.4e-03 |
| ovarian cancer | 1.400 | 1.9e-02 |
| pancreatic cancer | 1.200 | 6.0e-03 |
| pancreatic carcinoma | 1.200 | 6.0e-03 |
| tuberculosis and treatment for 3 months | -1.200 | 7.1e-03 |
| Accession | Q9P021 |
| Symbols |
SSMDF HSPC139 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG |
