Tbio CRIPAK Cysteine-rich PAK1 inhibitor

Protein Summary

Description

Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence. CRIPAK is a negative regulator of PAK1 (MIM 602590) that is upregulated by estrogen (Talukder et al., 2006 [PubMed 16278681]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8N1N5
• Q8NB03
• CRIPak

Gene Name

• CRIPAK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.69
tissue sample	0.58
biological process	0.49
tissue	0.44
transcription factor perturbation	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 3   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0