Tbio CREB3L3 Cyclic AMP-responsive element-binding protein 3-like protein 3

Protein Summary

Description

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q68CJ9
• B2R7S6
• B7ZL69
• M0QYW7
• Q6ZMC5
• Q96TB9
• cAMP-responsive element-binding protein 3-like protein 3

Gene Name

• CREB3L3

Ensembl ID

• ENST00000078445
• ENSP00000078445
• ENSG00000060566
• ENST00000595923
• ENSP00000469355
• ENST00000602147
• ENSP00000470119
• ENST00000602257
• ENSP00000472399

Symbol

• CREBH
• CREBH
• CREB-H
• HYST1481

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
biological process	0.66
gene perturbation	0.65
cellular component	0.57
cell type or tissue	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.79   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.79   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0