Property Summary

NCBI Gene PubMed Count 464
PubMed Score 3764.11
PubTator Score 1826.72

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
juvenile dermatomyositis 1189 3.02065192579629E-13
osteosarcoma 7933 6.29396612350754E-8
primitive neuroectodermal tumor 3031 4.19780363904497E-6
ependymoma 2514 6.1624147412734E-6
primary Sjogren syndrome 789 3.62367150487511E-5
group 4 medulloblastoma 1875 4.99120562770088E-5
Pick disease 1893 8.0166756188389E-5
ovarian cancer 8492 1.07530249131274E-4
medulloblastoma, large-cell 6234 1.09323572079325E-4
atypical teratoid / rhabdoid tumor 4369 1.21710579070639E-4
psoriasis 6685 0.00185437488955256
Gaucher disease type 3 76 0.0027042594179408
glioblastoma 5572 0.0116353502768805
pediatric high grade glioma 2712 0.0155867472162324
ulcerative colitis 2087 0.046665475327352
Disease Target Count
Angiomatoid fibrous histiocytoma 4


  Differential Expression (15)

Disease log2 FC p
psoriasis 1.200 0.002
osteosarcoma 1.766 0.000
ependymoma 1.400 0.000
group 4 medulloblastoma 2.200 0.000
atypical teratoid / rhabdoid tumor 1.300 0.000
glioblastoma 1.200 0.012
medulloblastoma, large-cell 1.500 0.000
primitive neuroectodermal tumor 1.500 0.000
ulcerative colitis -1.131 0.047
juvenile dermatomyositis 1.083 0.000
pediatric high grade glioma 1.100 0.016
primary Sjogren syndrome 1.100 0.000
Pick disease 1.100 0.000
ovarian cancer -1.200 0.000
Gaucher disease type 3 -1.100 0.003


Accession P16220 P21934 Q6V963 Q9UMA7 CREB-1
Symbols CREB




  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid
Zebrafish OMA EggNOG

Gene RIF (402)

27049759 demonstrated that GSK-3alpha is regulated by CREB in lung cancer and is required for the cell viability. These findings implicate CREB-GSK-3alpha axis as a novel therapeutic target for lung cancer treatment
26996991 miR-124 suppresses seizure activity and regulates CREB1 activity. (Review)
26823765 C/EBPalpha inhibited breast cancer cell growth via a novel miR-134/CREB signaling pathway.
26757817 Both OGG1 and UNG2 impede CREB1 from binding to a binding site consensus sequence (CRE)substrate when the CRE site contains the specific DNA lesion recognized by each glycosylase.
26755589 TRAF3 regulates B-cell survival via inhibition of CREB stability
26669856 MyD88s is positively regulated by IKKbeta and CREB and negatively regulated by ERK1/2 signaling pathways.
26655813 Taken together, we conclude that CREB protects tumor cells from gamma-irradiation, and combination of CREB inhibition plus ionizing radiation will be a promising radiotherapeutic approach.
26649298 PFOS may inhibit BDNF-ERK-CREB signalling by increasing miR-22 levels, which may, in part, explain the mechanism of PFOS neurotoxicity
26642955 This study demonstrates a new role for CREB as a regulator of ER stress, which is required to properly respond to stressful conditions, such as hypoxia.
26626456 Anxiety disorder comorbidity was the stronger predictor of current suicide risk and significant associations were found with variations in rs13515 (MAPK1) and rs6740584 (CREB1) polymorphisms.

AA Sequence


Text Mined References (477)

PMID Year Title
27049759 2016 GSK-3? Is a Novel Target of CREB and CREB-GSK-3? Signaling Participates in Cell Viability in Lung Cancer.
26996991 2016 The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.
26823765 2015 C/EBP? inhibits proliferation of breast cancer cells via a novel pathway of miR-134/CREB.
26757817 2016 Transcription Factors and DNA Repair Enzymes Compete for Damaged Promoter Sites.
26755589 2016 Nuclear TRAF3 is a negative regulator of CREB in B cells.
26669856 2015 Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKK? and CREB Pathways and Negative ERK1/2 Pathway.
26655813 2016 Inhibition of cyclic AMP response element-directed transcription by decoy oligonucleotides enhances tumor-specific radiosensitivity.
26649298 2015 PFOS Disturbs BDNF-ERK-CREB Signalling in Association with Increased MicroRNA-22 in SH-SY5Y Cells.
26642955 2016 CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1? and PERK.
26626456 2016 Clinical and genetic factors associated with suicide in mood disorder patients.