Tbio CRB3 Protein crumbs homolog 3

Protein Summary

Description

Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9BUF7
• A8KA91
• D6W643
• Q8N0V8
• Q8WVA0

Gene Name

• CRB3

Ensembl ID

• ENST00000308243
• ENSP00000310123
• ENSG00000130545
• ENST00000356762
• ENSP00000349204
• ENST00000598494
• ENSP00000469707
• ENST00000600229
• ENSP00000472010

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.63
cellular component	0.56
transcription factor perturbation	0.54
transcription factor	0.52
cell type or tissue	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.74   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.74   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0