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Tchem
CRACR2A
EF-hand calcium-binding domain-containing protein 4B

Protein Summary
Description
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252322
  • ENSP00000252322
  • ENSG00000130038
  • ENST00000440314
  • ENSP00000409382

Symbol
  • EFCAB4B
  • EFCAB4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
histone modification site profile
0.73
cellular component
0.68
phenotype
0.61
disease
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.89   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.89   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0