Tdark Complexin-4

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Positively regulates a late step in synaptic vesicle exocytosis.

This gene likely encodes a member of the complexin family. The encoded protein may be involved in synaptic vesicle exocytosis. [provided by RefSeq, Jan 2009]

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Property Summary

NCBI Gene PubMed Count	6
PubMed Score	13.96

PubTator Score	1.40

Knowledge Summary

Patent

No data available

TINX Plot

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.5

Disease	Target Count	Z-score	Confidence
Cocaine Dependence	51	3.523	1.8

Expression

Specificity
Differential

Brain - Cerebellum 17,983

Brain - Cerebellar Hemisphere 18,015

Testis 18,518

Artery - Aorta 17,896

Small Intestine - Terminal Ileum 17,954

Ovary 17,971

Brain - Hippocampus 18,011

Brain - Substantia nigra 17,981

Adipose - Visceral (Omentum) 17,937

Brain - Hypothalamus 18,169

Colon - Transverse 17,825

Brain - Nucleus accumbens (basal ganglia... 18,024

Esophagus - Muscularis 18,017

Lung 18,057

Adrenal Gland 18,071

Stomach 17,879

Heart - Atrial Appendage 17,896

Artery - Coronary 17,949

Pancreas 18,123

Colon - Sigmoid 18,089

Breast - Mammary Tissue 18,103

Brain - Cortex 18,039

Minor Salivary Gland 18,005

Pituitary 18,147

Cells - Transformed fibroblasts 17,577

Adipose - Subcutaneous 18,110

Cells - EBV-transformed lymphocytes 18,186

Thyroid 18,024

Spleen 17,614

Brain - Spinal cord (cervical c-1) 17,973

Prostate 18,213

Brain - Frontal Cortex (BA9) 18,069

Brain - Caudate (basal ganglia) 18,001

Muscle - Skeletal 17,778

Artery - Tibial 17,631

Brain - Amygdala 18,006

Skin - Sun Exposed (Lower leg) 17,968

Esophagus - Gastroesophageal Junction 18,000

Brain - Anterior cingulate cortex (BA24) 17,989

Liver 18,071

Heart - Left Ventricle 18,006

Adult Retina 10,115

Retina

bone marrow 14,571

cerebral cortex 16,630

epididymis 15,863

lung 16,312

skin 16,206

spleen 15,972

testis 17,936

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Brain 7,346

Cerebellum 698

Retina 337

See source...

Outer plexiform layer 5

Bipolar cell 25

Inner plexiform layer 6

Photoreceptor cell 46

See source...

Synonym

Accession	Q7Z7G2 F1T0L6
Symbols	CPXIV CPX-IV

Gene

CPLX4

Ortholog (12)

Species	Source	Disease
Rat 15,117	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Pig 10,168	OMA EggNOG
Opossum 12,230	Inparanoid OMA EggNOG
Platypus 5,703	Inparanoid OMA EggNOG
Chicken 7,827	Inparanoid OMA
Anole lizard 10,588	Inparanoid OMA EggNOG
Xenopus 10,468	Inparanoid OMA EggNOG
Zebrafish 9,726	Inparanoid OMA EggNOG
Chimp 14,140	OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG

UniProt Keyword (11)

Complete proteome 20,231

Reference proteome 20,231

Membrane 7,361

Lipoprotein 825

Methylation 973

Prenylation 170

Transport 1,985

Cell junction 709

Synapse 378

Neurotransmitter transport 37

See all...

GO Function (1)

syntaxin binding 69

GO Component (3)

membrane 1,917

cell junction 502

synapse 172

GO Process (3)

neurotransmitter transport 12

exocytosis 69

regulation of neurotransmitter secretion 16

Compartment GO Term (9)

Cell junction 960

Cone cell pedicle 13

Membrane 8,531

Photoreceptor ribbon synapse 13

Ribbon synapse 19

Rod spherule 7

SNARE complex 72

Synapse 663

cellular_component 18,320

MGI Phenotype (2)

vision-eye phenotype 1,622

nervous system phenotype 3,447

HCA RNA Cell Line (47)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493