Property Summary

NCBI Gene PubMed Count 21
PubMed Score 20.28
PubTator Score 20.07

Knowledge Summary


No data available


  Differential Expression (26)

Disease log2 FC p
astrocytoma -2.900 1.1e-02
ependymoma -3.000 8.7e-03
psoriasis -1.100 2.9e-03
glioblastoma -3.500 1.7e-07
oligodendroglioma -2.000 6.9e-15
medulloblastoma -3.300 1.4e-07
atypical teratoid / rhabdoid tumor -3.800 7.2e-11
medulloblastoma, large-cell -4.200 6.5e-08
primitive neuroectodermal tumor -3.500 1.8e-06
adrenocortical carcinoma -1.191 4.4e-02
non-small cell lung cancer -2.122 2.8e-25
intraductal papillary-mucinous adenoma (... -3.000 1.0e-05
intraductal papillary-mucinous carcinoma... -3.000 4.7e-05
intraductal papillary-mucinous neoplasm ... -3.100 3.0e-04
lung cancer -2.000 2.4e-05
colon cancer -2.200 1.1e-02
breast carcinoma -2.200 1.3e-04
fibroadenoma -2.100 8.8e-03
pediatric high grade glioma -2.800 2.4e-07
pilocytic astrocytoma -2.400 7.2e-07
primary Sjogren syndrome -1.300 3.0e-02
lung adenocarcinoma -2.496 4.0e-13
inflammatory breast cancer -1.600 1.6e-02
spina bifida -1.474 2.3e-02
ductal carcinoma in situ -2.400 1.6e-04
invasive ductal carcinoma -3.200 2.8e-04

 GWAS Trait (1)

Gene RIF (9)

25666558 We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle
22419111 Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples
20877624 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19843159 Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates.
18488190 While DNA methylation of the COX7A1 promoter was increased in muscle from elderly compared with young twins, the opposite was found for COX7A1 mRNA expression
18488190 Observational study of gene-disease association. (HuGE Navigator)
11997101 promoter contains and is regulated by sequence elements typical of contractile muscle as well as the element for the common transcription factor Sp1

AA Sequence

LGWASFPRN                                                                  71 - 79

Text Mined References (21)

PMID Year Title
25666558 2015 Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
22968485 2012 Muscle inflammatory signaling in response to 9 days of physical inactivity in young men with low compared with normal birth weight.
22592081 2012 High-resolution melting analysis of 15 genes in 60 patients with cytochrome-c oxidase deficiency.
22142811 2012 Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20413852 2010 Polymorphic variation in cytochrome oxidase subunit genes.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19843159 2009 Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
19779253 2009 Diabetes--role of epigenetics, genetics, and physiological factors.
18488190 2008 Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057824 2004 The DNA sequence and biology of human chromosome 19.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11997101 2002 Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH).
10335655 1999 Molecular evolution of the COX7A gene family in primates.
9752724 1998 Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.
9344674 1997 Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M.
2550906 1989 Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase.
1327965 1992 Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase.
1309697 1992 Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.