Tbio COQ8A Atypical kinase COQ8A, mitochondrial

Protein Summary

Description

Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144). This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NI60
• Q5T7A5
• Q63HK0
• Q8NCJ6
• Q9HBQ1
• Q9NQ67

Gene Name

• COQ8A

Ensembl ID

• ENST00000366777
• ENSP00000355739
• ENSG00000163050
• ENST00000366778
• ENSP00000355740
• ENST00000366779
• ENSP00000355741

Symbol

• ADCK3
• CABC1
• COQ8
• ADCK3
• ARCA2
• CABC1
• SCAR9
• COQ10D4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Atypical Group / Abc1 Family / Abc1-a Subfamily / Atypical Kinase Adck3, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.96   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.96   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0