Property Summary

NCBI Gene PubMed Count 1,572
PubMed Score 2841.15
PubTator Score 3771.85

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count P-value
ependymoma 2514 1.1e-09
tuberculosis 1563 2.3e-09
malignant mesothelioma 3163 8.8e-07
ovarian cancer 8491 4.7e-03
Disease Target Count Z-score Confidence
Velocardiofacial syndrome 45 5.586 2.8

Expression

  Differential Expression (4)

Disease log2 FC p
malignant mesothelioma 1.400 8.8e-07
ependymoma 1.100 1.1e-09
tuberculosis 1.900 2.3e-09
ovarian cancer 1.400 4.7e-03

Protein-protein Interaction (4)

Gene RIF (1926)

PMID Text
27074016 The AA genotype and the A allele of rs4680 (COMT) appeared to be inversely associated with the risk of prostate cancer in adjusted models for both Afro-Caribbean and native African men
27039372 Linear Regression showed COMT rs5993883 GG genotype predicted lower verbal learning (p = 0.0006) and memory (p = 0.0026) scores, and lower scores on a cognitive control(p = 0.004) in second generation antipsychotics treated pts. with bipolar disorder.
26986136 no association of rs4680 with post-traumatic stress disorder [meta-analysis]
26823844 COMT Val158Met polymorphism may have more impact on the modulation of blood pressure and lipid profiles in the average families than in the long-lived families in Bama region.
26818509 Prefrontal function was indexed by a polymorphism in the COMT gene, differences of which reflect dopamine levels in the prefrontal cortex
26810551 our updated meta-analysis suggested that COMT Val158Met polymorphism could decrease the risk of Alzheimer disease in the Asian population, but not in the Caucasian or the overall population.
26808641 rs1800497 and rs4633 play important roles in the anorexia nervosa (AN) susceptibility with respect to the Chinese Han population. The gene-gene interaction between DRD2 and COMT contributes to the risk of AN.
26798414 the association of CYP1A1 M1 (rs4646903) and COMT (rs4680) polymorphisms in 130 cervical cancer cases (c-cancer) and 179 controls, is reported.
26782546 No significant differences are found in the COMT gene polymorphism genotype distributions between cervical cancer patient and control groups.
26687156 COMT polymorphisms influence obsessive-compulsive patients' features.
26681027 the COMT rs4680 polymorphism is not associated with susceptibility to ovarian cancer.
26634548 ESR1 may be associated with low mineral osseous densitometry, while CYP17 and COMT gene polymorphisms were not associated with mineral osseous densitometry.
26632697 Decreased risk of Migraine was observed to be in association with COMT rs4680 polymorphism in overall analysis and in Caucasian group after subgroup analysis.
26621270 COMT Met/Met homozygous individuals with binge eating disorder (BED) might represent a specific group in the BED spectrum, which shows a higher behavioural impulsivity.
26620113 Our study offers evidence that the COMT and estrogen receptor alpha genes may also play a role in the susceptibility to depressive mood in postmenopausal women.
26576546 COMT Val (158) Met may preferentially modulate nonverbal cognition following uncomplicated mild traumatic brain injury.
26566126 interacting functional variants of COMT affect gray matter regional volumes in healthy subjects
26560201 These data clarify the importance of taking into account the combined effect of sex, hormonal status and COMT genetic variation.
26549298 COMT polymorphism status affects threat cue reactivity at the visuocortical level
26536074 COMT genotype has a strong impact on brain responses (oscillatory activity) during WM performance likely a consequence of compensatory activity during the delay and response periods.
26520222 The COMT Val(158)Met-irrationality association was significant only when individuals fell in the average to above average range of emotional distress.
26489634 The SNPs of COMT V108/158M and ABCB1 C3435T significantly influence pain perception in Chinese cancer patients.
26489081 Our study suggests that the COMT p.Val158Met polymorphism has a larger genetic contribution to tests of attention, cognitive flexibility and information processing speed at ages 43-56 than at ages 63-76.
26450530 Fetal Met-Met COMT genotype reduces COMT placental expression and activity in vitro and increases preeclampsia risk.
26419600 on a sequence learning task in 161 Caucasian participants, the COMT polymorphism predicted the ability to switch flexibly between two sequences
26415297 SNPs of OPRM1 118A>G and COMT 1947G>A affect the preoperative patients psychological status.
26376054 Combined genetic polymorphisms related to dopamine neurotransmission, COMT Val158Met and DRD3 Ser9Gly, might influence executive function in schizophrenia.
26346727 The COMT Val158Met variant might be associated with male sexual orientation and a recessive model was suggested.
26345603 The COMT gene rs4680 polymorphism was genotyped using a DNA sequence detection system. The heroin use status was evaluated for 5 years after discharged. the COMT rs4680 gene variants were different between relapse and abstinent groups.
26329592 genetic variants of TXN and COMT have roles in regulating abdominal obesity
26313260 High goal disturbance had the Met/Met variant of COMT in cancer.
26300284 This preliminary study failed to demonstrate the association between COMT genotypes with aggression in multiethnic Schizophrenia patients in Malaysia.
26272340 The prevalence of single nucleotide polymorphisms of COMT and glucocorticoid receptor-associated genes in chronic fatigue syndrome patients.
26255563 study evaluated association of COMT Val108/158 Met genotype with response to computerized neurocognitive remediation (CRT) in patients with DSM-IV-TR schizophrenia or schizoaffective disorder; Met allele (Met/Met; Val/Met) was associated with greater improvements in the MATRICS domains of Verbal Learning, Visual Learning and Attention/Vigilance after CRT
26253436 A polymorphism in the COMT gene appears to be associated with volume reduction in the caudate in major depressive disorder patients.
26253211 Chronic levels of physical activity, as seen in ultra-endurance athletes, show increased novelty seeking scores in COMT Met(158) homozygous allele carriers
26251232 Val-Val version of the COMT Val158Met gene is associated with higher executive function ability and interacts with adverse early life experience to influence the trajectory of executive function development in early childhood.
26245713 we did not find any significant associations of COMT or SLC6A3 with inhibitory performance or impulsivity
26239947 Study shows that performance of Parkinson's disease patients on tasks sensitive to frontal dopamine is influenced by their COMTval158met genotype
26234518 The ADRA2A C-1291G and COMT Val158Met genotypes and sex interact in predicting detection and perception of emotional valence in facial expressions
26233486 findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS severity.
26207649 Our results provide evidence for an essential role of the (a)-COMT isoform in nociceptive signaling and suggest that genetic variations in (a)-COMT isoforms may contribute to individual variability in pain phenotypes.
26198390 stress escalation was limited to incident cases with COMT diplotypes coding for low-activity COMT, signifying impaired catabolism of catecholamines
26147675 The present study provides the first evidence for an association between COMT and gout.
26123186 data show that in the leukocytes with mutant alleles treatment with 17beta-E2 up-regulates CYP1A1 and CYP1B1 and down-regulates COMT mRNA levels, resulting in major increments in 4-OHE2 levels
26096878 catechol-O-methyltransferase (COMT) gene (val158met) may modulate reward-guided decision making in healthy individuals... COMT met homozygotes had increased reward responsiveness and, thus, an increased propensity to seek reward.
26096691 this study examined the modulatory effects of the COMT Val158Met polymorphism on the neural response to acute nicotine
26080432 experimental and computational results are discussed in the context of active site compaction that requires an ionization of substrate within the enzyme ternary complex
26073896 COMT plays a role in the neurobiology of response inhibition.
26073434 The catechol-O-methyl transferase polymorphism rs165599 and the brain-derived neurotrophic factor polymorphism rs10835211 were found to predict dysphagia and have an interactive effect, which varied according to the carrier status of the other.
26070413 There are genetic effects of COMT polymorphism on the clinical benefits of add-on tDCS in treatment of persistent auditory hallucinations in schizophrenia.
26068888 these data provide further evidence for the risk effect of elevated proline levels combined with the COMT Met allele and support the possibilities of using 22q11DS as a model to investigate genotype effects on psychiatric disorders
26067582 The data of this study demonstrated that the Comt+ transcript contains regulatory miRNA signals in its 3'-untranslated region leading to mRNA degradation.
26055783 None of the SNPs in SLC6A4, COMT, or BDNF genes were significantly associated with depressive symptoms.
26054510 COMT Val158Met polymorphism is significantly associated with the network centrality of the left parahippocampus and individual working memory performance.
26053146 An interactive effect of serious life events and COMT genotype was observed. Children that faced serious life events and were Val homozygotes exhibited more aggression (p = .02) than did Met-carrying children.
26028545 Val/Val COMT genotype is associated with problem gambling and impairments across multiple cognitive domains.
26026741 meta-analysis to evaluate whether the COMT SNP rs4680 influences the risk of Alzheimer's disease in Asians; results showed that no any positive associations were observed
26010653 No significant association between the COMT Met allele and OCD risk or between the COMT Met allele and clinical responses.
26004676 COMT variants are associated with exploratory behavior and decision making.
25990287 COMT Val158Met was not associated with frontal EEG asymmetry.
25974322 TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotionalsignls
25974269 The middle frontal gyrus and anterior cingulate cortex /inferior parietal lobule activations were sensitive to differences between the COMT genotypes and between the HTR2A genotypes, respectively.
25930952 We evaluated treatment response by COMT genotype, with the a priori hypothesis that Val carriers would have improved response to computerized delivery of CBT.
25927430 SNP rs4646312 in COMT achieved statistical significance in both allelic and genotypic association with Type 2 Diabetes Mellitus. Two haplotypes of rs4646312 and rs4680 were also significantly associated with T2DM.
25896799 These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system.
25863100 No association was found between COMT polymorphisms between first-episode familial and sporadic schizophrenia.
25861704 This study suggested that the COMT Val158Met genotype not impact brain activation during working memory tasks.
25804664 COMT Val variant was associated with higher level accuracy in target discrimination with longer stimulus-onset asynchronies in metacontrast masking
25801838 Study found that the Val158Met SNP from the COMT gene was significantly associated with schizophrenia in a Pakistani sample
25793616 The findings do not support an association between DSM-IV OCD and the variants of COMT or MAO-A.
25772090 Studied the association between COMT and OPRM1 gene polymorphisms and pain and disability at baseline and long-term follow-up in patients treated for chronic low back pain.
25766270 Current evidence confirms an association of the COMT G (Val) allele with major depressive disorder.
25753458 Striatal denervation in Parkinson's disease differs according to COMT-Val158Met polymorphism.
25748092 This study shows that COMT genotype may exert only modest effects on cognitive training.
25744938 Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II.
25723014 Anxiety and the COMT genotype effects on performance effectiveness of selective attention depend on cognitive processes reflected in N100 parameters.
25722988 these findings contribute to the growing literature on sex-specific effects of COMT on the predisposition to psychiatric disorders and personality traits.
25722948 findings potentially broaden our understanding of the factors underlying clinical complaints to include the personality dimension of conscientiousness and its modification by COMT
25711924 COMT role in pancreatic cancer:COMT high expression predicted longer survival time in pancreatic cancer patients.
25682348 Results confirm the impact of COMT genotype on inhibitory processes during a WM task, with an advantage for Met allele carriers.
25675769 Gastrointestinal side effects of analgesic opioids in surgical patients may be related to single nucleotide polymorphisms in OPRM1 118A>G and COMT 1947G>A.
25674213 meta-analysis suggests that the COMT gene val(158)met polymorphism is not associated with fibromyalgia risk.
25666727 there is preliminary evidence to support the notion that the COMT Val158Met polymorphism and age jointly modulate dopamine and prefrontal cortex efficiency.
25636089 Polymorphisms of COMT and MAO-B genes has a unique characteristics among Chinese patients with Parkinson's disease. They may be related with differences in drug response in such patients.
25600541 The findings from this study confirm the association between COMT Val158 Met polymorphism and pre-morbid cannabis use in causing schizophrenia.
25599448 Functional variations in COMT (and GCH1) combined with clinical factors are predictive of postherniotomy-related impairment.
25598522 Results indicated that brain structure and function of the hippocampus are differentially affected by migraine in COMT val homozygotes compared with met carriers
25564193 Findings suggest that the COMTMet variant is associated with the disruption of dopaminergic influence on gray matter in schizophrenia, and the effect of the COMT gene on GMV in schizophrenia is mainly due to changes in cortical thickness.
25562165 Soluble cytoplasmic COMT (S-COMT), but not membrane-bound COMT (MB-COMT) levels in placentas were increased by 2.5 fold in the full term vs. the first trimester placentas
25560469 The findings support the hypothesis that COMT rs4680 and 5-HT1A-R rs6295 polymorphisms could influence the negative symptom response to clozapine, probably through modulation of the dopaminergic system.
25556215 fluoride exposure was adversely associated with children's intelligence, whereas the COMT polymorphism may increase the susceptibility to the deficits in IQ due to fluoride exposure
25551397 this paper shows that the influence of TPMT and COMT on the development of cisplatin-induced hearing loss may be less important than previously suggested.
25532943 COMT has tumor-suppressive functions for colorectal cancer cell lines in vitro and in vivo
25532715 COMT gene haplotype constructed by rs6269, rs4633, rs4818, and rs4680 contributes to the individual variation of postoperative analgesia with fentanyl
25525983 COMT genotype is associate with different patterns of renal functional changes and tubular stress response after open heart surgery.
25515329 The combination of HIV infection and the Val/Val COMT genotype leads to working memory deficits and altered prefrontal function in HIV-infected individuals.
25510857 Complex, multilevel impact of the dopaminergic system on the emotion-potentiated startle reflex suggesting increased phasic dopamine transmission driven by the more active COMT 158val allele.
25510658 higher prevalence of low MAOA activity among Afro-Caribbeans convicted of violent crimes in the Netherlands, but not of the COMT nor 5-HTTLPR polymorphisms.
25510197 Analyses revealed significant sex by genotype interactions for the capacity to switch attention. In relation to COMT, superior performance was noted in females with the Val/Val genotype.
25495556 modulation of ADHD-related grey matter volume alterations by Val158Met polymorphism in two key regions of COMT
25491588 *Although genetic association between the catechol-0-methyltransferase Val158Met polymorphism and the onset of AD in a Japanese population were not observed, the polymorphism affected the risk for high alcohol consumption in patients with AD.
25481766 Catechol-O-methyltransferase Val(158)Met polymorphism partly explains the individual differences in the ability of configural face processing.
25466290 review of role in regulation of sleep and wakefulness and sleep disorders
25455425 The results of this study provided further evidence that 5-HTTLPR and COMT Val(158)Met genotypes influence the vulnerability for the development of anxiety disorders via different mechanisms.
25451452 COMT allele rs4633C may be causally related and/or is in linkage disequilibrium with gene(s) that are causally related to PTSD symptoms. Carriers of these COMT alleles may be at increased risk for PTSD. The findings provide biological support for dividing DSM-IV category C symptoms into DSM-5 categories C and D.
25430946 COMT genes interact with DRD2 and ALDH2 genes in a Han Chinese population with bipolar II disorder.
25394948 Val158Met-polymorphism in the Catechol-O-Methyl-Transferase (COMT) is associated with the alteration of neural processes of appetitive conditioning.
25367407 this study suggested that Val158Met polymorphisms in COMT may increase the risk of wearing-off.
25358337 The first study finding associations of polymorphisms in BDNF and COMT genes with quantitative measures of numerical aptitude in healthy young participants.
25329975 moderating effect of race on the association between COMT genotype and posttraumatic stress disorder
25325218 results suggest that PRODH and COMT may interact to contribute to the ASD phenotype in individuals with VCFS
25320962 COMT Single Nucleotide Polymorphisms (val158met, rs737865, and rs165599) modulated the association between antenatal maternal anxiety and the prefrontal and parietal cortical thickness in neonates.
25319752 Study demonstrate that adolescent and adult resting state networks are dose-dependently and diametrically affected by catechol-O-methyltransferase genotypes following a hypothetical model of dopamine function that follows an inverted U-shaped curve.
25297602 Data indicate no significant difference among catechol-O-methyltransferase (COMT) Val/Val, Val/Met and Met/Met on the trail making test TMT-A and B in control subjects and schizophrenia patients.
25292091 COMT rs4680 polymorphism is not associated with ovarian cancer risk.
25283873 Results showed a significant interaction effect of COMT and STH polymorphisms on cognitive performances, strengthening the involvement of STH in cognitive impairments, especially in the domains commonly impaired in schizophrenia
25238960 Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism-a prime candidate for anxiety vulnerability-became significantly more anxious during the fMRI experiment
25222607 Significantly more drug-specific as well as general side effects were reported from homozygous carriers of the Val158 COMT variant during medication as well as placebo treatment compared to the other genotype groups
25218601 The data of this study suggest that the ability to predict the downstream effects of genetic variation on COMT activity is critically important to understanding the molecular basis of chronic pain conditions.
25216558 The COMT met allele was found to increase risk for some symptoms of disordered eating.
25205659 The results of this study confirm the impact of COMT genotype on frontal functions. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task.
25201318 This study demonstrated that white matter connectivity in youth with ADHD is associated with COMT Val158Met genotypes
25195915 Results suggest that prefrontal cortex asymmetry is an endophenotype between COMT genotype and trait reward responsivity.
25190703 Relative to Val carriers, Met homozygotes made fewer errors when selecting and manipulating self-generated thoughts. This effect was partly accounted for by an association between COMT genotype and visuospatial working memory performance.
25185591 genetic variant of the COMT rs4680 single nucleotide polymorphism is associated with variability in opioid consumption in postoperative nephrectomy patients
25161818 Our findings support the assumption that the Val(158)Met single nucleotide polymorphism (SNP) influences character traits and not only temperament.
25159270 Children's internalizing behaviors and inhibitory control are associated with the interaction among COMT variants, parenting and gender.
25155931 Combined OPRM1 118A>G and COMT 472G>A genotype might serve as a predictor for the need of rescue morphine in premature and term newborns on mechanical ventilation.
25148110 Among the men, COMT Val/Val carriers had greater depressive symptom reduction compared with Met/Met carriers
25139113 Study examined the COMT genotype and its relationship to cognition and functional capacity in schizophrenia or schizoaffective disorder; more Met alleles was associated with better performance on tests of learning/memory and abstraction
25124664 the epistasis effects of COMT and MTHFR on inter-individual differences in mental health are consistent with the ''inverted U-shaped'' prefrontal dopamine model
25108642 The finding of this study suggests that COMT Val158Met may affect susceptibility to wearing-off in Parkinson's disease.
25107496 Genetic polymorphisms of catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) have shown promising but inconsistent linkages with executive function (EF) in normal aging.
25102390 sickle cell disease patients with the DRD3 homozygote genotypes, COMT 158 Met allele or Met/Met genotype, are more likely to have acute care utilization, an indicator of acute pain
25096984 Describe novel assay which could be implemented in the study of a large number of diseases and endophenotypes related to COMT dysfunction.
25084618 carriers of Met/Met allele have higher degrees of hypnotizability
25074639 Results demonstrate that subjects with the COMT Met/Met genotype at the Val159Met allele, as well as subjects with a more external locus of control measure, showed significant increases in exploration on tolcapone vs placebo
25068285 In first-episode psychosis patients with low maternal care and recent stressful life events, those who were also homozygotes for the COMT Val(158) allele had the highest level of positive symptoms.
25060648 the Val158Met polymorphism of COMT gene may be associated with Parkinson's disease in Japanese rather than Chinese population
25056932 the COMT polymorphism affects white-matter microstructure, indexed by fractional anisotropy and mean diffusivity, of several white-matter tracts in the oldest age group (81-87 years)
25038551 The results of this study suggested that no significant effect of the COMT Val158Met on orienting bias.
25037115 In elderly Chinese patients, the 158Met SNP in COMT is associated with irritable bowel syndrome pathogenesis.
25035343 Common COMT polymorphisms (rs4680, rs4818) were associated with incident CVD, and this association was modified by randomized allocation to aspirin or vitamin E.
25035107 Study suggests that the increased platelet study found COMT Val108/158Met polymorphism is associated with increased suicidality and early onset of alcohol dependence
25034874 The results of this study suggested that polymorphisms in COMT may increase the risk of wearing-off and dyskinesias.
25029900 99 adults were genotyped for the COMT Val158Met snp (rs4680) and divided into Met/Met, Val/Met, and Val/Val groups. Met/Met exhibited a greater increase in enemy targets destroyed and greater reduction in enemy red zone incursions across training blocks.
25012481 The COMT allele and genotype were found associated neither with AD onset nor with parameters of AD severity, such as cognitive impairment, age at onset, or disease duration.
25007787 Findings provide preliminary support for a differential impact of COMT genotype on working memory measures in adult patients with ADHD compared to healthy controls.
24990354 interaction of COMT and MTHFR was associated with an increased risk of neural tube defects, especially anencephaly, in a Chinese population
24988263 A main effect of COMT variation or its interaction with familial risk on Iowa Gambling Task performance was not seen.
24979760 Variation in genes that primarily regulate prefrontal dopamine clearance-catechol-O-methyl transferase and two isoforms of monoamine oxidase-modulated degree of belief learning across individuals.
24965973 Meta-analysis. COMT 158G/A and CYP1B1 432C/G polymorphisms may contribute to the risk of endometriosis and adenomyosis, particularly in Asian populations.
24956262 This study found a significant association between the COMT polymorphism and manual aiming control.
24956006 significant main and interaction effects of COMT and BDNF genotypes on reaction time (RT) and intraindividual variability in RT (IIV-RT)
24955500 The G allele of the rs165599 polymorphism may confer genetic susceptibility to negative cognitive outcomes arising from exposure to antenatal stress.
24951880 This meta-analysis identified an association between fibromyalgia risk and the COMT Val158Met polymorphism as well as the fibromyalgia impact score in fibromyalgia patients.
24946318 Results provide support for the influence of COMT on specific AX-Continuous Performance Task performance indices in children; suggests that the effects differ by levels of externalizing psychopathology
24936684 COMT Val158Met genotype is associated with measures of intra-subject variability on the behavioural and neural levels at different working memory loads.
24915010 This study evaluates the oxidative stress status, the role of catalase (CAT) and catechol-O-Methyltransferase (COMT) gene polymorphisms in the etiology of generalized vitiligo in Egyptians.
24914507 Val158Met genotype moderates the effect of disorganized attachment on social development in young children
24912046 Val158Met-COMT does not play a role in genetic predisposition to autism spectrum disorder in Thai children.
24904231 Analysis confirmed the previously association between COMT SNP rs4633 and disc degeneration.
24902721 COMT promoter methylation was associated with alcohol use and non-daily smoking but not with daily smoking. Adolescents with the Met/Met genotype and high rates of MB-COMT promoter methylation were less likely to be high-frequent cannabis users.
24889847 study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism and electroencephalographic alpha peak frequency in 2 independent cohorts of 187 (96 depressed/91 healthy participants) and 413 healthy participants
24889756 Results show that influence of COMT on social working memory (WM) performance was not accounted for by its influence on either standard WM paradigms; there was no main effect of DAT1 or MAOA, but significant COMTxDAT1 interaction on social WM performance
24888672 findings indicate remitted patients with schizophrenia have a relatively adaptive personality profile compared to symptomatic patients; the COMT Val158Met polymorphism might have a modulating effect on the relationship between personality and remission
24862404 Alleles rs2097603 and rs4680, and two COMT haplotypes, all indexing high activity, were indirectly associated with higher risk of psychotic experiences
24853458 Functional COMT, but not PRODH, variant affects IQ and executive functions in 22q11.2DS subjects during neurodevelopment with a maximal effect at adulthood
24852514 The gender-specific effect of the COMT genotype suggests that the COMT Val/Met genotype may influence a personality trait, openness to experience, in males with panic disorder.
24837210 Analyzing the effect of MB-COMT promoter DNA methylation on a neuroimaging phenotype can provide further evidence for the importance of COMT and epigenetic risk mechanisms in schizophrenia.
24825955 COMT gene rs6267 allele "T" associated with Parkinson disease pain
24820538 Gender significantly moderates COMT effects in the pre-SMA during successful motor inhibition
24819480 the COMT rs4680 polymorphism is not a major determinant of either the risk for Parkinson's disease or clinical, neuropharmacological and neurochemical features [review and meta-analysis]
24819065 For working memory, carriers of the val allele of the COMT polymorphism had lower baseline performance and larger performance gains from training than carriers of the met allele.
24814141 Three single nucleotide polymorphisms located in the 5' region were associated with remission in fluvoxamine-treated outpatients with moderate to severe depression.
24808926 A strong association between the COMT Val/Met polymorphism and the risk of premature ovarian insufficiency in Brazilian women.
24786534 It was concluded that there was little support for the influence of COMT Val(158)Met on cognitive function, or functional outcome measures, in the acute rehabilitation phase after traumatic brain injury
24782165 These results provide evidence for a role of the COMT Val(158)Met polymorphism in the etiopathophysiology of schizophrenia in Saudi population.
24777039 Single mucleotide polymorphisms in three estrogen metabolite enzymes (COMT, CYP1A1, CYP1B1) were found in a Chinese population. Some polymorphisms were risk factors for uterine leiomyoma and some were protective factors against it.
24773408 The feedback-related negativity to positive versus negative feedback was modulated by a significant COMT x dopamine antagonist interaction.
24772965 genetic variants of COMT, MAOB and DRD2 loci modulate susceptibility to PD in South Indian subjects
24772423 Age-related differences were qualified by an interaction with COMT genotype (P < .001), and this interaction was due to decreased behavioral plasticity in older adults carrying the Val/Val genotype
24762091 Val158Met polymorphism positively associated with fibromyalgia syndrome and plays a relevant role in the clinical symptoms
24751310 Individuals with the genotype COMT Met/Val and MTHFR C/T have more probability of suffering from MDD
24708432 Substance users and controls significantly differed in allele frequencies of COMT Val158Met but not in allele frequencies of DAT1 3'-UTR VNTR. Neither allele frequencies of COMT Val158Met nor DAT1 3'-UTR VNTR were associated with drug-induced psychoses.
24685226 The results indicate that genetic variants of the COMT and 5HTTLPR genes are differentially associated with specific measures of the self-estimated effectiveness of an individual's emotion perception and regulation in the intra-personal domain.
24684248 Polymorphisms in the COMT gene could predict long-term outcomes of medication overuse headache patients after withdrawal therapy.
24679122 The met allele of the Val158Met polymorphism of the COMT gene is associated with elevated levels of generalized anxiety.
24661160 We predicted that COMT Val158Met genotype would be associated with brooding rumination and heart rate variability, particularly among women with a history of past major depression. The results largely supported our hypotheses
24658585 This study report that functional genetic mutations in COMT modulate cortical thickening, neuronal density, and working memory performance with different profiles strongly dependent on the sex of the subject.
24657591 Large, non-clinical study reveals that the selected genetic polymorphisms regulating dopamine (COMT, DRD2 and DAT1) do not influence one aspect of response inhibition, action restraint, as measured by the Go/No-Go task
24630741 We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mRNA-level.
24625311 Report role of COMT polymorphisms in controlling actigraphy-derived sleep-wake cycles in young adults.
24618367 COMT Val158Met genotype was not a modifier of aggression in penetrating traumatic brain injury.
24607512 This study demonistrted that catechol-O-methyltransferase-val158met-polymorphism effect on the automatization of motor skills.
24593143 Among boys, numerous gene-Hg interactions were observed between individual catechol-O-methyltransferase (COMT) single nucleotide polymorphisms, as well as with a common COMT haplotype affecting multiple domains of neurobehavioral function.
24578196 Study combined resting-state fMRI, genotype at a COMT polymorphism (Val158Met), and personality measures in a model to predict the magnitude of placebo conditioning effect indicated by subjective pain rating reduction to calibrated noxious stimuli
24551149 COMT polymorphism might modulate white matter hypersensitivity (WMH) volumes and the effects of WMH on cognition.
24534796 There was no evidence for an association between the COMT polymorphisms that were examined and schizophrenia or schizotypy.
24533707 COMT SNPs may play a significant role in interindividual variation in postoperative pain perception and postoperative morphine requirements in children
24508446 This study deministrated tha the involvement of a BDNF x COMT x gender interaction in the pathogenesis of Panic disorder.
24503977 Results provide initial evidence of an influence of the COMT Val158Met polymorphism on alpha-amylase dysfunction and humoral immune system in fibromyalgia syndrome
24495967 Inheritance of prefrontal dysfunction 'risk alleles' (COMT Val and DRD2 T) is associated with reduced prefrontal activation in healthy individuals similar to prefrontal hypoactivity in schizophrenia during cognitive-affective processing.
24477323 meta-analysis identified an association between Alzheimer's disease(AD)and the COMT Val158Met polymorphism in Asians but not in Europeans, but it revealed no association between AD and the PPARgamma Pro12Ala polymorphism
24468545 gene variation in COMT was found to have no association with episodic memory performance, with the exception of a single measure of auditory memory. There was also little significance to active engagement in complex cognition.
24465960 Seventeen SNPs of CYP3A5, CYP3A4, COMT, IL-10 and POR were identified.
24465579 Women homozygous for the Met allele of the COMT polymorphism showed impaired inhibition of prepotent responses
24460628 The first comprehensive interrogation of COMT methylation, is reported.
24448899 Our findings suggest a potential association between rs4680 in COMT and elevated triglyceride levels, particularly among female schizophrenia patients.
24446536 genetic association study in a population in Mexico: Data suggest that a polymorphism in COMT (Val108/158Met) is associated with remission induction/drug resistance in subjects with major depressive disorder treated with fluoxetine.
24443099 A significant association between the COMT Val(108/158)Met polymorphism and polydipsia was found in schizophrenic patients after controlling for confounding factors.
24399714 Analysis of the COMT rs4680 polymorphism shows that some genetic factors may be relevant in analyzing the reasons for the differentiation of schizophrenic subtypes.
24390993 A meta-analysis suggests that the COMT Val/Val genotype might act as a potential endometrial cancer risk factor in postmenopausal women.
24390676 COMT Met/Met genotype may be a genetic risk factor that contributes to the development of both gambling and drinking problems.
24389396 results are consistent with the perspective that altered COMT mRNA expression in frontal cortical brain regions might contribute to suicide and/or depression.
24382678 Several COMT variants were associated with elevated risk of neural tube defects in a Chinese population and were related to the maternal tea consumption.
24373571 Results from the recruited cohort (N = 190) indicated strong statistical evidence for interactions between the COMT diplotype.
24373005 The results suggest no major effect of COMT or MTHFR on cognitive function alone. However, an interaction of COMT Val158Met and MTHFR C677T polymorphisms may be associated with cognitive function.
24342707 Results support the hypothesis regarding the association between COMT p.Val158Met polymorphism and central sensitization in fibromyalgia patients
24320736 genetic association studies in Han Chinese population in Nanjing: Data suggest that SNPs in COMT (IVS1+2329C>T/rs3087869; Val158Met/rs4680) are associated with susceptibility to uterine leiomyoma in the population studied.
24312552 individual differences in the attentional bias for emotional expressions are partially underpinned by the genetic polymorphisms in COMT and DRD2
24307619 current meta-analysis confirmed that the Val158Met polymorphism in the COMT gene may be a risk factor for cancer in Chinese population. In the future, more case-control studies are needed to validate our results
24300663 This meta-analysis provides evidence for sex and ethnic differences in the association of the COMT val158met polymorphism with anxiety traits.
24290452 The Met allele of the Val158Met polymorphism could be a potential risk factor for the development of pain in multiple sclerosis (MS) patients, but it is not a risk factor for the predisposition of MS itself.
24280759 HTTLPR may mediate the risk for SMB through modulation of some temperamental traits.
24268936 No interaction between COMT genotypes and cannabis use was found in schizophrenia.
24260145 None of the three gene variants, 5-HTTLPR, COMTval158met and TPH2 G-703T, was associated with long-term response to CBT for SAD.
24252819 The results of this study suggested that the possible epigenetic modulation of the expression of the COMT Val(158)Met polymorphism and consequent effects on cognition and symptoms in schizophrenia.
24236764 frontal cortex fMRI BOLD signal during working memory maintenance and manipulation was examined in relation to aging and COMT Val(158)Met status; younger adults and met carriers showed maximal BOLD response during manipulation; older adults and val carriers displayed elevated responses during the maintenance condition
24225542 individuals homozygous for COMT val158met demonstrate faster rates of motor learning and adaptation.
24224001 COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences
24210742 Our results confirmed that SNPs in DRD4 and COMT, but not DBH or MAOB are associated with autism and ADHD in small, ethnically homogeneous groups of non-related male Caucasians.
24193094 Interaction effects between DAT1 and COMT was regard to anger and hostility in Datoga males.
24178190 polymorphism in the catechol-O-methyltransferase gene may play an important role in the mechanism of pain perception
24174684 Significant COMT and DRD2 interaction effects reveal a functional system-dependent modulation of dopamine signaling.
24167357 No association between the COMT-Val158Met-(G/A) polymorphism and the appearance acute kidney injury after cardiac surgery.
24163823 assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (rs1800496, rs1801028, and rs1799732), DRD4 (rs4646984 and rs4646983), and COMT (rs165599 and rs740603) in Indian ADHD subjects with comorbid attributes
24147141 The COMT Val158Met polymorphism modulates gray matter volume and related resting-state functional connectivity within the default mode network, indicating a potential neural pathway by which this polymorphism may affect cognitive function.
24146281 this meta-analysis suggests that the COMT Val158Met polymorphism is not a risk factor for breast cancer development
24145376 These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1.
24127930 Following alcohol consumption, individuals with the COMT Val158 allele have greater opioid release in the right nucleus accumbens but less release in medial orbital frontal cortex.
24118473 COMT genotype was not associated with a history of violent or non-violent crime.
24107543 A significant main effect of the COMT polymorphism on resilience and a gene-gene interaction effect between the COMT and BDNF on resilience were observed for males.
24096006 Data suggest that megakaryoblastic leukemia 1 (MKL1) and histone acetyltransferase p300 could augment the expression of catechol-O-methyltransferase (COMT), increase estrogen metabolism, and thus reduce MCF-7 cell proliferation stimulated by estrogen.
24084577 This study did not observe an effect of COMT genotype in control smokers which is likely due to the fact that overnight abstinence did not impair task performance in this group.
24077552 A correlation analysis of the COMT Val158Met polymorphism, performance on FB2 task, neurocognitive and clinical symptoms suggests that in female patients the association was modified
24077209 indicated that the Val158Met polymorphism of catechol-O-methyltransferase seems not to be a risk factor for the development of carpal Tunnel syndrome
24074515 COMT genotype affects risk for development of PTSD symptoms following exposure to trauma.
24039968 These results suggest that met allele of val158met COMT polymorphism is associated with poor performance in decision-making/cognitive impulsivity task.
24035893 the COMT Val158Met polymorphism may not play a major role in the development of late-onset Alzheimer's disease in Han Chinese.
24035255 Results showed a lack of association between the COMT Val/Val genotype and attention deficit/hyperactivity disorder in Japan.
24030137 COMT variants associated with genetic predisposition to cognitive flexibility and learning.
24015051 The haplotypes of catechol-o-methyltransferase gene with rs6269 demonstrated significant evidence of an association with autism spectrum disorders.
24008922 Individual SNPs in COMT did not influence prevalence or time to onset of levodopa-induced dyskinesias in this Parkinson's disease patient cohort
24001377 Psoriasis patients with moderate/severe disease present higher S-COMT activity than controls. Although a good clinical response was observed, PUVA therapy does not change S-COMT activity.
23992923 This study confirm a robust effect of COMT hemizygosity on COMT activity and show complex interactions of variants within the COMT gene that influence COMT biology and confound conclusions based on associations with the Val158Met genotype alone.
23965265 The findings suggest that genetic variations of COMT and TPH2 have synergistic effects on social cognition in the general population
23963787 Genetic variants in the distal promoter contribute to persistent pain after motor vehicle collision directly and via the interaction with haplotypes in the coding region of the gene.
23963056 COMT polymorphhisms may predict the vulnerability to the development of the acute extrapyramidal effects in haloperidol-treated schizophrenic patients.
23956130 COMT may indicate a potential resiliency factor against neurocognitive effects of cancer and its treatment
23954148 The COMT Val(158)Met polymorphism may constitute a genetic risk factor for psychotic symptoms in the context of combined exposure to childhood maltreatment and cannabis use.
23952646 Variation in the COMT gene is associated with individual differences in nonverbal intelligence either directly or through interactions with schooling.
23943515 Study demonstrated an association of attentional biases with both the 5-HTTLPR and the COMTval158met polymorphisms
23939469 A meta-analysis suggested that the Val158Met polymorphism in the COMT gene was associated with decreased risk of uterine leiomyoma, especially in the black population
23937688 The effect of acute dopamine manipulations on delay-discounting (DA) depends on individual differences in frontal DA tone, which may have impeded some past efforts to characterize DA's role in immediate reward bias in humans.
23928748 Given the frequently reported alterations of 5-HT1A binding in anxiety and mood disorders, this study proposes an implication of the COMT genotype, more specifically the VAL158MET polymorphism, via modulation of the serotonergic neurotransmission.
23928267 conscientiousness scores of subjects with Val/Val genotype were the lowest by the age 25. By the age 25, males with Val/Met genotype had mainly secondary or vocational education, whereas female heterozygotes mostly had university education.
23924290 COMT allele status was not strongly associated with attentional performance or response to MP in the TBI sample. The met/met group, whilst performing slowly, had relatively preserved strategic control of attention.
23911251 RGS4 and COMT risk variants are associated with brain structural alterations in patient with schizophrenia.
23910792 The current study demonstrates that sensory gating impairments that are typical of schizophrenia are found in 22q11.2DS subjects. Our results further suggest that COMT and PRODH genetic variations contribute to sensory gating.
23907791 This meta-analysis discusses the pathomechanism of the COMT gene and its implication in attention-deficit/hyperactivity disorder (ADHD), which play a crucial role in the degradation of dopamine in the prefrontal cortex.
23901888 found that those with the low-activity COMT genotype, met/met, performed differentially on attentional set shift and executive tasks compared with the high-activity COMT genotype, val/val group.
23888755 The patients with genotype Val/ Val of polymorphism Val 158MetCOMT showed major cognitive deficits in paranoid schizophrenia.
23881096 The AP-2beta polymorphism significantly influenced cognitive performance, whereas the MAOA and COMT polymorphisms did not.
23880798 in this study of women with colorectal cancer, no evidence was found that common inherited variation in COMT is associated with survival time after diagnosis
23861766 Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
23859480 These observations support the hypothesis of a COMT Val/Met genotype modulation of the brain regions underlying proactive
23852765 We did not find an association between the Val158Met variation and knee osteoarthritis.
23834492 COMT polymorphism and memory dedifferentiation in old age
23828159 The COMT val158met polymorphism was associated with abstinence-related working memory deficits in two independent samples of smokers
23820299 our results indicated that TPMT or COMT genetic variation was not related to cisplatin ototoxicity in children with cancer and did not influence cisplatin-induced hearing damage in laboratory models
23818048 The results revealed gender effects of the COMT rs4680 Met allele on verbal fluency, with positive effects in males and negative effects in females.
23810996 The results suggest that genetic variation in comtVal158 Met polymorphism regulation relates to the organization of brain processing for working memory
23807274 Authors report the novel finding of an association between the Val158Met genotype and HIV serostatus that may be mediated through the impact of dopamine function on propensity for risk-taking.
23799032 There is a dose-response association between COMT genotype and stress-induced [18F]fallypride displacement.
23785672 Our data provide new information on gene polymorphisms in Greenlandic Inuit
23774999 The findings of this study suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.
23773341 These findings also underline a complex relationship between COMT genotypes and pain responder status
23769684 Our study indicates an association between rs4680, an SNP in the COMT gene, and lower risk of apathy.
23769682 SNP val158met homozygotes show stonger bias to perceive neutral facial expression as anger
23748501 Results of this study showed interaction effects of COMT Val158Met and SLC6A4 5-HTTLPR polymorphisms on the gray matter volumes of structures involved in emotion processing in healthy individuals
23731290 COMT was unrelated to infants' facilitation responses.
23728717 Our results suggest, for the first time, a significant relationship between functional SLC6A4 and COMT polymorphisms with specific human circadian phenotypes
23715639 These results suggest that the Met/Met genotype or the Met allele of the COMT Val108/158Met are significantly overrepresented in subjects with moderate or severe hyperactive-impulsive and inattentive symptoms
23706899 This study demonistrated that Responses to venlafaxine treatment in major depressive disorder were stratified by COMT genotypes (Val158Met, rs4680.
23701723 The findings of this study reemphasize the fundamental contribution of COMT to pain processes, and provide a fine-grained resolution of this contribution at the genetic level that can be used to guide future studies in the area of pain genetics.
23686330 By considering COMT, OPRM1, and UGT2B7 genotypes, as well as pharmacokinetic results, only COMT polymorphisms appear to be predictive of morphine need in postoperative pain therapy.
23668908 The allele encoding for the COMT with low enzymatic efficiency was found to be over-represented in borderline personality disorder, possibly resulting in excessive synaptic dopaminergic activity and ultimately affecting externalizing behaviours.
23646156 Bipolar patients with the low catabolic activity COMT genotype (Met/Met) have higher novelty seeking scores than patient carriers of the high catabolic activity genotype (Val/Val).
23643763 an association between COMT Val58Met polymorphism and hyperactivity symptoms in Egyptian children with ASD.
23636476 Studied a sample of 116 postpartum women to determine a link between postpartum depression and the COMT polymorphism. Results confirm previous studies that there is an association between postpartum depression symptoms and a COMT polymorphism.
23632726 Among infants with neonatal abstinence syndrome (NAS), variants in the OPRM1 and COMT genes were associated with shorter length of hospital stay and less need for treatment. These preliminary findings may provide insight into the mechanisms underlying NAS
23618651 MDD may be associated with dysfunctional white matter changes, and the valine homozygote of COMT gene may contribute to further abnormalities in these pathological changes.
23613504 The frequency of the COMT Val158/Val158 genotype in children with autism spectrum disorders was significantly lower than in controls.
23613193 Data idicate that the catechol-O-methyltransferase (COMT) Val158Met genotype is quite common in Turkey and that it is not a risk factor for conversion disorder in the Turkish population.
23602946 Val158Met variant with BDNF Val66Met variant associated with obsessive-compulsive-related dysfunctional beliefs
23598060 The resukts of this study found that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia.
23588304 A predictive model combining variants in TPMT, ABCC3, and COMT with clinical variables significantly improved the prediction of hearing-loss development as compared with using clinical risk factors alone
23566343 The COMT and OPRM1 common functional polymorphisms rs4680 and rs1799971 association with the incidence, intensity, or duration of chronic postsurgical pain in patients after lower abdominal surgery,were determined.
23549522 Stroke patients with COMT Val/Val alleles had higher motor functions and abilities of activities of daily living even at the beginning of the rehabilitation period.
23538286 The results of this study suggested that COMT may operate as a plasticity gene that provides differential cognitive capacity to respond to environmental streaaors.
23535252 These findings reaffirm the importance of baseline-dependency and suggest a subtle relationship between COMT genotype and baseline-stratified levels of sensory gating
23527885 the COMT Val158Met polymorphism therefore contributes to the development of neuropsychological and brain structural endophenotypes of schizophrenia.
23489762 The study found a significant association of the COMT genotype with working memory and reasoning but not with face recognition.
23475824 the COMT val158met polymorphism may have a role in early childhood depression internalizing symptoms
23466833 the COMT polymorphisms may be associated with Parkinson's disease in Asians rather than Caucasians
23459442 results support the rationale of pharmacologically inhibiting COMT to aid with smoking cessation among Val/Val genotype smokers
23449176 Cannabis users carrying the COMT val/val genotype exhibited lower accuracy of sustained attention.
23447558 Frontal alpha asymmetry on EEG was associated with a genetic variant known to modulate prefrontal dopamine levels (the catechol-O-methyltransferase Val158Met polymorphism).
23446089 COMT genetic polymorphisms exert a role in Temporomandibular Joint Disorders susceptibility
23445265 Val carriers at the Val158Met polymorphism of the COMT gene who were exposed to childhood abuse are vulnerable to the psychosis-inducing effects of cannabis.
23440431 These results suggest that COMT enzyme activity may be important in the regulation of impulsiveness among young adults
23421957 negative effects of antipsychotics on cognitive functioning in bipolar disorder may be moderated by SNP Val 108/158 Met
23421762 COMT Val allele was associated with larger hippocampal volume and better working memory in chinese young adults.
23408064 SNP Val158Met acts as a modifier of the age of onset in Parkinson disease with a sexual dimorphism
23398761 Parents with low levels of neuroticism and high levels of extraversion exhibited greater sensitive responsiveness and warmth, respectively, to youth with the valine/valine COMT genotype. Youth with this genotype exhibited lower levels of observed anger.
23383291 COMT and ANKK1-Taq-Ia genetic polymorphisms influence visual working memory.
23353103 COMT and MTHFR polymorphisms interacted on cognition, suggesting that the MTHFR enzyme activity might moderate the effects of the COMT enzyme.
23351565 Two highly correlated markers located in the membrane-bound (MB) COMT promoter region (rs2020917, rs737865) were significantly associated with both self-rated and clinician-rated depressive symptomatology.
23350368 The article reviews the relationship between polymorphism of sex hormone-related genes (CYP17, CYP19, CYP1A1, COMPT, ERalpha, ERbeta and others).
23344637 COMT Val158Met polymorphism and the promoter polymorphism in MAOA were associated with tardive dyskinesia neither independently nor jointly in Chinese population.
23337869 COMT in relation to N-Back working memory task performance in a large population-based cohort of young adults was analysed
23319194 data may suggest that the MAOB and COMT genetic polymorphisms do not play any role in the pathogenesis of Parkinson's disease in Iranians
23311613 Recent research suggests that functional catechol-O-methyltransferase gene polymorphism may affect brain volume.
23302985 This study was underpowered to draw firm conclusions on the influence of OPRM1 and COMT genotypes on labor analgesia with IV fentanyl
23295417 in the sample studied, there was no evidence of any association between schizophrenia and rs165599 (A/G) polymorphism in the non-coding region 3' of the COMT gene.
23292155 The COMT Val158Met polymorphism was found to be associated with attention deficit hyperactivity disorder in a study of adolescents of Mexico City.
23288874 No association between smoking status and COMT SNP rs4680 genotype was found, nor did we find a significant association to the degree of tobacco dependence.
23283688 Neonates homozygous for the COMT valine allele exhibited reduced gray matter in the temporal cortex and hippocampus, mirroring findings in adults.
23278923 The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.
23269216 findings provide evidence that in addition to other genes, COMT also has a significant role in the development of depression
23261162 COMT Val108/158Met and DBH -1021C>T polymorphisms do not show evidence of association with characteristics of the P300 ERP in an auditory oddball paradigm in healthy volunteers
23257985 This meta-analysis suggests that COMT Val158Met polymorphism might not be a risk factor for prostate cancer. [meta-analysis]
23238870 The COMT Val158Met polymorphism may be a risk factor for development of large fibroids in Turkish patients with uterine leiomyoma.
23237479 In COMT Met/Met allele carrier anodal transcranial direct current stimulation of the dlPFC was associated with a deterioration of set-shifting ability.
23228511 Our data show that COMT Val(158)Met affects the functional connectivity of the prefrontal cortex at rest
23219927 These data suggest that catechol-O-methyltransferase Met/Met homozygous individuals, in the context of addiction, have increased susceptibility to white matter structural alterations
23210659 The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.
23209597 results showed that the COMT gene rs2020917 and rs737865 SNPs were associated with cognitive theory of mind (ToM)performance, while the COMT gene rs5993883 SNP was related to affective ToM, in which a significant gender-genotype interaction was found
23184041 No evidence of an association between COMT Val108/158Met and schizophrenia in a Mexican population.
23178897 The present longitudinal study provides some evidence that COMT variation may affect cognitive function in a sex or developmental stage-specific manner.
23142068 these results yields a model whereby COMT affects prefrontal function by a mechanism involving dopaminergic modulation of the default mode network
23141115 COMT rs4680 could affect the white matter connectivity in panic disorder.
23124177 Our study demonstrated that the siblings have significant deficits in cognition and psychosocial functioning, which may not be associated with MB-COMT methylation in peripheral leukocytes.
23116175 There is no association between the COMT Val158Met polymorphism and PCa.[Meta-Analysis]
23110764 carriers of the met allele of the catechol-O-methyltransferase gene were maintainers of episodic memory
23110189 Data indicate that the catechol-O-methyltransferase (COMT) val158met polymorphism is a potential biomarker of placebo response.
23102922 Context processing deficits in schizophrenia patients and their relatives maybe mediated by COMT genotype.
23096092 The COMT l58Val/Met polymorphism might contribute to the overall prostate cancer risk.m [Meta-analysis]
23093014 The present data suggest that pharmacokinetic or pharmacodynamic factors other than the investigated genetic variants of the MAOB and COMT enzymes seem to determine the response to levodopa in the Iranian PD patients.
23088179 Associations between adolescents' physical activity and depressive symptoms are not modified by plasticity genes.
23069674 No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias
23046831 patients with anorexia nervosa differ in executive functioning and prefrontal functional connectivity according to the COMT genotype.
23039364 Meta-analysis: COMT Val158Met polymorphism may not contribute to breast cancer susceptibility.
23035936 This meta-analysis suggested the catechol-o-methyltransferase polymorphism was not associated with the susceptibility to Parkinson's disease in the study populations (Review)
23034259 genetic variations in the dopamine-modulating genes, COMT, DRD4 and DAT1, may contribute to AD pathogenesis in the Taiwanese population.
23030509 Our findings support and extend previous studies of COMT effects on cognition and neural activity
23026378 The results of this study provided that the COMT and BDNF genes interact in bipolar-II without anxiety disorder.
23025981 COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in fibromyalgia syndrome
23015122 Data indicate that high expression of catechol-O-methyl transferase (COMT) significantly correlated to early T stages.
23008195 variations in the COMT gene exert complex effects on susceptibility to depression involving various intermediate phenotypes, such as impulsivity and executive function
22997551 The COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making.
22992330 genetic association study in population in Francisco: Data suggest that 8 SNPs in COMT, mostly located in 3' end of COMT gene, are associated with improvement in cognition following computer-assisted cognitive training in patients with schizophrenia.
22972758 genetic association study evaluating COMT SNPs with the phenotype of high aggression in children with a possible role for the COMT marker in callous-unemotional traits. No significant association found.
22963606 Our results do not support the association of COMT with schizophrenia in the Han Chinese population.
22952320 Startle reactivity and prepulse inhibition of the acoustic startle response are modulated by catechol-O-methyl-transferase Val(158) Met polymorphism in adults with 22q11 deletion syndrome
22939231 Study showed no significant association between the COMT Val108/158Met polymoprhism and smoking in patients with schizophrenia or alcohol dependence. [Letter]
22935916 COMT gene polymorphism, SNP rs9606186, is associated with risperidone therapy efficiency in the Chinese population
22922787 Results do not support the hypothesis that the polymorphisms of the COMT gene may be associated with susceptibility to Alzheimer Disease with and without behavioral and psychological symptoms of dementia.
22920836 There was no significant link between hippocampal volumes and COMT polymorphism among subjects with 22q11.2 deletion syndrome.
22905266 male schizophrenia patients who carry the low activity Met allele in the COMT gene are at a modestly elevated risk of violence
22903038 The results of this study suggested that the reward modulates decision thresholds rather than clock speed, and that these effects are specific to COMT epistasis effects that presumably constitute a balanced prefrontal and striatal dopamine transmission.
22901597 In schizophrenic patients, we found a decrease in neural responses in areas that ensure a cognitive control of emotion that is paralleled by perceived distress in interpersonal situation; this pattern seems to be influenced by rs4680 COMT polymorphism.
22900954 reward responsiveness shapes reward-seeking, therefore suggesting a novel framework by which COMT may modulate behaviour.
22890094 An association is found between COMT GG genotype (Val/Val) and APOE epsilon4 carrier status and the risk of Alzheimer's disease and mild cognitive impairment.
22890010 COMT: rs4680: A>G and rs4633: C>T polymorphisms were found to significantly affect disease risk.
22886584 Presence of placental Val158Met COMT polymorphism is associated with a decreased risk to develop pre-eclampsia, suggesting a protective role.
22872161 Comt overexpression in the prefrontal cortex reversed behavioral abnormalities of Df1/+ mice, and normalized abnormal responsiveness to GABA-A receptor agonists.
22844499 influences of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O-methyltransferase genes (COMT) on the time-course of visual processing in a contingent negative variation
22843413 The genotypic variation, COMT Val(158)Met, influences the fronto-striatal cognitive deficits of Parkinson's disease.
22832813 Effect was predominantly present in val/val homozygotes of the functional val158met polymorphism of the catechol O-methyltransferase (COMT) enzyme and in short-allele carriers of the serotonin-transporter length 5-HTTLPR polymorphism.
22832732 We have demonstrated that in fear processing condition, an interaction between 5-HTTLPR (S) and COMT (met) low activity alleles was associated with reduced reciprocal connectivity within the brain circuitry.
22832518 The COMT Val(108/158)Met genotype implicated in human long-term memory, supporting efficient remembering via the adaptive suppression of interfering memories.
22831878 the results indicated a COMT Val158Met effect on startle response.
22810728 COMT met/met carriers showed a pronounced This study demonistrated that feedback P3 amplitude independent of valence, and a gradual increase in risk taking during the gambling task.
22790479 COMT gene polymorphisms is associated with systemic atherosclerosis
22784685 The Met158 allele of the COMT gene confers a significantly increased risk for aggressive and violent behavior in schizophrenia.
22771913 examined the APOE epsilon4 allele, a known risk factor for Alzheimer's disease, and the COMT Val 158 polymorphism, previously implicated in schizophrenia, for association with lowered memory functioning in healthy adults
22765285 Val158Met single-nucleotide polymorphism of the COMT gene along with 1021CT SNP of the DBH Gene was typed in 171 of 196 SIDS cases but also in 213 of 244 controls. Further study of the noradrenergic system is needed as a modulator for SIDS.
22763378 increased corpus callosum volume in children with 22q11DS is associated with COMT polymorphism.
22740151 Smoking status in Thai males was significantly associated with the COMT Val (108/158) Met polymorphism.
22733030 The rsults of this study suggested that comt polymorphisms involved to trait variations in Bulimia-Spectrum Disorders.
22722321 The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pain that could be associated with the COMT single nucleotide polymorphism rs4680.
22718527 Verbal pain/sedation scores, opioid use, and physiologic responses in the immediate postoperative period were examined for association with genetic variants in Caucasians genotyped for OPRM1 single nucleotide polymorphisms A118G and C17T and COMT SNPs
22713126 Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global cognitive dysfunction during manic and mixed episodes in bipolar disorder.
22708262 COMT gene polymorphism affects pain sensitivity
22707271 genetic association studies in male subjects in United Kingdom: investigation of whether an SNP in COMT (rs4680) might explain variations in effects of green tea extract as a dietary supplement on vascular function and blood pressure
22705295 data indicate that genetic variation of MB-COMT could be associated with schizophrenia and negative symptom severity in the Xhosa population.
22695756 the COMT Val/Val genotype was associated with a greater improvement in smoking cessation using Nicotine replacement treatment
22683321 findings suggest that genes acting in the dopamine system interact to influence both eating-related and personality psychopathology.
22658813 Patients with the COMT rs4680 single-nucleotide polymorphism G allele had a reduced risk of developing non-small-cell lung cancer, especially a risk of developing adenocarcinoma.
22640745 Significant associations were found between performance on the delayed-match-to-sample task and COMT genotype in attention deficit disorder.
22617852 DRD4 and COMT epistatically interacted on the prefrontal response control , whereas single genes and diagnosis showed no significant impact.
22617427 complex interactions between genetically determined dopamine signalling and risk for schizophrenia on brain activity in the prefrontal cortex during emotion processing
22614783 Children with more COMT Met alleles seemed more susceptible to maternal positive discipline than children with more COMT Val alleles.
22612913 The results suggest an influence of genetic variants of COMT gene in describing the variation in pain after treatment for low back pain.
22575334 Results indicate that females, but not males, who are carriers of the COMT 158Met allele had higher risk-taking propensity scores on the BART-Y compared to Val homozygotes.
22573634 COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures.
22560999 results suggest that the catechol-o-methyltransferase (COMT) Val/Met carriers may see greater improved cognitive function from risperidone treatment.
22548395 Ultraviolet radiation differentially modifies COMT activity in melanoma cells and HaCat. Furthermore, tolcapone increased death of HaCat after irradiation but did not affect melanoma cells.
22530780 This study demonistrated that significant association was found between an SNP in the catechol-O-methyltransferase (COMT) gene (rs4680) encoding the low-activity Met allele and executive function.
22528689 Haplotypes of the COMT gene and genotypes of the Val158Met polymorphism play a key role on pain sensitivity in fibromyalgia patients.
22509987 An individual's sensitivity to childhood adverse experience is moderated by the COMT genotype. Exposed carriers of a low-activity Met allele have a higher risk to develop severe alcohol dependence than individuals homozygous for the Val allele.
22503421 Under stress, working memory performance of the Met homozygotes for catechol-O-methyltransferase was significantly worse than that of the Val homozygotes. Importantly, this genotype effect was restricted to the medium difficulty level of the n-back task.
22487033 The COMT gene coding for catechol-O-methyl transferase selectively influences computational model estimates of working memory capacity.
22483299 A review of the role of catechol-O-methyltransferase(COMT) in sleep, in schizophrenia and schizophrenia-related phenomena, such as reduced cognitive performance.
22483294 A review of the biological effects of COMT which may be relevant to Alzheimer's disease (AD) pathophysiology and the associations of COMT gene variants with AD diagnosis and AD-related phenotypes.
22479488 We failed to find any statistically significant association with grey matter volume and Met allele loading in the COMT gene or interaction affects between COMT and gender.
22475780 study provided evidence in favor of COMT being a candidate gene for conferring genetic susceptibility to preeclampsia in a South West Chinese population
22474103 COMT Val158Met and DRD2 Taq1A may confer their risk of alcohol dependence through reduced dopamine receptor sensitivity.
22466345 Compared with nonsmokers, European-American COMT Val158Met double-variant carriers who smoked had increased odds of hot flashes.
22457502 findings for the first time demonstrate an interaction of BDNF by COMT on human cortical plasticity.
22451510 analysis showed no association between COMT alleles/haplotypes and ADHD diagnosis and executive function parameters.
22438994 The 10-repeat allele of the variable number of tandem repeats marker (VNTR) in the dopamine transporter gene and the Met allele of the catechol-o-methyl transferase (COMT) Val158Met polymorphism were associated with greater vulnerability to time-on-task.
22436418 COMT variants are associated with differences in infants' brain responses to fearful faces over centro-parietal regions.
22425188 analyzed electrophysiological markers of conflict and error monitoring. both the conflict-N400 as well as the error-related negativity (ERN) were diminished in homozygous carriers of the COMT Val(158)Met polymorphism
22417933 This study did not find an association between the COMT variant rs4680 and antidepressant treatment response in this generalized anxiety disorder sample.
22416031 no associations with genetic variants in the COMT gene and musculoskeletal complaints were found.
22414959 This review discusses a missense polymorphism (G/A, rs4680) in the COMT gene resulting in a Val/Met substitution which has been reported to influence enzyme activity, as one of 7 genes with phenotypic consequences in Alzheimer's disease.
22414663 The findings support the previous reports that the catechol-O-methyltransferase Val allele of rs4680 polymorphism might be related to the negative symptoms of schizophrenia.
22414277 Results show that polymorphism of catechol-O-methyltransferase is associated with response to citalopram
22401966 Our finding suggests that the COMT gene may not be a susceptibility gene for neurotic disorders.
22391769 The results of this study suggest that COMT promoter region methylation is largely influenced by COMT genotype and that physical activity plays a significant role in epigenetic modulation of COMT.
22387174 The present results support a potentially female-specific-role of the COMT val158met polymorphism in the genetic and neural underpinnings of anxiety- and depression-related intermediate phenotypes
22384243 ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
22368081 we used a multiple mediator model to test a gene-brain-cognition pathway by which activity in 4 prefrontal brain regions mediates the effects of catechol-O-methyltransferase gene on cognitive control and IQ
22366815 Meta-analytically combined evidence from the present genotypings and the literature search shows that the Val158Met polymorphism (rs4680) of the catechol-O-methyl transferase gene is not associated with anorexia nervosa.
22364739 Catechol-O-methyltransferase (COMT) metabolizes dopamine.
22354729 The COMT gene polymorphisms may not contribute to the susceptibility to schizophrenia, but may contribute to the negative symptoms of schizophrenia among Han Chinese.
22349272 results confirm previous finding of enhanced delay-discounting among val/val adults relative to met-allele carriers.
22344634 This study did not observe an association between COMT genotype and performance on a measure of attention.
22337560 We conclude that the functional COMT Val158Met SNP contributes to long lasting low back pain, sciatica and disability after lumbar disc herniation.
22337325 Variants within the COMT gene are associated with pain perception.
22336227 mRNA levels of comt were significantly higher in neonates and infants.
22331461 The COMT rs4680 A allele was positively associated with lung cancer in Singapore Chinese female never smokers (for G/A or A/A vs. G/G, OR = 1.46, 95% CI: 1.12, 1.90) but not in ever smokers.
22309446 present study employed transgenic mice expressing the human COMT-Val variant to determine the effects of the high-activity COMT allele on electrophysiological markers and effects of nicotine on these measures
22306803 The typical association of the COMT val/val genotype with neural inefficiency was found only for subjects with high externalizing
22303032 Genetic variants in COMT are associated with Ecstasy-induced hyponatraemia.
22297695 The COMT Val158Met polymorphism may be associated with decreased breast cancer risk in Caucasian population. [Meta-analysis]
22293393 the COMT polymorphism affects serum ALT activity to maintain liver function
22292056 distinct alleles of the dopamine receptor 4 promoter (DRD4P) and catecholamine-O-methyltransferase (COMT) that affect synaptic dopamine were predominant in traders.
22270685 Our findings replicate previous results and suggest a role for COMT in the etiology of disruptive behavior disorders in children and adolescents with attention-deficit/hyperactivity disorder
22270476 Schizophrenia risk gene ZNF804A does not influence macroscopic brain structure
22253202 COMT activity do not play a significant role in pain perception and TEAS-induced analgesia in the Chinese Han male population.
22247753 COMT val158met polymorphism is associated neural pain processing.
22245443 This study demonistrated that the comt Val158Met polymorphism may not releate to conflict adaptation in youth with chromosome 22q11.2 deletion syndrome.
22222175 This is the first study suggesting that catechol-O-methyltransferase rs4680 modulates facial emotion recognition differently during bipolar disorder episodes and in healthy controls.
22217949 Associations between 3 single nucleotide polymorphisms (SNPs) in MA dependence, catechol-O-methyltransferase (COMT) Val158Met, brain-derived neurotrophic factor (BDNF) Val66Met, and the mu opioid receptor (OPRM1) Asn40Asp polymorphisms.
22216231 the COMT Val158Met polymorphism related to individual differences in sleep homeostatic, but not executive functioning and cognitive responses to chronic partial sleep deprivation, suggesting these measures may be orthogonal and associated with distinct genetic mechanisms
22210062 Catechol-o-methyltransferase genotype predicts severity of pain in hospitalized burn patients.
22208661 Alcohol dependent subjects were more than twice as likely to carry the GG or AG genotypes compared to the AA genotype, indicating a dominant mode of inheritance. The rs4680 SNP showed a weak association with alcohol dependence at the allele level.
22199302 SNPs (HSD17B1 (rs2010750, rs598126 and rs676387), COMT (rs4680), UGT1A1 (rs8175347) and ESR1 (rs9340799)) seem to be related to mammographic density in the same direction of their associations with breast cancer risk
22190034 HIV-1 Vpr is identified to have a physical interaction with catechol-O-methyltransferase (COMT) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
22180998 extraversion and intelligence associated with Val158Met SNP
22178088 Our findings suggest that common variants and haplotypes of the Catechol-O-methyltransferase (COMT) gene are not major contributors to risk for polycystic ovary syndrome, but that COMT genotype may influence prolactin levels.
22159223 COMT overexpression combined with 4-OHE(2) induces upregulation of growth arrest- and DNA damage-inducible protein alpha (GADD45alpha).
22158829 genetic association studies in populations of women in Tennessee: Data suggest that a single-nucleotide polymorphism in COMT (rs4818) in the fetus/newborn is associated with preterm birth in African Americans.
22152146 Linear regression analysis revealed a significant effect for COMT in stressful life events
22148860 These data indicate that odor identification impairments observed in schizophrenia are influenced by the COMT val158met polymorphism.
22138198 This review gives an overview of recent findings on the effect of COMT single nucleotide polymorphism (SNP) Val158Met carrier status on behavioral and imaging correlates of brain function.
22133998 The results of this study indicate that these COMT polymorphisms do indeed influence the ANS response to stress.
22132136 These findings may help explain the inconsistencies in reported findings of the impact of COMT in pain regulation.
22128864 Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on MTHFR C677T genotype.
22124994 There was no significant overall association between the COMT genotype and individual susceptibility to breast cancer.
22113132 Genotyping was performed for variants of the DRD2 Taq1A (rs1800497), COMT Val(158)Met (rs4680), DAT1 (3' UTR 40bp VNTR). Variants of DRD2 Taq1A, COMT and DAT1 were not associated with the risk of developing ICDs.
22103306 This study reported novel data showing an effect of dopamine COMT gene on spatial updating processes in older but not in younger adults, indicating potential magnification of genetic effects in old age.
22101356 These results confirm the impact of the COMT Val(108/158)Met polymorphism on the mu-opioid receptor system
22083803 The results of this study suggested that Catechol-O-methyltransferase Val158Met factor may affect susceptibility to dyskinesias in Parkinson's disease.
22083731 This study demonstrated that NR3C1 and COMT markers exert their separate, as well as interactive, effects on DLPFC function.
22082040 This study did not find evidence to support direct or interactive effects of COMT and HIV disease severity on neurocognitive functioning.
22071171 investigation of substrate specificity and metabolite profiles of COMT from placenta cytosol; studies include molecular modeling
22070166 Met/Met homozygotes were at a significantly increased risk of behavioural and emotional problems at the ages of 7 and 11 years , relative the Val158Met polymorphism, but only when they were exposed to maternal stress in utero.
22053918 COMT gene polymorphisms were not associated with criminal behavior in schizophrenic patients.
22049425 This study demonistrated that the Dopamine effects on human error processing depend on catechol-O-methyltransferase VAL158MET genotype.
22036916 The COMT Val158Met polymorphism is significantly associated with panic disorder (PD) in a Turkish population of PD patients.
22013977 The findings of this study do not support the hypothesis of an interaction between s-allele and l-allele carriers of the 5-HTT gene and the COMT Val158Met polymorphism in the processing of emotional faces.
22009217 Catechol-O-methyl transferase (COMT)is a key enzyme for regulating dopamine signaling and neurotransmission in the cortex.
21998713 COMT genotype and plasma proline levels were assessed in 22q11DS individuals
21974969 breast cancer survivors carrying Met/Met genotype reported higher cortisol concentration, alpha-amylase activity and greater cancer-related fatigue than those with Val/Met (P < 0.05) and Val/Val (P < 0.001) genotypes
21965191 There was a significant interaction between COMT genotype and emotional arousal in relation to recollection.
21948748 Based on allele and genotype frequencies in both groups, we found no significant association of DRD3 Ser9Gly polymorphisms and COMT (rs165656) with schizophrenia in Malays.
21940152 found significant association of COMT SNPs with suicide risk in MDD patients not responding to antidepressant treatment.
21936936 the case-control study suggests no association between COMTmet and suicidal behavior in a Mexican population. This same negative association was observed in the meta-analysis.
21934644 investigated the association between the catechol-O-methyl transferase genotype and the TMT-B performance
21934638 study found association of COMT haplotypes with methamphetamine abuse, further refining and isolating the association of rs4680 previously reported
21934178 COMT SNPs and diplotypes are not associated with chronic pancreatitis.
21912392 Genetically based reduced MAOA and COMT functioning is associated with the cortisol stress response
21898113 breast cancer survivors carrying the Met/Met genotype exhibit higher fatigue, neck pain, and pressure pain hypersensitivity over the neck and shoulder area.
21895373 results suggest a possible role of COMT Val158Met polymorphism in the psychological distress observed in fibromyalgia
21884617 There was no consistent relation between individual epigenotype and the Val158Met polymorphism in the enrichment of 158Val alleles with COMT promoter hypomethylation.
21883922 There was a significant interaction of COMT genotype by argument strength in the model of narrative processing
21876500 We did not find any significant association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence using the population-based or family-based design
21872942 The G-G-G haplotype was found to show a highly significant association with schizophrenia in Malaysian.
21870366 suggesting influence of COMT Val 158 met polymorphism on human frontal lobe controlling impulsivity
21860037 [review] COMT is involved in the metabolism of dopamine, a key neurotransmitter found to be associated with schizophrenia pathophysiology.
21857968 Findings that COMT is associated with both NS personality traits and with the age of onset of heroin use helps to clarify the complex relationship between genetic and psychological factors in the development of substance abuse.
21846718 analysis of orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons
21820670 Data show that MB-COMT promoter was hypo-methylated in DNA derived from the saliva in SCZ and BD compared to the control subjects.
21790467 meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms
21788083 This study demonistrated that COMT rs165737 and a diplotype containing COMT rs165599 and COMT rs165737 were associated with HAMD(17) total score changes.
21785189 this study demonistrated that of Association Between COMT Polymorphisms and Apathy in Alzheimer's Disease.
21783175 The results of this study suggested Val158Met genotype moderates the effect of PTSD-related processes on right ACC volume.
21781348 We investigated the relationship of catechol-O-methyltransferase (COMT), COMT rs4680 and MAOB rs1799836 polymorphisms may increase susceptibility to Parkinson's disease risk among Japanese
21776034 The Met allele of COMT Val158Met is associated with higher blood pressure and higher prevalence of hypertension in Japanese men, and energy intake may interact with this effect
21769726 This study supported thatCOMT has sexually dimorphic effects on brain function and its dysfunction in psychiatric disorders.
21749372 We found no consistent additive genetic associations for attachment security and attachment disorganization. However, specific tests revealed evidence for a codominant risk model for COMT Val158Met.
21695287 role of the COMT enzyme functional polymorphisms in human pain phenotypes such as pain sensitivity, chronicity, severity and response to pain medicine (Review)
21691708 COMT-158 Val/Val genotype was associated with a lower risk of osteoporotic fracture in Chinese population, especially to vertebral fracture.
21691248 The Val158Met catechol-O-methyltransferase polymorphism not appear to be involved in predisposition to suffer from chronic tension-type headache in children
21688126 Data suggest that not only do COMT and DBH influence independently on response inhibition in females, but also exert a significant interaction on response inhibition.
21656904 we conclude that COMT is associated with cocaine-induced paranoia, possibly as a result of its role in the metabolism of dopamine and norepinephrine.
21648315 Preliminary data showed significantly impaired performance in several neuro-cognitive tests in carriers of Met/Met genotype in patients with dementia compared to either Met/Val or Val/Val catechol-O-methyltransferase genotype carriers.
21622560 COMT may play a critical role in the detoxication of PAH o-quinones generated by aldo-keto reductases
21620981 we show that variation in Val158Met genotype within the gene encoding catechol-o-methyltransferase modulates the tempo of cortical maturation in health brain development.
21613790 the COMT gene is a promising candidate gene for delirium in the elderly, functional genetic variations were not associated with delirium
21609749 preferential transmission of COMT rs4680 A allele and A-A haplotype was observed specifically in male IID probands w/o any behavioral problem. Markers failed to show any significant epistatic interaction by MDR analysis
21600957 partial replication of previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects
21595525 SNPs associated with bipolar disorder and auditory sensory gating deficit
21575337 COMT Val158Met and 5-HTTLPR might not be the susceptible genes of children's aggression.
21550019 These results suggest an effect of the COMT genotype on the trajectory of oppositional defiant disorder symptoms improvement with methylphenidate treatment in boys with ADHD.
21543598 The relationship of methylation of the COMT Val(158) allele with stress, gene expression, working memory performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene
21531374 Severe preeclampsia may not be associated with a decrease in placental COMT expression.
21530215 MAOAu-VNTR and COMT Val158Met polymorphisms might have an impact on children's eating behavior.
21514925 These results suggest that COMT genotype effects on working memory brain activity and behavior are not static during development.
21501166 The COMT gene confers an increased risk of psychiatric symptoms and behavioral problems due to the critical role in the metabolism of CNS dopamine and norepinephrine.
21495799 The COMT val/met polymorphism is not associated to endometriosis-related infertility in the Brazilian population evaluated.
21486747 Results suggest a novel structural mechanism whereby functional synonymous variations near the translation initiation codon affect the translation efficiency via entropy-driven changes in catechol-O-methyltransferase mRNA dynamics.
21486391 our results showed the overpresentation of the Met/Met genotype in male control subjects compared with male suicide victims, suggesting that this genotype of the COMT Val(108/158) Met might be a protective factor against suicide.
21471954 The COMT gene plays a role in personality traits for males, contributing to the growing literature on sex differences in gene-behavior connections.
21465565 These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.
21462137 In the population of Yuedong region of China, the eight SNPs (rs4680, rs4818, rs165599, rs737865, rs2075507, rs6267, rs6269 and rs4633) in the COMT gene are unlikely to play a major role in the susceptibility to schizophrenia.
21458532 The COMT val158Met polymorphism does not appear to be a clinically useful biomarker of cognitive improvement following CRT in schizophrenia.
21449006 Effects of gene polymorphisms on clinical improvement were analyzed with an analysis of variance with each gene (SERTPR, 5-HT(1A) , and COMT) as factors and the Hamilton Rating Scale for Depression variation from baseline to the end of the treatment.
21447540 Suggest intriguing, but complex, interactions between COMT polymorphism, gender and additional factors on dopamine metabolism, and its relationship with schizophrenia.
21445667 Older adult carriers of COMT variants, which result in lower enzyme activity and therefore probably enhanced dopamine signaling, showed stronger startle activity.
21445620 genetic association study: Data suggest that a common SNP in COMT [Val(158/108)Met] does not influence absorption/metabolism of catechins in decaffeinated green tea extract (Sunphenon 90LB); data are from pilot study.
21440309 This study demonistreated that COMT polymorphism(rs4680) are more common among Posttraumatic Stress Disorder.
21438753 the associations between soy isoflavone intake and the CYP1A1 Ile462Val, CYP1B1 Val432Leu, and COMT Val158Met polymorphisms and breast cancer
21437260 An association was found between the val/val genotype of the val158met COMT gene and irritable bowel syndrome (IBS) as well as to specific IBS related bowel pattern in IBS patients.
21432838 COMT Val158Met polymorphism alone does not seem to be a major factor in alexithymia in healthy students. This is true even if patients with mental disorders covering a broader range of alexithymia are included.
21425136 The results suggest that persons treated with chemotherapy for breast cancer who also possess the COMT-Val gene are susceptible to negative effects on their cognitive health.
21414668 The results of this study suggested that the Val158Met polymorphism has a weak association with schizophrenia in the Malaysian population.
21402125 The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated.
21397529 These findings suggest that even after controlling for established risk factors, the involvement of COMT genotypes in bladder cancer risk differs among men compared with women in South Egypt.
21397335 We suggest that rs4680 could be an inheritable aspect of the mechanisms of dopamine regulation that influence the individual susceptibility of patients with bipolar disorder to develop manic episodes of illness.
21356267 The result of this study 5-HTTLPR s-carriers and COMT met/met carriers may be more sensitive to the detection of biologically and socially relevant information and suggest a mechanism behind this for the 5-HTTLPR.
21356266 The COMT Val108/158Met polymorphism (rs4680) significantly interacted with maternal cigarette smoking during pregnancy to predict youth aggressive behavior at ages 15 and 20.
21355050 A low COMT activity haplotype is associated with recurrent preeclampsia in the study.
21352928 These results support the epistasis of COMT and ankyrin repeat and kinase domain containing 1 phenotypes in the flexible control of contextual information in humans
21344643 study supports the involvement of the COMT -287A/G polymorphism in the genetic susceptibility to obsessive-compulsive disorder in Chinese Han population.
21342622 COMT rs6267 polymorphism may not contribute to susceptibility to attention deficit hyperactivity disorder (ADHD).
21312287 none of the COMT SNPs were associated directly with nicotine dependence (ND); the interaction of intronic COMT SNP, rs9332377, with CHRNA3 3'UTR SNP rs660652 was significantly associated with ND
21310591 This study suggested that the involvement of COMT polymorphisms in the association between cannabis use and schizophrenia as well as the existence of additional factors mediating this association.
21309949 COMT encodes catechol-O-methyltransferase, an enzyme important for the degradation of central nervous system catecholamines and critical for degradation of dopamine in the prefrontal cortex.
21304959 Epistasis between COMT and MTHFR in maternal-fetal dyads; fetal ATCA COMT haplotype and the fetal MTHFR minor "T" allele interact to increase preeclampsia risk; maternal ACCG COMT haplotype was associated with reduced risk for preeclampsia
21304229 For the male subjects, there was a significant difference in genotype distributions and allele frequencies between control subjects and suicide attempters.
21302344 study found no evidence for main effects of MAOA variation on cognitive functions, but there were apparent interactions between the COMT and MAOA genes in their effects on working memory in boys
21300759 Data show that the L858R mutation of EGFR is associated with SNP of estrogen biosynthesis and metabolism genes CYP17, CYP19A1, ERalpha, and COMT in never-smoking female lung adenocarcinoma patients.
21300128 These findings suggest a possible role for COMT variants and related haplotypes in bulimia nervosa and its subphenotypes
21272388 no significant effects of polymorphorphisms on working memory task performance
21255265 No significant differences in allele or genotype frequencies are observed between schizophrenia patients and controls, for all variants investigated among Han Chinese.
21231925 It has been suggested that the Cathecol-O-Methyl Transferase gene (COMT) may modulate the association between cannabis use and psychosis emergence.
21215384 The results of this study suggested that deleterious genotypes for DAOA and COMT might contribute to the pathophysiology of schizophrenia.
21195697 This study examines modulatory effects of COMT Val158Met on neural interactions, as indicated by connectivity strengths in young females, and to clarify whether there is gender difference on this gene-brain interaction.
21193954 COMT val158met status and aviation expertise affect flight simulator performance and cognitive ability
21184832 a high prefrontal efficiency as suggested by the COMT Met/Met genotype is associated with to a poor sensory gating of the N100 component
21156209 the Met allele of COMT modulates neural activation in regions associated with emotional awareness
21154325 association between the genetic polymorphisms of COMT gene and psychiatric disorders
21150912 These results did not find prefrontal cortex activity modulation with COMT (catechol-O-methyltransferase) val(108/158)met polymorphism during working memory, planning, and response inhibition.
21144115 SNP Val158Met effect on memory in schizophrenic patients and healthy controls
21144101 This study suggests the heterogeneity in COMT effects reported in the literature may be due in part to gene-gene interactions that influence central dopaminergic systems.
21144097 genetic association studies: impact of missense mutation in COMT on vascular reactivity following green tea extract (diet supplement); pulse stiffness index/insulin response to glucose load differ with COMPT genotype; pilot study, UK population
21142930 Serotonin transporter gene length polymorphism is not associated with life events in neuroticism and anxious depressive symptoms.
21135332 The high-activity COMT genotype in ADHD is associated with antisocial behavior in part via impaired social understanding.
21130573 Genetic variation in the COMT Val(158)Met polymorphism may affect fibromyalgia pain through pathways of pain-related cognition.
21127283 Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects.
21125150 Analysis of the COMT polymorphism in patients showed a frequency of 17.65% and 45.10% for genotypes H/H and L/H, respectively
21120493 Single nucleotide polymorphisms rs4680 and rs4818 of the COMT gene may be associated with fibromyalgia and pain sensitivity in Brazilian patients.
21116946 This study suggested that Catechol-O-methyltransferase-A allele, A/A genotype were risk factors of early cerebral vasospasm after subarachnoid hemorrhage.
21113497 changes in functional status of mental exercise were studied in carriers of variants of DAT1, DRD2 and COMT; significant relationship between DAT1, DRD2 and COMT polymorphism and changes in mental sphere status were revealed -- most pronounced in girls
21110842 patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms in panic disorder as compared to those with the met/met genotype
21106664 COMT remains a plausible candidate gene for smoking behavior phenotypes, in particular, heaviness of smoking.
21099450 The interaction effect between monoaminergic genes and environmental stressors is likely to contribute to vulnerability for Postpartum depression.
21083670 Observational study of gene-disease association. (HuGE Navigator)
21080103 Data show a significant relationship between the COMT met allele and PTSD among cases and victims of violence without PTSD and between cases and community control group.
21080103 Observational study of gene-disease association. (HuGE Navigator)
21073668 Differential sensitivity to environmental stress occasioned by COMT Val158Met may be contingent on higher order interactions with genetic variation underlying psychotic disorder
21073668 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21061227 Our results suggest that epistasis between COMTval158met and the two DRD2 single nucleotide polymorphisms contributes to individual differences in cooperativeness in teamwork settings
21061227 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
21059181 Observational study of gene-disease association. (HuGE Navigator)
21051090 This study provided evidence that the COMT Val158Met polymorphism may be associated with personality traits.
21051090 Observational study of gene-disease association. (HuGE Navigator)
21049304 Observational study of gene-disease association. (HuGE Navigator)
21049025 Observational study of gene-disease association. (HuGE Navigator)
21048527 There is no conclusive evidence that catechol-O-methyl transferase 472G/A is a marker associated with alcoholism.
21048527 Meta-analysis of gene-disease association. (HuGE Navigator)
21047975 Hypomethylation of the COMT promoter is not associated with pre-eclampsia.
21041608 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21037510 Observational study of gene-disease association. (HuGE Navigator)
21030481 The data of this study indicated that the Val allele representing strong catabolism of dopamine is related to altruism.
21030481 Observational study of gene-disease association. (HuGE Navigator)
21029471 findings indicate that middle-aged women carriers of the Val158 allele, associated with high activity COMT, showed significant advantage over Met allele in executive processes and cognitive flexibility
21029471 Observational study of gene-disease association. (HuGE Navigator)
20979431 Polymorphic variation in COMT Val158Met and XPD Lys751Gln may be important for esophageal squamous cell carcinomal susceptibility.
20979431 Observational study of gene-disease association. (HuGE Navigator)
20975619 This article reviews human studies that have explored the association between COMT polymorphisms and addiction to drugs, alcohol or tobacco.
20974455 novel mutation p.R58S changed codon (58 from arginine to serine) in COMT. introduction of serine residue in critical regions of the protein results in structural alteration; influence of mutation on high pain sensitivity.
20934310 Our results confirm that COMT is a good candidate for schizophrenia risk, by replicating the association with rs4680 and identifying a novel SNP association.
20934310 Observational study of gene-disease association. (HuGE Navigator)
20931244 Our study suggests the possible involvement of genetic polymorphisms in COMT in the regulation of blood pressure and plasma uric acid.
20931244 Observational study of gene-disease association. (HuGE Navigator)
20887769 The CYP1B1 and COMT proteins were examined by Western blotting and immunohistochemical staining and rt-pcr.
20878993 Our results do not support a direct effect of COMT val158met genotype on attention and executive function in Parkinson Disease, but they suggest that genotype may interact with dopaminergic medication use to influence cognitive ability.
20878993 Observational study of gene-disease association. (HuGE Navigator)
20878621 No association between COMT 1947 G>A (rs4680)& breast cancer was found in Mexican women.
20878621 Observational study of gene-disease association. (HuGE Navigator)
20877624 Observational study of gene-disease association. (HuGE Navigator)
20877297 One SNP, rs13306278, located in the distal promoter region of catechol O-methyltrasferase, showed significant association with remission in White non-Hispanic subjects with major depressive disorder.
20877297 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20868372 Data show that COMT Val/Val genotype interacted with maternal smoking during pregnancy in increasing stereotyped behavior.
20863768 is the first study to report an association between surgical treatment success in lumbar degenerative disc disease and genetic variation in the putative pain sensitivity gene COMT
20863768 Observational study of gene-disease association. (HuGE Navigator)
20862259 Observational study of gene-disease association. (HuGE Navigator)
20860878 results confirmed associations between Met allele and aggressive behaviour or violent suicide attempts in various psychiatric diagnoses, and suggested that Met allele of COMT Val108/158 Met might be used as an independent biomarker of suicidal behaviour
20860878 Observational study of gene-disease association. (HuGE Navigator)
20842020 We report an early demonstration of a COMT SNP association with a clinically meaningful pain outcome after elective surgery.
20842020 Observational study of gene-disease association. (HuGE Navigator)
20836853 Our results do not support a simple stability/flexibility model of dopamine COMT Val/Met effects on cognition
20836853 Observational study of gene-disease association. (HuGE Navigator)
20828831 Val158Met polymorphism is associated with depression and motivation in men from a Swedish population
20828831 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20815183 The Val158Met polymorphism of COMT modulates the effects of modafinil on the NREM sleep EEG in recovery sleep after prolonged wakefulness.
20815183 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20800689 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20736997 results link variation in genes y influencing dopamine signaling in the prefrontal cortex (COMT(Val158Met)) and the striatum (DAT1(10/6)) with discounting rates in a hypothetical task and self-ratings of trait impulsivity in ADHD-CT and healthy controls.
20736997 Observational study of gene-disease association. (HuGE Navigator)
20734064 Observational study of gene-disease association. (HuGE Navigator)
20732903 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20729792 The relationships between COMT and CYP17A1 polymorphisms and the risk of preeclampsia, were studied.
20729792 Observational study of gene-disease association. (HuGE Navigator)
20729390 Observational study of gene-disease association. (HuGE Navigator)
20728009 Association was found between COMT genotypes and novelty seeking in both heroin dependent and control subjects
20728009 Observational study of gene-disease association. (HuGE Navigator)
20712524 Clinical trial of gene-disease association. (HuGE Navigator)
20698735 SNP interaction with DRD3 SNPs in bipolar I but not bipolar II disorder
20691427 Observational study of gene-disease association. (HuGE Navigator)
20688576 this study suggested that genetic variations affecting stress response system function influence the somatic and psychological response to MVC, and provide the first evidence of genetic risk for clinical symptoms after motor vehicle collision.
20688576 Observational study of gene-disease association. (HuGE Navigator)
20678555 Observational study of gene-disease association. (HuGE Navigator)
20677440 The patients with genotype of 4/4 of polymorphism VNTR MAO-A showed deeper empathy/theory of mind deficits
20677440 Observational study of gene-disease association. (HuGE Navigator)
20672519 no connection between analysed polymorphism of genes: DRD2, DRD3, DRD4, DAT, COMT and schizophrenia was stated.
20672519 Observational study of gene-disease association. (HuGE Navigator)
20667552 Our findings suggested that COMT variants may not be directly implicated in suicidal behavior, however evidence of a COMT role in the modulation of personality traits has been found.
20667552 Meta-analysis of gene-disease association. (HuGE Navigator)
20667170 Our results suggest that the COMT Val158Met polymorphism has a pleiotropic effect within the neural networks subserving emotional processing. The Met158 allele further reduces cortical efficiency in the vlPFC in individuals with affective morbidity.
20667170 Observational study of gene-disease association. (HuGE Navigator)
20659569 Single nucleotide polymorphism, Valine-methionine polymorphism is signifantly associated with reduced size of the corpus callosum in adolescents and young adults.
20659569 Observational study of gene-disease association. (HuGE Navigator)
20646666 The COMT gene is over-expressed in the colorectal cancer tissue but not in the distant normal mucosa.
20643532 The result of this stuy suggested that COMT does not appear to be a risk factor for schizophrenia.
20643532 Observational study of gene-disease association. (HuGE Navigator)
20643317 The hypothesized association between Val-homozygosity and higher average AP scores relative to average AP scores of Met-carriers did not quite reach statistical significance.
20643317 Observational study of gene-disease association. (HuGE Navigator)
20634197 Meta-analysis of gene-disease association. (HuGE Navigator)
20633049 Observational study of gene-disease association. (HuGE Navigator)
20628863 Only NAT1 showed a significant lower DNA methylation rate in the control group than in the tamoxifen-resistant breast cancer group, and no significant difference in methylation was found in COMT, CYP1A1, CYP2D6, and SULT1A1 genes.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627703 This article presents associations of the COMT pain sensitivity haplotype and baseline pain levels in female patients with major depressive disorder
20627703 Observational study of gene-disease association. (HuGE Navigator)
20620172 We report significant epistasis between COMT Val(1)Met and DAT1 VNTR on cortisol reactivity and stress recovery.
20620172 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20619899 The 'Met/Met' variant of the COMT gene was the best genetic predictor of treatment outcome to antidepressant medication in patients with major depressive disorder.
20619611 This is the first study that reports a positive effect of rs4680 polymorphism on antidepressive efficacy of fluvoxamine, and the third independent report of its influence on response to selective 5-HT reuptake inhibitors (SSRIs).
20619611 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20605701 Present results support the hypothesis that the Val158Met variants have an impact on working memory performance specifically in schizophrenia
20605701 Observational study of gene-disease association. (HuGE Navigator)
20603187 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20591499 This study demonistrated that the COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response.
20591499 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20591221 In postmenopausal women, the COMT-LL genotype may increase the risk for breast cancer.
20591221 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20586531 Catechol-O-methyltransferase is an enzyme that degrades catecholamines including dopamine Read More: http://informahealthcare.com/doi/full/10.3109/15622975.2010.486043
20586531 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20584552 The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms in the prediction of the response to fluoxetine after 4weeks of treatment.
20584552 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20579008 Patrons with the S/S genotype were three times more likely to intend to drive a motor vehicle (after drinking on the night of study participation) compared with those with the L/L genotype.
20577990 Inconsistent 5-HTTLPR GxE findings to date may be partly attributable to unmeasured epistatic effects between 5-HTTLPR and COMT val158met.
20577990 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20570835 There was no evidence of association between the COMT 'pain sensitivity' haplotypes and chronic widespread pain in two population-based cohorts.
20570835 Observational study of gene-disease association. (HuGE Navigator)
20570494 Data suggest that COMT Val allele might be related to poor performance on detecting the interpersonal problems, and attention in schizophrenia.
20570494 Observational study of gene-disease association. (HuGE Navigator)
20567893 COMT was not associated with cognitive ability in this population.
20567893 Observational study of gene-disease association. (HuGE Navigator)
20565774 Observational study of genotype prevalence. (HuGE Navigator)
20562760 Interaction of Val108/158Met polymorphism with other genes and environmental factors is an important avenue for future research.
20561508 Deletion of COMT increased pain sensitivity and not alterated the anti-nociceptive effects of acute systemic THC (8.0mg/kg).
20551163 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20531207 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20520724 Genetic and functional interactions between COMT and AKT1 may provide novel insights into pathogenesis of schizophrenia and other ErbB-associated human diseases such as cancer.
20520724 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20517217 The results suggest that the functional Val158Met COMT polymorphism is one of the significant markers of genetic predisposition to addiction diseases.
20517217 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20510373 Our results support previous reports of a COMT-genotype-dependent difference in amygdala responsivity as well as connectivity.
20510373 Observational study of gene-disease association. (HuGE Navigator)
20509977 The functional neuroimaging study shows an effect of the COMT val158met polymorphism on cerebral pain processing.
20509977 Observational study of gene-disease association. (HuGE Navigator)
20509070 Val158Met SNP associated with hypnotizability
20509070 Observational study of gene-disease association. (HuGE Navigator)
20505544 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20493536 The Val158Met polymorphism of the COMT interacts with cannabis use in the modulation of risk of psychosis. Affects age of onset and duration of untreated psychosis.
20493536 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20488547 This study demonistrated that the Met allele is association with child with anxiety and chromosome 22q11.2 deletion syndrome.
20488547 Observational study of gene-disease association. (HuGE Navigator)
20488458 The COMT functional polymorphism rs4680 contributes to schizophrenia genetic susceptibility.
20488458 Observational study of gene-disease association. (HuGE Navigator)
20483479 The finding of this study suggested that the COMT gene may a etiologically contribute to the severity of negative symptoms in schizophrenia, but its precise mechanism needs further investigating.
20483479 Observational study of gene-disease association. (HuGE Navigator)
20483173 The results of this study did not suggest an association between the polymorphism in the COMT gene and susceptibility to schizophrenia in the Chinese Han population.
20483173 Observational study of gene-disease association. (HuGE Navigator)
20478633 Observational study of gene-disease association. (HuGE Navigator)
20468064 Observational study of gene-disease association. (HuGE Navigator)
20464957 The high frequency of chromosome aberrations was associated with homozygotes of the high activity COMT G/G and HFE CC. Heterozygotes for G1947A COMT and C187G HFE reveal negative association with the high frequency of chromosome aberrations.
20464957 Observational study of gene-disease association. (HuGE Navigator)
20464630 Meta-analysis strongly suggests that catechol-O-methyltransferase Val108/158Met polymorphism is not associated with increased breast cancer risk.
20464630 Meta-analysis of gene-disease association. (HuGE Navigator)
20464528 Observational study of gene-disease association. (HuGE Navigator)
20457471 This study found a significant excess of the Val allele in both male and female patients.
20457471 Observational study of gene-disease association. (HuGE Navigator)
20453000 Observational study of gene-disease association. (HuGE Navigator)
20450956 The VAL allele is associated with increased EEG delta/theta activity. The VAL allele of the COMT VAL(158)MET is associated with increased extraversion scores.
20450956 Observational study of gene-disease association. (HuGE Navigator)
20437850 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20434465 This study supported the idea that low prefrontal dopamine levels promote cognitive flexibility.
20434465 Observational study of gene-disease association. (HuGE Navigator)
20434221 The effects of BDNF Val66Met polymorphism on boredom susceptibility of sensation seeking traits could be modulated by COMT Val158Met polymorphism in female.
20434221 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20431430 The interaction between polymorphisms of catechol-O-methyltransferase (COMT) and serotonin receptor 2A genes was examined in relation to novelty seeking and its different subscales in healthy Finnish adults.
20431430 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20421850 COMT associates with differences in cortisol secretion during adolescence.
20421850 Observational study of gene-disease association. (HuGE Navigator)
20419368 Observational study of gene-disease association. (HuGE Navigator)
20414144 The results of this study extend earlier findings with the COMT genotypes to additional measures of cognition, and suggest that the presence of the val allele is associated with poorer performance and greater improvement with a stimulant drug.
20414144 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20411349 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20407490 Observational study of gene-disease association. (HuGE Navigator)
20404311 These findings suggest that the Val allele has a protective impact on cognitive decline in late life.
20404311 Observational study of gene-disease association. (HuGE Navigator)
20403637 Examined the impact of the catechol-O-methyltransferase (COMT) val(158)met allele on depressive symptoms in young children exposed to early severe social deprivation. Genexenvironment interaction in the setting of early social deprivation was found.
20403637 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20398908 Observational study of gene-disease association. (HuGE Navigator)
20398774 the Val158Met polymorphism also has disease-specific effects on dorsolateral prefrontal cortex activation in schizophrenia
20398774 Observational study of gene-disease association. (HuGE Navigator)
20381444 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20373853 We conclude that COMT polymorphisms on their own do not seem to play a relevant role as major genetic risk factors for German multisomatoform disorder patients.
20373853 Observational study of gene-disease association. (HuGE Navigator)
20357758 These results support the importance of genetic variation in COMT in regulating prefrontal cortical GABA function.
20357758 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20351714 Observational study of gene-disease association. (HuGE Navigator)
20307169 Observational study of gene-disease association. (HuGE Navigator)
20230086 Analyses revealed a significant gene x experience interaction for COMT, such that individuals with met/met genotype experienced a greater decline in positive affect on days when pain was elevated than did either val/met or val/val individuals.
20230086 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20219642 Observational study of gene-disease association. (HuGE Navigator)
20216107 When stratified by the COMT high activity haplotype, a beneficial effect of propranolol on pain perception was noted in patients not carrying this haplotype, a diminished benefit was observed in the heterozygotes, and no benefit was noted in homozygotes.
20216107 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20214802 Observational study of gene-disease association. (HuGE Navigator)
20210499 A significant effect of the COMT valine158methionine (Val158Met) polymorphism was found in attention in infancy.
20210499 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20206656 Val158Met substitution in catechol O-methyltransferase gene influences the plasma concentrations of homovanillic and 3,4-dihydroxyphenylacetic acids in schizophrenic patients and in bipolar patients
20206656 Observational study of gene-disease association. (HuGE Navigator)
20205808 Observational study of gene-disease association. (HuGE Navigator)
20188797 Carriers of the high activity COMT variant are more prone to develop a higher level of nicotine dependence, or that they release more dopamine than carriers of Met/Met or Met/Val genotypes.
20188797 Observational study of gene-disease association. (HuGE Navigator)
20184941 No significant influence of the val158met polymorphism on the occurrence of RLS was seen in this German population.
20184941 Observational study of gene-disease association. (HuGE Navigator)
20184498 Polymorphisms in catechol-O-methyltransferase predispose towards Madurella mycetomatis-induced mycetoma susceptibility.
20184498 Observational study of gene-disease association. (HuGE Navigator)
20167428 Observational study of gene-disease association. (HuGE Navigator)
20156565 A greater P3a amplitude was found for the COMT-ValVal group relative to MetMet in a modified oddball task that featured infrequent but task-irrelevant novel sounds in addition to frequent standard and rare target tones
20156565 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20153759 These findings suggest the BDNF Val66Met may affect the emotional decision making performance, but COMT Val158Met polymorphism produced no significant effect on performance.
20153759 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20150638 Results suggest that genetic variation in COMT has no significant association with breast cancer risk among Caucasian women.
20150638 Observational study of gene-disease association. (HuGE Navigator)
20139013 the COMT Met allele modulates neural substrates of negative versus positive emotion processing
20130981 COMT Val158Met polymorphism may be a low-penetrant risk factor for breast cancer development in European population
20127886 Sexually dimorphic interaction between DRD1 and COMT genes in schizophrenia is reported.
20127808 Observational study of gene-disease association. (HuGE Navigator)
20125193 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20123031 in Velo-cardio-facial syndrome , the effect of the COMT Val108/158Met polymorphism is moderated by gender during the processing of emotional stimuli
20122740 We observed a significant association between homozygosis for the rs4680 COMT low-activity variant and a reduced risk of experiencing illness episodes with psychotic features during the course of the illness.
20110158 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20102668 The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val158Met or BDNF Val66Met genotypes, if present, must be very subtle.
20090380 The present results suggest a possible association between the DRD4 VNTR and COMT Val158Met polymorphisms and disgust sensitivity in Korean subjects.
20090380 Observational study of gene-disease association. (HuGE Navigator)
20083391 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20083203 the development of white matter in healthy children is related to COMT genotype
20083203 Observational study of gene-disease association. (HuGE Navigator)
20080926 study investigated a possible association between ecstasy use and verbal fluency in subjects genotyped for 5-HTT (5-HTTLPR and 5-HTTVNTR) and COMT (val(108/158)met, rs165599 and rs2097603) polymorphisms, to find a potential implication of genetic factors
20080926 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20074440 Our results are consistent with carriers of the COMT met/met genotype showing increased sensitivity to pain as one mechanism for the role of this gene in conferring risk for fibromyalgia
20074440 Observational study of gene-disease association. (HuGE Navigator)
20071037 This study could not demonstrate any significant difference in the distribution of this COMT single-nucleotide polymorphism (SNP) in the treatment response to selective serotonin reuptake inhibitors or between patients with MDD and control subjects.
20071037 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20070134 COMT Val158Met 'Met' allele predicted a 2.10-fold risk of smoking post-hurricane, independent of PTSD
20070134 Observational study of gene-disease association. (HuGE Navigator)
20069120 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20060911 the neural correlates within hippocampal-prefrontal regions demonstrate a link between COMT val(158)met carrier status and brain areas associated with declarative memory processing.
20060911 Observational study of gene-disease association. (HuGE Navigator)
20053888 Default network connectivity that involves the prefrontal cortex is modulated by COMT val(158)met through differential effects on prefrontal dopamine levels.
20053459 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20038933 findings provide further support that COMT is a modifying gene that plays a role in determining interindividual variability in the proclivity for violent behaviour in subjects without major mental disorder
20038933 Observational study of gene-disease association. (HuGE Navigator)
20038544 Valence-related brain activations are seen in the ventral striatum, anterior cingulate cortex, and inferior parietal cortex and are modulated by the COMT polymorphism with greater effects for valine/valine participants, in a gambling paradigm.
20038544 Observational study of gene-disease association. (HuGE Navigator)
20037207 COMT wild type in combination with CYP1B1 heterozygous variant and COMT heterozygous variant in combination with CYP1B1 wild type (Leu(432)Leu) showed significant protective association with premenopausal breast cancer risk
20037207 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20033274 genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits
20026221 the COMT Val108/158Met polymorphism was shown to influence medial temporal lobe volumes in a linear-additive manner
20026221 Observational study of gene-disease association. (HuGE Navigator)
20022223 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20005296 findings suggest that COMT haplotypes can nonlinearly modulate the intelligence-related white matter integrity of the prefrontal lobes by more significantly influencing prefrontal dopamine variations than does val158met
20005296 Observational study of gene-disease association. (HuGE Navigator)
20004480 This study suggested that the COMT gene polymorphism in the therapeutic response to mood stabilizers in manic patients.
20004480 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20002200 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19997043 Val allele of the Val158Met polymorphism significantly associated with conduct disorder diagnosis and symptoms; Met allele associated with ADHD symptoms
19997043 Observational study of gene-disease association. (HuGE Navigator)
19956635 Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19946720 We examined the association of the functional Val158Met COMT polymorphism and SES-both as linear and interactive effects-with oppositional defiant problems, conduct problems, and attention deficit/hyperactivity problems.
19946720 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19946713 These findings support previous results implicating COMT in attention-deficit/hyperactivity disorder symptom severity and early adverse familial environment as risk factors for co-morbid conduct disorder
19946713 Observational study of gene-disease association. (HuGE Navigator)
19944766 Observational study of gene-disease association. (HuGE Navigator)
19944543 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19944409 this study indicated a gene-environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing posttraumatic stress disorder.
19944409 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19941049 Gene-gene interaction between COMT and MAOA may have a role in intelligence of attention-deficit hyperactivity disorder boys in China
19941049 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19915868 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19906087 This study of gene x environment interaction in female BPD patients suggests an association between SLEs and impulsive aggression, as well as a modulating effect of the COMT Val(158)Val genotype on the relation between SLEs and impulsive aggression.
19906087 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19900710 These results suggest that the COMT Met allele is related to the higher sympathetic nervous function observed in PD.
19900710 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19898482 the strong associations of cisplatin-induced hearing loss with specific genetic variants in COMT were identified
19895544 Observational study of gene-disease association. (HuGE Navigator)
19892319 schizophrenia, brain structures important for executive and affective processing show activity that is differentially predicted by COMT allelic variation in an opposing manner even at rest.
19892319 Observational study of gene-disease association. (HuGE Navigator)
19881467 Study provide the evidence that in a Korean population, COMT on the 22q11 locus is likely involved in the development of schizophrenia, but not in the SPEM function abnormality.
19881467 Observational study of gene-disease association. (HuGE Navigator)
19874574 Observational study of gene-disease association. (HuGE Navigator)
19863350 Observational study of gene-disease association. (HuGE Navigator)
19858760 This article confirms and expands previous studies suggesting that genes moderate ADHD treatment response. The ADHD outcomes are not unitary but reflect both behavioral and learning domains that are likely influenced by different genes.
19858760 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19852950 The genotype of catechol-O-methyltransferase in two polymorphisms rs4633 and rs4680 increased the risk of having ED over fivefold and over sevenfold the risk of having bulimia.
19852950 Observational study of gene-disease association. (HuGE Navigator)
19836927 Observational study of gene-disease association. (HuGE Navigator)
19829167 Observational study of gene-disease association. (HuGE Navigator)
19827313 Observational study of gene-disease association. (HuGE Navigator)
19822738 behavioral advantage for the phylogenetically ancestral Val/Val genotype in an instrumental reversal learning task that requires rapid and flexible adaptation of decisions to changing reward contingencies in a dynamic environment
19818050 Observational study of gene-disease association. (HuGE Navigator)
19812213 Observational study of gene-disease association. (HuGE Navigator)
19809499 Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptors ERalpha and PR signaling in leiomyoma cells
19799358 Observational study of gene-disease association. (HuGE Navigator)
19795175 genotype is not related with alterations in baseline D2 receptor availability in vivo in the cortex or the striatum.
19793392 COMT (Val158 Met) polymorphism is not an independent risk factor for Alzheimer Disease or mild cognitive impairment, but shows a synergistic effect with apolipoprotein E epsilon4 allele that proves greater in women with AD.
19789190 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19776291 Observational study of gene-disease association. (HuGE Navigator)
19772578 Observational study of gene-disease association. (HuGE Navigator)
19751749 Observational study of gene-disease association. (HuGE Navigator)
19738929 Observational study of gene-disease association. (HuGE Navigator)
19727210 Observational study of gene-disease association. (HuGE Navigator)
19726643 Val158Met polymorphism of COMT predicts difference in an individual's alpha peak frequency in the waking electroencephalogram (EEG).
19726643 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19721400 Data show that there is an association between the catechol-O-methyltransferase gene and violent behavior in Chinese schizophrenics.
19721400 Observational study of gene-disease association. (HuGE Navigator)
19717274 Observational study of gene-disease association. (HuGE Navigator)
19702491 Catechol-O-methyltransferase valine158methionine polymorphism is associated with greater perceived social acceptance than homozygous methionine-allele carriers.
19702491 Observational study of gene-disease association. (HuGE Navigator)
19700233 High school students homozygous for COMT 158Met allele performed more poorly in an academic performance exam.
19700233 Observational study of gene-disease association. (HuGE Navigator)
19699472 the synonymous rs4818 COMT polymorphism has an effect on human PrePulse Inhibition, working memory, and probably mood and determines the effects of tolcapone on these functions.
19699472 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19693267 Observational study of gene-disease association. (HuGE Navigator)
19692168 Observational study of gene-disease association. (HuGE Navigator)
19690620 No significant associations were observed of 5HT2A rs6311, 5HT2C rs3813929 and COMT rs4680 with obesity, except that COMT rs4680 GG-genotype was associated with fat-BMI
19690620 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19676096 the low activity M158 COMT allele has a role in reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents
19676096 Observational study of gene-disease association. (HuGE Navigator)
19673036 Observational study of gene-disease association. (HuGE Navigator)
19672140 The results of this study show that 5-HTT, DRD4, and COMT genes less likely have an effect on fear during childbirth in Korea.
19672140 Observational study of gene-disease association. (HuGE Navigator)
19666577 These data demonstrate that COMT and DAT genes interact nonadditively to modulate cortical function during executive processing.
19666577 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19647329 COMT val(158)met genotype not association with smooth pursuit eye movements in schizophrenia.
19647329 Observational study of gene-disease association. (HuGE Navigator)
19646713 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19642882 Observational study of gene-disease association. (HuGE Navigator)
19641441 The common COMT 108Val > Met polymorphism is associated with human liver S-COMT activity and thermal stability, but additional COMT SNPs also contribute to variation in activity
19641441 Observational study of gene-disease association. (HuGE Navigator)
19641018 the results of this study suggested that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output.
19641018 Observational study of gene-disease association. (HuGE Navigator)
19633959 The two sunsect group did not differ with respect to the prevalence of adolescent cannabis abuse or presence of affective symptoms
19625176 Observational study of gene-disease association. (HuGE Navigator)
19625011 The carriers of low activity variants of monoamine oxidase A both and catechol-O-methyltransferase and the high activity variant of 5-HTT, developed depressive symptoms in the course of the peripartum.
19625011 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19621370 Observational study of gene-disease association. (HuGE Navigator)
19620978 A gene primarily controlling prefrontal dopamine function (COMT) is associated with a particular type of directed exploration.
19617637 Over-expression of TXNRD2, COMT and ARVCF affects incentive learning and working memory in transgenic mice.
19605537 Observational study of gene-disease association. (HuGE Navigator)
19596974 COMT polymorphism may influence the susceptibility to gene methylation in the gastric mucosa
19596974 Observational study of gene-disease association. (HuGE Navigator)
19593178 Report monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder.
19593178 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19585392 allelic variation at the COMT Val (158)Met locus may influence signal discrimination capacity in schizophrenia and is associated with greater cognitive flexibility, which in turn may influence other cognitive measures
19585392 Observational study of gene-disease association. (HuGE Navigator)
19584770 the rs4680 genotype of COMT may not play a role in spontaneous smoking cessation
19584770 Observational study of gene-disease association. (HuGE Navigator)
19582565 SNP Val158Met association with anxiety, ADHD and tics in autism spectrum disorder
19579610 COMT gene Val158Met polymorphism is associate with a reduced risk of developing more severe intestinal metaplasia in H. pylori infected older subjects.
19578924 the low-activity allele (Met) of rs4680 in COMT gene possibly confers risk for bipolar disorder in the Han population, while it needs further evidence for concluding its association with BP in the Caucasian population
19578796 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19574343 Observational study of gene-disease association. (HuGE Navigator)
19573260 The results showed no evidence of association between variation in COMT genotype and lateral ventricular, and left or right hippocampal volumes. Neither was there any effect of the BDNF, 5-HTTLPR, NRG1 and DTNBP1 genotypes on these regional brain volumes.
19559505 Observational study of gene-disease association. (HuGE Navigator)
19551860 Germline polymorphisms in COMT is associated with breast cancer.
19551860 Observational study of gene-disease association. (HuGE Navigator)
19548263 Observational study of gene-disease association. (HuGE Navigator)
19547755 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19545856 This study confirmed in an independent sample of healthy volunteers that PPI is influenced by genetic variation in the catechol-O-methyltransferase gene.
19545856 Observational study of gene-disease association. (HuGE Navigator)
19539269 The COMTval(158)met polymorphism modulates both the activity and functional connectivity of brain regions within working memory networks.
19539269 Observational study of gene-disease association. (HuGE Navigator)
19521967 There was a trend for an association of the COMT 158Met allele with OCD in males, and an interaction between the COMT Val158Met genotype and sex on the somatic and sensory phenomena symptom dimension, with females showing lower scores
19521967 Observational study of gene-disease association. (HuGE Navigator)
19520435 Effect of rs4680 on response to sleep deprivation combined with light therapy (36 h awake followed by a night of undisturbed sleep, with 10,000 lx light administered for 30 min during the night awake and upon awakening) in 87 bipolar depressed patients.
19520435 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19514368 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19513381 Observational study of gene-disease association. (HuGE Navigator)
19506906 Meta-analysis of gene-disease association. (HuGE Navigator)
19506579 Observational study of gene-disease association. (HuGE Navigator)
19500679 This is the first study of COMT-related brain perfusion differences in children, and it is clear that basal perfusion differs as a function of COMT genotype
19500679 Observational study of gene-disease association. (HuGE Navigator)
19482231 These data suggest that the neurophysiological response during response inhibition may be a suitable intermediate phenotype as the influence of COMT variation was detectable on neural response.
19482231 Observational study of gene-disease association. (HuGE Navigator)
19482061 Our results confirm that important aspects of cognitive development including attention depend on the interaction of genes such as COMT and early environment.
19482061 Observational study of gene-disease association. (HuGE Navigator)
19476811 Observational study of gene-disease association. (HuGE Navigator)
19474754 we found significant associations of bodyweight gain by more than 4 kg during antidepressant treatment with polymorphisms in genes coding for COMTand TPH1.
19474754 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19465875 The SLC6A4 gene was not associated with either symptom subtype.
19453261 Observational study of gene-disease association. (HuGE Navigator)
19447357 This is the first report of epistasis between COMT and DAT1 genes on eating behavior. Specifically, the Met/10 and Val/9 genotypes were associated with elevated binge eating and eating psychopathology.
19447296 Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells. The majority of COMT dopamine-methylating activity was found to be present in the cytosol.
19443378 No statistically significant effects on bladder cancer risk with CYP1A1, CYP1B1 and COMT genotypes were observed
19429001 The activation of [oxy-Hb] on the right lateral prefrontal cortex was observed in the Met/Met genotype of the COMT gene polymorphism of panic disorder patient groups in the analysis of NIRS, which seems to be related to the autonomic dysfunction.
19429001 Observational study of gene-disease association. (HuGE Navigator)
19424794 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19424500 Spatiotemporal characteristics of the association between prefrontal hemodynamic activation and the COMT genotype, was investigated.
19424500 Observational study of gene-disease association. (HuGE Navigator)
19417742 Meta-analysis of gene-disease association. (HuGE Navigator)
19415821 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19415745 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19406978 Homozygosity of a G-to-A polymorphism in the fourth exon is an independent risk factor for shock, acute kidney injury, and hospital stay after cardiac surgery.
19406978 Observational study of gene-disease association. (HuGE Navigator)
19403893 Catechol-O-methyltransferase genotype affected the early posterior negativity amplitudes for unpleasant stimuli, but not for pleasant ones. Met/Met carriers respond more sensitively to unpleasant stimuli compared with Val/Val carriers.
19403893 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19398820 Observational study of gene-disease association. (HuGE Navigator)
19383894 COMT SNPs do not support the role of genetic variation in the catechol estrogen metabolism pathway and breast cancer risk in postmenopausal women.
19383894 Observational study of gene-disease association. (HuGE Navigator)
19381707 COMT val(158)met status modulates brain activation during the language production on a semantic level in an area related to executive functions.
19381707 Observational study of gene-disease association. (HuGE Navigator)
19371223 Association between COMT gene polymorphism and ADHD in Kopean population is reported.
19371223 Observational study of gene-disease association. (HuGE Navigator)
19369177 COMT may contribute to the genetic risk for schizophrenia not through the Val 108/158 Met polymorphism, but through other variants that are situated 3' to this region.
19369177 Observational study of gene-disease association. (HuGE Navigator)
19367610 Observational study of gene-disease association. (HuGE Navigator)
19367581 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19365560 Data suggest that both minor synonymous and nonsynonymous single nucleotide polymorphisms in the coding region are markers of functional haplotypes rather than independent contributors to catechol-O-methyltransferase activity.
19360691 Observational study of gene-disease association. (HuGE Navigator)
19352218 Observational study of gene-disease association. (HuGE Navigator)
19352216 results do not support the hypothesis that the COMT gene could be associated with Tourette syndrome (TS), TS symptoms severity, and drug response in TS
19343046 Observational study of gene-disease association. (HuGE Navigator)
19339270 Observational study of gene-disease association. (HuGE Navigator)
19339052 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19329282 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19309019 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19308019 The COMT(Val158Met) polymorphism genotype effect on cortical morphology in a right prefrontal cortical region intimately linked to key aspects of cognition.
19308019 Observational study of gene-disease association. (HuGE Navigator)
19297741 finding further supports the notion that the COMT Val158Met polymorphism may play a role in cognitive function
19297741 Observational study of gene-disease association. (HuGE Navigator)
19296553 COMT Val(158)Met polymorphism was not associated with cognitive performance in depressed or nondepressed, nor did it account for the fact that depressed performed worse than nondepressed on several neuropsychological tests that are affected by depression
19296553 Observational study of gene-disease association. (HuGE Navigator)
19296409 Associations were evaluated between a functional single nucleotide polymorphism (Val158Met) in the gene encoding the catecholamine catabolic enzyme catechol O-methyltransferase (COMT), dental mercury exposure, and self-reported symptoms and mood
19296409 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19291302 These findings provide the first evidence for NF-kappaB-mediated inhibition of COMT expression in the central nervous system, suggesting that COMT contributes to the pathogenesis of inflammatory pain states.
19291230 This study showed that COMT effects on working memory performance are modulated by the DRD2/ANKK1-TAQ-Ia polymorphism and the specific working memory component process.
19291230 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19290789 Interacting effects within the COMT gene polymorphisms may influence the disease status and response to risperidone in schizophrenia patients.
19290789 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19282863 Observational study of gene-disease association. (HuGE Navigator)
19278671 The results of this study indicated that the met158 allele is associated with increased gray matter volume and heightened reactivity during emotional processing within the limbic system in children as young as 10 to 12 years of age
19278671 Observational study of gene-disease association. (HuGE Navigator)
19268435 schizophrenia might involve increased COMT expression in glial cells in the frontal cortex, which might be associated with a neuronal-glial abnormality and a disturbed dopamine-glutamate interaction
19259017 Observational study of gene-disease association. (HuGE Navigator)
19251248 The results demonstrate the role of the COMT Val/Met polymorphism in the processing of reward
19251248 Observational study of gene-disease association. (HuGE Navigator)
19246329 Our results support that a single gene, COMT, could modulate prefrontal cortex-dependent cognition.
19246329 Observational study of gene-disease association. (HuGE Navigator)
19235787 findings do not support a major role for COMT or MTHFR alone, however, an epigenetic interaction of COMT Val158Met and MTHFR C677T polymorphisms may contribute to putamen volumes differences between depressed and nondepressed subjects.
19235787 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19228412 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19223155 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19219857 Observational study of gene-disease association. (HuGE Navigator)
19210038 younger age and COMT Met/Met genotype, associated with low COMT activity and higher prefrontal dopamine content, were independently linked to better performance in most of the tested domains.
19210038 Observational study of gene-disease association. (HuGE Navigator)
19207030 Polymorphisms in this protein may be involved in genetic susceptibility to schizophrenia.
19207030 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19193231 the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder
19193231 Observational study of gene-disease association. (HuGE Navigator)
19180497 A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain.
19180497 Observational study of gene-disease association. (HuGE Navigator)
19174490 COMT gene polymorphism is associated with non-small cell lung cancer.
19174490 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19170664 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19170196 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19167252 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19160592 COMT Met/Val polymorphism is strongly associated with smoking cessation. The Met allele is the risk allele that decreases the likelihood of smoking cessation in men and women.
19160592 Observational study of gene-disease association. (HuGE Navigator)
19159868 These findings provided convincing evidence that epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes plays an important role in the pathogenesis of schizophrenia
19159868 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19156168 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19143007 Although expression of activating and/or detoxifying enzymes (CYP1B1, NAT1, and COMT) may be higher in the peripheral zone of the prostate, PAH-DNA adduct levels appear to be similar in peripheral zone and transition zones.
19127255 Observational study and meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator)
19124506 Observational study of gene-disease association. (HuGE Navigator)
19116388 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19112571 COMT-158 polymorphism has an effect on the risk of generalized vitiligo in the Han Chinese population.
19112571 Observational study of gene-disease association. (HuGE Navigator)
19104049 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19095219 Single nucleotide polymorphisms in COMT were associated with symptom change in duloxetine-treated patients with MDD. If replicated, the magnitude of the COMT genotype effect is of clinical relevance.
19095219 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19094875 There is a minor influence of COMT G158A on schizophrenia risk and a greater importance of polymorphisms in the P2 promoter regions of COMT, such as -278A/G
19094875 Observational study of gene-disease association. (HuGE Navigator)
19094200 This study suggests that genetic variability in the COMT gene influence the efficacy of morphine in cancer patients with pain.
19094200 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19077667 identification of a new haplotype of the human COMT gene with triplet point mutations, which encodes the D51G/S60F/K162R mutant of the soluble COMT and the D101G/S110F/K212R mutant of the membrane-bound COMT
19077118 genetic variants in COMT might be involved in modulation of neurocognitive functions and hence conferring increased risk to schizophrenia
19077118 Observational study of gene-disease association. (HuGE Navigator)
19077115 Observational study of gene-disease association. (HuGE Navigator)
19076243 Our study in Plains American Indians has shown that COMT influences several aspects of cognition and some of its effects are moderated by educational adversity
19076243 Observational study of gene-disease association. (HuGE Navigator)
19071221 Observational study of gene-disease association. (HuGE Navigator)
19065145 Data suggest a novel brain-behavior mechanism that may underlie the increased susceptibility to nicotine dependence and smoking relapse associated with the COMT val allele.
19065145 Observational study of gene-disease association. (HuGE Navigator)
19064581 No association between COMT polymorphisms and risk for hepatocellular carcinoma.
19064581 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19064572 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19058789 Observational study of gene-disease association. (HuGE Navigator)
19054502 variation in the COMT gene on regional brain function during executive processing is different in patients with schizophrenia compared with healthy individuals
19054502 Observational study of gene-disease association. (HuGE Navigator)
19042106 the COMT gene moderates the negative effect of Ecstasy on memory
19031960 Observational study of gene-disease association. (HuGE Navigator)
19025226 As a group, relatives of patients with schizophrenia who were homozygous for the val allele of the COMT polymorphism showed the highest elevations in self-reported social and physical anhedonia.
19025226 Observational study of gene-disease association. (HuGE Navigator)
19024004 Observational study of gene-disease association. (HuGE Navigator)
19023276 Alcohol-induced BP elevation may be related to the effects of catecholamines and their genetically determined inactivation.
19023276 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19020775 identification of a new haplotype of the COMT gene with triplet point mutations, which encodes the D51G/S60F/K162R mutant of soluble COMT & the D101G/S110F/K212R mutant of membrane-bound COMT
19015200 Observational study of gene-disease association. (HuGE Navigator)
18997477 Based on the presence or absence of mood incongruent symptoms, the Val108/158Met polymorphism of the COMT gene alone does not appear to be a crucial determinant in the division of psychotic bipolar patients.
18997477 Observational study of gene-disease association. (HuGE Navigator)
18989660 The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting.
18989660 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18988738 MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.
18988738 Observational study of gene-disease association. (HuGE Navigator)
18983999 No differences were found for the three different 5-HTTLPR or COMT genotypes regarding (i) attention to wins versus losses, (ii) updating rate, or (iii) response consistency.
18983999 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18980759 Observational study of gene-disease association. (HuGE Navigator)
18958211 Observational study of gene-disease association. (HuGE Navigator)
18958202 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18937309 Sex factor effects are described for COMT in genetic association with ADHD.
18937309 Observational study of gene-disease association. (HuGE Navigator)
18936597 Findings from this study suggest that high pain catastrophizing and COMT diplotype were predictive of elevated induced shoulder pain ratings after performing a standard fatigue protocol.
18936597 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18929622 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18922583 Observational study of gene-disease association. (HuGE Navigator)
18832011 Observational study of gene-disease association. (HuGE Navigator)
18828035 COMT-V158M polymorphism was not associated with suicidal behavior in a Caucasian sample of mood disorder subjects, or with possible clinical or biological endophenotypes.
18828035 Observational study of gene-disease association. (HuGE Navigator)
18826446 Observational study of gene-disease association. (HuGE Navigator)
18821565 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
18820009 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18814869 inconclusive findings in attempt to correlate a specific phenotype concerning paranormal belief with COMT polymorphisms
18814869 Observational study of gene-disease association. (HuGE Navigator)
18808401 catechol-o-methyltransferase gene (COMT Val158Met) may moderate the psychosis-inducing effects of cannabis
18808401 Observational study of gene-disease association. (HuGE Navigator)
18802928 Association between COMT haplotypes and severity of hyperactivity symptoms in adults is reported.
18802928 Observational study of gene-disease association. (HuGE Navigator)
18796186 The COMT Val108/158Met polymorphism impacts on gender-related patterns of activation in limbic and paralimbic regions but the functional significance of any oestrogen-related COMT inhibition appears modest.
18796186 Observational study of gene-disease association. (HuGE Navigator)
18789857 Observational study of gene-disease association. (HuGE Navigator)
18769474 Observational study of gene-disease association. (HuGE Navigator)
18760272 No association between COMT genotype and gastrointestinal dysfunction in familial amyloidotic polyneuropathy patients was noted
18760272 Observational study of gene-disease association. (HuGE Navigator)
18756498 These data suggest an involvement of altered dopaminergic and/or noradrenergic neurotransmission as well as an interactive effect of COMT and 5-HTTLPR gene variants in the etiology of borderline personality disorder
18756498 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18755576 COMT val158met genotype was related to performance on an executive function test, with the met/met carriers scoring highest. Subjects carrying the met/met genotype also scored higher in the disorganization domain of the SPQ-B personality inventory.
18755576 Observational study of gene-disease association. (HuGE Navigator)
18755526 The data of this study indicated age-related changes in global and regional grey matter with the val158met polymorphism of COMT.
18755526 Observational study of gene-disease association. (HuGE Navigator)
18753372 Our data indicate a critical role for the COMT gene in an apparent evolutionary trade-off between cognitive and affective functions.
18752908 catechol-O-methyltransferase polymorphism is a risk factor for the development of large uterine fibroids in Brazilian women suffering from fibroids.
18752908 Observational study of gene-disease association. (HuGE Navigator)
18729643 The COMT 158Met allele to affective psychopathology and alterations in neural systems for emotional arousal and regulation
18729643 Observational study of gene-disease association. (HuGE Navigator)
18721261 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18715275 Haplotypes of the phenylethanolamine N-methyltransferase (PNMT), catechol-O-methyltransferase (COMT) have functionally important effects on alcohol-induced cardiovascular symptoms by affecting blood catecholamine levels.
18715275 Observational study of gene-disease association. (HuGE Navigator)
18705311 The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age.
18705311 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18704099 The low enzyme activity COMT 158Met allele or haplotypes containing this variant might have functional effects on dopamine-derived reward processes and cortical functions resulting in increased susceptibility for cocaine dependence.
18704099 Observational study of gene-disease association. (HuGE Navigator)
18702937 Observational study of gene-disease association. (HuGE Navigator)
18698234 Frequency of G_C_G_G (high activity) catechol-O-methyltransferase haplotype carriers was higher in late onset Parkinson's disease patients.
18698234 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18693431 Observational study of gene-disease association. (HuGE Navigator)
18684304 no difference in COMT genotype frequencies between PD patients and controls in the Greek population
18684304 Observational study of gene-disease association. (HuGE Navigator)
18676680 Observational study of gene-disease association. (HuGE Navigator)
18663384 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18663369 Observational study of gene-disease association. (HuGE Navigator)
18636124 Observational study of gene-disease association. (HuGE Navigator)
18635674 These preliminary results imply that PPI is influenced by COMT Val(158)Met genotype in schizophrenia as well. In concert with other findings, our data suggest that PPI is a polygenic trait.
18635674 Observational study of gene-disease association. (HuGE Navigator)
18634888 Current evidence and our results are compatible with an interpretation that construes this effect of COMT genotype on striatal reactivity as a result of a cortico-striatal interaction.
18634888 Observational study of gene-disease association. (HuGE Navigator)
18632656 two SNPs in the COMT distal promoter are associated with breast cancer risk
18632656 Observational study of gene-disease association. (HuGE Navigator)
18629431 Observational study of gene-disease association. (HuGE Navigator)
18615479 COMT val158met modulates association between brain white matter architecture and IQ.
18615479 Observational study of gene-disease association. (HuGE Navigator)
18596619 Data show that the patients who are BDNF met/met x COMT L carriers have more delusional symptoms and poorer cognitive flexibility.
18596619 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18596609 Data show that the confounding variables as cortical grey matter volume are associated a functional polymorphism in the targeting region of COMT gene.
18593984 Observational study of gene-disease association. (HuGE Navigator)
18583979 Meta-analysis of gene-disease association. (HuGE Navigator)
18580877 These results suggest that the COMT Val(108/158)Met polymorphism modulates task-oriented behavior, but it does not modulate the response of this behavior with MPH treatment.
18580877 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18579277 Observational study of gene-disease association. (HuGE Navigator)
18578865 COMT gene contains a functional polymorphism, Va1158Met, which has been linked to anxiety and depression.
18578865 Observational study of gene-disease association. (HuGE Navigator)
18574484 study from 45 populations of 63 SNPs in a region of 172 kb across the region of 22q11.2 encompassing the COMT gene; found haplotypes are from diverse evolutionary lineages that could harbor as yet undetected variants with functional consequences
18571901 The COMT Val allele was associated with greater positive symptomatology in schizophrenia, whereas Met homozygosity was associated with greater positive symptomatology in bipolar disorder.
18571901 Observational study of gene-disease association. (HuGE Navigator)
18571372 Observational study of gene-disease association. (HuGE Navigator)
18566989 the important role of COMT gene expression in protecting against E(2)-induced endometrial cancer.
18562342 The results suggest that COMT val(158) carrier status is associated with better performance on the antisaccade task.
18562342 Observational study of gene-disease association. (HuGE Navigator)
18553389 Observational study of gene-disease association. (HuGE Navigator)
18547681 These findings suggest a differential effect in relating the Val(158)Met polymorphism to gait and to cognitive function while supporting the previously described sexual dimorphism in the phenotypic expressions of COMT.
18547681 Observational study of gene-disease association. (HuGE Navigator)
18545092 COMT polymorphism moderated the job strain-Atherosclerosis association in men. Job strain was associated with higher Intima Media Thickness in Val/Val carriers but not among others.
18545092 Observational study of gene-disease association. (HuGE Navigator)
18536698 Enhancement of prefrontal cortex DA signaling with tolcapone improves both PPI and working memory in a COMT Val158Met genotype-specific manner.
18535998 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18533273 sexually dimorphic effect is found in catechol-O-metrhyltransferase polymorphism on clinical response to fluoxetine in major depressive patients.
18533273 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18510611 Observational study of gene-disease association. (HuGE Navigator)
18499348 Observational study of gene-disease association. (HuGE Navigator)
18497887 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18486967 Observational study of gene-disease association. (HuGE Navigator)
18486144 The crystal structures of the 108V and 108M variants of the soluble form of human COMT bound with S-adenosylmethionine (SAM) and a substrate analog, 3,5-dinitrocatechol, is described.
18474266 W143 dominates the tryptophan fluorescence of the folded COMT and accounts for most of the decrease in fluorescence that accompanies unfolding by GuHCl
18469803 COMT protein expression (membrane-bound and soluble) was significantly lower in the third-trimester pre-eclamptic placentae than in the gestational age-matched control placentae
18466879 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18446263 was detected for alleles of the COMT polymorphisms in early onset of obsessive-compulsive disorder.
18442637 Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.
18442637 Observational study of gene-disease association. (HuGE Navigator)
18440204 The functional val158met polymorphism in the catechol-O-methyltransferase (COMT) gene has been found to be associated with panic disorder and to influence limbic and prefrontal brain activation in response to unpleasant stimuli.
18440204 Observational study of gene-disease association. (HuGE Navigator)
18436194 Variations in the COMT gene contribute to genetic risk shared across a range of anxiety-related phenotypes.
18436194 Observational study of gene-disease association. (HuGE Navigator)
18424907 Observational study of gene-disease association. (HuGE Navigator)
18423838 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18407467 Observational study of gene-disease association. (HuGE Navigator)
18390078 no associations were noted betweeno the exon 4 NlaIII restriction site polymorphism (RSP), the P2 promoter HindIII RSP at -1217, and the exon 6 BglI RSP polymorphisms in COMT (catechol-O-methyltransferase) genes and leiomyoma size
18390078 Observational study of gene-disease association. (HuGE Navigator)
18387741 This study suggest that the COMT Val158Met genotype may contribute to differences in normal cognitive aging, particularly in the area of general attention.
18387741 Observational study of gene-disease association. (HuGE Navigator)
18384078 found no association between genetic variants and neuroticism, depression, anxiety, panic disorder and agarophobia, and obsessive compulsive disorder.
18384078 Observational study of gene-disease association. (HuGE Navigator)
18382477 A significant association is found between a COMT polymorphism and working memory scores in the combined adult and young cohorts.
18382477 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18381357 Observational study of gene-disease association. (HuGE Navigator)
18379473 Observational study of gene-disease association. (HuGE Navigator)
18374902 activity in the hippocampus in the exact opposite direction of DAT 10/10-repeat alleles based on COMT Val(158)Met genotype during different memory conditions.
18374902 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18366720 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18351593 DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents.
18351593 Observational study of gene-disease association. (HuGE Navigator)
18350156 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18339359 We conducted a meta-analysis of reported associations between the COMT Val158/108Met polymorphism and measures of memory and executive function.
18339359 Meta-analysis of gene-disease association. (HuGE Navigator)
18328676 The Met allele may be involved in the causation of psychopathology, at least in populations with a genetic predisposition to psychosis.
18328676 Observational study of gene-disease association. (HuGE Navigator)
18324659 polymorphisms in COMT codon 62 and codon 158 altered protein expression levels in EC, suggesting that they may be risk factors for endometrial carcinoma in Caucasians
18324659 Observational study of gene-disease association. (HuGE Navigator)
18317466 Prominent role of COMT in regulating dopamine transmission in cortex but not striatum.
18317466 Observational study of gene-disease association. (HuGE Navigator)
18302304 aim of this prospective study was to evaluate the impact of codon 158 polymorphism at the catechol-O-methyltransferase (COMT) gene on prescription of antipsychotic medication in a general population
18302304 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18294618 Observational study of gene-disease association. (HuGE Navigator)
18287936 This study provides evidence that the Val(108/158)Met polymorphism of the COMT gene might be responsible for individual variation in the human brain morphology.
18287936 Observational study of gene-disease association. (HuGE Navigator)
18270997 Possible association of the Val158Met COMT variant with opiate addiction in Hispanic women.
18270997 Observational study of gene-disease association. (HuGE Navigator)
18270970 Observational study of genotype prevalence. (HuGE Navigator)
18261249 These results suggest that PPI is regulated by DA neurotransmission in the PFC and its levels depend on the COMT Val158Met gene polymorphism.
18261249 Observational study of gene-disease association. (HuGE Navigator)
18258609 Observational study of gene-disease association. (HuGE Navigator)
18257092 Single nucleotide polymorphisms in catechol-O-methyltansferase enzyme was associated with central side effects to morphine in cancer patients
18257092 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18252743 influence of the COMT val(158)met polymorphism upon the neural circuitry supporting fluid intelligence
18252743 Observational study of gene-disease association. (HuGE Navigator)
18250258 Observational study of gene-disease association. (HuGE Navigator)
18250258 We present replicated evidence that the COMT valine/methionine polymorphism at codon 158 (COMT Val158Met) was associated with phenotypic variation among children with ADHD.
18235427 The findings may be compatible with a hypothesis on the role of COMT val(158)met genotype in tonic and phasic dopamine levels in brain and differential effects on cognitive measures of stability (eg prosaccades) and plasticity (eg antisaccades).
18235427 Observational study of gene-disease association. (HuGE Navigator)
18214865 COMT Val58Met polymorphism is associated with methylphenidate response in ADHD children.
18214865 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18214863 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18213617 Val158Met polymorphism (COMT gene) might account for individual differences on dopamine-dependent prefrontally related neurocognitive functions.
18213617 Observational study of gene-disease association. (HuGE Navigator)
18201871 the val allele of the COMT polymorphism may be associated with an underdeveloped self-concept phenomenologically similar to made volition and passivity experiences comprising first-rank symptoms of schizophrenia.
18201871 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18199630 Disease status seems to modulate the impact of COMT Val108/158Met on cognitive performance.
18199630 Observational study of gene-disease association. (HuGE Navigator)
18198266 Observational study of gene-disease association. (HuGE Navigator)
18197080 Observational study of gene-disease association. (HuGE Navigator)
18196244 Observational study of gene-disease association. (HuGE Navigator)
18194840 Observational study of gene-disease association. (HuGE Navigator)
18194538 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18193072 Observational study of gene-disease association. (HuGE Navigator)
18192898 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18192686 diet might influence catechol-O-methyltransferase activity in cultured MCF-7 cells to a greater extent than heretofore recognized
18189241 High activity variants of COMT interact with the low activity variant of MTHFR to increase plasma total homocysteine levels.
18189241 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18189003 Observational study of gene-disease association. (HuGE Navigator)
18186041 It is plausible that cumulative effects of the MTHFR T and COMT Val alleles on intracellular methylation profiles and prefrontal dopamine transmission underlie their interactive effect on perseverative errors.
18186041 Observational study of gene-disease association. (HuGE Navigator)
18184800 Observational study of gene-disease association. (HuGE Navigator)
18182829 COMT gene Val158Met polymorphism may be related to the intelligence of Chinese girls.
18182829 Observational study of gene-disease association. (HuGE Navigator)
18180754 Meta-analysis shows a protective effect against antipsychotic-induced tardive dyskinesia for Val158Met heterozygotes and Met carriers.
18180754 Meta-analysis of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18178571 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18164902 our data suggest that the four analyzed genes do not play an important role in susceptibility to schizophrenia.
18164902 Observational study of gene-disease association. (HuGE Navigator)
18163391 Observational study of gene-disease association. (HuGE Navigator)
18163386 There is a highly significant association between a haplotype of two functional SNPs and aggressive behavior in schizophrenia.
18163386 Observational study of gene-disease association. (HuGE Navigator)
18160646 Observational study of gene-disease association. (HuGE Navigator)
18160646 Genotype at the Val158Met polymorphism of the catechol-O-methyltransferase gene predicts both impulsive choice behavior and activity levels in the dPFC and PPC during decision making.
18094258 Observational study of gene-disease association. (HuGE Navigator)
18094258 Polymorphism of catechol-O-methyltransferase affects dopaminergic functioning in the prefrontal cortex in this study on neurophysiological correlates of performance monitoring.
18092319 Val158Met genotype of catechol-O-methyltransferase may have a role in the etiological model for schizophrenia and other psychotic disorders.
18092319 Observational study of gene-disease association. (HuGE Navigator)
18081002 haplotype analysis with all COMT SNPs (rs737865-rs4680-rs165599) showed that the T-A-G haplotype was associated with lower loudness dependence of auditory evoked potentials (LDAEP) scores
18081002 Observational study of gene-disease association. (HuGE Navigator)
18075475 Observational study of gene-disease association. (HuGE Navigator)
18075475 Role of COMT in modulating aggressive behavior, and are extended to people with personality disorders.
18064318 Observational study of gene-disease association. (HuGE Navigator)
18064318 COMT rs4680 variant modulates total plasma homocysteine, and might be associated with venous thrombosis risk as well.
18063308 Observational study of gene-disease association. (HuGE Navigator)
18057197 In working memory, COMT genotype can be used as a genetic marker for differential dopaminergic modulation of neural circuitry.
18046978 Polymorphisms of genes MAO-A and COMT were described in relation to their expression altered activity; influence on cognitive functions, affective and anxiety disorders, learning disabilities, aggressive behaviour, eating disorders or gender differences.
18045777 Variation in COMT is implicated as risk factor for schizophrenia.
18037454 Results show that the COMT gene (rs4818 C/G) polymorphism imparts strong and differential effects on cognition and prefrontal cortex functions.
18037454 Observational study of gene-disease association. (HuGE Navigator)
18037170 Findings do not support the hypothesis that two of the most prominent dopaminergic candidate loci (DRD2 Taq Ia and COMT Val158Met) effect prepulse inhibition the study does not exclude the relevance of the dopaminergic system in general.
18023073 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17994190 Results do not support the hypothesis that common variants in the COMT genes is associated with ADHD.
17994190 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
17980711 Report investigated the effects of val108met polymorphism on protein turnover in human cells and show that the half-life of S-COMT L compared to S-COMT H protein was significantly shorter at 3.0 days.
17978319 There was no evidence of association between schizophrenia and CNR1 (OR=0.97, 95% CI 0.82-1.13) or CHRNA7 (OR=1.07, 95% CI 0.77-1.49) genotypes, or of interactions between tobacco use and CHRNA7, or cannabis use and CNR1or COMT genotypes.
17978319 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17973921 In parents with the combination of genes leading to the least efficient dopaminergic system functioning (COMT val/val or val/met, DRD4-7Repeat), more daily hassles were associated with less sensitive parenting.
17973921 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17962094 COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men
17962094 Observational study of gene-disease association. (HuGE Navigator)
17961261 In Spanish fibromyalgia patients there was a significant association between three single nucleotide polymorphisms and the presence of disease compared to healthy controls.
17949513 This study demonstrated the association of a particular COMT haplotype with susceptibility to both ADHD and OCD in 22q11.2DS.
17949513 Observational study of gene-disease association. (HuGE Navigator)
17948281 The COMT Met allele may be associated with deficits in schizophrenia that are unrelated to neural systems supporting sustained attention or working memory.
17948281 Observational study of gene-disease association. (HuGE Navigator)
17945417 Observational study of gene-disease association. (HuGE Navigator)
17945417 These results suggest that the Val/Met polymorphism of the COMT gene may play a role in HA in Japanese population.
17944104 5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow.
17941097 Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression.
17931436 Genotypes and haplotypes of four single nucleotide polymorphisms in COMT were investigated in 179 incarcerated adolescent delinquents.
17931436 Observational study of gene-disease association. (HuGE Navigator)
17928119 Observational study of gene-disease association. (HuGE Navigator)
17924258 Role of COMT in schizophrenia pathogenesis, and associations between COMT and cognitive and behavioral correlates of schizophrenia and related disorders. [REVIEW]
17909067 Observational study of gene-disease association. (HuGE Navigator)
17893706 Observational study of gene-disease association. (HuGE Navigator)
17885625 Observational study of gene-disease association. (HuGE Navigator)
17885625 This study may suggest a role of the COMT Val158Met polymorphism in smoking behavior in Japanese individuals.
17869399 COMT Val/Met polymorphism was not associated with suicide in bipolar patient.
17869399 Observational study of gene-disease association. (HuGE Navigator)
17850881 Observational study of gene-disease association. (HuGE Navigator)
17850222 Observational study of gene-disease association. (HuGE Navigator)
17850222 No evidence supports an association between alcohol dependence or habitual smoking and variation in catechol-O-methyltransferase.
17767149 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17763983 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17763983 relationship between the DRD4 and COMT genes and different aspects of executive functions and the absence of such a relationship in relation to verbal memory.
17761405 Observational study of gene-disease association. (HuGE Navigator)
17760745 Observational study of gene-disease association. (HuGE Navigator)
17760745 Val158Met polymorphism not associated with the risk of sporadic or latent prostate cancer in Japanese
17728665 Meta-analysis of gene-disease association. (HuGE Navigator)
17728665 No conclusive evidence showing that 472G/A polymorphism in this enzyme is a reliable marker for panic disorder.
17718510 The secretory pro-hormone chromogranin A (CHGA) is densely packed into storage granules along with catecholamines, playing a catalytic role in granule biogenesis.
17716874 The COMT 324AA genotype was not associated with an increased risk of schizophrenia.
17716874 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17707921 the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing.
17707347 Observational study of gene-disease association. (HuGE Navigator)
17707347 This study confirmed the findings of a val(108/158)met effect on WM function, and suggest that combinations of alleles within COMT may modulate the val(108/158)met effect in a nonlinear manner.
17706335 Observational study of gene-disease association. (HuGE Navigator)
17706335 genetic variations of COMT can contribute to the enlargement of the lateral ventricles described in early phases of non-affective psychosis
17704407 Observational study of gene-disease association. (HuGE Navigator)
17700596 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17689985 Observational study of gene-disease association. (HuGE Navigator)
17689985 our results support a role of COMT variable number of tandem repeat in both brain activation and cognition
17687265 Ability to experience reward increased with the number of COMT 'Met' alleles of the subject, and this differential effect of genotype was greater for events that were experienced as more pleasant.
17687265 Observational study of gene-disease association. (HuGE Navigator)
17686583 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17682677 Observational study of gene-disease association. (HuGE Navigator)
17682677 The results suggest that the COMT polymorphism may not be linked with appearance and development of endometrial cancer.
17657431 Observational study of gene-disease association. (HuGE Navigator)
17657431 Studies of 130 subjects showed that carriers of the Met/Met genotype of the COMT gene had a greater intensity of the novelty-seeking trait than carriers of the Val/Val and Val/Met genotypes, though this association was seen only in women.
17640440 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17640440 Finds the COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms.
17636223 Observational study of gene-disease association. (HuGE Navigator)
17636223 No associations between fibroids and Val158Met were observed among African American or white participants. This study suggests that variation in this polymorphism alone does not affect fibroid prevalence.
17636131 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17636131 extend putative brain dopaminergic and glutamatergic relationships indexed by COMT and glutamate receptor metabotropic 3 to a systems-level interaction in human cortical circuits implicated in working memory dysfunction such as in schizophrenia
17627014 Observational study of gene-disease association. (HuGE Navigator)
17612537 COMT overexpression with subsequent increased level of 2-ME2 may lead to ovulatory dysfunction.
17608961 Findings support the involvement of the COMT Val158Met polymorphism in mediating the relationship between trauma and psychopathology.
17606708 Observational study of gene-disease association. (HuGE Navigator)
17606708 Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms have roles in development of Lynch syndrome colon cancer
17604122 Observational study of gene-disease association. (HuGE Navigator)
17604122 ]. We conclude that SNP Val158Met (rs4680) in the COMT gene may be associated with some schizotypal traits in male subjects, but our results are not conclusive.
17602170 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17601704 Observational study of gene-disease association. (HuGE Navigator)
17601704 Catechol O-methyltransferase Val158Met polymorphism is not associated with broad-based cognitive functioning in schizophrenia.
17599809 Observational study of gene-disease association. (HuGE Navigator)
17599809 Intron 4 SNPs in estrogen receptor alpha were significantly associated with premenstrual dysphoric disorder only in those individuals with a Val/Val COMT genotype; patient groups with Val/Met or Met/Met genotypes were not associated.
17588591 In this work, a new approach was employed for the purification of recombinant human soluble COMT (hSCOMT) using hydrophobic interaction chromatography, as the main isolation method, from an Escherichia coli culture broth.
17588204 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17577421 Observational study of gene-disease association. (HuGE Navigator)
17577421 During 10 year of follow-up, the catechol-O-methyltransferase Val158Met polymorphism had no impact on survival in a general population
17573783 Leukocyte exposure to morphine down-regulated catechol-O-methyl transferase (COMT) and CYP2D6 by approximately 50% compared with control values.
17562079 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17562079 polymorphism of genes involving estrogen-metabolizing pathway, estrogen- biosynthesizing pathway and estrogen receptor pathway may play an important role in the etiology of BRCA1/2 negative breast cancer with hereditary predisposing factors.
17548664 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17548664 COMT genotype may moderate the effect of active transdermal nicotine patch compared with placebo
17548151 Observational study of gene-disease association. (HuGE Navigator)
17548151 This study adds to the evidence that the Val/Val polymorphism has a detrimental effect on cognition, extending upwards the age range in which such an effect has been detected.
17547583 Observational study of gene-disease association. (HuGE Navigator)
17526059 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17525974 catechol-O-methyltransferase (Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms.
17525974 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17525973 a relationship between suicidal behavior and COMT, and the relationship differs for males and females (Meta-Analysis)
17525973 Meta-analysis of gene-disease association. (HuGE Navigator)
17522626 A potentially beneficial effect of an antidepressive add-on therapy with substances increasing dopamine availability individually tailored according to COMT val158met genotype.
17522626 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17521892 Observational study of gene-disease association. (HuGE Navigator)
17521892 After controlling for demographics, Val158 allele homozygotes exhibited significantly smaller temporal lobe and hippocampal volumes, with a trend for smaller amygdala volumes
17517149 Observational study of gene-disease association. (HuGE Navigator)
17517149 This study provides evidence for a possible influence of the COMT polymorphism on emotion recognition abilities in healthy subjects.
17516763 Observational study of gene-disease association. (HuGE Navigator)
17510945 Catechol-O-methyltransferase polymorphism resulting in high activity genotype is associated with suicide attempters
17507624 Observational study of gene-disease association. (HuGE Navigator)
17507616 These results support the hypothesis that the formation and accumulation of catechol estrogens in breast tissue through increased CYP1B1 expression and reduced COMT expression may play a significant role in breast cancer risk.
17504906 Observational study of gene-disease association. (HuGE Navigator)
17504906 COMT Val158Met polymorphism is associated with fracture risk in elderly men
17504250 there was a double-recessive interaction effect in which the odds of reporting persisting generalized anxiety were more than twofold reduced among carriers homozygous for both the COMT Met(158) and the 5HTTLPR Short alleles
17504246 Our results suggest that genetic variation in COMT and PRODH has significant effects on brain regions known to be affected in schizophrenia.
17504246 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17497175 COMT may be an important molecular target to evaluate for new treatments regarding obesity.
17497175 Observational study of gene-disease association. (HuGE Navigator)
17493297 Observational study of gene-disease association. (HuGE Navigator)
17483451 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17482701 Observational study of gene-disease association. (HuGE Navigator)
17482701 The present study shows that these five functional COMT polymorphisms do not play a major role in conferring susceptibility to schizophrenia in Japanese.
17477346 results demonstrate multiple COMT mRNAs in brain, revealing an additional complexity to the biology of COMT. The alternate gene products may be of significant functional importance, and differentially impacted by polymorphisms within the COMT gene
17475791 Catechol O-methyltransferase genotype impacts on executive function in Parkinson Disease patients through directly influencing frontoparietal activation.
17466074 Observational study of gene-disease association, gene-gene interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17453062 Observational study of gene-disease association. (HuGE Navigator)
17453062 The effects of COMT on the release of adrenocorticotrophin hormone depend on the presence of the low-expression MAOA variant in the same individual.
17451372 Observational study of gene-disease association. (HuGE Navigator)
17451372 catechol-O-methyltransferase val158met polymorphism modulates the association between physical activity, Areal BMD, and trabecular volumetric BMD
17448448 Observational study of gene-disease association. (HuGE Navigator)
17448448 COMT Is a genetic determinant of the auditory P50 paired-click gating paradigm endophenotype
17442488 Observational study of gene-disease association. (HuGE Navigator)
17442488 The results of this study suggest a positive association between the genetic variants of the COMT gene and MR in the Chinese Han population in the Qinba region.
17442187 Observational study of gene-disease association. (HuGE Navigator)
17429315 Observational study of gene-disease association. (HuGE Navigator)
17427186 study was unable to replicate previous report of an association of COMT polymorphisms and schizophrenia in a Chinese Han population
17419009 COMT gene is probably not "a gene for" any mental disorder, but the Val158Met polymorphism appears to have pleiotropic effects on human behavior (Review)
17417063 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17417063 Possible role for catechol-o-methyltransferase polymorphism in the response to psychological stress and susceptibility in major depression disorder.
17407801 Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli.
17385677 Observational study of gene-disease association. (HuGE Navigator)
17383818 Clinical trial of gene-environment interaction. (HuGE Navigator)
17383818 COMT polymorphism influences individual capacity to recover from cognitive deficit through rehabilitation therapy after a wider intervention also including deficit-specific cognitive exercise as a potentiating tool.
17372243 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17372239 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17363961 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17363961 Show an influence of the Val 158 Met polymorphism on the severity of psychotic symptoms in schizophrenia spectrum disorders and on the response to treatment.
17363580 Observational study of gene-disease association. (HuGE Navigator)
17357147 Meta-analysis of gene-disease association. (HuGE Navigator)
17357147 The present meta-analysis provides tentative support for the COMT val158met polymorphism as a possible risk factor for panic disorder, with differential effects in Caucasian and Asian populations, and suggests a female-specific effect
17337160 Observational study of genotype prevalence and genetic testing. (HuGE Navigator)
17325717 Meta-analysis of gene-disease association. (HuGE Navigator)
17325717 This meta-analysis concludes that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia.
17309660 Relative hand skill was significantly associated with a functional variant in the catechol-O-methyltransferase gene. Authors speculate that this polymorphism may influence brain lateralization.
17301257 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17299513 Observational study of gene-disease association. (HuGE Navigator)
17299513 High COMT enzyme activity associated with the Val allele predisposes to high sensation seeking scores in female subjects and add to increasing evidence for a gender specific role of COMT in normal and dysfunctional behavior.
17295924 Observational study of gene-disease association. (HuGE Navigator)
17270484 Observational study of gene-disease association. (HuGE Navigator)
17266899 Observational study of gene-disease association. (HuGE Navigator)
17264883 Data suggest that the functional COMT Val158Met polymorphism is associated with increased risk of acute coronary events and it may interact with high serum tHcy levels.
17264883 Observational study of gene-disease association. (HuGE Navigator)
17264842 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
17264842 The study replicated reports of an increased met(158) allele frequency in men with OCD, with no effect in women. The finding also extends the evidence for sexual dimorphism in COMT and in OCD.
17220335 Observational study of gene-disease association. (HuGE Navigator)
17217814 Observational study of gene-disease association. (HuGE Navigator)
17217235 Observational study of gene-disease association. (HuGE Navigator)
17211439 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17208375 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17206495 Observational study of gene-disease association. (HuGE Navigator)
17205121 Heavy coffee consumption increases the incidence of acute coronary events in men with low but not high COMT activity.
17205121 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17202556 Observational study of gene-disease association. (HuGE Navigator)
17198907 Observational study of gene-disease association. (HuGE Navigator)
17198907 The Val/Val genotype at codon 158 appears to be associated with a higher prevalence of increased systolic blood pressure.
17187009 Observational study of gene-disease association. (HuGE Navigator)
17187009 The Met allele of the COMT gene Val158Met polymorphism is associated with low COMT enzyme activity and high endogenous dopamine synaptic levels in the prefrontal cortex. This leads to a decrease in dopaminergic neurotransmission in nucleus accumbens.
17185601 the major COMT haplotypes varied with respect to messenger RNA local stem-loop structures, such that the most stable structure was associated with the lowest protein levels and enzymatic activity
17176215 Observational study of gene-disease association. (HuGE Navigator)
17173666 Observational study of gene-disease association. (HuGE Navigator)
17156920 Observational study of gene-disease association, gene-gene interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17156920 Polymorphisms in genes coding for the mu-opioid receptor (A118G) and catechol-O-methyl transferase (Val158Met) may be important modulators of opioid efficacy
17146014 Observational study of gene-disease association. (HuGE Navigator)
17143180 Observational study of gene-disease association. (HuGE Navigator)
17135598 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17123785 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17123481 COMT genotype modulated the relation between the negative schizotypal phenotype and cognitive performance.
17113268 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17113268 an interaction of the dopamine receptor D2 C957T and COMT Val158Met may be involved in the generation of some working memory deficits in schizophrenia
17109713 Observational study of gene-disease association. (HuGE Navigator)
17106420 Observational study of gene-disease association. (HuGE Navigator)
17079080 Observational study of gene-disease association. (HuGE Navigator)
17077994 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17077994 SHBG, but not CYP17, CYP1B1, or COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors
17075359 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17071544 Observational study of gene-disease association. (HuGE Navigator)
17063156 This study demonstrates enhancement of prefrontal cortical function in normal human subjects with a nonstimulant drug having COMT inhibitory activity.
17047485 Observational study of gene-disease association. (HuGE Navigator)
17044099 Observational study of gene-disease association. (HuGE Navigator)
17044099 The present study suggests that dopamine candidate genes are associated with increased vulnerability to ADHD in the Han Chinese population.
17034018 Observational study of gene-disease association. (HuGE Navigator)
17034018 functional COMT polymorphism could be involved in different psychotic dimensions
17029783 Observational study of gene-disease association. (HuGE Navigator)
17029783 These findings suggest that gender may be an important variable in consideration of the impact of COMT on cognition.
17028449 Observational study of gene-disease association. (HuGE Navigator)
17028449 This study suggest that a turnover of catecholamines, connected with polymorphism determining high activity of COMT enzyme, is connected with the risk of ED occurrence, particularly anorexia nervosa.
17025189 Observational study of gene-disease association. (HuGE Navigator)
17018638 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17018638 Our data do not support a substantial overall association between COMT haplotypes and breast cancer. The suggestion of increased risk associated with a haplotype in the 3' UTR of COMT needs to be confirmed.
17016617 Observational study of gene-disease association. (HuGE Navigator)
17014828 Observational study of gene-disease association. (HuGE Navigator)
17014828 COMT genotype modulated working memory, attention, fine motor coordination.
17014827 Observational study of gene-disease association. (HuGE Navigator)
17014827 the COMT Val allele is associated with an increased risk of schizophrenia in subjects at increased familial risk, in whom it has demonstrable effects on prefrontal brain structure and function
17006672 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17006672 epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes
16985250 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16984965 These studies are the first to reveal that the membrane bound-COMT promoter DNA is frequently hypomethylated in schizophrenia and bipolar disorder patients, compared with the controls, particularly in the left frontal lobes.
16971197 Observational study of gene-disease association. (HuGE Navigator)
16969494 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16969277 Observational study of gene-disease association. (HuGE Navigator)
16969276 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16969275 Observational study of gene-disease association. (HuGE Navigator)
16969269 Observational study of gene-disease association. (HuGE Navigator)
16956909 Observational study of gene-disease association. (HuGE Navigator)
16950222 Observational study of gene-disease association. (HuGE Navigator)
16950222 The COMT Val allele was associated with: relatively poorer performance at retrieval; reduced recruitment of neuronal resources in HF and increased recruitment in VLPFC during both encoding and retrieval.
16939639 Observational study of gene-disease association. (HuGE Navigator)
16939639 Data showed shorter N170 latency associated with the presence of 1-2 catechol-O-methyltransferase met158 alleles, and family-based association tests confirmed the association
16936704 Observational study of gene-environment interaction. (HuGE Navigator)
16936704 Experimental effects of Delta-9-THC on cognition and psychosis are moderated by COMT Val(158)Met genotype, but the effects may in part be conditional on the additional presence of pre-existing psychosis liability.
16930369 Observational study of gene-disease association. (HuGE Navigator)
16921721 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16921496 Observational study of gene-disease association. (HuGE Navigator)
16917939 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16905560 Observational study of gene-disease association. (HuGE Navigator)
16905560 RGS4 mRNA was inversely correlated with COMT enzyme activity in the dorsolateral prefrontal cortex
16899231 The present finding are in line with a limited effect size of the Val/Met variant in schizophrenia both in Asians and in Europeans.
16897602 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16896040 Observational study of gene-disease association. (HuGE Navigator)
16884927 Observational study of gene-disease association. (HuGE Navigator)
16876132 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16876132 COMT haplotypes at rs737865 and rs165599 may predict a favorable outcome for bupropion treatment for smoking cessation.
16869230 The COMT val158met polymorphism correlated positively with activity in control- and task-related regions during performance under emotional distraction.
16865041 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16860541 Observational study of gene-disease association. (HuGE Navigator)
16857316 Observational study of gene-disease association. (HuGE Navigator)
16850246 Observational study of gene-disease association. (HuGE Navigator)
16848906 Observational study of gene-disease association. (HuGE Navigator)
16837133 Observational study of gene-disease association. (HuGE Navigator)
16837108 Observational study of gene-disease association. (HuGE Navigator)
16837108 The present findings provide evidence of COMT genetic variations' role in the susceptibility to AD-related psychosis.
16829779 Observational study of gene-disease association. (HuGE Navigator)
16829779 Allele frequency of catechol-O-methyl transferase is associated with patients who experienced methamphetamine psychosis and spontaneous relapse.
16828262 Observational study of gene-disease association. (HuGE Navigator)
16823382 Observational study of gene-disease association. (HuGE Navigator)
16816940 Observational study of genotype prevalence. (HuGE Navigator)
16815691 Observational study of gene-disease association. (HuGE Navigator)
16800379 Observational study of gene-disease association. (HuGE Navigator)
16786032 In normal subjects, there is a functional Val158Met and a single-nucleotide polymorphism which predicts inefficient prefrontal working memory response.
16780746 Observational study of gene-disease association. (HuGE Navigator)
16756688 Observational study of gene-disease association. (HuGE Navigator)
16756688 COMT genetotype was risk factor for onset of both major depression and bipolar disorder, in conjunction with adversities.
16741933 Observational study of gene-disease association. (HuGE Navigator)
16734939 Observational study of gene-disease association. (HuGE Navigator)
16734939 main finding of this study is that velocardiofacial syndrome subjects who suffer from either ADHD or OCD have significantly higher frequency of the low-activity COMT allele compared with those who are not affected
16730930 Observational study of genotype prevalence. (HuGE Navigator)
16730334 Observational study of gene-disease association. (HuGE Navigator)
16730334 The val(108/158)met genotype(COMT) was significantly associated with prefrontal "noise"; homozygous Val-carriers had greatest prefrontal "noise" values.
16725119 Observational study of gene-disease association. (HuGE Navigator)
16712949 Observational study of gene-disease association. (HuGE Navigator)
16698101 Observational study of gene-disease association. (HuGE Navigator)
16691129 Observational study of gene-disease association. (HuGE Navigator)
16691129 The COMT genotype may contribute to the deficit in prefrontal-dependent memory processes in SPD as it does in schizophrenia.
16688411 Observational study of gene-disease association. (HuGE Navigator)
16679343 Observational study of gene-disease association. (HuGE Navigator)
16676224 Meta-analysis of gene-disease association. (HuGE Navigator)
16676224 No significant association was present between the most common COMT gene polymorphism and the catechol-O-methyltransferase gene.
16674809 Observational study of gene-disease association. (HuGE Navigator)
16674809 No significant association was found between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints.
16674552 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16672066 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16648777 Observational study of gene-disease association. (HuGE Navigator)
16623937 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16611807 Subjects homozygous for the COMT Met allele and the dopamine transporter(DAT) 10-repeat allele have the most focused response, whereas the COMT Val and the DAT 9-repeat alleles have the least.
16610957 Observational study of gene-disease association. (HuGE Navigator)
16608396 Observational study of gene-disease association. (HuGE Navigator)
16596327 Observational study of gene-disease association. (HuGE Navigator)
16595228 Observational study of gene-disease association. (HuGE Navigator)
16595228 Carriage of the ESR1 IVS1-397 T/C (PvuII), COMT G158A, and the CYP17A 34T-->C SNPs is not associated with the susceptibility to uterine leiomyoma in a Caucasian population.
16584839 Observational study of gene-disease association. (HuGE Navigator)
16584839 These results suggest that genetic variants of the COMT Val158Met gene may play a role in HA in Korean females but not in males.
16582043 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
16569655 Observational study of gene-disease association. (HuGE Navigator)
16564429 Observational study of gene-disease association. (HuGE Navigator)
16542735 Observational study of gene-disease association. (HuGE Navigator)
16542388 Observational study of gene-disease association. (HuGE Navigator)
16542182 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16538182 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16527884 Observational study of gene-disease association. (HuGE Navigator)
16527884 COMT, but not CYP1A1 or CYP17, appears to have roles in adenomyosis and endometriosis
16525418 Observational study of gene-disease association. (HuGE Navigator)
16525418 These results support the hypothesis that the valine allele of the Val158Met COMT polymorphism or a nearby locus is involved in the etiopathogenesis of panic disorder.
16511839 Data suggest that this functional COMT polymorphism may play a gender-moderated role in determining the neuroanatomic phenotype of individuals with velo-cardio-facial syndrome.
16505837 In this review, current state of evidence and the implications both for further studies of COMT and more generally for studies of other genes are considered.
16499480 Observational study of gene-disease association. (HuGE Navigator)
16492910 Observational study of gene-disease association. (HuGE Navigator)
16490416 Pharmacological manipulations of COMT val(108/158)met have reliably produced alterations in cognitive function. (review)
16483362 The expression of COMT does not appear to be altered in the cerebellum of individuals suffering from schizophrenia, bipolar disorder or depression, but does appear to be influenced by single nucleotide polymorphisms within the gene.
16476412 COMT is a promising therapeutic target for ameliorating the cognitive deficits associated with schizophrenia--{REVIEW}
16475806 simulations indicated that replacing valine with the larger methionine residue led to greater solvent exposure of residue 108 and heightened packing interactions between M108 and helices alpha2, alpha4 (especially with R78), and alpha5.
16453988 Observational study of gene-disease association. (HuGE Navigator)
16443508 Observational study of gene-disease association. (HuGE Navigator)
16443508 high-activity Catechol-O-methyltransferase (COMT) Val/Val genotype is associated with increased risk of Uterine leiomyomas
16427255 Observational study of gene-disease association. (HuGE Navigator)
16427255 There was a trend to a low-activity catechol-O-methyl-transferase allele in male obsessive-compulsive disorder patients compared to male controls.
16424823 Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16424823 DRD4 and COMT gene polymorphisms may have a role in genetic susceptibility to tardive dyskinesia among schizophrenia subjects
16417624 Observational study of gene-environment interaction. (HuGE Navigator)
16414251 Observational study of gene-disease association. (HuGE Navigator)
16406650 PGJ2 treatment reduced the expression and activity of COMT, induced its sequestration into perinuclear aggregates and potentiated dopamine toxicity.
16395295 Observational study of gene-disease association. (HuGE Navigator)
16387984 Observational study of gene-disease association. (HuGE Navigator)
16362639 Genetic analysis revealed an association between the VAL allele of COMT and the inattention scale, the hyperactivity/impulsivity scale, and the total ASRS scale,with highest scores in carriers of the MET/MET genotype.
16361958 Observational study of gene-disease association. (HuGE Navigator)
16361958 COMTL allele was related with increased tonic dopamine activity and cognitive 'stability', which may induce cognitive inflexibility in schizophrenia.
16360899 Observational study of gene-disease association. (HuGE Navigator)
16356553 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16330500 Observational study of gene-disease association. (HuGE Navigator)
16284375 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16281377 Observational study of gene-disease association. (HuGE Navigator)
16275815 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16260521 Observational study of gene-disease association. (HuGE Navigator)
16257094 Observational study of gene-disease association. (HuGE Navigator)
16257094 Modeling Neuropsychiatric Inventory symptom-endophenotype-genotype relationships, & taking into account possible confounds by latent variable models, COMT & 5-HTTLPR genetic variation correlated with frontal & psychosis endophenotypes in Alzheimer disease
16247488 A 39 kDa isoform of membrane-bound COMT was isolated, which may be differentially regulated in psychiatric disorders.
16234808 Observational study of gene-disease association. (HuGE Navigator)
16234808 This study identified the catechol-O-methyltransferase low-activity allele (COMT(L)) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of psychotic symptoms during adolescence.
16233957 Observational study of gene-disease association. (HuGE Navigator)
16231731 Observational study of gene-disease association. (HuGE Navigator)
16231731 Transmission disequilibrium test and the haplotype analysis suggested that there was no association between ADHD and the COMT gene in the Chinese population.
16214922 Observational study of gene-disease association. (HuGE Navigator)
16202920 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16191465 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16142442 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16142442 No association found between COMT polymorphism and breast cancer in older white women
16135635 Observational study of gene-disease association. (HuGE Navigator)
16130011 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16127282 Observational study of gene-disease association. (HuGE Navigator)
16126332 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16118784 Observational study of gene-disease association. (HuGE Navigator)
16118784 Risk and protective haplotypes may carry molecular variations in the COMT gene or its vicinity that are relevant to the pathophysiology of restrictive anorexia nervosa in the Israeli-Jewish population.
16109444 Observational study of gene-disease association. (HuGE Navigator)
16103451 Observational study of gene-disease association. (HuGE Navigator)
16102234 Observational study of gene-disease association. (HuGE Navigator)
16102234 The Catechol O-methyltransferase Val158Met polymorphism is associated with cognitive performance in nondemented adults.
16094249 Observational study of gene-disease association. (HuGE Navigator)
16092759 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16077979 Observational study of gene-disease association. (HuGE Navigator)
16077979 Results suggest that COMT polymorphism may be implicated as a genetic trait affecting the susceptibility to breast cancer in a Japanese population and be an important genetic risk factor in the development of breast cancer in post-menopausal women.
16043283 Observational study of gene-disease association. (HuGE Navigator)
16043283 These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated with liability to schizophrenia-obssessive compulsive disorder.
16043133 Observational study of gene-disease association. (HuGE Navigator)
16040257 mechanisms other than an enkephalin-dependent receptor turnover must be responsible for COMT-related differences in mu receptor binding site availability in the human brain
16037677 Observational study of gene-disease association. (HuGE Navigator)
16037677 These results support the hypothesis that the COMT Val(158)Met polymorphism influences executive functions in schizophrenia and the neuromotor performance in the deficit subtype only.
16027741 Observational study of gene-disease association. (HuGE Navigator)
16027741 COMT genetic variation is associated with risk of psychosis in Alzheimer's disease
16026865 This study investigated two dopaminergic candidate genes (COMT VAL158MET and DRD2 TAQ IA) for endophenotypes of cognitive functioning. Results showed associations of the COMT gene with attention and with time estimation.
16006997 Observational study of gene-disease association. (HuGE Navigator)
15987428 Clinical trial of gene-disease association. (HuGE Navigator)
15985686 Observational study of gene-disease association. (HuGE Navigator)
15985686 the COMT(LL) genotype results in increased free estradiol levels and earlier pubertal development
15979789 Observational study of gene-disease association. (HuGE Navigator)
15979789 This study suggested that COMT genotype may contribute to differences in normal cognitive aging and to differences in some of the major personality traits in old age.
15973162 Observational study of gene-disease association. (HuGE Navigator)
15965969 Observational study of gene-disease association. (HuGE Navigator)
15965967 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15965967 Study suggests that the status the functional COMT(L) variant may be potentially useful to select PD patients for high dose pyridoxine therapy.
15956988 Observational study of gene-disease association. (HuGE Navigator)
15956988 The val158met polymorphism of COMT would be associated with both high neuroticism and low extraversion, making it a plausible candidate locus for anxiety susceptibility.
15941966 Observational study of gene-disease association. (HuGE Navigator)
15941945 Observational study and clinical trial of gene-disease association. (HuGE Navigator)
15936529 Observational study of gene-disease association. (HuGE Navigator)
15935994 Observational study of gene-disease association. (HuGE Navigator)
15927391 Observational study of gene-disease association. (HuGE Navigator)
15927391 These results suggest that genetic variation in the COMT gene may contribute to variability in the efficacy of morphine in cancer pain treatment
15901995 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
15901785 Effect of catechol-O-methyltransferase val158met genotype on attentional control.
15900232 Observational study of gene-disease association. (HuGE Navigator)
15900232 Catechol-O-methyltransferase gene polymorphism is not associated with the development of alcohol dependence, but may affect the susceptibility to a clinical heterogeneity of alcohol dependence in the Korean population.
15900225 Observational study of gene-disease association. (HuGE Navigator)
15900225 These data replicate previous findings suggesting association between the ValMet polymorphism and specific expressions of anxiety among females.
15900212 Observational study and clinical trial of gene-disease association. (HuGE Navigator)
15896265 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
15866551 Observational study of gene-environment interaction. (HuGE Navigator)
15862471 Observational study of gene-disease association. (HuGE Navigator)
15852364 Observational study of gene-disease association. (HuGE Navigator)
15846854 Observational study of gene-disease association. (HuGE Navigator)
15824744 Meta-analysis of gene-disease association. (HuGE Navigator)
15824744 The results of this meta-analysis do not support an association between the COMT Val allele and schizophrenia case status.
15774541 Observational study of gene-disease association. (HuGE Navigator)
15753616 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15747357 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15734954 Observational study and meta-analysis of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
15717291 Observational study of gene-disease association. (HuGE Navigator)
15673663 Observational study of gene-disease association. (HuGE Navigator)
15673663 COMT genotype had no significant impact on brain activation by pleasant stimuli but was related to the neural response to unpleasant stimuli.
15668720 Observational study of gene-disease association. (HuGE Navigator)
15668720 these findings do not support a major role for COMT in increasing susceptibility for schizophrenia or in mediating frontal lobe function
15668497 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
15654584 the slower clearance of dopamine associated with the methionine variant of the COMT gene polymorphism may be disadvantageous to cognition in attention deficit disorder with hyperactivity
15654505 Observational study of gene-disease association. (HuGE Navigator)
15652872 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
15652872 No statistically significant differences were found in allele or genotype frequencies between patient and normal control subjects, although a nonsignificant overrepresentation of the Val allele in schizophrenia patients was suggested.
15645182 Observational study of gene-disease association. (HuGE Navigator)
15626819 Observational study of gene-disease association. (HuGE Navigator)
15626819 This study did not provide evidence supporting an association between BDNF and COMT genes and declarative memory phenotypes.
15613245 Observational study of gene-disease association. (HuGE Navigator)
15596044 Up-regulation of catechol O-Methyltransferase is associated with bladder cancer
15591802 Observational study of gene-disease association. (HuGE Navigator)
15584875 COMT (Val158Met) leads to neurobiology differences in executive cognitive function, stress/anxiety response, and opioid function that increase susceptibility to alcoholism.
15583953 Observational study of gene-disease association. (HuGE Navigator)
15583702 Observational study of gene-disease association. (HuGE Navigator)
15583702 An association was found between the high-activity COMT Val allele, particularly the COMT Val/Val genotype and early-onset major depressive disorder.
15572182 Observational study of gene-disease association. (HuGE Navigator)
15570503 Observational study of genotype prevalence. (HuGE Navigator)
15569909 Observational study of gene-disease association. (HuGE Navigator)
15567073 Observational study of gene-disease association. (HuGE Navigator)
15548428 Observational study of gene-disease association. (HuGE Navigator)
15538046 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15537663 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
15537444 Observational study of gene-disease association. (HuGE Navigator)
15537444 the COMT val158met polymorphism is associated with peak BMD in young adult men
15522252 Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15522252 Patients homozygous for the COMT met allele displayed significant improvement on the working memory task after treatment.
15520843 Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15505638 Results indicate the Val/Met polymorphism is not disease-causing and is simply in strong linkage disequilibrium with a causative effect, which interacts with another as yet unidentified variant approximately 20 kb away.
15488308 Observational study of gene-disease association. (HuGE Navigator)
15488308 COMT polymorphism influences on the risk of psychosis since the early stages, and claims for the possibility to identify distinct phenotypes on genetic basis among AD patients.
15465976 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
15457497 Observational study of gene-disease associa