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Tbio COMM domain-containing protein 7

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).

 Comments

Property Summary

NCBI Gene PubMed Count 17
PubMed Score 9.82
PubTator Score 2.78

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
osteosarcoma 7950 1.0e-04
ovarian cancer 8520 2.4e-03
Disease Target Count Z-score Confidence
Acute chest syndrome 9 3.402 1.7
hepatocellular carcinoma 547 3.102 1.6

Expression

  Differential Expression (2)

Disease log2 FC p
osteosarcoma 1.090 1.0e-04
ovarian cancer 1.100 2.4e-03

Synonym

Accession Q86VX2 A2BHJ2 B3KTZ2 Q5JYB0 Q96SI7 Q9BW53
Symbols C20orf92
dJ1085F17.3

Gene

COMMD7

  Ortholog (10)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (7)

 GO Function (1)

 GO Component (3)

 GO Process (4)

 Compartment GO Term (15)

 GWAS Trait (3)

 HCA RNA Cell Line (56)

See all...

Pathway (3)

Gene RIF (7)

AA Sequence 

MGRLHCTEDPVPEAVGGDMQQLNQLGAQQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRS      1 - 70
IVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWK     71 - 140
FGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECFC              141 - 200
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Text Mined References (21)

PMID Year Title