Property Summary

NCBI Gene PubMed Count 15
PubMed Score 7.41
PubTator Score 4.12

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
cystic fibrosis 1670 1.1e-05
ovarian cancer 8491 7.5e-05
pancreatic cancer 2300 2.3e-03
primary pancreatic ductal adenocarcinoma 1271 5.5e-03
Disease Target Count Z-score Confidence
Hypertension 293 3.056 1.5

Expression

  Differential Expression (4)

Disease log2 FC p
cystic fibrosis 1.278 1.1e-05
primary pancreatic ductal adenocarcinoma 1.011 5.5e-03
ovarian cancer 1.600 7.5e-05
pancreatic cancer 1.200 2.3e-03

Gene RIF (5)

PMID Text
24515317 the hypertension-related, calcium-regulated gene (HCaRG/COMMD5) is involved in renal repair.
21921141 HCaRG accelerates repair of renal proximal tubules by modulating cell proliferation of resident tubular epithelial cells and by facilitating redifferentiation.
19795399 Observational study of gene-disease association. (HuGE Navigator)
18949406 The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.
11871861 The gene for human HCaRG is located on chromosome 8q24.3.

AA Sequence

MSAVGAATPYLHHPGDSHSGRVSFLGAQLPPEVAAMARLLGDLDRSTFRKLLKFVVSSLQGEDCREAVQR      1 - 70
LGVSANLPEEQLGALLAGMHTLLQQALRLPPTSLKPDTFRDQLQELCIPQDLVGDLASVVFGSQRPLLDS     71 - 140
VAQQQGAWLPHVADFRWRVDVAISTSALARSLQPSVLMQLKLSDGSAYRFEVPTAKFQELRYSVALVLKE    141 - 210
MADLEKRCERRLQD                                                            211 - 224
//

Text Mined References (18)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25355947 2015 COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.
24515317 2014 Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair.
23637203 2013 Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.
23563313 2013 CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling.
21921141 2011 HCaRG accelerates tubular repair after ischemic kidney injury.
21778237 2011 COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
21269460 2011 Initial characterization of the human central proteome.
19795399 2009 Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.
18949406 2008 Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression.
15799966 2005 COMMD proteins, a novel family of structural and functional homologs of MURR1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11871861 2002 Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene.
10931946 2000 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
10918053 2000 HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation.