Property Summary

NCBI Gene PubMed Count 25
PubMed Score 38.90
PubTator Score 15.36

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (6)

Disease log2 FC p
hepatocellular carcinoma 1.100 1.7e-04
glioblastoma -1.100 5.7e-07
medulloblastoma, large-cell -1.200 2.7e-03
primitive neuroectodermal tumor -1.100 1.2e-05
diabetes mellitus -1.100 1.1e-03
ovarian cancer 1.800 9.3e-03

 MGI Phenotype (1)

Gene RIF (9)

PMID Text
26260076 study presents 7 additional patients with 4 novel COG6 mutations; genotype-phenotype correlation can be discerned ranging from deep intronic mutations found in Shaheen syndrome as the mildest form to loss-of-function mutations leading to early lethal congenital disorders of glycosylation phenotypes
25264125 The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population.
25197382 Our findings implicate COG6 rs9548934C-->T genotypes and circulating miRNA-1 phenotype in modulating the occurrence and major adverse cardiovascular events of coronary artery disease.
25179963 Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication
23606727 data implicate COG6 in the pathogenesis of a novel hypohidrotic disorder in humans that is distinct from congenital disorders of glycosylation.
23057818 COG6 interaction with SNARE proteins via universal SNARE-binding motif of COG6 is important for Golgi complex intergrity.
22883088 COG6 rs9548934C-->T polymorphism is associated with lower risk of premature coronary artery disease, especially in female subjects and subjects with lower serum lipid levels.
21807881 COG directly and positively regulates endosome-to-TGN retrograde transport by specific and direct interaction with the t-SNARE Stx6 via its Cog6 subunit.
17331980 This paper reports a new congenital disorder caused by mutations in the human COG8 gene and describes the affect this mutation has on the other COG components.

AA Sequence

MAEGSGEVVAVSATGAANGLNNGAGGTSATTCNPLSRKLHKILETRLDNDKEMLEALKALSTFFVENSLR      1 - 70
TRRNLRGDIERKSLAINEEFVSIFKEVKEELESISEDVQAMSNCCQDMTSRLQAAKEQTQDLIVKTTKLQ     71 - 140
SESQKLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLE    141 - 210
IMEQMALLQETAYERLYRWAQSECRTLTQESCDVSPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRG    211 - 280
FIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTTQGVEENIQEVVGHIT    281 - 350
EGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIVGNSATALLTTIEEMHLLSKKIFFNSLSL    351 - 420
HASKLMDKVELPPPDLGPSSALNQTLMLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSAS    421 - 490
NLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRVGLSYIYNTVQQH    491 - 560
KPEQGSLANMPNLDSVTLKAAMVQFDRYLSAPDNLLIPQLNFLLSATVKEQIVKQSTELVCRAYGEVYAA    561 - 630
VMNPINEYKDPENILHRSPQQVQTLLS                                               631 - 657
//

Text Mined References (29)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
26260076 2015 Key features and clinical variability of COG6-CDG.
25264125 2014 Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population.
25231870 2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
25197382 2014 Polymorphism in miRNA-1 target site and circulating miRNA-1 phenotype are associated with the decreased risk and prognosis of coronary artery disease.
25179963 2014 Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication.
24390342 2014 Genetics of rheumatoid arthritis contributes to biology and drug discovery.
23606727 2013 A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency.
23057818 2013 COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
22883088 2012 [Association study on the microRNA-1 target gene polymorphism and the risk of premature coronary artery disease].
21807881 2011 The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport.
21269460 2011 Initial characterization of the human central proteome.
20605848 2010 Fatal outcome due to deficiency of subunit 6 of the conserved oligomeric Golgi complex leading to a new type of congenital disorders of glycosylation.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
18369459 2008 A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17331980 2007 COG8 deficiency causes new congenital disorder of glycosylation type IIh.
17220172 2007 A new inborn error of glycosylation due to a Cog8 deficiency reveals a critical role for the Cog1-Cog8 interaction in COG complex formation.
16051600 2005 Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.
16020545 2005 Subunit architecture of the conserved oligomeric Golgi complex.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057823 2004 The DNA sequence and analysis of human chromosome 13.
15047703 2004 The binary interacting network of the conserved oligomeric Golgi tethering complex.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11980916 2002 Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.
11929878 2002 Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.
11703943 2001 The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic.
10574461 1999 Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.