Tbio COG5 Conserved oligomeric Golgi complex subunit 5

Protein Summary

Description

Required for normal Golgi function. The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9UP83
• A4D0R6
• A4D0R7
• O14555
• O95008
• Q6NUL5
• COG complex subunit 5

Gene Name

• COG5

Ensembl ID

• ENST00000297135
• ENSP00000297135
• ENSG00000164597
• ENST00000347053
• ENSP00000334703
• ENST00000393603
• ENSP00000377228

Symbol

• GOLTC1
• GTC90
• CDG2I
• GTC90
• GOLTC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
microRNA	0.77
virus perturbation	0.76
interacting protein	0.73
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.16   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.16   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0