Tbio CNTN1 Contactin-1

Protein Summary

Description

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q12860
• A8K0H9
• A8K0Y3
• Q12861
• Q14030
• Q7M4P0
• Q8N466

Gene Name

• CNTN1

Ensembl ID

• ENST00000347616
• ENSP00000325660
• ENSG00000018236
• ENST00000348761
• ENSP00000261160
• ENST00000547702
• ENSP00000448004
• ENST00000547849
• ENSP00000448653
• ENST00000551295
• ENSP00000447006

Symbol

• F3
• GP135
• MYPCN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
protein domain	0.85
virus perturbation	0.83
kinase perturbation	0.81
tissue sample	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.94   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 283   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.94   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0