Tbio CNN1 Calponin-1

Protein Summary

Description

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).

Uniprot Accession IDs

• P51911
• B2R868
• B4DUX6
• O00638
• Q15416
• Q8IY93
• Q99438

Gene Name

• CNN1

Ensembl ID

• ENST00000252456
• ENSP00000252456
• ENSG00000130176

Symbol

• SMCC
• Sm-Calp
• HEL-S-14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93
gene perturbation	0.85
kinase perturbation	0.71
small molecule perturbation	0.67
hub protein	0.58

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Calponin-1

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Calponin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.57   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 957   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 176.57   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 957   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0