Tbio CNGB1 Cyclic nucleotide-gated cation channel beta-1

Protein Summary

Description

Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• Q14028
• H3BN09
• O43636
• Q13059
• Q14029
• Q9UMG2

Gene Name

• CNGB1

Ensembl ID

• ENST00000251102
• ENSP00000251102
• ENSG00000070729
• ENST00000311183
• ENSP00000311670
• ENST00000564448
• ENSP00000454633

Symbol

• CNCG2
• CNCG3L
• CNCG4
• RCNC2
• CNG4
• GAR1
• GARP
• RP45
• CNCG2
• CNCG4
• GARP2
• RCNC2
• RCNCb
• CNCG3L
• CNGB1B
• RCNCbeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
cellular component	0.81
biological process	0.74
protein domain	0.58
microRNA	0.57

Protein Classes

DTO Classes

Protein / Ion Channel / Cyclic Nucleotide-gated Cation Channel Family / Cngb1 Subfamily / Cyclic Nucleotide-gated Cation Channel Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.51   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.51   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0