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Tbio
CNBP
Cellular nucleic acid-binding protein

Protein Summary
Description
Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression. This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000422453
  • ENSP00000410619
  • ENSG00000169714
  • ENST00000441626
  • ENSP00000410769
  • ENST00000446936
  • ENSP00000400444
  • ENST00000451728
  • ENSP00000399488
  • ENST00000500450
  • ENSP00000426223
  • ENST00000502976
  • ENSP00000421323
  • ENST00000504813
  • ENSP00000422110

Symbol
  • RNF163
  • ZNF9
  • DM2
  • ZNF9
  • CNBP1
  • PROMM
  • RNF163
  • ZCCHC22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
interacting protein
0.96
virus perturbation
0.85
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.85   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 327.85   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0