Tchem CLK4 Dual specificity protein kinase CLK4

Protein Summary

Description

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HAZ1

Gene Name

• CLK4

Ensembl ID

• ENST00000316308
• ENSP00000316948
• ENSG00000113240

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule	0.98
molecular function	0.94
disease perturbation	0.87
transcription factor binding site profile	0.83
virus perturbation	0.83

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Clk Family / Dual Specificity Protein Kinase Clk4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.53   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.53   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 173

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4