Tchem CLK3 Dual specificity protein kinase CLK3

Protein Summary

Description

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P49761
• D3DW59
• Q53Y48
• Q9BRS3
• Q9BUJ7

Gene Name

• CLK3

Ensembl ID

• ENST00000345005
• ENSP00000344112
• ENSG00000179335
• ENST00000395066
• ENSP00000378505
• ENST00000483723
• ENSP00000431825

Symbol

• PHCLK3
• PHCLK3/152

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
molecular function	0.96
ligand (protein) perturbation	0.83
virus perturbation	0.83
kinase perturbation	0.76

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Clk Family / Dual Specificity Protein Kinase Clk3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.85   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.85   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0