| Tbio | CAP-Gly domain-containing linker protein 1 |
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| periodontitis | 293 | 1.8e-22 |
| Breast cancer | 3578 | 7.1e-10 |
| psoriasis | 6694 | 9.1e-07 |
| Pick disease | 1894 | 1.4e-04 |
| medulloblastoma, large-cell | 6241 | 1.7e-04 |
| posterior fossa group B ependymoma | 416 | 2.0e-04 |
| glioblastoma | 5792 | 3.1e-04 |
| osteosarcoma | 7950 | 5.9e-04 |
| ovarian cancer | 8520 | 1.9e-03 |
| hereditary spastic paraplegia | 318 | 6.7e-03 |
| gastric carcinoma | 807 | 7.8e-03 |
| lung cancer | 4740 | 8.7e-03 |
| sonic hedgehog group medulloblastoma | 467 | 8.9e-03 |
| esophageal adenocarcinoma | 737 | 2.8e-02 |
| spina bifida | 1074 | 3.0e-02 |
| adult high grade glioma | 3801 | 3.7e-02 |
| progressive supranuclear palsy | 676 | 4.0e-02 |
| aldosterone-producing adenoma | 665 | 4.2e-02 |
| Rheumatoid arthritis | 1191 | 4.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Rigid spine muscular dystrophy 1 | 14 | 3.708 | 1.9 |
| Charcot-Marie-Tooth disease axonal type 2L | 5 | 3.514 | 1.8 |
| Neurodegenerative disease | 414 | 3.045 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| lung cancer | -1.600 | 8.7e-03 |
| adult high grade glioma | -1.100 | 3.7e-02 |
| aldosterone-producing adenoma | -1.043 | 4.2e-02 |
| Breast cancer | -1.200 | 7.1e-10 |
| esophageal adenocarcinoma | -1.300 | 2.8e-02 |
| gastric carcinoma | 1.100 | 7.8e-03 |
| glioblastoma | -1.300 | 3.1e-04 |
| hereditary spastic paraplegia | -1.169 | 6.7e-03 |
| medulloblastoma, large-cell | -1.500 | 1.7e-04 |
| osteosarcoma | 1.573 | 5.9e-04 |
| ovarian cancer | 1.600 | 1.9e-03 |
| periodontitis | -1.100 | 1.8e-22 |
| Pick disease | 2.200 | 1.4e-04 |
| posterior fossa group B ependymoma | -1.200 | 2.0e-04 |
| progressive supranuclear palsy | 1.500 | 4.0e-02 |
| psoriasis | -1.400 | 9.1e-07 |
| Rheumatoid arthritis | 1.200 | 4.9e-02 |
| sonic hedgehog group medulloblastoma | -1.200 | 8.9e-03 |
| spina bifida | -1.194 | 3.0e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRVGERVWVNGNK 1 - 70 PGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTT 71 - 140 PASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGER 141 - 210 ELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTK 211 - 280 IGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 281 - 350 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 351 - 420 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARIKELEQSLLFEKTK 421 - 490 ADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE 491 - 560 VTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 561 - 630 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 631 - 700 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATE 701 - 770 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 771 - 840 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 841 - 910 EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 911 - 980 DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 981 - 1050 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1051 - 1120 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1121 - 1190 DEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLR 1191 - 1260 GENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1261 - 1330 VDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMS 1331 - 1400 EDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF 1401 - 1438 //
