Tbio CLCF1 Cardiotrophin-like cytokine factor 1

Protein Summary

Description

Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9UBD9
• B4DNT4
• Q6NZA4

Gene Name

• CLCF1

Ensembl ID

• ENST00000312438
• ENSP00000309338
• ENSG00000175505
• ENST00000533438
• ENSP00000434122

Symbol

• BSF3
• CLC
• NNT1
• CLC
• NR6
• BSF3
• NNT1
• BSF-3
• CISS2
• NNT-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
virus perturbation	0.92
transcription factor binding site profile	0.8
cell type or tissue	0.74
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.2   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.2   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0