| Tbio | Galectin-10 |
Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 3.4e-08 |
| facioscapulohumeral dystrophy | 288 | 7.9e-08 |
| osteosarcoma | 7950 | 2.2e-06 |
| Waldenstrons macroglobulinemia | 765 | 1.9e-03 |
| interstitial cystitis | 2312 | 2.4e-03 |
| uncontrolled asthma | 56 | 3.1e-03 |
| Rhinitis | 54 | 1.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Schizophrenia | 1160 | 0.0 | 1.4 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypereosinophilic syndrome | 71 | 3.981 | 2.0 |
| Galactosemia | 19 | 3.74 | 1.9 |
| Eosinophilic pneumonia | 5 | 3.409 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| facioscapulohumeral dystrophy | 3.600 | 7.9e-08 |
| interstitial cystitis | 4.600 | 2.4e-03 |
| non-small cell lung cancer | -1.804 | 3.4e-08 |
| osteosarcoma | -6.511 | 2.2e-06 |
| Rhinitis | 1.300 | 1.2e-02 |
| uncontrolled asthma | 2.200 | 3.1e-03 |
| Waldenstrons macroglobulinemia | 4.268 | 1.9e-03 |
