Tbio CLASP1 CLIP-associating protein 1

Protein Summary

Description

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q7Z460
• A2RU21
• B7ZLX3
• F5GWS0
• O75118
• Q2KHQ9
• Q5H9P0
• Q8N5B8
• Q9BQT5

Gene Name

• CLASP1

Ensembl ID

• ENST00000263710
• ENSP00000263710
• ENSG00000074054
• ENST00000397587
• ENSP00000380717
• ENST00000409078
• ENSP00000386442
• ENST00000541377
• ENSP00000441625
• ENST00000646274
• ENSP00000496269

Symbol

• KIAA0622
• MAST1
• MAST1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
transcription factor perturbation	0.94
cellular component	0.93
interacting protein	0.93
transcription factor binding site profile	0.9

Protein Classes

PANTHER Classes

Protein / Structural Protein / Clip-associating Protein 1

DTO Classes

Protein / Cellular Structure / Clip-associating Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.19   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.19   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0