| Tbio | Cell death activator CIDE-3 |
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dermatitis, Allergic Contact | 67 | 0.0 | 0.0 |
| Lipodystrophy, Familial Partial | 8 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ductal carcinoma in situ | 1745 | 1.1e-04 |
| invasive ductal carcinoma | 2951 | 2.7e-04 |
| psoriasis | 6694 | 5.0e-04 |
| breast carcinoma | 1638 | 3.1e-03 |
| Atopic dermatitis | 952 | 1.5e-02 |
| fibroadenoma | 559 | 2.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Familial partial lipodystrophy | 12 | 0.0 | 5.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Obesity | 678 | 4.303 | 2.2 |
| Lipodystrophy | 40 | 4.12 | 2.1 |
| Adiposis dolorosa | 2 | 3.27 | 1.6 |
| Fatty liver disease | 103 | 3.082 | 1.5 |
| diabetes mellitus | 1728 | 3.064 | 1.5 |
| Panniculitis | 9 | 3.046 | 1.5 |
| Disease | Target Count |
|---|---|
| LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 5 | 1 |
| Disease | log2 FC | p |
|---|---|---|
| Atopic dermatitis | -1.400 | 1.5e-02 |
| breast carcinoma | -2.500 | 3.1e-03 |
| ductal carcinoma in situ | -4.100 | 1.1e-04 |
| fibroadenoma | -3.400 | 2.0e-02 |
| invasive ductal carcinoma | -4.400 | 2.7e-04 |
| psoriasis | -1.300 | 5.0e-04 |
