Property Summary

NCBI Gene PubMed Count 64
PubMed Score 116.00
PubTator Score 90.94

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (10)

Disease log2 FC p
Multiple myeloma 1.193 1.2e-02
glioblastoma 1.400 6.6e-03
medulloblastoma, large-cell -2.000 8.7e-05
lung cancer -1.200 5.3e-03
group 4 medulloblastoma -1.300 4.8e-05
posterior fossa group B ependymoma 1.200 8.8e-07
subependymal giant cell astrocytoma 1.244 4.5e-02
invasive ductal carcinoma 1.073 3.7e-03
nasopharyngeal carcinoma -1.200 2.2e-05
ovarian cancer 2.200 1.8e-05

Gene RIF (36)

PMID Text
26105795 a large subset of TNBCs depend on CIB1 for cell survival and tumor growth, independent of CIB1 expression levels.
25012820 KIP binding to TRF2 enhances the telomere-binding activity of TRF2, suggesting that KIP acts as a positive regulator of TRF2 function.
24585405 High serum CIB1 levels are associated with pancreatic cancer.s
24550731 these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 mediated signaling involved in its entry
24464679 mRNA and protein expression levels of CIB1 were decreased in the oligoasthenozoospermia patients.CIB1 may be involved in the pathogenesis of oligoasthenozoospermia by the CDK1 signaling pathway.
24011356 we present data that show that CIB1 binds to seven additional alpha-integrin CT peptides, bringing the total number of alpha-integrins that can associate with CIB1 to eight.
23503467 CIB1a is a novel mediator of PKD2-driven carcinogenesis.
22964641 Results indicate that CIB1 is uniquely positioned to regulate PI3K/AKT and MEK/ERK signaling and that simultaneous disruption of these pathways synergistically induces a nuclear GAPDH-dependent cell death.
22547769 The CIB1 and calcineurin expression was increased in AF atrial tissue and was related to the type of AF. This finding suggests that CIB1 may be involved in the pathogenesis of AF in VHD patients.
21857112 CIB1 may be used as a novel prognostic factor and possibly an attractive therapeutic target for hepatocellular carcinoma.
21748785 results suggest that CIB1 positively regulates cell migration and is necessary for the recruitment of FAK to the focal adhesions. Furthermore, CIB1-induced cell migration is dependent on MAP kinase signaling and its function is attenuated by PAK1
21388953 analysis of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain
21215777 CaMy1 via SCG10 couples Ca(2+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain.
20951827 Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20473878 CIB1 may be a potential biomarker and target for therapeutic intervention of breast cancer.
19923078 content of DNA-PKcs was significantly higher in A549 cells than in H1299 cells
19913121 Observational study of gene-disease association. (HuGE Navigator)
19854831 CIB1 interacts with SK1 in a Ca(2+)-dependent manner at the previously identified "calmodulin-binding site" of SK1.
19388079 data identify low affinity (K(d), 10(-2)M) Ca(2+) binding events that influence the structures of the N- and C-terminal extensions of CIB1 under high (300 mM) Ca(2+) crystallization conditions
18989529 Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members.
18627437 The function of CIB1 on InsP3-evoked Ca2+ release from the ER is most likely mediated by its interaction with the InsP3 receptor. Thus, CIB1 seems to be an inhibitor of InsP3-dependent Ca2+ release in vivo.
17516631 communication between the paired EF-hand domains as well as between the N- and C-lobes of CIB1 is distinct from the ancestral proteins calmodulin and troponin C, which might be important for the unique function of CIB1 in numerous biological processes
16825200 Data report the structural characteristics of calcium- and integrin-binding protein 1 in solution and the mechanistic details of its interaction with a synthetic peptide derived from the alphaIIb integrin cytoplasmic domain.
16723353 CIB1 is a ubiquitously expressed activating and inhibiting protein ligand of the InsP(3)R
16418530 CIB1 appears to inhibit integrin activation by competing with talin for binding to alphaIIbbeta3, thus providing a model for tightly controlled regulation of alphaIIbbeta3 activation.
16061695 CIB1 as a key regulator of PAK1 activation and signaling.
15933764 Data indicate that although calmyrin forms stable covalent dimers in vitro, it most probably functions as a monomer in vivo.
15885068 calmyrin may be involved in the pathogenesis of AD.
15574431 crystallographic structure of CIP1, an EF-hand-containing protein
15190070 KIP has a role in telomere length maintenance and regulation
14992593 CIB may exist in multiple structural and metal ion-bound states in vivo which may play a role in its regulation of target proteins such as platelet integrin.
12881299 CIB regulates platelet spreading through the regulation of FAK activation.
12714504 An association between GPIIb/IIIa and calcium- and integrin-binding protein (CIB) is required for the process of platelet spreading.
12023286 describes regions within CIB and alpha(IIb) that interact with one another
11856312 binds NBR1 protein

AA Sequence

MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFK      1 - 70
ERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGE     71 - 140
DTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL                       141 - 191
//

Text Mined References (71)

PMID Year Title
26105795 2015 CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25012820 2014 DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres.
24585405 2014 Profiling of autoantibodies in sera of pancreatic cancer patients.
24550731 2014 CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.
24464679 2014 Calcium- and integrin-binding protein-1 is down-regulated in the sperm of patients with oligoasthenozoospermia : CIB1 expression in patients with oligoasthenozoospermia.
24011356 2013 Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23503467 2014 A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22964641 2013 CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling.
22779914 2012 Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.
22547769 2012 Calcium- and integrin-binding protein-1 and calcineurin are upregulated in the right atrial myocardium of patients with atrial fibrillation.
22283712 2012 Structural basis for the activation of platelet integrin ?IIb?3 by calcium- and integrin-binding protein 1.
21857112 2011 Proteomic identification of CIB1 as a potential diagnostic factor in hepatocellular carcinoma.
21748785 2011 Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling.
21388953 2011 Solution structures of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain.
21264284 2011 Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.
21215777 2011 Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth.
20951827 2011 Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.
20639889 2010 CIB1 is a regulator of pathological cardiac hypertrophy.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20473878 2011 Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
19923078 2009 [Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radiosensitivity].
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19854831 2010 Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1.
19805025 2009 CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1.
19388079 2009 Auxiliary Ca2+ binding sites can influence the structure of CIB1.
19190083 2009 Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.
19054851 2008 Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
18989529 2008 Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members.
18627437 2008 Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3-dependent Ca2+ release in vivo.
17516631 2007 Domain stability and metal-induced folding of calcium- and integrin-binding protein 1.
16825200 2006 The interaction between calcium- and integrin-binding protein 1 and the alphaIIb integrin cytoplasmic domain involves a novel C-terminal displacement mechanism.
16723353 2006 CIB1, a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channel.
16582881 2006 Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.
16418530 2006 CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation.
16061695 2005 Essential role of CIB1 in regulating PAK1 activation and cell migration.
15933764 2005 Calcium-binding calmyrin forms stable covalent dimers in vitro, but in vivo is found in monomeric form.
15885068 2005 The Alzheimer disease-related calcium-binding protein Calmyrin is present in human forebrain with an altered distribution in Alzheimer's as compared to normal ageing brains.
15883187 2005 Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin alphaIIb cytoplasmic domain.
15840829 2005 The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions.
15685448 2005 G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell.
15574431 2005 Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15475008 2004 Calcium binding sequences in calmyrin regulates interaction with presenilin-2.
15231747 2004 A protein interaction framework for human mRNA degradation.
15203218 2004 Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.
15190070 2004 DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase.
14992593 2004 Metal ion binding properties and conformational states of calcium- and integrin-binding protein.
12881299 2003 Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen.
12714504 2003 Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen.
12651910 2003 The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12023286 2002 Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain.
12011095 2002 EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response.
11997098 2002 The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3.
11856312 2002 NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube.
11756406 2002 The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.
11323029 2001 The interaction of the calcium- and integrin-binding protein (CIBP) with the coagulation factor VIII.
11039900 2000 Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.
10826701 2000 Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP).
10822252 Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies.
10523297 1999 The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity.
10477286 1999 Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton.
10366599 1999 A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein.
9852683 1998 Chromosomal assignment of the gene for human DNA-PKcs interacting protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid analysis and fluorescence in situ hybridization.
9372844 1997 Interaction between DNA-dependent protein kinase and a novel protein, KIP.
9030514 1997 Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain.