Tchem CHRNA9 Neuronal acetylcholine receptor subunit alpha-9

Protein Summary

Description

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840). This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9UGM1
• Q14CY7
• Q4W5A2
• Q9NYV2

Gene Name

• CHRNA9

Ensembl ID

• ENST00000310169
• ENSP00000312663
• ENSG00000174343

Symbol

• NACHRA9
• NACHRA9
• HSA243342

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
protein domain	0.85
virus perturbation	0.72
cell type or tissue	0.66
phenotype	0.57

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-9

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-9

Protein / Receptor / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-9

Protein / Receptor / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-9

DTO Classes

Protein / Ion Channel / Neurotransmitter Receptor, Cys Loop, Ligand-gated Ion Channel (Lic) Family / Acetylcholine Receptor Subfamily / Alpha-9/chrna9 Sub-subfamily / Neuronal Acetylcholine Receptor Subunit Alpha-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.29   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.29   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0