| Tbio | Calcineurin B homologous protein 2 |
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 4.2e-07 |
| osteosarcoma | 7950 | 5.8e-07 |
| colon cancer | 1478 | 6.5e-04 |
| active ulcerative colitis | 764 | 1.9e-03 |
| interstitial cystitis | 2312 | 2.3e-03 |
| cutaneous lupus erythematosus | 1057 | 2.6e-03 |
| Atopic dermatitis | 952 | 2.7e-03 |
| head and neck cancer and chronic obstructive pulmonary disease | 239 | 8.0e-03 |
| active Crohn's disease | 922 | 1.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -2.490 | 1.1e-02 |
| active ulcerative colitis | -1.943 | 1.9e-03 |
| Atopic dermatitis | -1.200 | 2.7e-03 |
| colon cancer | -3.900 | 6.5e-04 |
| cutaneous lupus erythematosus | -2.900 | 2.6e-03 |
| head and neck cancer and chronic obstruc... | -2.000 | 8.0e-03 |
| interstitial cystitis | -2.600 | 2.3e-03 |
| osteosarcoma | 1.176 | 5.8e-07 |
| psoriasis | -2.000 | 4.2e-07 |
