Tbio CHCHD6 MICOS complex subunit MIC25

Protein Summary

Description

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Uniprot Accession IDs

• Q9BRQ6
• D6R9U0
• D6RIB4
• H8Y0Y7

Gene Name

• CHCHD6

Ensembl ID

• ENST00000290913
• ENSP00000290913
• ENSG00000159685

Symbol

• CHCM1
• MIC25
• CHCM1
• Mic25
• MICOS25
• PPP1R23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
transcription factor binding site profile	0.64
cell type or tissue	0.62
transcription factor perturbation	0.61
interacting protein	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.08   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.08   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0