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Tbio MICOS complex subunit MIC25

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 31.81
PubTator Score 2.79

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Expression

  Differential Expression (7)

Disease log2 FC p
astrocytic glioma -1.400 1.5e-02
ependymoma -1.300 3.8e-02
atypical teratoid / rhabdoid tumor -1.100 1.9e-04
glioblastoma -1.200 4.8e-04
adult high grade glioma -1.100 3.6e-03
non primary Sjogren syndrome sicca 1.100 2.5e-02
pituitary cancer 1.100 2.4e-06

Synonym

Accession Q9BRQ6 D6R9U0 D6RIB4 H8Y0Y7
Symbols CHCM1
Mic25
PPP1R23

Gene

CHCHD6

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (11)

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 GO Component (3)

 GO Process (2)

 Compartment GO Term (43)

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 HCA RNA Cell Line (56)

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Pathway (1)

Gene RIF (5)

PMID Text
26530328 mitochondria exhibited lower cristae density in CHCHD6-knockout cells. CHCHD6 directly interacted with Sam50.
22228767 CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19240061 Observational study of gene-disease association. (HuGE Navigator)
17624330 anti-mitofilin mAb immunocaptures its target protein in association with six other proteins, metaxins 1 and 2, SAM50, CHCHD3, CHCHD6 and DnaJC11, respectively

AA Sequence 

MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLP      1 - 70
RSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLARE     71 - 140
LESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRD    141 - 210
RPHEVLLCSDLVKAYQRCVSAAHKG                                                 211 - 235
//

Text Mined References (17)

PMID Year Title
26530328 2015 Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
25997101 2015 QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25781180 2015 Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits.
24687277 2014 Uniform nomenclature for the mitochondrial contact site and cristae organizing system.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
22228767 2012 CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
21269460 2011 Initial characterization of the human central proteome.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19389623 2009 Docking motif-guided mapping of the interactome of protein phosphatase-1.
19240061 2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17624330 2007 The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.
16641997 2006 The DNA sequence, annotation and analysis of human chromosome 3.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11329013 2001 Creation of genome-wide protein expression libraries using random activation of gene expression.