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Tdark Cilia- and flagella-associated protein 100

May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.

 Comments

Property Summary

NCBI Gene PubMed Count 5
PubMed Score 4.18
PubTator Score 2.95

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
posterior fossa group B ependymoma 1530 5.4e-10
nasopharyngeal carcinoma 1056 3.8e-07
Disease Target Count Z-score Confidence
Facial paralysis 15 3.0 1.5

Expression

  Differential Expression (2)

Disease log2 FC p
posterior fossa group B ependymoma 3.100 5.4e-10
nasopharyngeal carcinoma -1.400 3.8e-07

Synonym

Accession Q494V2 D3DNA8 Q494V1 Q494V4 Q8N838
Symbols MIA1
CCDC37

Gene

CFAP100

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (8)

 GO Function (1)

 GO Component (3)

 GO Process (3)

 Compartment GO Term (26)

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 HCA RNA Cell Line (18)

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Gene RIF (1)

PMID Text
22011669 We confirmed that the expression of CCDC37 in squamous cell carcinoma is regulated by DNA methylation of its specific promoter region.

AA Sequence 

MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQER      1 - 70
NKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKE     71 - 140
KNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCS    141 - 210
SVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHS    211 - 280
FLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQ    281 - 350
PSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSH    351 - 420
TLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYR    421 - 490
HCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHL    491 - 560
QRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEELLFFFT                       561 - 611
//

Text Mined References (5)

PMID Year Title
23569216 2013 The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility.
22011669 2012 Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.