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Tbio
CES5A
Carboxylesterase 5A

Protein Summary
Description
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isofor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290567
  • ENSP00000290567
  • ENSG00000159398
  • ENST00000319165
  • ENSP00000324271
  • ENST00000518005
  • ENSP00000428571
  • ENST00000521992
  • ENSP00000428864

Symbol
  • CES7
  • CES5
  • CES7
  • CAUXIN
  • CES4C1
  • HEL126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
virus perturbation
0.64
protein domain
0.58
tissue sample
0.5
cell line
0.46


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0