Property Summary

NCBI Gene PubMed Count 12
PubMed Score 9.32
PubTator Score 8.36

Knowledge Summary


No data available


  Differential Expression (4)

Disease log2 FC p
medulloblastoma, large-cell 1.200 8.6e-05
non-small cell lung cancer 1.226 7.6e-08
cystic fibrosis 1.500 4.6e-03
psoriasis 1.700 2.4e-38

Gene RIF (6)

26887952 These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths.
26045466 testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility.
23898208 HIV-1 Tat upregulates the expression of ceramide synthase 3 (CERS3) in human primary T cells
23754960 these data present a novel pathway involved in ARCI development and, moreover, provide the first evidence that CERS3 plays an essential role in human sphingolipid metabolism for the maintenance of epidermal lipid homeostasis.
23549421 Our findings demonstrate that synthesis of very long chain ceramides by CerS3 is a crucial early step for the skin barrier formation and link disorders presenting with congenital ichthyosis to defects in sphingolipid metabolism and lipid architecture.
20304771 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

AA Sequence

EEEEEATKGKEMDCLKNGLRAERHLIPNGQHGH                                         351 - 383

Text Mined References (12)

PMID Year Title
26887952 2016 Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.
26045466 2015 Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors.
23754960 2013 Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans.
23549421 2013 Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length.
22038835 2012 Loss of ceramide synthase 3 causes lethal skin barrier disruption.
20304771 2010 A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
19364519 2009 Ceramide biosynthesis in keratinocyte and its role in skin function.
18308723 2008 Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16572171 2006 Analysis of the DNA sequence and duplication history of human chromosome 15.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.