Tbio CELSR3 Cadherin EGF LAG seven-pass G-type receptor 3

Protein Summary

Description

Receptor that may have an important role in cell/cell signaling during nervous system formation. This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q9NYQ7
• O75092

Gene Name

• CELSR3

Ensembl ID

• ENST00000164024
• ENSP00000164024
• ENSG00000008300

Symbol

• CDHF11
• EGFL1
• FMI1
• KIAA0812
• MEGF2
• FMI1
• EGFL1
• HFMI1
• MEGF2
• ADGRC3
• CDHF11
• RESDA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor binding site profile	0.92
transcription factor perturbation	0.84
kinase perturbation	0.81
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Cadherin Egf Lag Seven-pass G-type Receptor 3

Protein / Cell Adhesion Molecule / Cadherin / Cadherin Egf Lag Seven-pass G-type Receptor 3

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / Cadherin Egf Lag (Celsr) Receptor / Cadherin Egf Lag Seven-pass G-type Receptor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.19   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 293   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.19   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0