Property Summary

NCBI Gene PubMed Count 28
PubMed Score 8.19
PubTator Score 12.90

Knowledge Summary


No data available


  Differential Expression (9)

Disease log2 FC p
Multiple myeloma 1.098 3.3e-02
malignant mesothelioma 1.600 2.4e-06
osteosarcoma -1.161 4.6e-03
glioblastoma 1.900 2.8e-03
adrenocortical carcinoma 1.093 3.4e-03
intraductal papillary-mucinous neoplasm ... 1.400 4.6e-03
sonic hedgehog group medulloblastoma 1.100 1.3e-03
non primary Sjogren syndrome sicca 1.100 2.9e-02
ovarian cancer 1.700 3.4e-05


Accession P53567 B2R946 Q5U052 C/EBP gamma
Symbols GPE1BP


  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 GO Component (2)

Gene RIF (11)

25669928 These findings suggest that CEBPG may play an oncogenic role in BCP-ALL and relies on a mechanism different from CEBPA.
24658403 HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins
24244375 HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways
24244375 HIV-1 Tat-mediated upregulation of CCL5 involves JAK2/3, AKT2/3, p38delta, NF-kappaB (p65/p50), C/EBP alpha/gamma, and AP-1 proteins
23775115 High CEBPG expression correlated with poorer clinical prognoses in several human cancers, and C/EBP gamma depletion decreased proliferation and induced senescence in lung tumor cells.
23160200 CEBPG mediates the myeloid differentiation arrest induced by CEBPA deficiency in acute myeloid leukemia.
22437320 C/EBPgamma positively regulates wound repair both in vitro and in vivo, at least in part, by affecting EGFR signaling.
20237496 Observational study of gene-disease association. (HuGE Navigator)
17893230 CEBPG regulates ERCC5 expression and this regulation is modified by E2F1/YY1 interactions.
16255782 CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals
12618752 Ig/EBP (C/EBPgamma)is constitutively multiubiquitinated & then degraded by the proteasome. Ubiquitination and degradation are suppressed by forming dimers through the leucine zipper domains.

AA Sequence

TTADGDNAGQ                                                                141 - 150

Text Mined References (30)

PMID Year Title
25669928 2015 B-cell precursor acute lymphoblastic leukemia with isolated t(14;19)(q32;q13) abnormality involving the CEBPG gene.
25416956 2014 A proteome-scale map of the human interactome network.
24244375 2013 HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-?B, AP-1, C/EBP? and C/EBP? transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.
23775115 2013 C/EBP? suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBP?.
23160200 2012 C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
22437320 2012 C/EBP? regulates wound repair and EGF receptor signaling.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20102225 2010 Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17893230 2007 CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions.
16255782 2005 CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15833715 2005 C/EBPdelta and C/EBPgamma bind the CCAAT-box in the human beta-globin promoter and modulate the activity of the CACC-box binding protein, EKLF.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12805554 2003 Comprehensive identification of human bZIP interactions with coiled-coil arrays.
12618752 2003 C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12177065 2002 C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters.
8628277 1996 Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.
8089482 1994 Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.
7665092 1995 Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.
7501458 1995 Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators.
1884998 1991 A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro.
1709121 1991 Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1.
1377818 1992 Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma.
1371974 1992 cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.