| Tbio | Chromodomain Y-like protein |
Isoform 3: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672). Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin.
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Small Cell Lung Carcinoma | 41 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Small cell carcinoma of lung | 45 |
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 9.1e-10 |
| malignant mesothelioma | 3232 | 3.5e-06 |
| pediatric high grade glioma | 1064 | 7.5e-05 |
| psoriasis | 6694 | 2.5e-04 |
| sonic hedgehog group medulloblastoma | 467 | 1.9e-03 |
| lung cancer | 4740 | 3.0e-03 |
| spina bifida | 1074 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chronic obstructive pulmonary disease | 184 | 0.0 | 2.2 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Gingival recession | 13 | 3.724 | 1.9 |
| Azoospermia | 110 | 3.205 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| ependymoma | 1.400 | 9.1e-10 |
| lung cancer | 1.200 | 3.0e-03 |
| malignant mesothelioma | 1.100 | 3.5e-06 |
| pediatric high grade glioma | 1.100 | 7.5e-05 |
| psoriasis | -1.400 | 2.5e-04 |
| sonic hedgehog group medulloblastoma | 1.100 | 1.9e-03 |
| spina bifida | -1.390 | 4.3e-02 |
MTFQASHRSAWGKSRKKNWQYEGPTQKLFLKRNNVSAPDGPSDPSISVSSEQSGAQQPPALQVERIVDKR 1 - 70 KNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKESTLTRTNRTSPNNARKQISRS 71 - 140 TNSNFSKTSPKALVIGKDHESKNSQLFAASQKFRKNTAPSLSSRKNMDLAKSGIKILVPKSPVKSRTAVD 141 - 210 GFQSESPEKLDPVEQGQEDTVAPEVAAEKPVGALLGPGAERARMGSRPRIHPLVPQVPGPVTAAMATGLA 211 - 280 VNGKGTSPFMDALTANGTTNIQTSVTGVTASKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQD 281 - 350 GFTHILLSTKSSENNSLNPEVMREVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRES 351 - 420 TKMAEAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMF 421 - 490 PKIMGGASANEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMK 491 - 560 MELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF 561 - 598 //
