| Tbio | Cerebral dopamine neurotrophic factor |
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Comments
| PMID | Text | |
|---|---|---|
| 26149686 | showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers | |
| 25975173 | Results suggest that CDNF treatment selectively enhances long-term memory consolidation | |
| 25511018 | Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease. | |
| 21320571 | Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found. | |
| 19429035 | Study suggests that there is no association between variants in the CDNF gene and cocaine dependence. | |
| 19429035 | Observational study of gene-disease association. (HuGE Navigator) | |
| 19258449 | structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain | |
| 17611540 | expressed in several tissues; might be beneficial for the treatment of Parkinson's disease |
| PMID | Year | Title | |
|---|---|---|---|
| 26149686 | 2015 | The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against ?-Synuclein Oligomers. | |
| 25975173 | 2015 | Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. | |
| 25511018 | 2014 | Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra. | |
| 21320571 | 2011 | Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease. | |
| 19429035 | 2009 | Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. | |
| 19258449 | 2009 | The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. | |
| 18561914 | 2008 | Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. | |
| 17611540 | 2007 | Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15146197 | 2004 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11752456 | 2001 | Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. | |
| 11329013 | 2001 | Creation of genome-wide protein expression libraries using random activation of gene expression. |
