Tchem CDKL1 Cyclin-dependent kinase-like 1

Protein Summary

Description

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases that accumulates primarily in the nucleus. [provided by RefSeq, Nov 2018]

Uniprot Accession IDs

• Q00532
• J3KMW1
• Q2M3A4
• Q6QUA0
• Q8WXQ5

Gene Name

• CDKL1

Ensembl ID

• ENST00000395834
• ENSP00000379176
• ENSG00000100490

Symbol

• P42
• KKIALRE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
protein domain	0.73
tissue sample	0.63
disease perturbation	0.62
histone modification site profile	0.59

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase-like 1

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase-like 1

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdkl Family / Cyclin-dependent Kinase-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 315   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0