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Tchem
CDK9
Cyclin-dependent kinase 9

Protein Summary
Description
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modificatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373264
  • ENSP00000362361
  • ENSG00000136807

Symbol
  • CDC2L4
  • TAK
  • TAK
  • C-2k
  • CTK1
  • CDC2L4
  • PITALRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
0.99
biological process
0.98
protein complex
0.95
pathway
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 595.46   (req: < 5)
Gene RIFs: 163   (req: <= 3)
Antibodies: 503   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 595.46   (req: >= 5)
Gene RIFs: 163   (req: > 3)
Antibodies: 503   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 282
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1