Tbio CDK5R2 Cyclin-dependent kinase 5 activator 2

Protein Summary

Description

Activator of CDK5/TPKII. The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13319
• Q4ZFW6
• CDK5 activator 2

Gene Name

• CDK5R2

Ensembl ID

• ENST00000302625
• ENSP00000304250
• ENSG00000171450

Symbol

• NCK5AI
• P39
• NCK5AI
• p39nck5ai

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.72
disease perturbation	0.68
PubMedID	0.61
transcription factor binding site profile	0.6
biological process	0.56

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-dependent Kinase 5 Activator 2

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cyclin-dependent Kinase 5 Activator 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.8   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0