Tchem | Cyclin-dependent-like kinase 5 |
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Comments
Property Summary
Ligand Count | 38 |
NCBI Gene PubMed Count | 262 |
PubMed Score | 1238.43 |
PubTator Score | 542.82 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Lissencephaly 7 with cerebellar hypoplasia | 1 | 0.0 | 0.0 |
Tauopathies | 3 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
Breast cancer | 3578 | 9.4e-21 |
lung carcinoma | 2843 | 4.3e-20 |
atypical teratoid / rhabdoid tumor | 5112 | 3.3e-09 |
Astrocytoma, Pilocytic | 3081 | 2.9e-08 |
tuberculosis | 2010 | 1.5e-07 |
malignant mesothelioma | 3232 | 6.1e-06 |
lung cancer | 4740 | 6.6e-05 |
adult high grade glioma | 3801 | 6.6e-05 |
medulloblastoma | 720 | 1.3e-04 |
glioblastoma | 5792 | 1.8e-04 |
medulloblastoma, large-cell | 6241 | 5.9e-04 |
astrocytic glioma | 2597 | 2.3e-03 |
invasive ductal carcinoma | 2951 | 3.5e-03 |
ependymoma | 4679 | 8.0e-03 |
Pick disease | 1894 | 1.0e-02 |
oligodendroglioma | 2850 | 1.6e-02 |
colon cancer | 1478 | 4.4e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Neurodegenerative disease | 414 | 0.0 | 4.0 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | -1.500 | 6.6e-05 |
astrocytic glioma | -1.400 | 2.3e-03 |
Astrocytoma, Pilocytic | -1.700 | 2.9e-08 |
atypical teratoid / rhabdoid tumor | -1.600 | 3.3e-09 |
Breast cancer | 1.500 | 9.4e-21 |
colon cancer | 1.200 | 4.4e-02 |
ependymoma | -1.700 | 8.0e-03 |
glioblastoma | -1.300 | 1.8e-04 |
invasive ductal carcinoma | 1.400 | 3.5e-03 |
lung cancer | 1.800 | 6.6e-05 |
lung carcinoma | 1.100 | 4.3e-20 |
malignant mesothelioma | -1.300 | 6.1e-06 |
medulloblastoma | -1.300 | 1.3e-04 |
medulloblastoma, large-cell | -1.300 | 5.9e-04 |
oligodendroglioma | -1.200 | 1.6e-02 |
Pick disease | -1.100 | 1.0e-02 |
tuberculosis | 1.500 | 1.5e-07 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
CHEMBL365855
pIC50 7.60
CHEMBL3775677
pIC50 7.68
CHEMBL3775608
pIC50 7.77
CHEMBL186240
pIC50 7.80
CHEMBL187903
pIC50 7.89
CHEMBL184404
pIC50 7.89
CHEMBL187256
pIC50 7.89
CHEMBL191003
pIC50 7.90
CHEMBL186470
pIC50 7.92
CHEMBL363954
pIC50 8.00
CHEMBL3774932
pIC50 8.05
CHEMBL3775470
pIC50 8.10
CHEMBL364213
pIC50 8.10
CHEMBL384304
pKd 8.13
CHEMBL186898
pIC50 8.16
CHEMBL23254
pIC50 8.22
CHEMBL3775509
pIC50 8.30
CHEMBL3774632
pIC50 8.30
CHEMBL362560
pIC50 8.30
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pIC50 8.30
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVL 1 - 70 HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL 71 - 140 KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDD 141 - 210 QLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEA 211 - 280 LQHPYFSDFCPP 281 - 292 //